A new injectable hydrogel has been developed with enhanced shear-thinning properties, improved cellular biocompatibility, and significantly reduced clotting times. The biomaterial was created by adding sodium phytate to a gelatin-based compound, promoting even greater cohesion and triggering the initiation of blood coagulation.
Researchers have developed an injectable shear-thinning hydrogel that exhibits enhanced cohesive strength, resisting fragmentation even under pulsating liquid flows. The gel, similar to toothpaste, retains its structure when force is removed, making it a potential breakthrough in treating critical vascular conditions.
Researchers at Terasaki Institute create micro-organospheres for direct viral infection, immune cell penetration, and high-throughput therapeutic drug screening. The technology holds promise for personalized medicine, tumor therapy and rapid drug testing.
Scientists have developed a smart contact lens that can capture and detect exosomes, nanometer-sized vesicles found in bodily secretions, which hold promise for cancer diagnostics. The lens was designed to bind to antibodies capturing exosomes found in tears, offering a potential platform for non-invasive cancer screening.
Researchers at TIBI developed a minimally invasive method for targeted delivery of immunotherapeutic treatments, resulting in slower tumor growth and higher activation of T-cells. The injectable gelatin biomaterial containing silicate nanoplatelets showed sustained drug release and controlled ICI delivery.
Researchers discover G6PD's pivotal role in activating pentose phosphate pathway to counter oxidative stress, leading to increased cell death and tumor shrinkage. Ovarian cancer cells' reliance on fatty acid metabolism fuels oxidative compound production, which can be offset by G6PD inhibition.
A high-fat diet can lead to increased fructose metabolism in the small intestine, resulting in the release of glycerate into circulation. This can cause damage to insulin-producing pancreatic beta cells, increasing the risk of glucose tolerance disorders and Type 2 diabetes mellitus.
Researchers developed a droplet-based microfluidic technology to produce micro-organospheres from cancer patient biopsies within an hour. These miniature tumors retain the original microenvironment and can be used for testing many drug conditions, showing almost perfect correlation with actual clinical treatment outcomes.
A team from the Terasaki Institute for Biomedical Innovation has created a method to repair tendons using silk fibroin scaffolds, which showed improved healing and regeneration of injured tendons. The scaffold combines silk fibroin with GelMA to promote cell attachment, growth, and differentiation.
Researchers at Terasaki Institute for Biomedical Innovation have developed a flexible, antibacterial conductive hydrogel-ePatch that accelerates wound healing with minimal side effects. The e-Patch uses silver nanowires and alginate to promote cell proliferation and migration, resulting in faster wound closure and reduced scarring.
A recent study published in Developmental Cell reveals that Kras mutation causes chromatin rearrangement, leading to stem-like cell regeneration and tumor onset. The team discovered a protein complex called AP-1 as the mediator of this process, which can be targeted with small-molecule drugs.
Scientists develop hairy cellulose nanocrystals to capture and remove excess chemotherapy drugs from the blood. The nanocrystals effectively removed over 6,000 milligrams of doxorubicin per gram, increasing DOX capture by two to three orders of magnitude compared to existing methods.
Researchers developed a new fabrication method for wearable pressure sensors that enhance durability, sensitivity and transparency. The sensors can detect various body movements and health indicators, such as pulse, sweat, and temperature.
Scientists develop injectable hydrogels to effectively prevent post-surgical adhesions, reducing complications and hospital costs. The hydrogel barriers demonstrate superior mechanical properties and effective prevention of cell adherence.
Researchers from Terasaki Institute for Biomedical Innovation develop methods to enhance mechanical properties of hydrogels, including toughness, stretchiness, and adhesive strength. By introducing dopamine and alkaline conditions, they create gel-like materials with improved biocompatibility and regenerative capabilities.
Researchers from Terasaki Institute for Biomedical Innovation developed a method to fabricate ultrathin gold shells around silver nanowires, improving their stability and effectiveness. The gold-coated nanowires showed superior durability and performance in various tests, outperforming commercial nanowires.
Researchers developed an image-based detection system using artificial intelligence models to diagnose COVID-19 from chest X-rays. The model accurately differentiated between COVID-19, pneumonia, and healthy patients, showing great promise for precision medicine.
Researchers created a wearable sensor that can detect a wide range of strains, from low-level wrist pulses to high-level elbow bending movements. The sensor's novel structural design mimics the scaly structure of snake skin, resulting in exceptional stretchiness and sensitivity.
The Terasaki Institute has been awarded a grant by the Good Food Institute to develop an innovative method for producing cultivated meat. The project aims to address scalability and cost challenges in alternative protein production, using unique microcarriers to differentiate cell cultures.
A team from Terasaki Institute for Biomedical Innovation developed soft pressure sensors using OECTs and ionic hydrogels, enabling high sensitivity and low power consumption. This advancement facilitates long-term monitoring of patients with real-time data collection.
Researchers at Terasaki Institute for Biomedical Innovation have developed a breast cancer-on-a-chip system to test immunotherapy drugs. The chip enables high-volume testing of immunotherapeutic drugs against tumor cells, allowing for the rapid screening of potential treatments.
Researchers have created a new composite hydrogel with tantalum particles that can effectively seal off damaged blood vessels, providing rapid and stable bleeding control. The gel exhibits shear-thinning capabilities, allowing for easy deployment using standard catheters.
Researchers have developed a contact lens that uses tiny channels to collect tears and measure biomarkers like sodium ions and glucose molecules. The lens can detect changes in tear pH and flow rates, offering a potential solution for preventing dry eye disease and monitoring diabetic patients.
A collaborative team developed an organs-on-a-chip system to monitor heart toxicity from breast cancer drugs. The dual-organ system closely mimics bodily tissues and provides evidence that the interplay between the heart and breast cancer tissues influences cell function and disease progression.
A six-month mass media campaign, Living Donation Storytelling Project, aims to capture 500 living donor kidney transplant (LDKT) stories, educating medical providers and patients about innovative resources. The project uses digital storytelling to supplement traditional education practices, allowing real people to share their experiences.
Researchers at Terasaki Institute create wearable pressure-sensitive devices using a gelatin-based hydrogel that offers superior elastic properties and skin compatibility. The device enables real-time monitoring of vital signs with high sensitivity and consistency.
Researchers developed a tailored education system called 'Your Path to Transplant' that increases patient knowledge and readiness to pursue kidney transplant. The program, tested on over 800 patients, showed significant improvements in transplant preparedness and living donor transplant rates.
A newly developed oxygen-releasing bioink has been shown to enhance the ability of implanted cells to grow and regenerate new tissue. The bioink was tested extensively to optimize its properties, delivering oxygen to cells in tissue constructs for the necessary period for blood vessels to develop fully.
Researchers describe ways to achieve optimal patient advocacy for kidney recipients and donors during the COVID-19 pandemic. Key areas include informing patients fully in their care decision process and honoring patient priorities in all care innovations and policies.
Researchers at Terasaki Institute for Biomedical Innovation have identified collagen V as a key factor regulating cardiac scar tissue size after a heart attack. The study found that fibroblasts without collagen V produce larger, more irregularly-structured scars, leading to reduced shrinkage and increased risk of complications.
Researchers are developing biomaterials to boost the body's natural healing process, with two approaches: incorporating cells or designing materials to stimulate cellular response. This can lead to improved success rates in tissue regeneration, reducing regulatory barriers and increasing available options.
Researchers have created a technology to print tissues directly in the body, using a specially-formulated bio-ink that can be crosslinked safely using visible light. This breakthrough enables minimally-invasive laparoscopic options for tissue repair and engineering, saving time and cost.
Researchers at Terasaki Institute developed a minimally invasive approach using 'Detachable Microneedle Depots' to deliver MSCs into damaged tissues, accelerating wound healing in mouse models. The technique targets damaged areas with high spatial precision, utilizing microneedles to deploy therapeutic cells and promote healing.
Researchers at Terasaki Institute develop a microneedle patch to extract skin interstitial fluid, providing an alternative source for biomarker testing and overcoming issues with blood sampling. The patch, made of gelatin methacryloyl, is highly absorbent and biocompatible, eliminating the need for hollow needles.
A collaborative research team has developed a multi-component biomaterial-based screening approach that identifies material compositions and mechanical stimuli enabling human stem cells to differentiate into cells capable of generating higher-quality articular cartilage. The study uses high-throughput screening with multiple combinatio...