A new study published in the Journal of the National Comprehensive Cancer Network (JNCCN) identifies significant long-term health risks among testicular cancer survivors treated with contemporary chemotherapy regimens. Researchers found that survivors treated with etoposide and cisplatin (EPx4) had higher odds of renal impairment, hear...
Researchers will investigate the therapeutic potential of psychedelics to treat methamphetamine addiction, with a focus on serotonin receptors and potentially leading to new treatments. The project aims to advance psychedelics as a promising option for treating stimulant use disorder.
Scientists at Medical College of Wisconsin create biased agonists that reduce hallucinogenic effects while preserving therapeutic potential. These compounds, designed to selectively activate serotonin receptors, show promise in treating depression and other mental health conditions.
A study published in Science Advances found that abnormal cell stress in the placenta's syncytiotrophoblast layer may lead to preeclampsia. Researchers also developed a mouse model to demonstrate the effects of this stress, showing similar signs of high blood pressure and kidney damage.
A Medical College of Wisconsin research team has identified a new role for liver protein tPA in influencing blood cholesterol levels. The study found that increased tPA production leads to decreased VLDL assembly in the liver, which may provide a novel target for heart disease treatment.
Researchers will explore characteristics of misplaced calcifications in eyes and brains, and their roles in AMD and AD. The team aims to examine calcifications at multiple levels, from atomic structures to aggregated morphologies, and their accumulation in cells and animals.
Researchers from Medical College of Wisconsin found that older breast cancer survivors, particularly those exposed to chemotherapy, showed greater epigenetic aging than their same-aged peers without cancer. This acceleration in biological aging may be associated with worse functional outcomes and quality of life for these patients.
In a multicenter trial, pirtobrutinib demonstrated reversible and effective inhibition of defective B-cells in patients with poor survival prognosis. Over half of patients responded to the drug, with a median duration of response of 21.6 months.
Medical College of Wisconsin scientists have identified PD-L2 as a therapy-relevant marker for predicting early recurrence of breast cancer. High levels of PD-L2 protein in cancer cells are associated with an elevated risk of progression and may indicate patients who can benefit from immunotherapies such as PD-1 inhibitors.
The study reveals that multiple high-level cortical areas process word meanings, including the classical language areas. Interestingly, regions not previously considered for language processing contained significant information about word meaning.
Researchers at the Medical College of Wisconsin uncovered that conceptual knowledge is tied to perceptual and experiential information. They used fMRI to measure neural activity while participants read hundreds of words, finding that experiential information was key to understanding word meaning.
Researchers have solved the mystery of how praziquantel works, a key to treating schistosomiasis. The discovery highlights new opportunities for drug development and may help combat this debilitating disease affecting over a billion people worldwide.
Scientists have developed a new mouse model that enables the growth and metastatic spread of human breast tumors in mice. This breakthrough could lead to more effective treatments for estrogen receptor-positive breast cancer, which is responsible for most breast cancer deaths.
Researchers at Medical College of Wisconsin discovered a non-opioid based target to alleviate chronic touch pain and spontaneous pain in mice. The target, TRPC5, is expressed in both mouse and human neurons that send pain signals to the spinal cord.
Scientists discovered molecular basis for how shapeshifting immune system protein XCL1 evolved, outlining principles for designing metamorphic proteins as transformers. These principles can be used to develop biosensors, build nanoscale machines, and even create therapeutics.
The MCW Medical Scientist Training Program will provide a stipend and full tuition scholarship to students pursuing a dual MD-PhD degree. The grant supports the growth of physician scientists conducting research in basic sciences with academic careers in medicine.
A new five-year grant aims to develop novel treatments for diseases that inhibit blood cell growth and abnormalities in the bone marrow environment. The study focuses on the role of laminin in maintaining healthy bone marrow and identifying potential targets for treating bone marrow failure syndromes.
Dr. Qizhen Shi's team aims to investigate a novel gene therapy approach that induces immune tolerance for hemophilia A, overcoming the challenge of inhibitory antibodies. The project seeks to develop a clinically translatable gene therapy protocol that provides therapeutic FVIII protein.
Researchers aim to understand why diabetic patients lack cardioprotection during surgery, a condition that poses serious health issues. They will assess the role of cellular and environmental factors in protecting against ischemia-reperfusion injury.
A study published in Journal of Biological Chemistry identifies CCL28 as a key player in inducing asthma pathology even without a viral infection. This finding opens the door for developing potent and specific CCL28 inhibitors to prevent post-viral asthma in young children.
The Medical College of Wisconsin has received a $8 million grant to fund the Rat Genome Database, providing a globally-accessible collection of data from ongoing rat genetic and genomic research. The database holds nearly 4.5 million functional data annotations for rat, human, and mouse genes, as well as files on specific animal strains.
Researchers have developed a technology that mimics the cellular environment to restore organ function and promote tissue regeneration. The bioengineered miniature structures can release biologically active peptides to protect and repair damaged heart muscle cells.
Researchers identified a link between a PARK2 gene mutation and familial lung cancer, implicating the mutation as a genetic susceptibility factor. The findings suggest potential targeted therapies for individuals with this mutation variant.
Scientists at MCW found a link between sleep loss and cell injury, particularly in the liver, lung, and small intestine. Recovery sleep from deprivation restores balance and decreases cell injury, elucidating previous research on sleep abnormalities as risk factors for diseases like cardiovascular disease and cancer.
A new gene, Tpcn2, has been discovered as a key player in the development of diabetes. Variants in this gene have been associated with fasting glucose levels and insulin response in animal models, as well as human populations.
Despite improvements in supportive care, the mortality rate remains high due to sepsis. Statin therapy showed no significant difference in outcomes for patients with sepsis and ARDS, highlighting the need for further research into alternative treatments.
A new study found that access to electronic health records (EHRs) can significantly impact the interpretation of head CT scans, potentially leading to adverse effects on medical management. In nine percent of cases, EHR data was deemed crucial for accurate diagnosis, highlighting the importance of widespread EHR adoption.
A team of researchers identified the TBC1D20 gene as responsible for Warburg Micro syndrome, a rare genetic disorder characterized by severe physical and mental impairments. The study found that five distinct mutations in the gene cause the disease, with implications for understanding human development and related disorders.
Researchers used next-generation sequencing to identify clinically relevant genetic variants associated with CAS. In eight cases, clinically significant variants were found, confirming previous reports and identifying novel associations.
A new bioinformatics software tool, DrGaP, has been developed to identify genetic mutations responsible for cancers. The tool combines statistical methods and bioinformatics tools to distinguish between driver mutations and passenger mutations, leading to a more complete identification of altered genes and signaling pathways in cancer.
Researchers documented irregular brain activity within hours of a concussive injury and increased brain activity weeks later, indicating the brain may compensate for the injury. The study suggests a new approach to deciding when athletes can return to play after a concussion.
Researchers have found that diapocynin, a synthetic antioxidant molecule, protects neurobehavioral function in mice with Parkinson's Disease symptoms. The treatment prevented expected deficits in motor coordination, suggesting potential therapeutic benefits.
A new evidence-based algorithm guides treatment of autosomal recessive polycystic kidney disease in children, recommending simultaneous kidney and liver transplantation for select patients. The approach aims to decrease overall mortality and morbidity, particularly in those with end-stage renal disease and congenital hepatic fibrosis.
A review of literature suggests that lowering salt intake is associated with decreased cardiovascular disease and mortality. National studies in Finland and Great Britain show a significant decrease in death due to stroke and coronary heart disease after instituting a national salt-reduction program.
A pilot study assesses the Primary Practice Physician Program for Chronic Pain (4PCP) and its impact on patients with chronic pain. The program improves symptoms, including reduced pain, fatigue, and depression, as well as boosts physician confidence and efficiency.
Researchers found significant improvement in quality of care measures, particularly in diabetes-related measures, with double-digit percentage gains observed. The public reporting led to prioritization and engagement in quality improvement efforts among participating physician groups.
Researchers at the Medical College of Wisconsin and Children's Hospital of Wisconsin found that immunodeficient patients with secondary lung disease can experience improved pulmonary function and radiographic abnormalities when treated with a combination of rituximab and azathioprine. This treatment targets specific types of lymphocyte...
Researchers identified novel biomarkers in rat feces after radiation exposure, which persisted for at least 21 days. These findings hold promise for rapid, accurate diagnosis of radiation exposure, enabling timely resource allocation for patients in need of intervention.
Researchers found that patients receiving bone marrow transplants from unrelated donors had the same survival rates as those receiving blood stem cell transplants. However, PBSCs resulted in better engraftment but higher rates of chronic graft-versus-host disease (GVHD), a serious post-transplant complication.
A study by researchers at the Medical College of Wisconsin suggests a possible link between norovirus and food allergies. The team found an immunoglobulin E response to egg protein in mice infected with norovirus, indicating a potential connection between gastrointestinal viruses and allergic diseases like asthma.
Researchers at Medical College of Wisconsin show that CXCL12 protein inhibits metastasis in colon and melanoma cancers. The protein, naturally expressed in bone marrow and other organs prone to cancer metastasis, effectively blocks tumor growth and improves survival time.
Using powder-free latex gloves significantly reduced the rate of latex sensitization among healthcare workers. A study found a 16-fold reduction in latex sensitization after institutions switched to powder-free gloves, preventing allergic sensitization and allowing some sensitized workers to lose sensitivity.
Researchers aim to create a 'virtual rat' model to predict and understand physiological function and disease, filling a gap in understanding complex diseases. The Virtual Physiological Rat (VPR) project will use computer simulations to translate findings from animals to humans, targeting diseases like hypertension and heart failure.
Researchers at The Medical College of Wisconsin developed virtual nasal surgery using computer simulation techniques to predict post-surgical outcomes for patients with nasal obstruction. The study showed promising results, demonstrating the potential of computational fluid dynamics (CFD) in predicting post-surgical parameters.
Researchers at the Medical College of Wisconsin found that children with type 1 diabetes often develop early cardiovascular disease before puberty, characterized by stiffer blood vessels and vascular inflammation. The study highlights the need for long-term studies to monitor the progression of these changes in young patients.
A new CPR technique using compression-decompression and negative intrathoracic pressure increases blood flow to the heart and brain by nearly three times, leading to a 53% improvement in long-term survival. The study involved 46 EMS agencies and showed that this alternative method is more effective than standard CPR.
Researchers at Medical College of Wisconsin sequenced all genes in a boy's DNA to identify a previously-unknown mutation responsible for his rare bowel disease. A cord blood transplant successfully treated the disease, allowing the boy to eat healthily again.
Researchers at Medical College of Wisconsin and University of California, Riverside create synthetic chemical mimicking abscisic acid to improve crop resistance to drought. The discovery paves the way for developing new molecules that activate or turn on receptors.
Two studies examine the effects of oral steroids and propranolol on infantile hemangiomas, revealing potential side effects and complications. Researchers aim to develop safer treatment options for this common childhood skin disorder.
A new study found that cochlear implants improve hearing for older adults with age-related hearing loss. However, the effectiveness of implants decreases with increasing age, highlighting the need to reassess implant criteria for elderly patients.