A new study found that mothers who underwent surgery before pregnancy have a 1.6 times higher risk of neonatal abstinence syndrome, a condition characterized by opioid withdrawal symptoms in newborns. The study suggests that careful postoperative pain management can help prevent this condition.
A study published in Nature Immunology reveals that HIV drug therapy leaves 'holes' in the immune system, which may contribute to the lack of viral control. The researchers identified key differences in gene expression between HIV patients with and without effective immune responses.
Researchers at CRCHUM found that Ran protein is essential for ovarian cancer cells to migrate and invade healthy tissues. Inhibiting Ran expression can break down RhoA, a protein necessary for cell migration, leading to a loss of cancer cells' ability to move.
Researchers from CRCHUM identified the genetic signature of an ineffective immune response to cancer, including 28 genes that are also found in patients with other diseases. This signature could help predict which patients will fare worse.
Researchers at University of Montreal Hospital Research Centre develop a two-step combination therapy to destroy cancer cells. They manipulate cellular aging to force cancer cells into senescence, then use senolysis to eliminate them. This strategy shows superior therapeutic effectiveness on ovarian cancer patients.
A recent study by CRCHUM researchers has identified a key brain protein, acyl-CoA-binding protein (ACBP), in controlling food intake and energy expenditure. The study found that this protein enables astrocytes to communicate with neurons, regulating weight maintenance.
A new surgical technique using ultrasonic energy to seal pulmonary artery branches has been shown to reduce post-operative bleeding, complications, and pain in patients with lung cancer. The study's results have the potential to make this less invasive procedure more widely available, leading to faster recovery times for thousands of C...
Researchers visualize HIV's shape and vulnerabilities using single-molecule Förster resonance energy transfer (smFRET) technology. The study provides a direct means of seeing the dynamic machine-like structure of the HIV envelope, which can be targeted by antibodies to eliminate infected cells.
Researchers at CRCHUM have shown that anti-cancer immunotherapy treatments can reveal hidden HIV viruses to the immune system, reducing their presence in cells. This approach could lead to new therapies for HIV treatment.
Researchers at CRCHUM successfully reduced chromosome abnormalities in mouse embryos by half, a major cause of infertility. The discovery could improve infertile couples' chances of giving birth if applied to humans in the future.
Researchers have discovered interleukin IL-22 as a new target to inhibit the progression of liver disease and prevent cancer. The study reveals how IL-22 accelerates fibrosis during chronic hepatitis by amplifying the signal of the fibrogenic cytokine TGF-β.
A diet rich in saturated fat results in inflammation in the nucleus accumbens, a part of the brain that controls mood and reward. This inflammation leads to depressive, anxious, and compulsive behaviors associated with metabolic dysfunction and obesity.
Researchers develop ultrafast imaging method to map cell elasticity, revealing mechanical properties of cells and tissues. The technology has potential applications in cancer, pathogen-induced infection, scarring, and tissue engineering.
A team of researchers at the University of Montreal Hospital Research Centre has discovered a promising solution to improving treatments for cystic fibrosis. By adding quorum-sensing inhibitors to current drugs, they were able to restore treatment efficacy in cells of cystic fibrosis patients.
Researchers have discovered a potential treatment for amyotrophic lateral sclerosis (ALS) using the medication pimozide, which was found to stabilize progression and alleviate symptoms in animal models. A limited clinical trial on human subjects suggests that pimozide may be effective in improving patients' quality of life.
Researchers at the University of Montreal Hospital Research Centre have discovered a molecule that stimulates HIV replication in CD4 T cells located in the gut. By targeting this molecule, medications can significantly reduce HIV replication in undetectable patients, potentially leading to a functional cure.
Researchers at the University of Montreal Hospital Research Centre discovered a way to modify white blood cells to accelerate cutaneous healing. The treatment uses a special protein called MFG-E8 to control macrophage behavior, promoting anti-inflammatory and pro-reparatory reactions.
A training program evaluating clinical best practices and self-assessment reduced medically unnecessary caesareans by a slight margin without adverse effects on maternal and neonatal health. The program generated significant savings for the healthcare system, primarily due to better case management leading to fewer neonatal complications.
Researchers at University of Montreal Hospital Research Centre discovered a defect in eggs of older mice, causing errors in chromosome segregation. This may also be found in human eggs, contributing to age-related infertility and increased risk of miscarriage.
A recent study published in the Canadian Family Physician journal reveals that more than half of Canadian family doctors are using outdated manual devices to measure blood pressure, resulting in inaccurate diagnoses. This can lead to unnecessary medication and increased healthcare costs.
Researchers have discovered a new cell structure responsible for previously unexplained rejections following an organ transplant, which may lead to the development of a new drug to prevent this type of rejection. This breakthrough could one day transform transplant practice by improving assessment of rejection risks.
Researchers at the University of Montreal Hospital Research Centre have identified a new syndrome in mice with deleted Armc5 gene, characterized by adrenal gland abnormalities and immune system compromise. The study opens up new avenues for understanding and treating diseases linked to the ARMC5 gene.
A research team at CRCHUM discovered that the ABHD6 enzyme in certain brain neurons plays a key role in controlling body weight. Blocking this enzyme disrupts normal metabolism and prevents mice from losing weight, even under ideal conditions.
Nearly all Canadian provinces and territories restrict access to direct-acting antivirals for treating hepatitis C, citing cost concerns. The disease affects over 220,000 Canadians, who often face lengthy delays in receiving treatment.
A study by CRCHUM researchers reveals that chronic kidney disease can cause secondary diabetes through the buildup of urea in the blood. The disease impairs insulin secretion from pancreatic beta cells, leading to increased blood glucose levels and potentially progressing to diabetes.
A new discovery has identified cell markers to target HIV reservoirs, opening new treatment perspectives. The study found that using antibodies specifically binding to these markers could destroy HIV reservoirs and potentially cure infected individuals by allowing them to stop antiretroviral therapy.
A new minimally invasive surgical approach for lung cancer patients has shown promise in reducing bleeding risk and post-operative pain. The VATS lobectomy procedure uses ultrasonic energy to seal pulmonary arteries, allowing for faster recovery times and potentially improving survival rates.
A groundbreaking Phase 3 clinical trial aims to demonstrate that intense physical exercise can extend the life of patients with metastatic prostate cancer, potentially reducing mortality by at least 22% and offering a new anticancer therapy.
Researchers discovered that maple syrup, rich in polyphenols, can prevent the development of ALS in C. elegans worms by protecting neurons from toxic proteins. The study found that a combination of sugar and polyphenols may have a neuroprotective effect.
A new eHealth solution is being developed to improve direct and rapid access to youth mental health services in Canada. The pilot program will facilitate self-referral through a web portal and secure communication platform, with the goal of empowering young people to undertake the initial consultation process.
A study conducted by researchers at the University of Montreal Hospital Research Centre found that young adults who binge drink have higher blood pressure, increasing the risk of developing hypertension. The study reveals that over one in four young adults who binge drink meet the criterion for pre-hypertension.
Scientists at the University of Montreal Hospital Research Centre have discovered an enzyme that can stop the toxic effects of sugar in various organs. The enzyme, glycerol 3-phosphate phosphatase (G3PP), plays a central role in controlling glucose and fat utilization and has been shown to detoxify excess sugar from cells.
A study published in the Proceedings of the National Academy of Sciences reveals that micronuclei structures can cause aneuploidy and lead to mosaic embryos. This discovery may provide early non-invasive detection of aneuploidy, improving the chances of success for infertile couples who rely on medically assisted reproduction methods.
A new cellular structure responsible for previously unexplained rejection of organ transplants has been identified. Researchers have found a way to neutralize the enzyme driver of this structure, which could revolutionize transplantation practice by modifying risk assessment of rejection.
A new drug combination is being tested for its effectiveness in treating metastatic prostate cancer. Researchers are optimistic about the results, citing improved quality of life and delayed disease progression in patients participating in a Phase 3 clinical trial.
Researchers at the University of Montreal Hospital Research Centre have developed a new injectable biogel that can deliver anti-cancer agents directly into cancerous tumours. The biogel is effective in killing cancer cells and has shown promising results in laboratory tests, including the destruction of melanoma and kidney cancer cells.
A team led by Dr. Marie-Josée Hébert discovered a new class of antibodies - anti-LG3 - which can trigger severe rejection episodes and high organ loss rates in kidney transplant patients. This breakthrough holds promise for developing new therapies to prevent or limit organ rejection.
Researchers at CRCHUM made a key discovery about insulin secretion regulation in the body, which has important implications for treating Type 2 diabetes. The study mapped the pathway that glucose stimulates to produce insulin and identified genetic processes involved.
Dr. Andrés Finzi's 'Reverse Fusion' project aims to deliver toxic genes to HIV-infected cells to eliminate them. The approach targets the virus's unique key and lock, using modified envelope glycoproteins and receptors to deliver a Trojan horse that eradicates infected cells.
Researchers have discovered a new mechanism of action for Herceptin, revealing its ability to stimulate interferons and activate lymphocytes. Combining Herceptin with lymphocyte-stimulating therapies greatly increases efficacy in animals, paving the way for targeted therapies.
A new gene, SYN1, has been identified as a predisposing factor for both autism and epilepsy in individuals from Quebec. Mutations in this gene lead to impaired synaptic function, causing communication between neurons to break down. This study provides a key to understanding the comorbidity of these devastating diseases.
A large clinical study found Omega-3 supplementation to be effective in improving depression symptoms among patients with unipolar depression unaccompanied by anxiety. The study used high-quality EPA supplements and demonstrated efficacy comparable to conventional antidepressant treatments.
A new clinical trial, IMPACT-CABG, evaluates the safety and efficacy of injecting stem cells into the hearts of patients undergoing coronary bypass surgery. The study aims to promote healing and regeneration of damaged heart muscle, offering a less invasive alternative to heart transplant.
Researchers have identified a new form of adult-onset muscular dystrophy caused by recessive ANO5 mutations, which lead to abnormal membrane repair of muscle fibers. This discovery may lead to better treatments for all muscular dystrophies where such abnormalities play a role.
Researchers at the University of Montreal Hospital Research Centre have developed a new surgical technique to treat refractory epilepsy, with nine patients showing successful results. The innovative approach reduces risks and complications associated with previous insular surgeries.
A team of researchers has discovered MEDNIK Syndrome, a debilitating genetic syndrome characterized by mental retardation, enteropathy, deafness, and peripheral neuropathy. The AP1S1 gene mutation causes this disorder, affecting development in the skin and spinal cord.
Researchers have shown that early treatment for Hepatitis C virus (HCV) within the first months following an infection develops a rapid poly-functional immune response against HCV. This finding suggests that early treatment can restore immune response and help eliminate the virus rapidly, contributing to the development of new treatments.