A new study has found that abnormality of intracortical inhibition in patients with progressive myoclonic epilepsy type 1 is associated with the magnitude of genetic change. The results suggest that transcranial magnetic stimulation could be useful in assessing patient prognosis and may have use as a marker of GABAergic impairment.
Researchers at Iowa State University have identified a metabolic switch that can be modified to control fat production, which could lead to more effective treatments for childhood obesity and cancer. The discovery involves altering the acetylation levels of fatty acid synthase, an enzyme critical to de novo lipogenesis.
A new type of optical manipulation has been developed, using laser light to pull macroscopic objects. The researchers designed a graphene-SiO composite structure specifically for laser pulling, which creates a reversed temperature difference when irradiated with a laser beam.
Scientists created Cyborg Cells by combining synthetic polymer networks with bacterial cells, giving them enhanced stress resistance and ability to invade cancer cells. This breakthrough demonstrates the therapeutic potential of Cyborg Cells for various applications.
A recent Yale-led study failed to replicate findings linking brain activity to post-traumatic stress disorder (PTSD) symptoms, highlighting the need for more research to develop reliable models. The study suggests that neuroimaging technology still has kinks to be ironed out before it can accurately diagnose psychiatric disorders.
A team of researchers at the University of Iowa has identified three genes that are directly associated with cleft lip and palate. The study, which analyzed DNA from over 1,000 patients with the disorder, found that deleting these genes can cause cleft lip or palate.
A study found that remote workers are more likely to protect IT resources when faced with fear and a clear understanding of potential security threats. Employers can encourage secure behaviors by clearly communicating threats and promoting self-efficacy, and also consider integrating stewardship theory to promote a sense of collectivism.
Scientists have recorded another year of record-breaking ocean temperatures, indicating a perpetually heating climate. The added heat content has serious consequences, including ocean deoxygenation, altering the exchange of heat, carbon, and oxygen between the ocean and atmosphere.
A phase II study found that posoleucel, an off-the-shelf T-cell therapy, demonstrated promising antiviral efficacy and safety in patients with blood cancers and other hematologic disorders. The therapy reduced viral load by an average of 97% and showed limited rates of graft-versus-host disease.
Drivers in these regions will benefit from cleaner power grids and low electricity prices, reducing transport costs and emissions. The study found that 71% of US drivers could halve their transport bills by going electric, with over 80% of households experiencing lower costs.
This study proposes using gamification and virtual reality to create quality learning experiences for digital twin students and employees. The technology aims to enhance learner motivation, acquire knowledge, and foster a personalized and cooperative learning environment.
A new study suggests that women in the late-reproductive stage may experience multiple symptoms often associated with menopause, including hot flashes and depression. These symptoms can impair overall quality of life, regardless of when they occur.
A study by Kingston University found that Covid-19 conspiracy theories led to a lower engagement with health prevention methods among the UK Black community. The research revealed that perceived racial injustice and mistrust of institutions contributed to this phenomenon.
Establishing ecological corridors among western US national parks can enlarge mammal populations and allow species to shift geographic ranges in response to climate change. This could increase the long-term persistence time of mammal species by a factor of 4.3, compared to fragmented individual parks.
A novel imaging agent, 68Ga-FAPI, has been shown to reduce the number of false-positive PET/CT findings among cancer patients recently vaccinated for COVID-19. This can help prevent costly follow-up and false management decisions for cancer patients.
A study by Columbia University Mailman School of Public Health found a link between recreational cannabis legalization and increased asthma prevalence among teens, especially minority racial and ethnic groups. Exposure to secondhand smoke is a key risk factor for asthma in children.
Researchers developed a bioeconomic model to overcome the cost barrier of high-density planting for weed suppression. The study found distinct physiological differences in crops that impact the balance needed to achieve a cost-neutral result.
Researchers at WashU Medicine discovered a link between obesity and diabetes, highlighting the importance of an enzyme in fatty acid processing. The study suggests that defects in this enzyme contribute to insulin hypersecretion and beta cell failure, paving the way for potential therapeutic interventions.
The study reveals that achieving low forcing levels relies on negative CO2 emissions, particularly through carbon capture and storage methods. Regional contributions show the US, China, and EU as top contributors, with China's share projected to increase under future scenarios.
Researchers discovered that urinary tract infections can arise after sterile tubes are inserted into the urinary tract, even when no bacteria are detectable beforehand. This study suggests that screening patients for hidden reservoirs of dangerous bacteria could supplement infection-control efforts and help prevent deadly infections. B...
Researchers recreated interstellar cloud and asteroid conditions to understand how carbonaceous chondrites acquired amino acids, finding that interstellar cloud conditions are resilient to asteroid processing but influence the amount of amino acids present.
Research by Anglia Ruskin University found that soft laws in over 14,000 companies across 99 nations led to a 20% average percentage of women on corporate boards. Quotas increased female directors by 11.7%, but only when sanctions were applied. Firms complied better with realistic targets and sufficient time.
Researchers discovered that pre-surgery immunotherapy significantly improved patient outcomes for locally advanced colorectal cancer. The treatment showed substantial longer survival benefits, including low recurrence rates, in patients with mismatch repair-deficient or microsatellite instability-high (dMMR/MSI-H) CRC.
Scientists have discovered a new form of carbon, LOPC, formed by heating fullerenes with lithium nitride. The new carbon consists of 'broken C60 cages' connected with long-range periodicity, exhibiting unique electrical conductivity properties.
A multidisciplinary team of UC students developed a new understanding of spinal column formation and reengineered the process in mutant zebrafish. This breakthrough could lead to possible treatments for scoliosis in humans.
A recent study by University of Missouri researcher Jake Haselswerdt suggests that partisan beliefs do not overshadow how people perceive the severity of COVID-19 in their communities. Local public health information appears to get through to individuals, regardless of their political leanings.
UC Berkeley chemists designed and synthesized porous materials that bind and release ammonia at moderate pressures and temperatures, saving energy. The new MOFs could enable a more sustainable fertilizer production by producing ammonia closer to farmers.
Researchers at NYU Langone Health developed an iScore system that correlates inflammation levels with survival rates in patients with acute myeloid leukemia (AML), with those having low scores surviving the longest.
A new UC Riverside-led study reveals that drought-tolerant trees in urban areas use significantly more water than their natural counterparts. The research found that even 'drought-tolerant' species like eucalyptus and ficus increase their water intake when irrigated.
Researchers developed a computational model of mesenchymal migration to understand how cancer cells navigate tissue. The model confirms that cells adapt their movement based on surface stiffness, using internal biochemical signals and chemical cues from surrounding tissues.
A $749,960 NSF grant will develop AI-powered AAC devices to improve outcomes for individuals with limited speech and language. The technology aims to reduce the burden on users and enhance their participation in education and workforce activities.
Hiroshima University researchers have generated a high-quality genome assembly of red perilla, allowing scientists to harness its abundance of potentially useful bioactive chemicals. The study enables targeted gene editing for enhanced phytochemical production, paving the way for new medical applications.
Researchers used zebrafish to study an inflammatory lipid called 5-oxoETE, which plays a role in airway inflammation and neutrophil response. The study identified the 5-oxoETE/OXER1 pathway as an important immune pathway that may prevent some cancers.
Researchers developed a novel framework to quantify the difficulty of controlling brain state transitions, which could lead to a better understanding of cognitive loads and psychiatric disorders. The study found that different brain regions play significant roles in controlling mean and covariance, with implications for future research...
A clinical trial found that boiling peanuts for up to 12 hours can desensitize children with peanut allergies. The therapy involved sequential doses of boiled and roasted peanuts, achieving high success rates in participants. While promising, the study's findings require confirmation in larger trials.
Researchers found that underwater light intensity plays a critical role in the energy expended by coral's symbiotic algae, highlighting the importance of water clarity for coral conservation. Preserving water optical quality is vital to protecting coral biodiversity and preventing reef degradation.
A study found that Black, Latino, and Native Hawaiian people with epilepsy are less likely to receive newer medications than white individuals. People who saw a neurologist had more than three times the odds of being prescribed newer drugs.
Researchers at the University of Minnesota Medical School conducted a large clinical trial comparing two commonly prescribed generic drugs, chlorthalidone and hydrochlorothiazide. The study found that both medications were equally effective in preventing cardiovascular disease and non-cancer death, contradicting current clinical guidel...
A new understanding of how particle shape controls grain flow can help engineers plan for downstream impacts of restoring a river or removing a dam. The MIT team's better formula estimates bed load transport by considering a grain's drag and friction, rather than its exact shape.
A research team from the University of Queensland has developed a tool to guide the global beef industry in reducing costs and greenhouse gas emissions. The study found that as much as 85% of emissions could be cut without an overall economic hit, by opting for more efficient feeds and locations.
A phase 2 clinical trial using boiled peanuts followed by roasted peanuts showed promising results in desensitizing 80% of children with peanut allergies. Treatment-related adverse events were reported in 61% participants.
The UK National Health Service is launching a new guidance to address human errors and adverse events in healthcare, with the aim of reducing their impact. The guidance, published in the journal Anaesthesia, provides recommendations for designing safe systems, using checklists, and encouraging staff to speak up about safety concerns.
Researchers have developed a novel hybrid catalyst that combines enzymatic and single-atom catalysis, achieving high efficiency in one-pot chemoenzymatic reactions. This breakthrough simplifies chemical production and separation processes, offering a promising strategy for efficient synthesis of pharmaceutical intermediates.
A study by Yale School of Public Health and University of North Carolina at Charlotte found that annual or biannual COVID-19 boosters significantly reduce the risk of future infection. Boosting every six months provides strong suppression of infection, with only one in 10 people projected to contract COVID-19 over a six-year period.
A team of researchers has developed an experimental method to manipulate the Rydberg state excitation in hydrogen molecules using bicircular two-color laser pulses. By controlling the photon effect and field effect, they were able to generate Rydberg states while varying the extent to which each effect contributed to the process.
Researcher Dana Hawley found that finches with mild and strong conjunctivitis symptoms spread a pathogen at higher rates than healthy birds. This suggests that pathogens can evolve to cause more harm to their hosts, leading to increased transmission.
A recent study from researchers across 63 institutions, including Argonne National Laboratory, evaluated the impacts of various drivers on energy exchange in the Arctic. They found that vegetation type is a primary predictor of how energy is exchanged during the Arctic summer.
Researchers used the Panchromatic Hubble Andromeda Treasury Triangulum Extended Region — or PHATTER — survey to study the Triangulum galaxy. The team discovered two drastically different structures depending on the age of the stars, with younger and older stars having distinct distributions.
A novel 'retipping' method produces nine-times as many plants in a similar amount of floor space compared to traditional stem cuttings. The research found that all three methods resulted in similar plant growth and chemical profiles, with retipping requiring the least propagation space.
A new Duke University study found that most clergy members prioritize medical understanding of depression, with only a small minority recommending solely religious treatments. The survey results alleviate concerns about clergy advising congregants to pray instead of seek medical help for depression.
A team of researchers from Erlangen and Würzburg developed a method to bind specific molecules in samples and serums to iron oxide particles, allowing for their identification using an inexpensive and compact detector. This method enables highly sensitive measurements in a short time with little technical outlay.
A new data-driven approach assesses resilience in six countries, including the US, Brazil, India, and Sweden, highlighting regional differences and impact of education on pandemic response. The study finds significant discrepancies between predicted and actual resiliency, with diverse sectors affected across countries.
Researchers genetically engineered yeast to produce vindoline and catharanthine, two pharmacologic precursors of the powerful anticancer drug vinblastine. The team successfully optimized biosynthetic pathways using advanced genetic engineering and synthetic biology-based approaches.
Researchers at the University of Cambridge developed an artificial pancreas that can help maintain healthy glucose levels in type 2 diabetes patients. The device doubled the time spent in the target range for glucose and halved the time spent with high glucose levels, reducing average glucose levels and glycated haemoglobin levels.
Experiments show that UV light from the sun breaks down plastics on the ocean surface, turning them into smaller, invisible nanoplastic particles. This process could account for a substantial amount of the 'Missing Plastic Paradox', where plastic waste in the ocean is only a fraction of what has been littered.
Researchers have uncovered the most detailed look yet at Earth's recent climatic history by analyzing Antarctic ice cores. The study provides a record of summer and winter temperatures dating back 11,000 years, offering an important baseline for understanding climate change.
Researchers have made a key breakthrough in developing a new treatment for hereditary blindness by using lipid nanoparticles to deliver messenger RNA to the photoreceptor cells. The technology, inspired by COVID-19 vaccines, shows promise in animal models for treating blindness associated with rare genetic conditions.
Researchers advocate for descendant community involvement in ancient DNA research to ensure benefits and risks are shared fairly. Without such guidance, the science can be exploitative, perpetuating colonial practices and harming modern Indigenous groups.
Computer modeling by Oregon State University scientists shows that Douglas-fir trees are likely to experience more stress from drier air as the climate changes. This is crucial for understanding forest sensitivity to a shifting climate, given their widespread ecological, cultural and economic significance.
A new model predicts US recessions and slowdowns by analyzing the aggregate probability of financial misreporting in the economy. The model improves recession prediction by about 25% over existing models, providing regulators with more lead time to prepare for a recession.