Researchers developed a novel fluorescent nanosensor to detect IPA, an emerging biomarker linked to gut health and disease. The sensor offers rapid detection within minutes, distinguishing IPA from closely related metabolites, enabling accurate measurement even in complex biological environments.
Bacteria like Enterococcus faecalis release lactic acid in wounds, suppressing immune cells and preventing them from fighting infections. This creates an environment where other bacteria can take hold, leading to persistent and hard-to-treat wound infections.
Researchers developed a rapid and non-destructive method to monitor iron flux in mesenchymal stromal cells (MSCs) using micromagnetic resonance relaxometry (µMRR). This breakthrough enables real-time insights into MSC's ability to form quality cartilage tissue, paving the way for more consistent manufacturing of MSC-based therapy.
A new study by SMART has identified a strong statistical association between global air connectivity and patterns of multinational corporations' investments. The research found that few layovers meant more subsidiaries, with cities having better flight connections to influential hubs outperforming those with less-connected destinations.
Researchers developed a new AI control system that allows soft robots to learn a broad set of motions once and adapt instantly to changing conditions without retraining. The system combines structural learning with real-time adaptiveness, making it suitable for diverse tasks and environments.
The Singapore-MIT Alliance has launched a new research center to develop the world's first wearable ultrasound imaging system, enabling real-time monitoring of chronic conditions like hypertension and heart failure. The system will be validated through clinical trials at Tan Tock Seng Hospital.
Researchers at SMART Alliance for Research and Technology developed a powerful tool to scan thousands of biological samples and detect transfer ribonucleic acid (tRNA) modifications, which help control cell growth and response to diseases. The tool opens up new possibilities for disease research, diagnostics, and treatment development.
A new device, BLIPI, provides real-time insights into newborns' immune responses, enabling early detection of severe inflammatory conditions and timely interventions. The device requires only 0.05 ml of blood and delivers results within 15 minutes.
Researchers developed a universal nanosensor to detect indole-3-acetic acid (IAA) in living plants, providing real-time insights into plant health and stress response. The sensor enables accurate measurements without genetic modification or chlorophyll interference.
The Singapore-MIT Alliance for Research and Technology has launched the Wafer-scale Integrated Sensing Devices based on Optoelectronic Metasurfaces (WISDOM) research group, focusing on developing ultra-thin sensing devices for machines to perceive depth and spatial detail like human vision. This multi-million-dollar program aims to adv...
A new method using UV light and machine learning can detect microbial contamination in cell cultures, providing a quicker yes/no assessment within 30 minutes. This technology aims to reduce the time spent on sterility tests, making it crucial for life-saving treatments.
Researchers developed a first-of-its-kind nanosensor capable of detecting Fe(II) and Fe(III) in living plants with high spatial and temporal resolution. This innovation enables real-time non-destructive iron tracking, optimizing plant nutrient management and improving crop health.
A new COF sensor can detect pH changes in plant xylem tissues, providing early warning of drought stress up to 48 hours before traditional methods. This technology enables timely detection and management of drought stress, optimizing crop production and yield.
Researchers developed a novel method to enhance the efficacy of MSC-based therapy for articular cartilage repair by adding ascorbic acid during MSC expansion. The addition improved chondrogenic differentiation, reduced cell heterogeneity, and showed a robust shift in metabolic profile.
A study by Singapore-MIT Alliance for Research and Technology found that installing EVCS boosted spending at nearby establishments by 1.4% in 2019, leading to an overall increase of USD 6.7 million. Strategically placed EVCS also stimulated consumer spending in underprivileged areas, creating potential catalysts for economic growth.
A recent study reveals that a cellular process called transfer Ribonucleic acid (tRNA) modification influences the malaria parasite’s ability to develop resistance. This breakthrough discovery could help researchers develop new drugs to combat resistance and better tools for studying RNA modifications.
SMART researchers develop a nanosensor that selectively detects salicylic acid in live plants, vital for stress response. The sensor combines sensors for H₂O₂ and salicylic acid, enabling simultaneous monitoring of plant hormones and aiding in early diagnoses to improve crop resilience.
Researchers at SMART and NTU Singapore have developed a method to accurately measure the amount of carbon stored in bogs, which aids peatland restoration efforts. The new method uses satellite data and reduces the need for on-site sampling, making it possible to describe and compare the shape of bogs worldwide.
A novel contamination-detection method enables faster and safer T-cell therapy production, reducing the risk for patients and speeding up treatment. The method uses cutting-edge technology to identify harmful microorganisms within 24 hours.
A novel stress signalling system has been discovered by SMART researchers, enabling bacteria cells to adapt and survive against the immune system and certain antibiotics. The breakthrough discovery of RlmN as a stress sensor may lead to the development of new therapies to combat antimicrobial resistance.
SMART researchers have discovered a novel combination therapy using rifaximin and clarithromycin to treat antibiotic-resistant Mycobacterium abscessus infections. The study found that rifaximin potentiates clarithromycin against M. abscessus, increasing its sensitivity and effectiveness in killing the bacteria.
Researchers have developed a microneedle-based drug delivery technique for plants, which can precisely deliver controlled amounts of agrochemicals to specific plant tissues. This method has the potential to improve crop quality and disease management while minimizing resource wastage and environmental contamination.
Researchers develop a novel combination therapy using mitoxantrone and vancomycin to treat vancomycin-resistant Enterococcus faecalis (VRE) infections. The therapy stimulates the host immune system, accelerating wound healing and killing bacteria more effectively.
Scientists have created a non-destructive method to detect and differentiate gibberellins, a class of plant hormones crucial for growth. The new nanosensors can identify changes in GA levels across various plant species, enabling early interventions against salinity stress.
A team of scientists from SMART and NTU Singapore has developed a rapid point-of-care test kit that measures antibodies against SARS-COV-2 and its variants, offering personalized vaccination strategies. The test kit requires just 10 minutes to show results and has up to 93% accuracy.
Researchers developed a new quantitative RT-qPCR assay to detect and quantify the Omicron variant of SARS-CoV-2 in wastewater. The assay revealed that Omicron displaced Delta as the dominant variant within just 3 weeks in an Italian population.
Recent advancements in non-destructive sensors enable real-time monitoring of plant health, allowing for prompt adjustment of environmental conditions to augment crop productivity. The sensors convert plant signals into digital signals, establishing direct communication between plants and growers.
Researchers from CAMP have identified a secreted metabolite biomarker, nicotinic acid to nicotinamide ratio, to detect microbial contaminations in human cell therapy products. This method enables early-stage detection of microbial contaminants and differentiates between live and dead bacteria.
SMART researchers identified a novel phage lysin, Abp013, with promising antimicrobial ability against Acinetobacter baumannii and Klebsiella pneumoniae. The study demonstrated Abp013's ability to effectively target complex bacterial environments and could advance treatment methods for multidrug-resistant Gram-negative pathogens.
Researchers from Singapore-MIT Alliance for Research and Technology (SMART) have discovered a way to perform 'general inverse design' with high accuracy. This breakthrough enables the creation of materials with specific characteristics and properties, paving the way for revolutionizing materials science and industrial applications.
Researchers from SMART and TLL have developed a rapid Raman spectroscopy-based method to detect and quantify early bacterial infection in crops. This method enables non-invasive early diagnosis, which is crucial for plant disease management and agricultural productivity.
A new test can determine the presence of SARS-CoV-2 neutralising antibodies within 10 minutes, allowing for larger-scale screening and mass monitoring. The rapid cellulose pull-down viral neutralisation test has been developed using protein engineering technology and offers quick results with high accuracy.
SMART researchers have discovered a practical method to overcome current challenges in the manufacture of indium gallium nitride (InGaN) LEDs with considerably higher indium concentration. The new approach uses intrinsic defects in semiconducting materials to form quantum dots that emit long-wavelength light.
Researchers from SMART and collaborators have developed the first nanosensor to detect synthetic auxin plant hormones, transforming the screening process. The sensors enable real-time monitoring of plants' response to compounds like herbicides without causing damage.
Researchers develop open-source molecular detection method to track B.1.1.7 (Alpha) variant in wastewater, providing actionable community-level information for health authorities. The breakthrough expands utility of wastewater surveillance beyond SARS-CoV-2 testing.
Researchers developed RADICA, a molecular rapid testing methodology for detecting viral nucleic acids in 40-60 minutes. The method has been tested on SARS-CoV-2 synthetic DNA/RNA and Epstein-Barr virus and shows high sensitivity and specificity.
A Singapore-based study found that competition between autonomous mobility services and public transit can lead to increased profits, system efficiency, and benefits for the public. However, it may also result in uneven social costs, such as higher travel costs or longer travel times, especially for vulnerable groups.
Researchers have discovered a new way to control light emission from materials by stacking films at a twist angle, enabling efficient and systematic control of optical properties. The discovery has significant implications for applications in medicine, environmental technologies, and information systems.
A new synthetic framework, TB-ResNet, combines discrete choice models and deep neural networks to improve individual decision-making analysis in travel behavior research. The framework has been proven to be highly predictive, interpretable, and robust.
The study reveals indium atoms are randomly distributed in low-indium content InGaN and partially phase-separate in higher-indium content material. The findings advance understanding of atomic microstructure and its effect on LED performance, enabling future research to optimize compositional fluctuations.
The study found that ridesharing companies increased road congestion in the US, reducing public transport ridership by nearly 9%. Easy access to ridesharing discouraged commuters from using greener alternatives.
Researchers developed a novel label-free DLD assay to profile host inflammatory responses, providing faster, more accurate assessments than existing methods. The new technology can rapidly identify patients with severe immune responses, enabling timely intervention and improving patient outcomes.
Emerging technologies like plant nanosensors and Raman spectroscopy provide rapid, non-destructive insights into plant health and hormonal signalling. These species-independent tools bridge the gap between lab and field applications, offering new opportunities for plant science research.
Researchers have designed a portable device that can rapidly detect plant stress, including nitrogen deficiency, drought, heat, and light stress. The device uses a Raman leaf-clip sensor to probe the chemistry of leaves, allowing for early diagnosis and real-time monitoring of plant health.
Scientists from SMART DiSTAP have engineered a novel type of plant nanobionic optical sensor that can detect and monitor arsenic levels in the belowground environment. This non-destructive approach enables plants to serve as self-powered detectors of arsenic, marking a significant upgrade over conventional methods.
Researchers at Singapore-MIT Alliance for Research and Technology (SMART) have developed a method to produce customisable engineered lysins that can selectively kill specific bacteria while leaving others unharmed. This discovery presents a promising alternative to antibiotics for treating existing drug-resistant bacteria.
Researchers from SMART and TLL discovered a way to detect shade avoidance syndrome (SAS) in plants within hours using Raman spectroscopy, enabling farmers to intervene timely and improve crop yield. The method can be widely applied across various plant species and crops.
A new gelatin-based microcarrier offers significantly higher harvest rates of cells grown with over 90% compared to traditional standards. The microcarrier facilitates expansion of mesenchymal stromal cells used to treat various ailments, including heart attacks and immune system rejection.
SMART researchers have discovered a new way to manufacture human red blood cells that cuts the culture time by half compared to existing methods. The new protocol stores cultured cells in liquid nitrogen for 11 days and produces RBCs within 11 days.
A team at SMART has found that exposing bacteria to hydrogen sulfide can increase antimicrobial sensitivity in bacteria that do not produce H2S, potentially providing a breakthrough in treating drug-resistant infections. The study suggests that the results may be applicable to all bacteria that do not naturally produce H2S.