Researchers have developed a new technique using bowl-shaped nanoparticles to study Alzheimer's disease amyloid beta protein aggregates. The findings confirm multiple forms of these aggregates co-exist and not all convert into brain plaques, opening possibilities for diagnostic and treatment applications.
A recent study reveals an increase in cancer incidence and mortality rates in China, with rising rates seen in colorectal, pancreatic, and breast cancers. The study highlights the importance of implementing cost-effective approaches for primary prevention and collaborative efforts to reduce the cancer burden.
A new bioinformatics tool called PlasmidHawk has been developed by Rice University researchers to track the origin of synthetic genetic code. The tool uses a sequence alignment-based approach and was found to outperform recent deep learning approaches in lab-of-origin prediction, achieving 76% accuracy.
Researchers assessed at what age young people aged 12 to 17 started using cigarettes. The study found that most young people begin smoking between ages 14 and 16.
Research highlights social resilience as key factor in overcoming climate adversity, with aridification sparking development of agriculture and complex social structures. The study shows that population surged around 3,900 to 3,500 years ago due to human adaptations and innovations.
Researchers found that statin users had lower inflammation levels and a 50% reduced risk of death from COVID-19. However, randomized clinical trials are still needed to confirm these findings.
Bacteria use a carbohydrate slime to resist antibiotics and thinning agents used in cystic fibrosis treatments. The slime creates a protective layer around the bacteria, making them harder to kill.
The Critical Path to Therapeutics for the Ataxias (CPTA) Consortium aims to optimize clinical trials for inherited ataxias through a public-private partnership. CPTA will create a neutral space for stakeholders to share expertise and data, leveraging this input to guide the development of actionable solutions.
Researchers developed risk stratification models to predict COVID-19 patient outcomes, including mechanical ventilation and in-hospital death. The VICE and DICE scores utilize clinical data to differentiate between risk, with age being a significant predictor of mortality but not mechanical ventilation.
A University of Texas at Arlington researcher is studying the mechanics of blast-like events and their impact on brain cells. He aims to track bubble formation and its effects on brain tissue, with a goal of preventing traumatic brain injuries. The study will also explore the role of glial cells as shields against trauma.
The study found that early PDA closure in extremely low birth weight infants with moderate to large PDA improved respiratory status, facilitated faster weaning off supplemental oxygen and ventilator support, and promoted normal weight gain. Delayed PDA closure and pulmonary hypertension were associated with worse respiratory outcomes.
Researchers at VIB discovered the molecular architecture of the TPLATE complex, a crucial protein complex in plants that regulates the outer membrane composition. The study provides new insights into the evolution of this complex and its role in vesicle trafficking, essential for eukaryotic processes.
Researchers have developed a method to quantify transfer RNAs (tRNAs) in cells, which can reveal insights into tRNA regulation in health and disease. The mim-tRNAseq approach accurately measures tRNA abundance and modification status, enabling the study of tRNA dynamics in different tissues and during development.
Researchers have developed novel Bi-BiVO4 Mott-Schottky heterostructure catalysts for efficient urea synthesis under ambient conditions. The spontaneous charge transfer at the heterointerfaces promotes targeted adsorption and activation of CO2 and N2 molecules, effectively suppressing CO poisoning.
Researchers used electronic medical records to estimate SARS-CoV-2 transmission risk and identify risk factors for household transmission. The study found that addressing in the home address could be used to predict transmission risk.
New research shows that explicit instruction significantly improves reading skills, especially for adults struggling with basic reading skills. The study found that learners who received explicit instruction outperformed those who learned through natural experience.
The Genomic Data Commons has become a leading cancer genomics resource with over 84,000 anonymized patient cases and 65 projects contributing to the platform, providing a critical role in advancing precision medicine.
Research at York University found that maternal care of offspring leads to an expanding social life in bees, selecting more social genes over time. The study suggests a unifying principle driving social trait evolution across different species.
A Swansea University scientist's research explores how geometrical characteristics affect physical theories, revealing the need for contextual understanding in quantum mechanics. The study determines the structural properties that make a theory prone to contextuality.
A University of Illinois study reveals racial discrimination in the home-renting process actively sorts minority renters into neighborhoods with higher levels of pollution. This leads to disparities in residential pollution exposures and contributes to health issues like respiratory illnesses and stress.
A $35 million program implementing advanced practice registered nurses (APRNs) in 16 Missouri nursing homes reduced avoidable hospitalizations and emergency room visits, resulting in better overall health and cost savings. The APRNs' advanced training enabled them to recognize early issues and implement evidence-based interventions.
Researchers found that curcumin intake increases ApoA-II and HDL-cholesterol concentrations by activating the PPARα signaling pathway, leading to increased AApoAII amyloid deposition. This discovery provides a novel molecular target for understanding amyloidogenesis and treating metabolic disorders.
A new study uses neutron scattering to investigate casein micelles in milk, aiming to develop a better understanding of dairy products. The researcher successfully applied their model to existing data and found that even skimmed milk has complex structures at the nanoscale.
Researchers used LED lights to measure collective brain activities in a group of mice, finding that gamma bursts were reduced during social interactions. The findings suggest a 'social buffering effect,' where being together reduces stress and anxiety.
Researchers at KIMM developed an all-round gripper technology that can handle objects of various shapes and sizes. The gripper's soft structure allows it to perfectly match the target object contour, providing a firm grip and preventing damage.
Researchers found that heart failure causes impaired gene activity in the brain's memory center, leading to cognitive deficits. A specific drug alleviated mental deficits in mice, suggesting potential approaches for therapies.
Researchers discovered five proteins associated with neutrophil activation that can predict severe COVID-19 outcomes. These biomarkers are elevated in patients who later require ICU admission or die from the virus.
The article suggests that disagreements over scientific facts reflect deeper social value differences. Science can become suspect when it neglects competing values, leading to eroded public trust.
A recent survey from Michigan State University found racial and political differences in COVID-19 responses, with Black individuals more likely to adhere to public health standards. The study suggests that conservative White individuals are more likely to have noncompliance attitudes towards local and state COVID orders.
A series of experiments at the ALTO particle accelerator facility revealed that fragments resulting from nuclear fission obtain intrinsic angular momentum after fission, not before. The study analyzed gamma rays emitted in the process and found a saw-tooth dependence of spin on fragment mass.
A study published in PLOS Pathogens reveals that bacterial toxin colibactin is produced in patients with urinary tract infections (UTIs), a potential link to bladder cancer. The researchers detected colibactin in 55 of 223 patient samples and found it to induce DNA damage in bladder cells.
Research reveals how glycans on SARS-CoV-2's surface facilitate activation of the virus by altering spike protein structure. This finding holds potential for identifying treatments to block or prevent viral activation.
Researchers have identified a new signaling pathway that regulates the production of RNA-protein complexes in neurons, which are overproduced in neurodegenerative diseases such as ALS and senile dementia. This discovery may lead to better understanding and potential therapeutic options for these conditions.
Research published by the American Psychological Association found that black women and girls are more likely to engage in exercise and eat healthy when faced with discrimination. The study suggests that optimism plays a role in this positive response, contrasting with avoidant coping strategies seen in less optimistic individuals.
Researchers have discovered a new type of bone cell called 'osteomorphs' that may reveal new therapeutic approaches for osteoporosis and other skeletal diseases. The cells have a unique genomic profile, suggesting promising targets for therapy.
Rapidly rising levels of sight loss are largely due to untreated ocular conditions, affecting hundreds of millions globally. A new study highlights the need for standard terminology and robust definitions to measure non-visually impairing eye diseases.
Researchers found that robust IgM and IgG antibodies persist in recovered COVID-19 patients for at least 140 days after symptom onset, while VN antibodies decline rapidly after 60 days. This suggests a short window for donating convalescent plasma to ensure maximum immunity.
A study published in Cancer found that nearly one-third of Black patients would not have qualified for liver cancer screening using common cirrhosis measures. The researchers also discovered that the tumors in Black patients tended to be larger, more numerous, and more invasive at diagnosis.
Researchers identify nearly 108,000 previously undetected structural variants and 278 SV hotspots in diverse human populations. The findings provide fundamental insights into the structure and variation of the human genome.
Researchers propose using human rights principles to allocate COVID-19 vaccines, considering social vulnerability alongside medical risk. An intersectional approach would prioritize those with overlapping vulnerabilities, such as age and economic status.
Immunologists at St. Jude Children's Research Hospital have mapped the biological machinery that generates T cells to kill bacteria, viruses, and tumor cells. The study reveals mechanisms that inhibit development of long-lived memory T cells, which can be blocked with pharmacological or genetic approaches to boost protective immunity.
A large study found that people taking antidepressants were no more likely to have an intracerebral hemorrhage than those who didn't take such medications. Researchers analyzed data from over 127,000 stroke patients and found a slight decrease in risk associated with antidepressant use.
The study analyzed subtitles of 2,000 films from the past seven decades to find consistent biases in Bollywood and Hollywood movies. Bollywood films consistently depicted fair skin as a beauty standard, while male characters made up about 60-65% of all pronouns used.
Researchers found that certain species of pollen advanced their seasons by up to 2 days per year, while others moved theirs 0.5 days earlier on average, impacting local health and allergy patterns. The study highlights the importance of accounting for pollen transport in understanding climate change's effects on the environment.
A new study predicts that the Southeastern United States is at high risk of extreme drought, which could expose its water-supply infrastructure to stress beyond its design limit. The researchers used short-term climate modeling forecasts to highlight the urgency of drought risk and inform policymakers' actions.
A new study reveals that megatheropods like Tyrannosaurus rex shaped dinosaur communities by filling ecological niches, explaining low species diversity among smaller dinosaurs. Communities worldwide lacked mesocarnivores due to the flood of resources from rapidly growing juveniles.
A study by researchers from Linköping University found that men are discriminated against in female-dominated occupations during the application process. Discrimination was observed in jobs such as nursing, childcare, and house cleaning, but not in male-dominated fields like auto mechanics or IT development.
Researchers have gained insights into how tiny, powerful bubbles are formed by ultra-fast vibrations, which could improve dental hygiene devices and other technologies. The study's findings suggest that nanobubbles can form through boiling or cavitation processes, paving the way for future research.
A new study led by the University of Maryland Baltimore County estimates the Bahama Oriole population at 1300-2800 individuals, suggesting a much larger number than previously believed. The research reveals that pine forest is an important habitat for the birds, contrary to earlier findings.
Researchers found that SARS-CoV-2's spike protein moves on a different time scale than SARS-CoV-1, giving it more stability and increasing its ability to infect cells. This discovery could lead to the development of therapeutics that alter the protein's dynamics and make it less transmissible.
A new study shows that the Beaufort Sea freshwater release could impact the Atlantic Meridional Overturning Circulation, leading to significant changes in northern-hemisphere climate. The freshwater content has increased by 40% over the last two decades, with potential consequences for global climate patterns.
A recent study by Curtin University found that people grieving a COVID-related death require timely support to reduce challenges in everyday life. The research identified key psychological factors such as separation distress, dysfunctional grief, and post-traumatic stress as contributing to these difficulties.
Researchers at the University of Alberta identified a new mechanism responsible for plaque buildup on artery walls, which can restrict blood flow and lead to cardiovascular disease. They found that inhibiting this process with specific drugs could be a new strategy for treating cardiovascular disease.
A new tool has identified significant security and privacy risks in COVID-19 contact tracing apps, including the use of insecure cryptographic algorithms and tracking of personal data to third parties. The study's findings highlight the importance of addressing these issues to maintain user trust and ensure effective app functionality.
Researchers identified key risk genes associated with schizophrenia and their impact on antipsychotic medication efficacy. Examining these single nucleotide polymorphisms (SNPs) can help differentiate between responsive and treatment-resistant patients.
Researchers analyzed 70,000 ancient skeletons to find declining rates of transmission for these chronic infectious diseases. The analysis suggests that pathogens may evolve to cause less harm to humans over time, leading to reduced transmission.
Hypertrophic cardiomyopathy (HCM) is a complex disease characterized by thickening of the left ventricle. Researchers have identified patient-specific protein networks using RNA-seq and tissue samples from HCM patients. This study offers a path toward individualized medicine for treating HCM.
A new analysis indicates that patients with kidney failure associated with sickle cell disease benefit from kidney transplantation to a similar extent as patients with kidney failure from other causes. Despite this, the sickle cell population is less likely to receive transplants.
New research in INFORMS journal Management Science finds that real-time scheduling hurts server sales efforts and restaurant revenue, with a 4.4% drop in party checks for servers asked to stay longer during shifts.
Researchers explore incorporating Earth observation data into flood forecast-based early action to reduce disaster risk and losses. The study identifies opportunities for using EO data in FbA, focusing on predefined triggers and impact-based forecasting.