A new study shows that autologous stem cell transplant can improve nearly all measures for two years following treatment in patients with refractory juvenile systemic sclerosis. The procedure significantly reduces disease severity and improves skin thickness, intestinal symptoms, and lung function, offering a life-saving intervention f...
A recent study led by Duke-NUS Medical School found that prior maternal dengue immunity substantially increases the risk of severe birth defects induced by Zika virus infection during pregnancy. Pregnant mothers with pre-existing dengue antibodies are more likely to experience microcephaly and brain damage in their foetuses after Zika ...
Researchers have found that halophilic fungi can restructure their cell walls to withstand extremely salty conditions, minimizing water loss and maintaining structure. This discovery could lead to the development of new technologies harnessing these microbes for industrial processes.
The study found that Ryugu and CIs share a common genetic heritage, but the asteroid's Cr isotopes exhibit anomalies that could be caused by water-driven processes. These anomalies are thought to have arisen from the physicochemical fractionation of presolar nanoparticles and secondary minerals.
Researchers at UC Irvine have identified a critical gene for muscle repair and regeneration, enabling the creation of muscle in the lab that can support human stem cells. The discovery has immense implications for treating various chronic muscle disorders and injuries, including rotator cuff tears and Duchenne Muscular Dystrophy.
Researchers have shrunk a mode-locked laser to the size of an optical chip using a novel integrated platform. The device generates ultrashort pulses with high peak power and coherence properties.
A multinational study of almost one million individuals found a strong association between exposure to radiation from CT scans in young people and an increased risk of blood cancers. The study confirms that the benefits of computed tomography outweigh the risks, but emphasizes the need for strict radiological protection measures, parti...
New studies presented at the American College of Allergy, Asthma and Immunology Annual Scientific Meeting highlight the dangers of excess mold on individuals with asthma. Effective methods for getting rid of mold and airborne allergens include HEPA filters, activated carbon filters, and UV-based technology.
Researchers at the University of Sydney have developed a new technique using liquid metals to replace energy-intensive chemical engineering processes. The method reduces greenhouse gas emissions by up to 15% and enables the production of high-energy fuels like propylene, crucial for various industries.
A new study reveals a disturbing trend of increased short-duration extreme precipitation over mountainous regions in Southwest China, exacerbating climate change impacts. The research finds that these events are more frequent and intense than total precipitation, posing significant risks to lives and ecosystems.
Researchers found that breast cancer cells rely on vitamin B5 to grow and survive. In a study published in Nature Metabolism, scientists discovered that limiting vitamin B5 intake slowed the growth of breast cancer tumours in mice.
A new study finds that people with antibodies to common foods like dairy and peanuts are at a higher risk of cardiovascular-related death. The research suggests that these subtle immune responses may lead to inflammation and contribute to heart disease over time.
Researchers have successfully used a specially formulated toothpaste for Oral Mucosal Immunotherapy (OMIT) to desensitize adults with peanut allergies. The study showed that 100% of participants consistently tolerated the highest dose without severe reactions, and 97% adhered to treatment.
Scientists at Nagoya University have discovered a reliable cancer marker, stromal cell-derived factor 4 (SDF-4), that detects gastric cancer with high accuracy. The protein is found in high levels even in patients with stage I gastric cancer, suggesting its potential for early detection.
A study found that language difficulties lead to underdiagnosis of allergic conditions like asthma and eczema in children who speak a language other than English. A case report highlights the risks of pharmacy translation software interfering with prescription filling, causing delays in securing life-saving medications.
A team of researchers developed synthetic enzymes that can control the behavior of the signaling protein Vg1, which plays a key role in vertebrate embryonic development. The study uses zebrafish to investigate how Vg1 is formed and found that it must undergo additional processing before it can be activated.
New data from the James Webb Space Telescope reveals a surge in oxygen content within 500-700 million years after the Big Bang. This early appearance of oxygen suggests that life may have appeared sooner than previously thought.
A review of 15 years' worth of data found that prenatal vitamin D supplementation reduced rates of asthma and wheezing in children compared to standard prenatal multivitamin. Vitamin D levels during pregnancy were associated with a 50% reduction in asthma and wheezing.
A study tracked skin temperature in 600 participants for six months, finding that individual differences were more significant than sex-based variations. The team used wearable devices to monitor skin temperature and found patterns consistent with menstrual cycles in women.
The American Federation for Aging Research (AFAR) and the Glenn Foundation for Medical Research have awarded ten one-year fellowships to advance research on aging biology and geroscience. The fellowships provide $75,000 in research support to postdoctoral fellows studying basic mechanisms of aging.
Researchers analyzed data from over 420,000 participants across 41 countries and found no link between left-handedness and improved spatial skills. The study used a video game to measure navigational abilities and confirmed that factors like age, gender, and education do not influence hand preference and spatial ability.
Researchers identified a novel bacterial protein, MceF, that can prolong cell longevity by acting directly on mitochondria. The discovery could lead to new treatments for diseases relating to mitochondrial dysfunction, such as cancer and auto-immune disorders.
A team of researchers has developed a novel experimental system to simultaneously measure the mechanical properties and internal structure of rubber-like materials. The study found that strain within these materials is non-uniform, depending on the shape and size of composite particles.
A study by Cornell University found pesticides, herbicides, and fungicides in managed honeybee hives in New York, posing a risk to bee health and the environment. The chemicals, including acaricides and neonics, were detected in nearly all samples, highlighting the need for better protection of pollinators.
A recent study found that 72% of eczema patients experienced poor mental health symptoms for 1-10 days within the past month. Additionally, 35% reported never discussing their mental health with their allergist and 57% were never asked about it.
A novel computer simulation program 'iBridge' was developed at KAIST to predict gene targets for efficient production of valuable compounds in microbial cell factories. The system successfully established E. coli strains capable of producing three high-demand compounds, including panthenol and nylon components.
Scientists successfully created a live-birth chimeric monkey with a high contribution of human embryonic stem cells, breaking the record for successful chimerism in nonhuman primates. The study showcases the potential for using ESCs to generate complex gene-modified models.
A new study published in BMJ Mental Health reveals that people with severe mental health issues are almost twice as likely to experience multimorbidity, a combination of chronic diseases. The research emphasizes the urgent need for a comprehensive and integrated approach to address this critical issue.
Recent research focuses on improving CO2 reduction with acidic electrolyte to enhance carbon efficiency and energy efficiency. Approaches include adding alkali cations, surface decoration, nanostructuring, and electronic structure modulation to promote CO2 reduction while suppressing H+ reduction.
Researchers at Oak Ridge National Laboratory used quantum biology and artificial intelligence to sharpen the CRISPR Cas9 genome editing tool, improving its efficiency on microbes. The new model revealed key features about nucleotides that enable better guide RNA selection.
Researchers found that mothers increase egg size when they have more female helpers to feed their chicks. The study suggests that helpers allow mothers to invest more in offspring at the egg stage by lightening maternal workloads at the chick-feeding stage.
Two cases report flaxseed as an allergen causing severe reactions, including facial rashes and contact dermatitis. Flaxseed is increasingly used in baked goods, cereals, and oil paints, highlighting the need for awareness about its potential to trigger allergic reactions.
A systematic review found that climate change-related concerns are linked to less positive attitudes towards reproduction and a desire for fewer children or none at all. The study identified four key factors: uncertainty about the future of an unborn child, environmentalist views on overpopulation and overconsumption, meeting family su...
A new USC study reveals that variants of the autism-linked gene SYNGAP1 can disrupt early brain development in the cortex, a region involved in higher-order cognitive functions. The research found that disease-causing variants of SYNGAP1 alter the cells' cytoskeletons and lead to disorganized neural circuits.
Researchers tracked endangered thick-billed parrots using solar-powered satellite transmitters, revealing new critical habitat and migratory routes. Less than 20% of the newly identified habitat is protected from timber industry, highlighting the urgent need for conservation efforts.
Scientists from Tokyo Medical and Dental University created a synthetic polymer biomaterial that mimics the pancreatic adenocarcinoma microenvironment, enabling them to identify potential therapeutic targets. The study successfully recapitulates the complex interactions between cancer stem cells and their niche.
Researchers discovered narrow-spectrum Wnt signaling inhibitors can suppress breast cancer tumors and reduce chemo-resistant cells in mice. The treatment, derived from a bacterial toxin, targets specific receptors to minimize bone density side effects.
Researchers create CREATS method for imaging polymerization reactions at single-monomer resolution, revealing the sequence of monomers in copolymers. This allows for fine-tuning of material properties, such as stiffness or flexibility, and provides a guiding principle for designing tailored materials.
The PhRMA Foundation awarded two $500,000 Frontier Awards to researchers William Padula and Surachat Ngorsuraches for their patient-centered value assessment models. Their studies will advance the field of value assessment by applying theoretical models in a real-world context and engaging with patients to ensure their voices are inclu...
A group of 35 scientists calls out conflicts of interest in global plastic treaty negotiations, which have hindered timely action on health and environmental issues. They recommend implementing guidelines to prevent industry influence on the UN's Science Policy Panel on chemicals, citing past examples of pollution protection dilution.
The US has seen a significant increase in wildfire risk, especially in the wildland-urban interface, where houses and vegetation are close proximity. Over 55,000 homes have been lost due to rapid increases in wildfires and new housing expansion in fire-prone areas.
A Mayo Clinic study found patients with lower extremity lymphedema had twice the risk of developing skin cancer, including basal cell carcinomas and squamous cell carcinomas. Regular skin cancer screenings are crucial for these patients as early detection is critical.
A recent study suggests that umbilical cord milking is a safe procedure for preterm infants born after 28 weeks, reducing delay and risk of bleeding. The technique involves gently squeezing the cord to push blood into the newborn's abdomen, allowing for faster response times for infants in need of respiratory support.
Patients with post–COVID-19 chemosensory alterations experience improved recovery of smell function over a 3-year period. Taste dysfunction shows lower frequency and faster recovery compared to smell dysfunction.
A COVID Moonshot Consortium has made history by developing a potent SARS-CoV-2 antiviral lead compound through an unprecedented, crowdsourced approach. The project leveraged machine learning and high-throughput structural biology to identify novel compounds with excellent antiviral activity.
A new study found that mixed forests with four species have the highest carbon stocks relative to monocultures, increasing above ground carbon stocks by at least 70%. The results demonstrate the potential of diversification in planted forests to enhance carbon storage and support biodiversity.
A Pitt University study found that individuals with higher education levels are less likely to experience cardiovascular disease events later in life. On average, those with less than a high school education were 1.4-1.7 times more likely to have a heart attack or stroke compared to college graduates.
Researchers at Kanazawa University found that genetic alterations underlie the dual function of activins in colorectal cancer. Mutations in genes such as Kras and Trp53 can promote tumor progression while also suppressing it, highlighting the complex role of TGF-ß signaling.
A new five-year research project combines AI, virology, and ecology to anticipate future SARS-CoV-2 strains that could pass between animals and people. The team will use artificial intelligence to predict variants and assess risk of spillover from people to wildlife.
Scientists analyzed body fluids from firefighters after rigorous training to understand the effects of intense physical exercise on the body. They found a decrease in inflammatory signals, which can improve breathing, but also increase vulnerability to viral respiratory infections.
The research team led by Michal Hocek successfully pushes the boundaries of DNA structure and function. They demonstrate that heavily modified double helices are stable enough to be used in medicine, mimicking natural molecules with therapeutic potential.
A new method developed by Caltech's Alireza Marandi enables the creation of ultrafast mode-locked lasers on photonic chips, opening up opportunities for compact and affordable ultrafast photonic technologies. The breakthrough could lead to significant advancements in fields like frequency metrology and precision sensing.
Research reveals that lightning ignitions account for 77% of burned areas in intact extratropical forests, which store vast quantities of carbon. Climate change is projected to increase lightning frequency, posing a significant threat to these forests and the planet's carbon storage.
A study published in mSystems found that mice fed a broccoli sprout diet had milder disease symptoms and richer gut microbial communities compared to those not exposed. The researchers suggest that broccoli sprouts could be used as a treatment strategy for patients with IBD.
A team of researchers at the University of Liège has observed a glow in the night sky over Mars using the UVIS-NOMAD instrument on board the Trace Gas Orbiter satellite. This detection provides new insights into the Martian upper atmosphere and its variations throughout the year.
A new study has identified a brain connectivity variate that predicts psychiatric disorders in adolescents. The finding provides evidence for a transdiagnostic brain-based measure underlying individual differences in developing psychiatric disorders in early adolescence.
Research by the University of Bern reveals that poison dart frog personality traits impact mating success, clutch numbers, and offspring survival. These traits are present in tadpoles and remain stable after metamorphosis.
Regenstrief researchers and experts will address key issues in medical informatics at the 2023 AMIA Annual Symposium. The event features a wide range of scientific sessions on topics such as translational bioinformatics, clinical research informatics, and public health informatics.
The 2023 AAAS Kavli Science Journalism Awards recognized outstanding reporting on the impact of scientific racism, habitat restoration, and climate change. The winners included Ashley Smart and Ilan Goodman for their in-depth pieces on these topics.
The researchers propose a hybrid organic–inorganic gas sensor design that enhances gas sensing performance while maintaining sensing speed. The proposed design outperforms conventional sensors in terms of chemical sensitivity to NO2, showcasing impressive durability and higher potential for long-term installation.