A 'genomic-first' approach can identify rare genetic disorders earlier and more frequently than standard genetic testing driven by clinical symptoms. The study found that a majority of participants with associated genetic variants did not have matching diagnoses in their electronic health records.
A Geisinger study finds that Y chromosome genes increase height by 3.1 centimeters in individuals with sex chromosome aneuploidy, explaining approximately 23% of the average height difference between men and women.
A study published in JAMA Network Open found that more than 90% of participants with medically important genetic findings were unaware of their risk prior to participation in Geisinger's MyCode program. The initiative has disclosed genetic results to over 354,000 participants, who can now take proactive steps to prevent or detect disease.
A Geisinger study found a significant link between increased autism risk and the Y chromosome, offering a potential explanation for the disparity in ASD prevalence among males. The research analyzed genetic data from over 177,000 patients and confirmed prior work on Turner syndrome's association with ASD risk.
Melissa A. Kelly, co-director of Geisinger's MyCode Genomic Screening and Counseling Program, received the award for her work integrating genomic medicine into healthcare through Geisinger's MyCode Community Health Initiative. The initiative has reported over 5,000 medically relevant results to patient-participants, many of whom were u...
A study published by Geisinger College faculty and graduate students found that 55% of DSM-5-TR panel members received payments from industry, highlighting the need for stricter standards. The researchers argue that individuals with financial ties to industry should not have decision-making authority in guideline development.
A Geisinger Health System study found that genomic screening for hereditary hemochromatosis type 1 can identify underdiagnosed cases and encourage treatment. The screening program resulted in 69% of those notified proceeding with a lab test, and 69% of those showing iron overload beginning subsequent treatment.
A Geisinger-led study found that knowing the genetic cause of high cholesterol increases heart disease risk more than having high cholesterol levels alone. The study used UK Biobank data and observed distinct differences in heart disease rates among participants with different genetic causes.
A new study finds that one-time genomic screening of adults aged 20-60 for hereditary breast and ovarian cancer syndrome, Lynch syndrome, and familial hypercholesterolemia is cost-effective based on quality-adjusted life-year measures. The study suggests that this approach could improve disease management and reduce healthcare costs.
A Geisinger study supports genetic testing as a standard of care for people with cerebral palsy, similar to other neurodevelopmental disorders. The analysis found similar genetic diagnostic yield for CP and NDD, suggesting earlier identification of genetic changes and potential treatment through genetic testing.
A survey found that a substantial portion of Americans are willing to use polygenic embryo screening and gene editing to increase the chances of having a baby admitted to a top-100 ranked college. The study suggests growing interest in using genetic technologies to influence offspring traits, including educational attainment.
A Geisinger Health System study found that individuals with an additional X or Y chromosome have a four to five times higher risk of developing venous thromboembolism, a life-threatening condition. The analysis included data from over 642,000 patients and suggests that identifying those at high risk could minimize unnecessary illness a...
A Geisinger study found that genomic screening can help detect medullary thyroid cancer (MTC) in patients with RET gene variants. The research evaluated 75 patients who had the genetic results, and 12 were found to have cancer after undergoing surgery. Genomic screening provides opportunities for early detection and treatment of MTC.
A Geisinger study of over 90,000 patients confirmed a strong link between genetics and neuropsychiatric disorders. The research revealed that approximately one in 100 participants carried a rare gene variant increasing the risk for conditions like schizophrenia and autism spectrum disorder.
People with elevated blood pressure showed improvement after 12 weeks of a telehealth support program, with significant reductions in systolic blood pressure and increased self-reported physical activity. A dietitian-led intervention also showed greater reductions in systolic blood pressure while asleep and more weight loss.
Geisinger Health System is conducting a comprehensive study on the genetic causes of cerebral palsy, funded by a $3.3 million NIH grant. The research aims to identify individual genes and regions responsible for the condition, which affects 1 in 500 people worldwide.
A new ECG-based AI model developed by Tempus and Geisinger can predict patients at increased risk of undiagnosed structural heart disease. The rECHOmmend study found that the model achieved excellent performance, exceeding previous models in predicting any single disease.
Researchers found a strong association between chronic rhinosinusitis and non-cystic fibrosis bronchiectasis, with CRS diagnoses preceding bronchiectasis by an average of six years. Early treatment of sinus disease may offer therapeutic strategies for preventing bronchiectasis.
A machine-learning algorithm detected potential signs of colorectal cancer in high-risk patients who missed routine screenings. The algorithm identified patients as high-risk by analyzing age, gender, and recent CBC results, and subsequent screenings showed significant findings in 70% of the flagged group.
A Geisinger study found that adults with rare genetic causes of mental health disorders are more likely to have chronic illnesses like diabetes and dementia. The research also discovered that these individuals had twice as many annual emergency room visits compared to a control group without the genetic conditions.
A patient-centered rehabilitation program reduced hospital rehospitalization and mortality in high-risk patients with acute kidney injury. The study found that participation in the program significantly lowered rates of rehospitalization and mortality, with a 15% readmission rate compared to 34% for non-participants.
Researchers found that genomic screening can identify patients at risk for heart disease due to amyloidosis. The study used data from the MyCode Community Health Initiative and electronic health records to determine how often patients with specific transthyretin variants showed signs of cardiomyopathy.
A randomized trial found that individually addressed email reminders designed with behavioral science principles increased COVID-19 vaccination registration among healthcare workers, compared to those who did not receive an email. The emails led to more than twice as many registrations within three days.
Research found nearly two-thirds of patients with non-muscle-invasive bladder cancer had multiple co-existing chronic conditions, leading to a mean treatment burden of 8.9 days. Rural patients consistently had higher treatment burden than urban counterparts.
A team of researchers has identified a protein complex that promotes breast cancer growth, which can be disrupted to hinder tumor development. Non-toxic peptides were developed to prevent the abnormal interaction between RBM39 and MLL1 proteins in breast cancer cells.
Geisinger Health System has been awarded a $3.6 million contract from the National Cancer Institute to analyze genetic data from its MyCode Community Health Initiative. The study aims to identify specific gene variants linked to cancer risk, expanding the list of genes used for genetic cancer screening.
The FDA has granted Breakthrough Device Designation to Tempus' ECG Analysis Platform, which aids clinicians in identifying patients at increased risk of developing atrial fibrillation. The platform uses artificial intelligence to analyze ECG results and provide insight into a patient's risk of future atrial fibrillation events.
A survey of Geisinger employees showed increasing acceptance of COVID-19 vaccines after vaccine availability announcements, public events, and news coverage. 55.3% of employees indicated they intended to receive a vaccine, with most citing safety concerns as the main reason for hesitation.
Researchers developed an AI model that uses ECG data to predict atrial fibrillation and AF-related stroke risk. The model identified high-risk patients with 62% accuracy, allowing for earlier intervention.
Researchers at Geisinger Health System developed an AI algorithm using echocardiogram videos to predict mortality within a year. The model outperformed other clinically used predictors and improved cardiologists' prediction accuracy by 13 percent.
Researchers discovered a strong link between genetic changes and cerebral palsy, which often co-occurs with other neurodevelopmental disorders. The study identified disease-causing changes in 229 genes, decreasing the risk of recurrence for future children born to affected parents.
A study analyzing ischemic stroke data from 8,900 patients reveals that female patients have higher crude mortality rates but equal survival rates after controlling for comorbidities. The researchers found no evidence of a sex disparity in stroke recurrence or composite outcomes.
A team of Geisinger researchers developed a computational model to simulate ventilator sharing, finding that patients with similar lung function and oxygen saturation levels are most likely to succeed. The study provides guidelines for clinical patient selection in extreme circumstances.
A recent analysis of Geisinger Health System's electronic health records reveals chronic kidney disease as the leading risk factor for COVID-19-related hospitalization. The study found that patients with end-stage renal disease were 11 times more likely to be admitted to the hospital compared to those without kidney disease.
A Geisinger-Regeneron genomics study found that Familial Hypercholesterolemia (FH) is more common than thought, with 1 in every 256 people carrying a disease-causing mutation. The study identified 35 mutations causing FH and found many patients were undertreated due to lack of genetic confirmation.
Researchers discovered that using hydroxychloroquine reduces diabetes risk in rheumatoid arthritis patients by 53%. The study suggests HCQ improves glucose tolerance, preventing diabetes onset.
A new study by Geisinger Health System found that improving healthcare value leads to better patient outcomes, including reduced hospital admissions and unnecessary drug costs. The study's initiatives, such as the medical home program and ProvenCare, have eliminated common delivery issues and improved care coordination.
A Geisinger study found PTSD increases likelihood of heart disease death by 2x in Vietnam veterans, similar to smoking 2-3 packs/day for 20+ years. Chronic stress from PTSD causes inflammation and cardiovascular damage.
Research shows that people with temporal arteritis, an inflammatory artery disease, are three times more likely to experience blindness due to swollen arteries restricting blood flow. The disease is often accompanied by symptoms like headaches and jaw soreness, and if left untreated can lead to severe vision loss or stroke.
A new Geisinger-led study finds that hearing repeated stories of trauma from clients causes serious psychological stress in clinical social workers. A positive work environment helps reduce secondary trauma and job burnout.
A recent Geisinger study found that reviewing patient files in the Electronic Health Record reduces elderly patients' use of psychoactive medications linked to increased fall risk. This decrease in medication usage has the potential to significantly reduce falls among the elderly, a major cause of injury and death.
Geisinger's Electronic Health Record program improves blood sugar and cholesterol levels, increases vaccination compliance, and boosts tobacco cessation rates. The program also enhances patient engagement through its Internet portal, MyGeisinger.
Geisinger's rheumatology department redesigned osteoporosis and rheumatoid arthritis care by simplifying the ordering process for bone density scans. As a result, 88% of patients received the scan, compared to 18% previously, with quadrupling the number of patients who underwent testing.
A recent study found that workers with diabetic neuropathic symptoms lose an average of 1.4 hours per week due to health-related lost productive time, resulting in $3.65 billion annual costs. Those with diabetes without symptoms still experience a higher likelihood of unemployment compared to their non-diabetic counterparts.
A recent Geisinger Health System study reveals a clear connection between combat veterans' mixed handedness and the likelihood of developing post-traumatic stress disorder (PTSD). The research found that extreme mixed handedness increased PTSD risk by nearly five times.
A study by Geisinger Health System researchers found that EHR-based programs tripled the rate of osteoporosis screenings in at-risk women. High-risk women accounted for about half of those screened, highlighting the potential of EHRs to identify and prevent fractures related to osteoporosis.