Researchers distinguish between medical and community-based approaches to safe supply, proposing a framework for better describing care models. The study aims to inform policy changes and improve access to care, decrease overdoses, and reduce stigma around people who use drugs.
A molecule capable of opening the 'shell' of HIV allows specific antibodies to trigger a cytotoxic reaction, facilitating the elimination of infected cells. The compound, CJF-III-288, modifies the HIV envelope protein structure, making it detectable and vulnerable to the immune system.
Researchers investigate whether combining fostemsavir with antiretroviral therapy can lower 'bad' antibodies that damage CD4 cells. The trial aims to test if this treatment reduces cardiovascular problems in people living with HIV. Participants will undergo cardiac CT scans to measure coronary plaque progression.
A nationwide app called CHAMPS aims to support safer cannabis consumption among young adults who've experienced a psychotic episode. The pilot study found the app to be well-regarded and can be integrated into real clinical environments.
Astrocytes, a type of brain cell, are sensitive to early-life stress and affect physical activity levels in mice. This study found that astrocyte morphology changes can be a marker of dysfunction and may contribute to the development of depression in humans.
A team of researchers from CRCHUM has identified a set of biomarkers in blood samples that could help diagnose Parkinson's disease. The study found that immune cells in the blood were activated and overexpressed genes associated with stress responses in patients with Parkinson's, forming a unique genetic signature.
Researchers at CRCHUM have discovered a crucial biomarker, miR-423-5p microRNA, to predict kidney function and diagnose chronic renal failure. The breakthrough could lead to early diagnosis, targeted approaches, and improved treatment options for millions of patients worldwide.
Researchers at CRCHUM used single-cell RNA sequencing to study guinea pig pre-implantation development, finding striking similarities with early human embryogenesis. The discovery opens new possibilities for understanding women's infertility and developing therapeutics for healthy pregnancy.
Researchers at the University of Montreal Hospital Research Centre discovered that sister cells in mouse embryos can communicate through a stable cytoplasmic bridge, leading to coordinated cell death. This mechanism may help eliminate defective or unneeded cells, improving fertility and developmental processes.
Researchers at Université de Montréal's CRCHUM discovered that inhibiting a key brain enzyme can reduce body weight and improve physical activity in mice. The study suggests that targeting specific neuronal pathways in the brain could be crucial for fighting obesity and metabolic disorders.
Researchers at the University of Montreal Hospital Research Centre have discovered that metformin can help deplete and eliminate viral reservoirs in people living with HIV. Metformin inhibits the mTOR molecule, slowing down HIV replication and reducing chronic inflammation.
A recent study found that Quebec's drug-related mortality rates increased over time, peaking in 2020, due to the contamination of the drug market. Fentanyl and new synthetic opioids are on track to become the most commonly detected substances in opioid poisoning deaths.
A new meta-analysis published in eClinicalMedicine found that individuals with sickle cell disease or the sickle cell trait are more likely to die from COVID-19 compared to the general population. The study analyzed data from over 1,900 patients with sickle cell disease and 8,700 carriers of the sickle cell trait.
Researchers have developed magnet-guided microrobots that can target and treat liver tumors using an MRI device. The robots are guided by a magnetic field and use gravity to navigate to the tumor, preserving healthy cells.
Scientists identify a link between HIV's gp120 protein and chronic inflammation, leading to premature aging and comorbidities. A clinical trial aims to test the effect of Fostemsavir on reducing cardiovascular diseases and improving quality of life for women living with HIV.
A global fertility crisis affects one in six couples, with half the time originating from men. Researchers highlight the need for targeted treatments and improved diagnoses, citing lifestyle factors such as hormone-disrupting chemicals, poor diet, stress, and smoking as contributing causes.
A Canadian research team has identified the locations of HIV reservoirs in the body, revealing that they are concentrated in the spleen and lymph nodes. The discovery provides a potential window of opportunity for targeting these reservoirs with future therapies.
Researchers identified a molecule that allows HIV to hide in reservoirs within CD4+ T lymphocytes. The aryl hydrocarbon receptor protein plays a crucial role in viral latency and has shown potential as a good therapeutic target.
Researchers have discovered molecules in 3,000 diabetic patients that could help predict and monitor disease progression. The study identified 20 biomarkers associated with rapid disease progression, including a protein called NogoR.
Researchers successfully isolated infectious SARS-CoV-2 particles from hospital air samples collected over a year ago, demonstrating the presence of viable virus particles in aerosols. This breakthrough provides new insights into airborne transmission and informs the development of preventive strategies.
Researchers at the University of Montreal Hospital Research Centre identified two bacterial strains that can either increase or decrease the risk of intestinal leakage after surgery. Modifying patients' gut microbiota before surgery may reduce postoperative complications and improve recovery.
Researchers have discovered that HIV creates reservoirs as early as the first days of infection, hiding and persisting during antiretroviral therapy. This finding is a major obstacle to curing HIV, but it also offers new opportunities for treatment development.
Scientists at the CRCHUM have identified a protective probiotic for ALS, Lacticaseibacillus rhamnosus HA-114, that prevents neurodegeneration in the C. elegans worm model. The probiotic helps reduce motor disorders and restore balance to impaired energy metabolism, leading to a decrease in neurodegeneration.
Researchers discovered that expressing Vpu in infected cells makes them more difficult for non-neutralizing antibodies to target, allowing the virus to evade the immune system. The study provides valuable insights into developing effective vaccines against HIV-1.
A pan-Canadian study found that prescribing buprenorphine-naloxone at home is as effective as traditional methadone treatment in reducing opioid use. The flexible model of care offers improved access and autonomy for individuals with opioid use disorder. With over 270 participants, the OPTIMA study suggests a new approach to treating t...
Researchers at CRCHUM discover that cell division in mouse embryos occurs asymmetrically, with cytokinesis primarily pinched from one side. This finding challenges traditional textbook views of cell division and may have implications for embryo viability and human fertility.
Researchers at CRCHUM have identified damaged nanotubes connecting pericytes as a major contributor to glaucoma. The study reveals that restoring calcium equilibrium within pericytes can recover vascular and neuronal functions, paving the way for new therapeutic approaches.
A Brazilian berry has been found to enhance the effectiveness of a popular cancer treatment by modifying the gut microbiome. Researchers discovered that castalagin, a polyphenol from the camu-camu fruit, improves immunotherapy response in mice with resistant cancers.
A Montreal-based study found that alcohol, cannabis, and nicotine use remained stable among 24- to 33-year-olds from before the pandemic to now. However, people with lower education levels and those living alone were more likely to start or increase substance use during COVID-19.
Metabolic disorders, such as inflammation and insulin resistance, are key elements in the development of anxiodepressive disorders in obese individuals. Diet high in sugar and saturated fats leads to these changes in the brain, increasing the risk of depression and anxiety.
Scientists have identified transcription factor RORC2 as a key player in HIV infection, allowing the virus to persist in immune cells. Inhibiting RORC2 using small molecules can limit viral expansion and prevent replication in healthy individuals and those with HIV.
Researchers at Université de Montréal developed a statistical model using blood biomarkers to predict which patients are most at risk of dying from COVID-19. The model is based on the amount of viral RNA in the blood and has been validated on two independent cohorts, showing high predictive accuracy.
A research team at the University of Montreal Hospital Research Centre has found that cellular aging is caused by irreversible damage to the genome, not just telomere erosion. This discovery challenges the long-held scientific model and opens up new research opportunities for preventing cellular aging and genomic instability.
A phase III clinical trial found that a trio of drugs, apalutamide, abiraterone, and prednisone, slowed the progression of metastatic castration-resistant prostate cancer by 24 months compared to 16.6 months with abiraterone and prednisone alone.
A team of researchers has identified the KDM1A gene as responsible for a rare form of Cushing's Syndrome caused by abnormal expression of the GIP hormone. The discovery provides an early diagnosis tool and personalized medicine options, improving patient outcomes.
Researchers at Université de Montréal and McGill University have discovered a new multi-enzyme complex that reprograms metabolism and overcomes cellular senescence. The enzyme complex, named HTC, can inhibit cells from aging and has potential applications in treating various cancers.
A study published in Developmental Cell reveals that lagging chromosomes contribute to an uneven chromosomal distribution, leading to aneuploidy and infertility. Researchers propose artificially slowing down cell division to limit aneuploidy, offering a potential solution for improving egg quality in older patients.
Researchers at CRCHUM and Yale University develop a cocktail that limits viral replication and decreases the HIV reservoir by destroying infected cells. The study successfully delays virus rebound, offering promising new therapeutic avenues against HIV.
A personalized anti-cancer vaccine using peptides and oncolytic viruses has shown efficacy in mice, with the ability to target specific mutations in cancer cells. The approach differs from existing clinical trials, which do not use oncolytic viruses as adjuvants.
A pilot study published in EBioMedicine found that metformin can improve immune function and reduce viral reservoir size in people living with HIV. The drug, commonly used to treat type-2 diabetes, was well-tolerated by patients and showed beneficial biological effects on colon biopsies.
Researchers at University of Montreal Hospital Research Centre have identified biomarkers associated with the severity of COVID-19. The study found specific immune alterations linked to SARS-CoV-2 infection and disease progression, which could help stratify patients by risk and identify new therapeutic targets.
A study by Université de Montréal psychiatry professor Didier Jutras-Aswad and his team found that cannabidiol is not an effective treatment for cocaine use disorder. The 78-participant clinical trial showed no reduction in craving or relapse risk with cannabidiol, contrary to its growing popularity as a potential addiction treatment.
A study published in Obstetrics & Gynecology found that women with serious pregnancy complications are twice as likely to die after childbirth. The research team identified cardiac complications, acute renal failure, and strokes as the main causes of mortality after 42 days.
Scientists at the CRCHUM found that pericytes use tunneling nanotubes to communicate with each other, regulating blood supply and maintaining vision. The study's findings suggest that damaged tunnelling nanotubes may contribute to neurodegenerative diseases like stroke, glaucoma, and Alzheimer's.
A recent clinical trial published in The Lancet Neurology found that patients with brain arteriovenous malformations (AVMs) can experience a significant reduction in stroke risk and mortality when left alone to follow their natural course. In contrast, standard medical interventions may pose more harm than benefit.
Researchers found that starting ART immediately after HIV infection significantly reduces viral reservoirs, making them 100 times smaller. This discovery provides new hope for eradicating the virus.
Researchers have found that combining two anti-HIV antibodies with ART can suppress the virus and boost T cell responses, offering new hope for HIV treatment. The study suggests a potential interaction between humoral immunity and cell-mediated immunity, which could lead to improved control of the virus.
A new study published in the American Journal of Public Health estimates that 171,900 Canadians injected drugs in 2016, with a 30-per-cent increase from 2011. The study also found wide variations in service coverage across provinces and territories.
A study published in Science Translational Medicine founds that blocking the molecule ALCAM can delay the progression of multiple sclerosis. The disease causes symptoms such as fatigue, lack of coordination and vision problems in people like 20,000 Canadians with the disease.
Researchers from CRCHUM unveiled a mechanism that likely contributes to the low level of pregnancy success in some fertility clinics. Healthy cells usually have one nucleus, but many fertility clinics transfer so-called 'binucleated embryos' with two nuclei back to patients. The study found that binucleation increases the chances of an...