A study has uncovered a promising three-lncRNA signature that could improve early diagnosis and treatment strategies for non-metastatic hepatocellular carcinoma. The lncRNAs HEIH, MIAT, and HOTAIR were found to be significantly elevated in cancerous tissues.
Researchers develop a cohesive framework for designing high-performance flexible vdW electronic and optoelectronic systems, exploiting strain engineering to tune physical properties. The approach enables devices with improved mobility, sensitivity, and functionality, including sensing, memory, and computation capabilities.
Researchers at Tohoku University and Indian Institute of Technology Indore developed a Cu14 nanocluster with a single exposed Cu site, exhibiting high ammonia selectivity and production rate. The findings support the creation of efficient metal nanocluster catalysts for green energy production.
Researchers discovered high concentrations of Benzothiazoles in outdoor airport PM10, indicating significant input from airport activities. The findings suggest specific chemical markers for tracing airport non-exhaust emissions into the air.
Researchers found that nanoplastics entered the bloodstream and accumulated in organs within days of ingestion, potentially leading to disorders in nervous and reproductive systems. The particles were primarily expelled through the intestine, but some remained trapped for a long time.
A study of over 10,000 women aged 65 and older found that moderate tea consumption was associated with higher bone mineral density, a key indicator of osteoporosis risk. In contrast, excessive coffee consumption, particularly in those who drink alcohol, may be detrimental to bone health.
Researchers found that adding formic acid to traditional UV-based oxidation systems boosts PFOA defluorination rates from 27% to 89%, leveraging reductive radicals for efficient degradation. Acidic conditions and oxygen-free environments enhance performance.
A new Cochrane review found that free or subsidized school meals slightly improve math achievement and enrolment rates in low- and middle-income countries. School feeding programs also likely contribute to small gains in physical growth indicators, but evidence from high-income countries is limited.
Researchers at the National Institute for Fusion Science used high-precision diagnostic instruments to measure temperature, turbulence, and heat propagation in a plasma. The experiments revealed two types of turbulence: a mediator-type that connects distant regions quickly, and another type that carries heat outward more slowly.
A landmark UK study reveals that around £13 million is spent annually on hospital admissions and post-discharge care for acute heavy menstrual bleeding. The study suggests that many cases can be managed in the community or by outpatient services, reducing the need for expensive hospital admissions.
Teenagers who struggle with their bodies are at risk of developing eating disorders and depression in early adulthood, according to a new study. The research, which followed over 2,000 twins, found that body dissatisfaction at age 16 predicted greater symptoms of mental health issues well into the twenties.
A new study published by the University of Cambridge reveals that medieval Augustinian saints performed 'green-fingered' miracles, such as restoring swampy areas to fertility and healing diseased livestock. The research challenges major assumptions about the Catholic Church's forgotten early history.
A new study identifies genetic variants influencing both addiction risk and lower educational attainment. The researchers found a subset of genetic variants linked to substance use disorders and poorer health outcomes.
A UK-based study found that epilepsy can be a primary cause of death in people with intellectual disabilities, with those from ethnic minorities living in the UK being particularly at risk. The research highlights significant disparities in care and service provision, calling for systemic changes to prevent avoidable deaths.
A systematic review and network meta-analysis of 76 randomised controlled trials found that slow tapering of antidepressants combined with psychological support prevented relapse over the following year to a similar extent as remaining on an antidepressant. This approach could change how coming off antidepressants is managed globally.
A global survey of ECT recipients found that 84% reported childhood adversities, but only 32% had mental health services address these issues. Similarly, 81% reported recent stressors, with only 34% being asked about them.
A new seaweed-based carbon catalyst has been developed that can rapidly break down antibiotic norfloxacin in water without using toxic metals or sulfur chemicals. The catalyst, made from kappa carrageenan and doped with nitrogen and sulfur, shows high specific surface area and degrades antibiotics through non-radical pathways.
A new report highlights the surge in child sexual exploitation and abuse online, with AI-generated material increasing by 1,325% in a year. The WeProtect Global Alliance's Global Threat Assessment 2025 provides a practical tool for technology companies and governments to tackle the crisis.
Researchers developed an AI tool to identify patients with undiagnosed Alzheimer's disease using electronic health records, addressing underdiagnosis and healthcare inequities. The model achieved sensitivity rates of 77-81% across diverse populations, promoting fairness while maintaining high accuracy.
Researchers developed a non-invasive blood test to detect genetic material shed by tumors, which can identify adverse events related to immune checkpoint inhibitor therapy. The test found evidence of multi-organ injury in patients with immune-related adverse events, suggesting that the clinical syndromes may represent only a small frac...
Researchers used satellite data to study the 2025 Myanmar earthquake, which struck along a geologically 'mature' fault. The study found that the energy released by the earthquake was highly focused and came right to the surface, potentially leading to more intense ground shaking near the fault line.
The company's AI tool, RECTIFIER, uses generative AI to screen patients for clinical trial eligibility, significantly outperforming manual screening in accuracy and efficiency. The tool has been shown to more accurately identify eligible patients and reduce the burden of manual chart review in various healthcare settings.
A Montana State University economist's research found that wetland restoration through the Agricultural Conservation Easement Program can reduce ammonia and nitrogen concentrations in local waterways, resulting in decreased costs for communities. This can lead to tangible savings of up to $17,000 per year in smaller rural towns.
A new Mayo Clinic study found that an off-the-shelf dual-antibody therapy generates deep and durable responses in extramedullary multiple myeloma. In a trial of 90 patients, 79% responded to treatment, with nearly two-thirds maintaining disease control at one year.
Researchers used CRISPR technologies to discover previously unannotated DNA stretches in the 'dark genome', which control cell response to mechanical properties of their environment. This work could lead to new therapeutic targets for illnesses involving changes to tissue mechanics, including fibrosis and cancer.
A new mathematical model developed by University of Maryland researchers can help public health officials design effective vaccination and cancer screening policies for HPV-related cancers. The model suggests that expanding vaccine access, particularly to boys, could eliminate the disease in South Korea within 60-70 years.
Researchers developed multimodal models integrating imaging, clinical, and molecular data from TAILORx tissue biorepository for early-stage breast cancer. The models demonstrated enhanced prognostic performance compared to existing methods, highlighting their potential for personalized treatment decision-making.
The Institute for Quantum Innovation aims to accelerate discoveries from research to the real world, driving advancements in energy, national security, health, insurance, logistics, and critical infrastructure. The collaboration will provide best-in-class learning and research opportunities for students and faculty, putting Vanderbilt ...
Researchers in Australia and Aotearoa New Zealand will have expanded open access publishing options through a new three-year agreement. The partnership supports fully open access journals and enables the expansion of AI use in teaching and research.
Researchers have created a new crystalline material with unusual magnetic patterns that could be used for breakthroughs in data storage and quantum technologies. The team used structural frustration to generate complex patterns of spins, leading to the discovery of skyrmion-like spin textures.
Researchers at NYU Abu Dhabi have developed Spheromatrix, a platform that enables tumor models to be grown, frozen and stored for future use in cancer drug testing. The technology is made from specially engineered filter paper patterned to support the growth of tumor spheroids in a controlled manner.
Liu's project aims to translate optoretinography into a sensitive clinical biomarker for retinal disease assessment. The fellowship supports interdisciplinary problem-driven research and translation of new technologies into clinical practice.
The Association for Computing Machinery has named 61 new Distinguished Members, recognized for their contributions to AI for healthcare, data management, human-computer interaction, and other areas. The recipients include experts from top universities, corporations, and research institutions worldwide.
The Fuster Prevention Forum will teach clinicians effective ways to educate children, parents, and educators in their communities on nutrition, physical activity, and emotional well-being. The program aims to create a culture of prevention and promote sustainable, community-based initiatives.
A study of over 3,200 terrestrial mollusk species found that nearly half were described by non-local researchers, highlighting a neocolonial practice. This 'helicopter science' or 'parachute science' harms local researchers and can lead to less robust studies.
Researchers from Brazil confirm the safety and efficacy of Alternanthera littoralis (Joseph's Coat) in reducing inflammation and modulating inflammatory mediators. The study's findings support the plant's medicinal potential and suggest a safety profile at therapeutic doses.
A new study reveals that 16% of teens exposed to both phases of the Russo-Ukrainian war experience PTSD symptoms, while over 10% experience severe depressive symptoms. The study highlights the need for immediate and sustained attention to support Ukrainian youth's mental health needs.
A field experiment on Reddit examines what distinguishes passive from active users, testing interventions to increase participation. The results show that a heated environment can motivate the active minority to comment, while financial incentives and positive feedback increase activity.
Researchers at Ohio State University developed a new approach to immobilize extracellular vesicles in a way that mimics their interactions with tissues. This allows for the study of these particles and their complex interactions with cells, enabling potential applications in disease detection, drug delivery, and biomarker discovery.
A recent study by Tufts University researchers found that locally available foods with low monetary cost can also meet basic nutritional needs with minimal greenhouse gas emission. The study challenged the assumption that climate-friendly healthy eating requires paying more for premium products.
The American Academy of Neurology has issued a new guideline for the management of functional seizures, which are episodes that can look or feel like epilepsy or fainting. The guideline recommends psychological interventions such as cognitive behavioral therapy to increase the likelihood of achieving freedom from functional seizures.
A preliminary study suggests that GLP-1 drugs, used for diabetes and weight loss, may be linked to a lower risk of developing epilepsy. Researchers found an association between the use of these drugs and a reduced risk of epilepsy, with semaglutide showing the strongest correlation.
Recent research articles explore innovative methods for rehabilitating coral reefs, new observations of masquerading behavior in deep-sea squids, the rapid expansion of Sphagnum peat patches across Alaska's North Slope, trade-offs between protected areas and sustainable development goals, and a surprising first-time observation of moth...
Overleaf is introducing a new AI assistant that combines advanced capabilities with its intuitive editor. The tool helps researchers spend less time coding and more time producing high-quality work. The new features are available in Overleaf Labs and provide a research-focused writing assistant and a first-of-its-kind citation reviewer.
Researchers distinguish between medical and community-based approaches to safe supply, proposing a framework for better describing care models. The study aims to inform policy changes and improve access to care, decrease overdoses, and reduce stigma around people who use drugs.
Researchers model Baraitser-Winter syndrome using human brain organoids, finding altered actin genes lead to reduced brain growth and smaller size. The study reveals a single mutation in the cytoskeleton causes disruption in early brain development.
The MicroBooNE collaboration has ruled out the possibility of a light sterile neutrino, a hypothetical particle that had long been speculated as a solution to open questions in particle physics. This result narrows the field of possibilities for explaining one of today's biggest puzzles in neutrino physics.
The study reveals a new method to harness stray laser scatter to cancel out unwanted multi-photon emission, leading to a more efficient and secure single-photon line. This breakthrough could enable the development of advanced quantum computers and communication networks.
A new study by the University at Buffalo found that 12th graders who use two or more cannabis products are more likely to engage in binge drinking. The study suggests that certain modes of cannabis consumption, such as smoking and vaping, may be linked to higher risks of binge drinking.
A comprehensive review reveals AI's potential to predict resistance patterns, optimize antibiotic use, and strengthen early detection and intervention strategies. Machine learning and deep learning algorithms are transforming surveillance, diagnosis, treatment optimization, and drug discovery.
Researchers have identified two previously unknown circoviruses in short-finned pilot whales and orcas from the Caribbean region of the North Atlantic Ocean. The newly discovered viruses, named shofin circovirus and orcin circovirus, represent a distinct clade within the genus Circovirus.
A case report describes a woman with radiation-induced cellular changes in her Pap smear that mimicked cancer recurrence. The study emphasizes the importance of recognizing these changes to prevent misdiagnosis and unnecessary medical procedures.
This innovative module combines vibration-assisted penetration and real-time force sensing to reduce tissue damage and inflammation risks. The device achieves high precision and accuracy, making it suitable for biomedical applications such as neural probe implantation and single-cell puncture.
Researchers have uncovered clues about the ancient Hjortspring boat's origins, including a partial human fingerprint and carbon-dating results indicating it was built in the 4th or 3rd century BCE. The findings suggest that the boat may have come from the Baltic Sea Region, where pine forests were more abundant.
A newly developed wearable sensor uses polarized light to improve photoplethysmography (PPG) signal accuracy across different skin tones. The device splits light into two channels, detecting co-polarized and cross-polarized signals to filter out superficial scattering and capture stronger signals from deeper tissue.
The Universidad Carlos III de Madrid has been awarded two prestigious ERC Consolidator Grants to tackle major challenges in space propulsion and social mobility. The ROCINANTE project will develop more efficient space thrusters, while the EXKIN project will study intergenerational mobility and inequality.
The startup aims to bring human integration and industrial usability to its robots, which will operate safely and efficiently in industrial environments. The company's mission is to create a future where humans and robots collaborate daily.
Researchers at North Carolina State University have identified a novel kirkovirus associated with colitis and small colon impactions in horses. The study found that the virus was present in 24% of horses with colitis, suggesting it may be a potential culprit in some cases.
Researchers conducted two triple-blind human studies using real 5G signals in the 26 GHz band, finding no measurable biological effects on stress responses or brain electrical activity. Cortisol and alpha-amylase levels remained stable across all sampling points, indicating no acute biological changes related to stress.
This review advances thermal depolymerization by merging atomic-scale active site engineering and macromolecular-scale manipulation of polymer transient states. Breakthroughs in operando characterization techniques enable design paradigms for next-generation upcycling systems.
Researchers at USC's Keck School of Medicine have developed a new type of chimeric antigen receptor (CAR) T cell that elicits a more controlled immune response to cancer. The engineered CAR T cells may offer a way to more safely treat blood cancers and reduce the chance of relapse.
The webinar series aims to increase awareness of anti-amyloid treatment benefits and provide practical guidance for clinicians. Early intervention with these therapies can slow AD progression and preserve brain function.
Researchers at ETH Zurich have developed a solution to introduce artificial amino acids into bacteria efficiently. By hijacking a natural transport system, they can produce designer proteins with unnatural amino acids just as efficiently as their natural counterparts. This breakthrough enables the expansion of the 'amino acid toolbox' ...
A new study has revealed that the same bacteria causing bloodstream infections in newborns are also found in their gut, making it possible to identify infected infants through stool samples. The research highlights the need for improved surveillance, targeted antibiotic strategies, and interventions to prevent infections.
A NIH-led study identified key factors driving tumor evolution and influence outcomes in lung cancer, revealing a previously unknown origin of aggressive tumors associated with the ID2 mutational signature linked to LINE-1 reactivation. Major driver gene mutations also influenced tumor evolutionary trajectories.
Researchers developed a 4096-channel flexible brain-machine interface, NeuroCam, to capture large-scale neural signals. The device achieved high spatial resolution and scalability, opening up new opportunities for decoding complex neural activities and advancing neuroengineering applications.
A new study reveals that judiciously applying nitrogen can double dry-season rice yields and reduce reactive nitrogen pollution from rice paddies. The optimized nitrogen rates are found to boost farmer profitability while minimizing ecological and social costs, offering a sustainable solution for rice production in Myanmar.
Researchers identified CXCL10 and IFN-gamma as the major drivers of myocarditis in mRNA-vaccine recipients. The two proteins trigger an inflammatory response that damages heart muscle cells, leading to hospitalizations and deaths in severe cases. Most cases recover swiftly with full heart function retained.
A study published in JAMA Network Open reveals low adherence to cervical cancer screening guidelines among commercially insured US adults, with only 7.3% following recommended guidelines. The findings suggest that guideline confusion and lack of incentives are contributing factors to this issue.
Researchers develop comprehensive method to connect diseases with underlying genetic machinery, revealing intricate gene networks that influence complex traits. The new technique provides actionable insights into how specific genes affect cell functions, shedding light on biological mechanisms and potential therapeutic targets.
A new study has uncovered hidden stories of pollution, gender, and life in industrializing Britain by analyzing bone chemistry and isotopic analysis of skeletal remains from two English towns. The findings reveal that exposure to toxic elements varied significantly across communities, sexes, and social identities.
A new study found that vividly imagining positive encounters with someone can make you like them better and change how information about that person is stored in your brain. The study suggests that imagination can actively shape what we expect and choose, providing a mechanism-level reason for how it influences motivation and choices.
A research team at Nankai University has developed soft, stretchable 'power patches' that can be printed in various shapes and worn on the body to harvest low-grade heat. The patches generate a steady voltage when exposed to a temperature difference, making them suitable for wearable thermocells.
The event brings together industry experts to explore the convergence of agriculture and biotech for resilient food supply, sustainable protein sources, and open-access technology. Tufts University's Center for Cellular Agriculture is positioned at the forefront of food sustainability research and innovation.
A new framework demonstrates that urban watersheds release most ammonium through baseflow linked to leaking sewer systems, while agricultural regions shift seasonally between groundwater-dominated nitrate transport and storm-driven dissolved organic nitrogen pulses. Effective nitrogen management requires recognizing where pollution ori...
Researchers have identified a new immune function of human M cells, which can process and present gluten antigens, suggesting a potential link to celiac disease. This discovery sheds light on gut immunity and may support future research into celiac disease diagnosis or treatment.
Research from the University of Notre Dame finds that retail investors' buzz can lead to lower future returns, while institutional investors' attention acts as an early signal for higher returns. The study also reveals a bottom-up approach measuring individual stock attention works better than top-down approaches.
A study analyzing resharing behavior on X (formerly Twitter) shows that different expressed emotions unfold in the aftermath of celebrity suicides, with disgust being the most contagious emotion. The findings emphasize the need for emotion-specific approaches to both theoretical modeling and practical intervention in online environments.
A survey of 4,000 Chinese, Indian, Japanese, and US citizens found that people were more supportive of climate policies in their own country if they believed other countries were also taking action. The study's findings suggest that reciprocity plays a significant role in shaping public opinions on climate policy.
A new study found that adults hospitalized with RSV often struggle with breathlessness, reduced ability to perform everyday activities, and lower quality of life six to 12 months after their hospitalization. The study also showed that younger adults can experience serious RSV infections requiring hospitalization, similar to older adults.
Researchers developed a strategy to regulate the coordination environment of CeO2-x via indium doping, mitigating vacancy defect issues and enhancing photocatalytic CO2 conversion. The introduced In dopants form complexes that suppress unstable vacancy clusters, improving stability and catalytic activity.
The field of quantum structured light has transformed the way we communicate, measure and process information by combining quantum information with spatial and temporal structures of light. This technology enables simpler and faster circuits for quantum computing, as well as improved resolution techniques in imaging and metrology.
Tiny particles can coordinate motion and internal rhythms to exhibit complex collective behavior, similar to biological systems. The swarmalator model has potential applications in autonomous robotics and explores the emergence of complex dynamics from simple interactions.
A new species of Brachycephalus, a tiny pumpkin toadlet, has been discovered in the Serra do Quiriri mountains of southern Brazil. The discovery underscores the importance of conservation efforts in these fragile ecosystems.
The Singapore-MIT Alliance has launched a new research center to develop the world's first wearable ultrasound imaging system, enabling real-time monitoring of chronic conditions like hypertension and heart failure. The system will be validated through clinical trials at Tan Tock Seng Hospital.
A recent study sheds light on the spatial patterns of denitrification and anammox along a 3,500 km latitudinal gradient, highlighting their contributions to global nitrogen cycling. The research found that denitrification rates declined with soil depth, while anammox contributed more significantly in riparian bulk soils.
New research from the University of Texas at Austin finds that knowledge scouts who work across multiple divisions are less effective in launching successful projects. The study highlights the challenges of managing knowledge scouts and recommends companies be more strategic in rotating them across projects and time.
The Amazon is shifting to a hotter, drier climate with more intense droughts, stressing trees and increasing mortality rates. By 2100, hot drought conditions could occur up to 150 days per year, affecting tree species that are vulnerable to heat stress.
A Stanford Medicine-led study reveals that a signaling pathway controls the immune response, allowing researchers to potentially treat various diseases. The research focuses on peripheral immune tolerance, which prevents inappropriate attacks on healthy tissue.
Researchers will leverage genetic diversity and advanced phenotyping to understand sorghum's stress resilience, linking genotype to phenotype through genomics and gene editing. The project aims to develop crops that thrive in stressful environments, informing engineering and breeding strategies for future climates.
Researchers have successfully grown high-quality single crystals of Bi1/2Na1/2TiO3-based materials, exhibiting exceptional piezoelectric performance. The new approach facilitates record-breaking piezoelectricity in the BNT family, with a coefficient of 662 pC/N.
A Japanese study discovered dog ownership strengthens community ties through neighborhood interactions. The study compared dog owners with friends and acquaintances, finding a significant difference in social connections.
Researchers develop an integrated pipeline to analyze and visualize NHANES dental caries data, identifying age-driven heterogeneity and novel associations between caries status, environmental factors, and disease markers. The study demonstrates the value of integrating machine learning with large-scale observational data for deeper ins...
A light-based modulation tool has been developed to treat Huntington's disease by modulating brain plasticity. The optogenetic tool allows for precise control of cAMP signalling in astrocytes, enhancing synaptic plasticity and revealing alterations in the disease. This breakthrough opens new avenues for targeted therapies.
New seismic data reveals north-south horizontal compression as the regional stress field, consistent with both thrust and strike-slip faulting. The study proposes a tectonic model explaining megathrust earthquakes and mountain uplift through low-angle subduction of the Moho and flat-ramp geometry of the Indian plate.
A new AI method using aerial imagery can reliably identify aspen trees and standing dead trees, crucial indicators of forest biodiversity. The technique has been proven effective in all seasons and can be scaled up for monitoring forest environments.
Scientists have observed a swirling vortex in spacetime caused by a rapidly rotating black hole, confirming predictions made by Einstein more than a century ago. The team detected rhythmic changes in X-ray and radio signals from the event, showing that the disk and jet were wobbling in unison every 20 days.
Researchers developed a novel heterostructured titanium matrix composite with exceptional mechanical performance from room temperature to elevated temperatures. The composite balances strength and ductility, overcoming the traditional trade-off, for aerospace and high-temperature applications.
A new USF study found that tour boats and swimmers routinely violate Mexico's whale shark tourism rules, even when waters are less crowded. The research, based on drone footage from 2016 and 2022, suggests that the world's busiest whale-shark destination is struggling to manage demand, putting vulnerable animals at risk.
A study found that lung microbiomes play a significant role in pneumonia, with patients having oral-like pneumotypes more likely to recover. The researchers identified four distinct microbial patterns, or 'pneumotypes,' associated with different types of pneumonia.
Researchers uncover activation of neurotransmitter networks from the brainstem to cortical regions that aid recovery of consciousness after brain injuries. Therapies targeting these networks may improve patient outcomes for disorders of consciousness.
The International Linked Clinical Trials Program aims to change that by supporting and facilitating clinical trials of potentially disease-modifying treatments. Over 6,800 people with Parkinson's have participated in these trials, and approximately 40% of prioritized drugs have been approved for clinical trials.
A study analyzed 679 honey samples from Italy and found that 98% contained at least one bee pathogen. This analysis may provide clues to bees' health, highlighting the need for further research on bee health.
A recent study identifies pyrroline-5-carboxylate synthase (P5CS) as a key driver of metabolic fatty liver disease. P5CS upregulation impairs mitochondrial fatty acid oxidation, leading to hepatic lipid accumulation.
A framework has been developed to calculate fair distribution of the remaining greenhouse gas budget among European regions. The 'Equal Transition Opportunity Production-Based Allocation' (ETOPA) mechanism takes into account regional economic structures and risks in the transition to a climate-neutral economy.
A large study found that a family history of cardiometabolic diseases increases the risk of progressive heart damage in adolescents, with increased glucose levels partly explaining this association. The study suggests that early intervention and healthy lifestyle habits can help prevent premature heart damage in children.
A team of researchers emphasizes the need for an intelligent observation network to track and forecast tropical cyclones. By combining unmanned aerial, surface, and underwater vehicles, they aim to create a dynamic observation network across the atmosphere, ocean surface, and water column.
Casey Taft, a BU professor, has been awarded the Barbara Thompson Excellence in Research on Military and Veteran Families Award for his work on preventing intimate partner violence. His randomized controlled trial found that couples-based programs can prevent IPV on military installations.
A targeted treatment approach significantly reduces moderate and severe acute kidney injury after major surgery in high-risk patients identified by biomarkers. The study shows that a closely monitored set of clinical measures provides effective protection in the first hours after surgery.
Researchers at the University of Surrey have developed a new method to produce flexible perovskite solar cells using single-walled carbon nanotubes (SWCNTs), achieving high power conversion efficiency and stability.
A large-scale study found that individuals living in neighborhoods with high climate vulnerability indexes face a significantly higher risk of developing Type 2 diabetes over seven years. The association remained strong even after accounting for personal health and lifestyle factors.
A study published in The Journal of Finance and Data Science shows that integrating credit and debit data enhances the ability to predict credit card delinquency. By analyzing transaction patterns, the model identifies distinct behavioral segments with different risk profiles.
Waskyra, an ex vivo gene therapy, offers new hope for patients with Wiskott-Aldrich syndrome by reducing severe bleeding events and serious infections. The FDA approval confirms Fondazione Telethon's excellence in rare genetic disease research.
A study published in JAMA Network Open found that older adults with chronic kidney disease or cerebrovascular disease are at double the risk for developing neuroinvasive West Nile virus infection, which can lead to paralysis and death. The study identified several risk factors, including male sex, immune suppressants, and multiple scle...
A recent study analyzed Apollo-era samples to understand how space weathering affects lunar surface materials and their far-ultraviolet reflectance. The research provided valuable insights into the evolution of the lunar surface, enabling better interpretation of remote sensing data from lunar missions.
Researchers discovered that stone tool production in the African rainforest during the Late Stone Age remained relatively constant over a period of 5,000 years. The findings from Pahon Cave in modern-day Gabon indicate that there were no specific cultural associations with this practice.
A new robotic design uses vine-like structures to lift and grasp a variety of objects, including humans, with a gentler approach. The robot can snake around obstacles, squeeze through tight spaces, and even secure itself in a closed loop to create a sling.
Researchers will examine protein stability mechanisms in Thermus thermophilus to advance treatments for diseases such as Alzheimer's, ALS, and cancer. The team will explore the structure of Rieske proteins and their role in energy production to understand how to restore stability.
A memristor-based accelerator accelerates compressed sensing by 11 times through hardware-software co-optimization, achieving near-software accuracy and overcoming hardware non-idealities. The approach uses a 128Kb memristor chip with computing-in-memory architecture to eliminate data movement bottleneck.
A new AI-driven framework reimagines chemical risk assessment by merging high-throughput screening, AI-enabled toxicity mapping, and quantitative in vitro–to–in vivo risk modeling. This unified approach enables rapid identification of hazardous chemicals and prediction of risk thresholds.
Researchers have identified a novel role of DDAH1 in regulating hepatic lipid metabolism during fasting. Studies revealed that DDAH1 promotes lipid accumulation by increasing fatty acid uptake and inhibiting lipid droplet degradation, highlighting the complex context-dependent nature of metabolic regulators.
Researchers at UCLA have developed a new method for creating thorium-based nuclear clocks using an electroplating technique. This breakthrough could lead to smaller, more efficient nuclear clocks that can be used in navigation systems, including satellite-free navigation and submarine navigation.
Using GLP-1 receptor agonists may lower the risk of vertebral compression fractures and related surgical interventions in people with type 2 diabetes. The study suggests that these medications have a bone-protective effect, offering benefits for patients.
A team of scientists simulated high-pressure conditions and found that onion-like layering in iron alloys can explain seismic anomalies in the Earth's inner core. This discovery suggests a compositional gradient with increasing core depth, linking anisotropy to chemical stratification.
Researchers discovered a fingerprint in the tar used to build the Hjortspring boat, believed to be from an ancient seafarer. The find provides a direct link to the attackers who used the boat over 2,000 years ago.
A recent study found that home-delivered groceries can significantly improve blood sugar control among adults with type 2 diabetes who experience food insecurity. The program provided culturally relevant, medically tailored groceries and education materials, leading to a clinically meaningful reduction in hemoglobin A1c levels.
A new study published in Nature found that contraception and castration increase life expectancy in both males and females. In males, castration extends lifespan, while in females, various forms of sterilization are associated with increased life expectancy due to reduced energetic costs of pregnancy and lactation.
A University of Kansas scholar argues that decades of reform efforts have not improved education, instead trying to fix past problems. The new book proposes a focus on personalized learning and AI to customize education for each individual.
Researchers used AI to identify a new viral surface protein that triggers the production of neutralizing antibodies, offering a breakthrough for developing effective vaccines and antibody therapies. The discovery could also provide insights into treating smallpox, a related virus posing a bioterrorism risk.
A SETI Institute team monitored pulsar PSR J0332+5434 for 10 months to study its radio signal twinkling as it passes through gas between the star and Earth. The team observed slow, significant changes in the twinkling pattern over time, which can help distinguish human-made radio signals from signals from other star systems.
A new study describes a three-hit metabolic signaling model that reframes autism as a treatable disorder of cellular communication and energy metabolism. The model suggests that up to half of all autism cases might be prevented or reduced with prenatal and early-life interventions.
Insilico Medicine's Chemistry42 platform enables the efficient discovery of a potent, oral CBLB inhibitor with low toxicity risks and favorable ADME/PK profiles. The compound demonstrates strong in vitro activity and improved metabolic stability in mouse, rat, and dog models.
Scientists from Mass General Brigham and the Broad Institute have identified a genetic modifier for Friedreich’s ataxia, suggesting a potential treatment strategy. By understanding how cells can bypass the need for frataxin, researchers have discovered that reducing FDX2 levels can restore iron sulfur cluster synthesis and cell health.
Researchers developed a manure-integrated nitrogen management strategy that rebalances soil microbes to reduce N₂O emissions while maintaining high crop yields. The approach improved soil quality and enriched key N₂O-reducing microbes, leading to lower greenhouse gas emissions.
Research by Politecnico di Milano finds that even a small percentage of individuals who don't follow health measures can significantly increase the infection peak and strain healthcare facilities. The study emphasizes the need to monitor and adapt public health strategies to individual urban contexts, making interventions more effective.
New research using earthquake and satellite data reveals the Iberian Peninsula is rotating clockwise due to collision between Eurasia and Africa plates. The study provides insights into geodynamic processes and deformation fields in the region.
Researchers found systematic plant imagery in ancient Halafian pottery with precise symmetry and numerical sequences, suggesting early farming villages had sophisticated mathematical thinking about dividing space and quantities. The study contributes to ethnomathematics, identifying mathematical knowledge embedded in cultural expression.
A new Danish study reveals that social inequities in survival after atrial fibrillation have remained unchanged over the past 20 years. Individuals with low income, education, and social relationships live significantly shorter lives than those with high-income backgrounds.
A new study found that carrying rare archaic versions of human-specific DNA changes, such as the SSH2 variant, does not necessarily lead to noticeable consequences. However, some variants like TKTL1 showed no extreme differences in brain structure or cognitive function despite previous dramatic effects in lab-based experiments.
A new study used deep learning and large-scale computer simulations to identify structural differences in synthetic cannabinoid molecules that cause them to bind to human brain receptors differently from classical cannabinoids. Researchers found that these substances often trigger the beta arrestin pathway, leading to more severe psych...
A study published in Science Advances found that unusually large particles of wildfire smoke had a significant cooling effect on the region they were observed in, increasing outgoing radiation by 30-36% compared to smaller smoke particles. This effect has not been included in current climate models.
Researchers at University of California San Diego School of Medicine discovered that immune cells can slow fat breakdown when exposed to physiological stressors, helping early humans preserve energy stores. This finding provides new insight into the underlying metabolism of obesity and other metabolic disorders.
A new concept, tethered resilience, challenges the traditional 'move' or 'stay' dichotomy in climate migration. Individuals and families are drawn to alternative strategies that balance economic, social, and cultural factors. This approach recognizes the importance of social infrastructure and networks in enabling adaptation and future...
A study found that duckweed effectively suppresses HONO and NOₓ emissions but intensifies N₂O and NH₃ losses, posing environmental trade-offs. Duckweed improves nitrogen retention and may enhance nitrogen-use efficiency, but its use raises concerns about greenhouse gas emissions.
A new AI model has been developed to improve the accuracy of recurrence risk stratification in hormone receptor-positive, HER2-negative breast cancer. The model, called ICM+, uses a combination of clinical, molecular, and histopathological data to provide better prognostic information about cancer recurrence risk out to 15 years.
Researchers use nano-phases to create strong and tough materials by controlling the interface between nano-phases and Ti matrix. The optimal configurations include network and laminated structures, which effectively increase toughness and prevent catastrophic failure.
Researchers at MIT have identified three clusters of pragmatic skills that are based on the same kinds of inferences and may have similar underlying neural processes. These skills include interpreting social conventions, understanding physical world knowledge, and distinguishing between tones to convey emphasis or emotion.
Professor Sarah Bailey received an award for her career-long work promoting openness and transparency around animal research. She has championed openness, openly discussing her research with animals since the 2000s, and led the University's Openness Strategy to implement the Concordat's commitments.
Researchers at Florida Atlantic University have developed a deep learning model that detects and evaluates Alzheimer's disease (AD) and frontotemporal dementia (FTD) using EEG brainwave analysis. The model achieved over 90% accuracy in distinguishing individuals with dementia from cognitively normal participants.
This study introduces a carrier-free PDR nanoassembly with a tumor-suppressing peptide, pH-sensitive daunorubicin prodrug, and siRNA targeting the LILRB4 gene, achieving targeted therapy of acute myeloid leukemia. The combination treatment significantly enhances cytotoxicity and anti-leukemia effects.
Scientists at Northwestern University have developed the fastest test yet for diagnosing hepatitis C virus, delivering results in just 15 minutes – up to 75% faster than current rapid tests. The highly accurate diagnostic could revolutionize HCV care by improving diagnosis and accelerating treatment uptake.
Researchers at SwRI and Trinity University are working on a new prodrug to mitigate ischemia/reperfusion injury (IRI), which causes permanent cellular and tissue damage. The team aims to protect against IRI by targeting protein misfolding during cellular stress.
A recent study mapped the evolutionary history of Asia-Pacific Balanophora species, revealing its retained plastids despite losing photosynthetic genes. This allows it to survive entirely as a parasite on specific tree roots, with some species producing seeds without fertilization.
A study suggests that one in two individuals arrested and detained in London may have undiagnosed attention-deficit/hyperactivity disorder (ADHD), while one in 20 may have undiagnosed autism. Screening for neurodivergence could enable better support for vulnerable individuals.
The phase III lidERA trial found that giredestrant improved invasive disease-free survival compared to standard-of-care endocrine therapy. Patients who received giredestrant were 30% less likely to develop invasive disease progression and had a clinically meaningful superiority to currently established endocrine agents.
A new platform integrates magnetic actuation with electrophysiological sensing for high-fidelity, multisite monitoring on dynamic ex vivo tissue surfaces. The soft electrode platform successfully recorded stable signals from cardiac tissue and demonstrated excellent motion control and stretchability.
This study reveals two key aspects of intracontinental orogeny: independence from active plate boundaries and control by continental weak zones. Intracontinental orgens are formed through reactivation of tectonic weak zones, involving dual dynamic mechanisms.
Research from King's College London found that theobromine in dark chocolate is linked to lower biological age. The study tested blood-based markers of biological ageing and found a correlation between theobromine levels and reduced biological age.
For patients with HR-positive, HER2-negative advanced breast cancers who have received endocrine therapy, sacituzumab govitecan-hziy offers comparable progression-free survival rates as standard chemotherapy. The study also found higher response rates and longer response durations for patients treated with sacituzumab govitecan-hziy.
The study refines the 3-PG model by adding a carbon storage pool, allowing it to account for the 'carry-over effect' in tree growth. The updated model achieves stronger agreement with observations and improves predictions of annual variations in tree-ring widths.
Cholera-causing bacteria show substantial genetic diversity and widespread multi-drug resistance to commonly used antibiotics in Africa. A new study analyzed genomic data from 104 isolates across Cote d'Ivoire, Ghana, Zambia, and South Africa, highlighting the urgent need for antimicrobial stewardship.
The addition of tucatinib to first-line maintenance therapy with trastuzumab and pertuzumab delayed disease progression in HER2-positive metastatic breast cancer patients, particularly those with brain metastasis. This delay allowed for prolonged time off chemotherapy and maintained disease control.
Researchers have successfully detected the interaction of neutrinos with carbon atoms in a vast underground detector, marking a breakthrough in understanding stellar processes, nuclear fusion, and the universe. The observation uses a unique 'delayed coincidence' method to separate real neutrino interactions from background noise.
The SWIFTT project presents a hybrid seminar to showcase its platform that helps foresters detect and prevent insect outbreaks, analyse windthrow and fire damage. The event features live demos and presentations from the project team, highlighting the platform's benefits for sustainable forest management.
Researchers have developed the Joint Open Genome and Omics Platform 1.0 (JoGo 1.0), which organizes human gene types into four levels based on global frequency. The database catalogs 19,194 human genes with a novel naming system, enabling secure integration of sensitive datasets and linking each gene type to public resources.
Researchers at TUM have developed a method to boost oxidase biosensor accuracy from 50% to 99%, paving the way for new uses in personalized medicine, AI-driven healthcare, and agriculture. This breakthrough could enable on-site adjustments to fertilization, reducing environmental impact.
Researchers developed a simple mechanochemical strategy to modify hexagonal boron nitride flakes using liquid metal, achieving high-efficiency EMW absorption and thermal conductivity in a single composite. The optimized composites exhibit excellent performance in electromagnetic wave attenuation and heat dissipation.
A review of scientific literature reveals that artificial beaver dams can make waterways more resilient to climate change, increasing water storage and enhancing flood-plain connectivity. The practice has shown promise in improving fish habitat and contributing to fish-population growth.
Researchers found that thinning adjusts competition, maintaining forest productivity over time. Thinning levels the playing field, weakening large trees' dominance and giving smaller ones a chance to catch up.
Research reveals beech trees adjust roots to short-term changes in soil moisture, improving drought readiness and survival in fluctuating environments. Fine root traits vary more in upper 10 cm of soil due to nutrient availability.
A team of scientists has developed a novel Tb3+-doped glass scintillator that exhibits zero-thermal-quenching luminescence and excellent scintillating performance. The material shows improved thermal stability and high X-ray absorption capacity, making it suitable for use in extreme scenarios.
Researchers have identified two proteins that allow cancer cells to evade destruction by brain immune cells, known as microglia. By removing these proteins, microglia play a key role in eliminating cancer cells during the early stage of their arrival in the brain.
A new study by the University of Zurich suggests that Uranus and Neptune may be more rocky than icy, challenging their classification as ice giants. The researchers developed a unique simulation process to model the planets' interiors, which found that the two planets could have either water-rich or rock-rich compositions.
A new oral endocrine therapy, giredestrant, has been shown to significantly lower the risk of breast cancer recurrence in early-stage HR-positive/HER2-negative patients. In a large clinical trial, patients treated with giredestrant were 30% less likely to have invasive disease recur or progress.
Researchers developed a hybrid estimator that uses probability-based sampling to work directly with available data, generating reliable estimates for forest attributes. The method achieved a sampling precision of over 90% and was comparable in efficiency to conventional model-based methods using superior Sentinel-2 data.
The Global Virus Network has appointed eight distinguished leaders to its Board of Directors, including experts in virology, public health, and communications. The new board members aim to strengthen the network's mission to advance collaboration, foster innovation, and ensure global preparedness for viral threats.
Anode degradation in PEM water electrolyzers arises from chemical, electrochemical, mechanical, and impurity-driven processes. Advanced diagnostics and mechanism-informed lifetime models are needed to develop durable and cost-effective systems.
New research reveals heightened anxiety and declining optimism among young Americans, who perceive risk everywhere they turn due to factors like Covid-19 lockdowns and school shootings. Gen Z is increasingly cynical about changing the world, viewing politics and protests with skepticism.
Research suggests that co-infections such as Epstein-Barr virus and tuberculosis may contribute to long COVID symptoms. These infections could leave the immune system compromised, triggering persistent symptoms. The study's findings offer new lines of investigation into effective treatments for long COVID.
Scientists at Michigan Medicine have developed machine learning models that can analyze blood samples for biomarkers to detect ALS earlier and predict disease severity. The models show promising results, with predictions accurate up to 91% in some cases, and could lead to improved diagnostic accuracy and treatment options.
Hammock technology originated from indigenous cultures in the Atlantic world, according to a study at Binghamton University. The practice was later adopted by European colonists, who incorporated it into their daily lives.
A recent study published in JAMA found that initiating resuscitation of preterm infants with fraction of inspired oxygen levels of 0.6 versus 0.3 did not affect the risk of death or brain injury by 36 weeks' corrected gestational age.
A team of researchers at Waseda University has discovered a new correlation between spins, orbitals, and lattice distortions in spinel-type compounds. Magnetic ordering can trigger Jahn-Teller distortions through spin-orbit coupling.
Researchers found that a mitochondrial protein called COX7RP increases healthy lifespan in mice by improving its mitochondrial energy efficiency. The study also showed improved glucose homeostasis, healthier lipid profiles, enhanced muscle endurance, and lower fat accumulation in the liver.
Jeonbuk National University researchers have developed a novel, eco-friendly, and photo-switchable smart adhesive using biomass-derived materials. The adhesive demonstrates reversible light-controlled adhesion and retains over 90% of its original strength after repeated usage cycles.
A new species of ancient sea cow has been discovered in Qatar, revealing that sea cows have shaped the Arabian Gulf's seagrass ecosystems for over 20 million years. The fossil site, Al Maszhabiya, yielded more than 170 different locations containing sea cow fossils.
Residents at a Japanese squat sustain autonomy through collaborative maintenance, fostering safety and inclusion. Simple spatial interventions enable diverse residents to coexist, challenging common assumptions on urban planning.
Researchers developed a novel bioelectronic material that transforms from a rigid film to a soft, tissue-like interface upon hydration, enabling seamless integration with living tissues. The device, called THIN, has been shown to record biological signals with high fidelity and stability in animal experiments.
A new study published in the Journal of the American Heart Association has found that women with uterine fibroids are at an elevated risk of heart disease. The research, which analyzed data from over 450,000 women, suggests that fibroids may serve as a marker for identifying women at increased cardiovascular risk.
A new study found that dual users who couldn't stop smoking were more likely to reduce their smoking rate and chemicals in cigarette smoke than unsuccessful quitters. Vaping can also help smokers quit by reducing urges to smoke, allowing them to gradually wean off nicotine.
The IPK research team has developed a new statistical method to analyze gene interactions that contribute to heterosis, resulting in more robust and productive plants. The hQTL-ODS method quickly and accurately identifies relevant loci contributing to heterosis in wheat, potentially accelerating yield increases.
Researchers have developed a new test that uses microbes to determine the age of termite droppings, allowing for rapid on-site infestation assessments. The study found that the amount of DNA from E. coli bacteria in the pellets decreases significantly over time, with a nearly 190-fold drop by the 12-month mark.
A team led by ICE-CSIC analyzed C-type asteroids and carbon-rich minor bodies to assess their viability for resource extraction. The study supports the idea that these asteroids can serve as crucial material sources, but mining undifferentiated asteroids is still far from viable.
A team of astronomers detected with precision two huge tails of gas surrounding the ultra-hot Jupiter WASP-121b using the James Webb Space Telescope. The continuous observation revealed a trailing tail pushed back by radiation and a leading tail pulled towards the star, covering over three times the distance between planet and star.
Researchers tracked children from Wales to find that rates of mental ill health among young people have been rising. By 2023, one in five young people had accessed specialist NHS child and adolescent mental health services before their 18th birthday.
A recent study found that TikTok videos about gout are often misleading, inconsistent, or inaccurate. Gout is a painful inflammatory arthritis caused by high urate in the blood, and there are persistent gaps in awareness among patients and the public.
Researchers have linked the vanishing of specific heats at absolute zero to the second law of thermodynamics, completing a 100-year-old problem. The study provides a 'classical' thermodynamic explanation for the phenomenon without requiring quantum physics.
A subset of depressed individuals with chronic, low-grade inflammation may benefit from anti-inflammatory treatment, according to a systematic review and meta-analysis. The study found that anti-inflammatory medications significantly reduced depressive symptom severity and anhedonia in these patients.
Research found that anxiety symptoms reduce circulatory NK cells and sub-populations, while insomnia symptoms decrease total NK cells. This could lead to impaired immune function and increased disease susceptibility.
Researchers found that all Balanophora plants have an extremely reduced plastid genome, showing that even though they abandon photosynthesis, the plastid is still vital to their metabolism. Asexual reproduction likely evolved repeatedly in the group, with some species colonizing islands without fertilization.