Researchers at Terasaki Institute develop a wireless dual-compartment biochemical monitoring platform for real-time tracking of key biomarkers in perfusion fluid and bile during normothermic machine perfusion. The study shows improved interpretation of post-transplant outcomes with combined bile and perfusate data.
Researchers developed an injectable hydrogel combining silk proteins and a kudzu plant compound, achieving complete wound closure within 72 hours. The material's mechanical stability and cell viability exceeded expectations.
Terasaki Institute researchers and key pioneers publish comprehensive review on glioma organoid models, proposing a foundational classification framework to guide translational brain tumor research. The review provides an overview of human glioma organoid systems and aims to address methodological heterogeneity in the field.
Researchers developed a topical gel formulation with 4-aminopyridine to treat burn wounds, achieving near-complete closure in 21 days. The gel delivers the drug directly to the wound site, avoiding systemic risks associated with prolonged use.
Researchers at Terasaki Institute for Biomedical Innovation develop a smart contact lens that monitors intraocular pressure in real time and delivers treatment. The technology has shown promising results in preclinical models and aims to improve quality of life for patients with ocular diseases.
Dr. Yangzhi Zhu has been awarded a prestigious Career Development Award from the American Heart Association to support his research in translational biosensing and organ health assessment. The award aims to develop innovative sensing strategies for improving donor organ condition and supporting better clinical care.
The Terasaki Institute for Biomedical Innovation and UCLA Technology Development Group will co-curate an Advanced Organ and Tissue Repair (AToR) session at LABEST, featuring leading experts in regenerative medicine. The session aims to accelerate the translation of breakthrough technologies into real-world clinical solutions.
Dr. Aliesha O’Raw, Principal Investigator at TIBI and Co-Founder of OnVagus, has been selected for the 2026 ACS BrightEdge Entrepreneurs Program. The program provides mentorship, entrepreneur training, and early-stage investment support to advance cancer diagnostic and therapeutic solutions.
The partnership aims to accelerate biomedical innovation through joint research programs, faculty collaboration, and expanded student training opportunities. Researchers will have access to shared laboratory infrastructure, reciprocal faculty affiliations, and joint grant proposals.
Researchers are developing an organ-on-a-chip platform to study immune rejection in pig-to-human liver transplantation, addressing a major hurdle in xenotransplantation. The project aims to generate data supporting future preclinical studies and bring xenotransplantation closer to clinical use.
Researchers developed a vascularized liver tissueoid-on-a-chip that recapitulates key structural, functional, and immunological features of human liver tissue. The platform enabled the study of liver regeneration and immune-mediated allograft rejection in a physiologically relevant human system.
A new organ-on-a-chip platform recapitulates age-dependent immune responses, allowing for more accurate testing of cancer vaccines in older adults. The platform reveals functional differences in immune responses between young and old lymphocytes, which are not detectable with traditional 2D cultures.
Researchers at Terasaki Institute and Caltech will use stem cell-based models to identify factors influencing early human development. The goal is to gain insights into infertility, pregnancy loss, and developmental disorders.
Dr. Johnson V. John has been appointed as a standing member of the NIH's Musculoskeletal Tissue Engineering (MTE) Study Section, ensuring innovative research receives support. His expertise in biomaterials and tissue engineering will contribute to national research priorities.
Researchers developed a novel label-free biosensing platform to monitor cellular secretion of monoclonal antibodies in real-time. This approach enables rapid clone selection and cost-effective manufacturing of life-saving immunotherapies.
Researchers harness AlphaFold 3 to predict how T cells recognize peptides, opening avenues for precision immunotherapy and vaccine design. The approach enables in silico identification of immunogenic epitopes that could serve as vaccine targets.
Researchers have created a human vascularized liver cancer-on-a-chip model to evaluate vessel remodeling and cell death in response to embolic agents. This innovative platform replicates the microenvironment of liver tumors, providing unprecedented insight into how tumors respond to embolization.
The study demonstrates that modulating the vagus nerve can effectively halt the progression of cachexia, enhance chemotherapy outcomes, and improve survival in preclinical models. This intervention restores normal liver metabolism, reduces systemic inflammation, and alleviates cachectic symptoms.
Dr. Yangzhi Zhu has made outstanding contributions to the field of biosensors with his development of flexible biosensors and wearable bioelectronics. His research focuses on creating next-generation wearable devices for personalized healthcare, including electronic skin and smart contact lenses.
The Terasaki Institute and California State University, Northridge (CSUN) have launched a new collaboration initiative that brings advanced hands-on laboratory experience to CSUN Biology graduate students. Participating students will work alongside leading scientists on projects in various fields of biomedical research.
Scientists at Terasaki Institute engineer a novel 3D glioblastoma model that mimics brain tissue and pericyte role, showing increased resistance to chemotherapy. The model increases sensitivity of GBM cell lines to TMZ by 22-32%.
Researchers developed a method to produce tissues with controlled cellular organization, mimicking human tissue structure. The technique uses light-based 3D printing to create microgels with tailored internal architectures, enabling precise control of cell growth and behavior.
Dr. Ali Khademhosseini, TIBI Director, receives the 2025 MRS Mid-Career Researcher Award for his groundbreaking contributions to biomaterials science and tissue engineering. His research has revolutionized engineered tissue constructs for drug discovery and regeneration.
Researchers developed a dual-action nanotherapy that converts white fat into beige fat and reduces obesity-related inflammation, significantly improving metabolic health without detectable toxicity.
Researchers have created a novel self-healing electronic skin that repairs itself in seconds, surpassing existing technologies by up to 80%. This technology integrates artificial intelligence and offers real-time fatigue detection and muscle strength assessment with remarkable precision.
The Terasaki Institute for Biomedical Innovation has announced the recipients of its inaugural Keith Terasaki Mid-Career Innovation Award. Dr. Liangfang Zhang and Dr. Aydogan Ozcan were recognized for their innovative approaches to translating groundbreaking research into real-world impact.
The Terasaki Institute recognizes Dr. Cato Laurencin's groundbreaking contributions to regenerative engineering, while Dr. Jun Chen is recognized for his innovative technologies in soft bioelectronics and magnetoelastic materials.
Researchers at Terasaki Institute develop lipopeptide hydrogels to deliver peptide-based cancer vaccines, demonstrating sustained release and enhanced immune cell uptake. The system shows promise in overcoming limitations of traditional peptide-based vaccines.
The collaboration aims to develop advanced 3D mini-brain models for replicating human brain architecture, enabling researchers to explore neurological diseases and screen drug candidates. The platform offers a high-throughput screening method for rapid testing of potential drug candidates.
Researchers developed porous dermal fillers that accelerate tissue healing and regeneration for diabetic wounds. The novel approach combining electrospinning and electrospraying technologies creates biocompatible microspheres that promote cell migration, granulation tissue formation, and neovascularization.
Researchers at Terasaki Institute have developed simvastatin-loaded nanoparticles to target adipose tissue inflammation, promoting fat tissue browning and weight loss. The treatment effectively inhibits obesity-related inflammation, controlled white fat production, and demonstrated strong anti-inflammatory effects.
This innovative system combines remote health monitoring and drug delivery using 3D-printed hollow microneedles, advancing personalized medicine. The integrated theranostic microneedle array measures key health indicators like pH, glucose, and lactate levels, while enabling rapid, pumpless, and point-of-care drug administration.
A recent study published in Frontiers in Immunology highlights the crucial role of tissue-resident memory T cells in non-small cell lung cancer. The research found that these cells can significantly impact patient outcomes and guide personalized treatment strategies, particularly those involving immunotherapy.
Terasaki Institute scientists have created a novel bioink derived from egg whites, offering abundant proteins and excellent biocompatibility. This breakthrough technology has the potential to create more accurate tissue models for drug testing and develop functional tissue replacements for regenerative medicine applications.
Researchers have developed a multi-component hydrogel scaffold to mimic the amyloid-beta containing microenvironment associated with AD. The study found elevated levels of neuroinflammation and apoptosis markers in healthy neuronal progenitor cells cultured within this environment.
Scientists at TIBI employed AI to enhance the design and production of nanofibers used in acoustic energy harvesters, resulting in higher power density and energy conversion efficiency. The AI-generated nanofibers produced better performance than conventionally fabricated devices.
Researchers found a strong association between favorable survival outcomes and high populations of tissue-resident memory T cells in melanoma patients. The study identified 11 distinct gene signatures that correlate with T cell abundance and patient survival, suggesting a crucial role for T cells in immunomodulation.
Researchers developed an adhesive gel to seal and heal challenging gastrointestinal tract-to-skin connections, showing promising results in studies. The gel's unique composition ensures it can effectively seal fistulas, preventing further complications and aiding in healing.
Scientists have developed a drug-eluting hydrogel that provides sustained, pH-dependent drug co-delivery and promotes anti-tumor immune responses, reducing tumor cell proliferation and growth. The treatment shows promise in treating hepatocellular carcinoma, with enhanced efficacy compared to traditional methods.
Scientists have developed a novel organ-on-a-chip device with customizable screen-printed electrodes for measuring endothelial barrier integrity. The device overcomes traditional electrode fabrication challenges, providing a reliable and accurate method for studying the crucial roles of endothelial barriers in healthy and disease states.
Scientists at the Terasaki Institute for Biomedical Innovation have developed a new bioink that enhances the formation of mature skeletal muscle tissue from muscle precursor cells, increasing efficiency and potential therapies for muscle loss or injury. The bioink's sustained delivery of IGF-1 promotes muscle regeneration and repair.
Researchers create accurate tumor models using 3D bioprinting and a bioink made from Laponite, improving bonding and cross-linking capabilities. The study shows that Laponite enhances biological signaling in the tumor microenvironment, increasing cell viability and promoting anti-tumor drug development.
A new device combines rapid hemorrhage management, infection control, and sensing capabilities for long-term monitoring. The device features a tunable biodegradation rate and can detect bleeding in real-time using a nanowire-based capacitive sensor.
Scientists developed an injectable biomaterial with improved adhesion, stretchability, and toughness, making it ideal for surgical wound sealing. The material showed superior adhesive strength, stability, and biocompatibility in physiological conditions.
Researchers from TIBI have developed an advanced electronic skin patch that provides simultaneous, continuous monitoring of multiple bodily parameters. The new E-skin patch offers enhanced flexibility, thermal cooling abilities, and fluid absorption over conventional substrates while demonstrating excellent biocompatibility and biodegr...
The Terasaki Institute for Biomedical Innovation developed a contact lens prototype that facilitates tear flow in response to normal eye blinking, relieving CLIDE symptoms. The lenses, with microchannels and square cross-sections, can guide tear flow and combat dry eye syndrome.
A team of scientists from TIBI, UIC, and POSTECH has elucidated key points on how cartilage generation is facilitated and alternative bone formation can be avoided. They found optimal conditions for better cartilage regeneration while reducing excessive cartilage formation using human mesenchymal stem cells.
A new injectable hydrogel has been developed to rapidly stop bleeding from traumatic wounds. The material becomes solid when injected into the body and can be easily washed away with a cold saline solution.
The use of 3D-patient tumor avatars (3D-PTAs) is crucial for guiding treatment decisions in precision oncology. These avatars, including patient-derived organoids, 3D bioprinting, and microscale models, can accurately depict a tumor with its microenvironment, enabling the testing and prediction of therapeutic drug efficacy.
Researchers developed a nanofiber aerogel that promotes faster and more effective healing of diabetic wounds. The aerogel facilitates cell migration, oxygen, and nutrient delivery to the wound bed, while incorporating an anti-microbial peptide prevents bacterial growth and promotes healing.