Researchers at USC's Keck School of Medicine discovered how estrogen activates genes in breast-cancer cells through a protein called TIP60, which recognizes methylation signals in chromatin. This finding builds upon previous work and has broader implications for gene regulation and potentially global significance.
Georgia Institute of Technology experts developed RealOpt-ABM software to model guest movement through the aquarium. The tool accurately predicted guest flow, recommending strategies for show scheduling, resource allocation, and theater loading/unloading. Optimized designs minimized congestion and ensured an amazing guest experience.
A study published in The Lancet Oncology found that CT colonography significantly increased participation in colorectal cancer screening, with a more than 50% increase compared to traditional colonoscopy. This non-invasive technique has the potential to positively impact overall patient outcomes and reduce complications and costs.
A randomized controlled trial found that telephone-delivered cognitive behavioral therapy and an exercise program were associated with short-term positive outcomes for patients with chronic widespread pain. The combined intervention showed improvements in physical component score and reduced passive coping strategies.
Researchers at George Mason University have identified a key driver in inflammatory breast cancer, allowing for the development of new treatments. The study found that nearly all samples had high activation of the protein anaplastic lymphoma kinase (ALK), paving the way for targeted therapy.
Researchers found that prenatal exposure to xenoestrogens from urban pollution is associated with higher birth weights in infants. The study established a correlation between estrogenic burden in pregnant women's placenta and increased birth weight.
Researchers used laser capture microdissection to analyze individual root cells and discovered genes involved in arbuscular mycorrhizal (AM) symbiosis. The study found that even non-colonized cells are reprogrammed to prepare for fungal colonization, enabling plants to thrive in nutrient-depleted soil.
Research found that low-income older adults are at a higher risk of developing heart failure, regardless of their education level. The study highlights the need for affordable access to healthcare and healthy lifestyle promotion.
A new report calls for stronger institutions, improved public engagement, and alignment with national policies to enhance the effectiveness of carbon markets in promoting sustainable development. Key findings highlight the need for wider political changes to address the winners' and losers' from a low-carbon energy economy.
Researchers developed a gelatin-based drug-delivery system that can quickly restore blood flow by activating tissue plasminogen activator (tPA) in blood clots. The treatment, which uses soundwaves to reactivate tPA once it reaches the clot, shows promise for treating patients with chest pain en route to the hospital.
Researchers discovered Mycobacterium tuberculosis produces a protein that disables the immune response, allowing the bacteria to live comfortably in human cells. This breakthrough provides new targets for developing better treatments against this devastating disease.
Researchers are discovering promising treatments for pain, including mirror box therapy and a new opioid-like drug that relieves acute pain without euphoric effects. The studies also identify the neurobiological source of common morphine side effects.
The US Department of Energy has established a high-speed network connecting three top supercomputing centers in California, Illinois, and Tennessee. This network delivers data at 100 Gigabits per second, making it one of the fastest systems in the world.
A study by McMaster University researchers found that voters tend to prefer candidates with lower-pitched voices, perceiving them as more attractive and dominant. This preference is related to the cue of dominance, which has been an important factor in human leadership throughout evolution.
Researchers at Virginia Tech discovered that certain bats can deform their ears in just one-tenth of a second, changing their ultrasonic hearing patterns. This allows them to adapt to different acoustic sensing tasks, outperforming humans in spatial hearing sensitivity.
Professor Andreas Strasser has been awarded the 2011 Victoria Prize for his groundbreaking research into programmed cell death, which has shown that defects in apoptosis can lead to cancer and autoimmune disease. His work aims to improve anti-cancer treatments by increasing cancer cells' propensity to die.
Adults with congenital heart disease and implanted cardioverter defibrillators (ICDs) experience sexual performance problems due to fear of device shock. The study found men with ICDs had lower sexual function scores, especially those with high shock-related anxiety.
Climate change is expected to alter water flows in major river basins in Africa, posing a new challenge to food production and cross-border water conflicts. The Limpopo Basin, Nile Basin, and Volta Basin are particularly vulnerable to changes in temperature and rainfall patterns.
Researchers found that TDP-43 binds to NF-kB p65 in spinal cords of ALS patients, promoting inflammation and killing neurons. Treatment with an agent blocking p65 activity eased disease symptoms in a mouse model.
A national study led by Johns Hopkins cardiologist Thomas Aversano found that nonemergency angioplasty can be performed safely at hospitals without cardiac surgery backup, with low rates of complications and death. The study compared over 18,500 patients who underwent heart artery-opening angioplasty or stenting at hospitals with or wi...
A new study published in Psychological Science finds that individuals pay attention to negative information about a system when they believe the status quo can be changed. This shift in perspective allows people to focus on finding solutions to problems, rather than reinforcing the existing system.
Research from the University of Pennsylvania School of Medicine found that 57% of cardiac arrest patients' treatment with hypothermia involved documentation of poor prognosis, with 25% of patients having their care withdrawn within 72 hours after arrest. Despite this, over 20% of patients survived to discharge with good neurological ou...
A recent study found that a gene influencing empathy and sociability can be detected in strangers, who rated individuals with a particular genetic variation as more caring and trustworthy. The oxytocin receptor gene was linked to prosocial behavior, with those carrying the GG genotype exhibiting higher levels of kindness and trust.
A study found that retinal microvascular changes are associated with disability in daily activities among older adults. The presence of two or more retinal signs was linked to a higher risk of disability, independent of vascular risk factors and carotid atherosclerosis.
A Mayo Clinic study found that stem cells delivered two to three weeks after a heart attack do not improve heart function. The research provides vital information for the field of cell therapy and cautions against seeking stem cell treatment outside the US.
In a preliminary human trial, an injection targeting PCSK9, a cholesterol regulator, lowered low-density lipoprotein (LDL) or 'bad' cholesterol by 64% in healthy volunteers. The study found that increasing doses of the monoclonal antibody AMG145 improved cholesterol levels and reduced side effects.
A study published in Archives of Neurology found that breast cancer survivors who received chemotherapy demonstrated reduced activation in key brain areas and poorer executive function. The researchers also discovered that negative effects of chemotherapy may be exacerbated by factors such as age and educational level.
A University of Rochester Medical Center study found that high school football and hockey players showed subtle brain injuries after routine head hits, even without concussions. The research used diffusion tensor imaging to detect changes in white matter, which are similar to axonal injury at the cellular level.
A primary care-based weight intervention led to a significant weight loss of 10.1 pounds over two years in obese patients. The program, which included lifestyle counseling and meal replacements, also improved cardiovascular disease risk factors.
New research from Northwestern University and Texas A&M University suggests that ideal partner preferences can be flexible once meeting in person. People tend to focus on the whole person rather than individual traits, making preconceived notions less important.
A new study suggests a possible link between radon exposure and non-melanoma skin cancer in the southwest region of England. The research found a correlation between areas with high radon concentrations and squamous cell carcinoma cases.
Scientists at the University of Georgia have developed a new method to create neural crest cells, precursors of bone cells, smooth muscle cells, and neurons, using a single-step process that reduces production time by half. The method uses small molecules to activate specific signaling pathways, increasing consistency and reducing costs.
Researchers found that influenza viruses can circulate globally, with multiple urban centers acting as sources of seasonal epidemics. The study used RNA sequences from 2003-2006 and showed high rates of viral migration among cities, challenging the long-held theory that tropical areas are the only source of seasonal flu.
A six-month telephone-delivered cognitive behavioural therapy (CBT) program improved symptoms of chronic widespread pain, with significant benefits reported three months after treatment ended. Exercise also showed substantial improvements in self-rated global health.
The Allen Institute for Brain Science has launched a new brain atlas resource, the Allen Mouse Brain Connectivity Atlas, which provides a three-dimensional map of neural connections throughout the mouse brain. The Atlas will help scientists understand how the brain is wired and what goes awry in brain diseases and disorders.
Tel Aviv University researchers create mathematical models using machine learning and signal processing to improve echo localization and accuracy in medical imaging. The new technology could lead to earlier detection of defects in embryos and non-invasive cancer tumor detection.
Researchers at Northwestern University have created an electrode that allows lithium-ion batteries to hold a charge up to 10 times greater than current technology. The new technology can also charge 10 times faster, paving the way for more efficient and smaller batteries for electric cars.
The Singapore research team led by Associate Professor Xiaogang Liu developed a synthesis of lanthanide-doped core-shell nanocrystals with advanced optical properties, enabling efficient upconversion and tunable light emission. This breakthrough has significant implications for cancer detection, medical imaging, and therapeutic delivery.
Scientists have compared MINI-ME's observations with those from two other instruments to reveal a host of interrelated phenomena occurring together in the dynamic region. The findings show that oxygen ions course outward along Earth's magnetic field lines, driving ion outflow events.
Researchers have unearthed a prehistoric bronze artifact made of cast metal found in an ancient Eskimo dwelling in Alaska, which likely originated in East Asia around A.D. 600. The discovery suggests long-distance trade between continents.
Studies show how brain structure, genes, and chemicals interact to affect behavior in children with neurodevelopmental disorders. New findings suggest potential therapeutic targets for conditions like fragile X syndrome and bipolar disorder.
Researchers at the University of Rochester Medical Center will study different approaches to improve pain clinical trial design, including patient features, study planning, and site characteristics. The goal is to boost development of new, effective treatments for chronic and acute pain.
Researchers analyzed database of symptomatic patients to investigate optimal timing for carotid artery stenting. The study found no significant difference in outcomes between those receiving CAS at 30 days post-event and those receiving it more than 30 days after stroke or TIA.
Researchers found adult stem cells from bone marrow have potential to improve heart function after a heart attack. However, the original two-week timeframe was not favorable, but the concept still shows promise for recovering lost or damaged heart tissue.
Researchers found that uninsured patients had significantly shorter hospital stays for preventable and non-preventable conditions compared to insured patients. The study highlights the need for equal treatment of all patients regardless of insurance status.
A recent study conducted by researchers at UC San Diego Health System found that the text4baby mobile service is increasing users' health knowledge, facilitating interaction with healthcare providers, and improving adherence to appointments and immunizations. The service has already enrolled over 2,200 individuals in San Diego County.
A new analysis of ancient midge larvae reveals that the region was significantly cooler than expected during the early Holocene epoch. The findings offer a detailed record of temperature variation over the last 10,000 years in Alaska and have important ecological and societal implications.
Researchers confirm cytomegalovirus as a cause of common salivary gland cancers, with implications for human health. The study suggests CMV's role in cancer development and potential new prevention and treatment methods.
A phase 1 clinical trial of cardiac stem cells has shown promising results in patients with severe heart failure after a heart attack. LVEF increased from 30.3% to 38.5% at 4 months, and further improvement was seen at 1 year.
A new study from Washington University School of Medicine finds that adolescent girls with a family history of breast disease have a higher risk of developing benign breast disease as young women, and this risk rises with increasing alcohol consumption. The researchers suggest limiting alcohol intake to lower risk or avoid increasing it.
A new study by Intermountain Medical Center researchers found that heart patients taking vitamins with warfarin are less likely to take their medication as prescribed. Patients who use vitamin supplements with warfarin are more likely to experience unexplained bleeding and need non-surgical transfusions.
A recent Mayo Clinic study found that smoke-free workplaces significantly reduced the incidence of heart attacks and sudden cardiac deaths in Olmsted County, Minn. residents. The study showed a 50% reduction in sudden cardiac death rates after a comprehensive smoke-free ordinance took effect.
A longitudinal study published in Arthritis & Rheumatism found a strong association between poor sleep habits and the risk of developing fibromyalgia in women. The study, which followed over 12,000 women for ten years, found that women with severe sleep problems were at increased risk of developing fibromyalgia.
A recent study published in Obstetrics & Gynecology found that hysterectomies increase the risk of early menopause among younger women. The research tracked over 900 women for five years and found that 14.8% experienced menopause, compared to 8% of healthy controls.
A new study found that childhood aggression is strongly linked to poorer health in adulthood, with increases in medical visits, injuries, and lifestyle-related illnesses. People with lower education levels were more likely to use health services.
Researchers found that mice with high amyloid burden experienced significant brain inflammation after receiving the vaccine, while those with lower amyloid burdens showed a significant benefit. The study suggests that vaccines may work best for patients with early disease and lower amyloid burden.
A study by Brigham and Women's Hospital found that eliminating copayments for heart attack medications increased patient adherence, reducing major vascular events and healthcare spending. Rates of combined endpoint were not significantly improved, but individual outcomes such as readmission and angina showed significant reductions.
A recent study found that people select future social partners based on cooperative behavior, not punishment of egoism. This contradicts the expectation that punishing others for self-interest would be beneficial for one's reputation and relationships.
Researchers found zircon crystals with ages matching those from western source sites, indicating a dramatic shift in atmospheric winds. The study improves climate modeling by suggesting alternating northwesterly and westerly sources for loess during glacial periods.
Jian Li, a NYU postdoctoral fellow, has won the prestigious Peter and Patricia Gruber International Research Award in Neuroscience. His cutting-edge work focuses on understanding brain circuits' underlying learning and behavior, with implications for neural systems of reward processing and decision-making.
A new clinical trial funded by NIH found that delayed stem cell therapy after a heart attack is safe, but it does not improve heart function six months later. The study suggests future clinical benefits may still be possible.
A study by Bo Hu and Shi-Yuan Cheng found that PDGFR-alpha overexpression in glioblastomas triggers a signaling cascade promoting tumor growth and invasion. Manipulating Dock180 to block this pathway inhibits PDGFR-alpha's role in glioma tumorigenesis.
A $7.5 million NIH grant will fund a Center of Excellence at Ohio State University to develop novel enzyme-based antidotes for nerve agents and pesticides. The team aims to create efficient enzymes that can neutralize multiple toxic agents, paving the way for new treatments and preventive measures.
Research identifies regions and functions of the brain involved in risk-taking decisions, shedding light on mechanisms driving economic behavior. The findings have potential applications for treating brain disorders characterized by poor decision-making.
A Rice University-led team recommends building a floodgate across the Houston Ship Channel and adding new levees to protect densely populated areas. The report also suggests creating a 130-mile-long coastal recreation area to utilize wetlands as a natural storm-surge barrier.
Researchers at Princess Margaret Cancer Program have identified a promising approach to treating leukemia using the antibiotic tigecycline. By cutting off energy production in leukemia stem cells, the drug can selectively destroy these cancerous cells while sparing healthy ones.
Researchers have discovered evidence of a late Pleistocene landslide-dammed lake along California's Eel River, which formed around 22,500 years ago. The lake's existence explains the genetic similarity between two types of ocean-going steelhead trout found in the river today.
Invasive false brome grass has spread rapidly in Oregon, thanks to its ability to evade fungal and mollusk enemies, with generalist insects being the primary attackers. The grass now threatens ecosystems and forests across the state, highlighting the need for public awareness and cleanup efforts to control its spread.
Researchers found that once a word is learned, it is stored in a purely visual dictionary in the brain, allowing for fast and efficient recognition. This concept may help explain why people with dyslexia struggle with reading due to difficulties forming a finely tuned visual representation of words.
A Journal of the American College of Surgeons study found that malpractice lawsuits against US surgeons can lead to depression, stress, and professional dissatisfaction. The study also showed that surgical specialties such as neurosurgery and cardiothoracic surgery report high rates of malpractice lawsuits.
Scientists discovered that variant forms of tyrosine can slow tumor growth and prevent metastasis. This finding could lead to a simple and safe type of therapy to manage malignant disease.
A study by researchers at the Medical College of Wisconsin suggests a possible link between norovirus and food allergies. The team found an immunoglobulin E response to egg protein in mice infected with norovirus, indicating a potential connection between gastrointestinal viruses and allergic diseases like asthma.
A study by Binghamton University found that positive observational behavior data increases sales, while negative observations have little impact. This discovery should ease fears for online retailers, who can now display statistics on consumer behavior without discouraging purchases.
A study found that elite female marathoners have less plaque buildup than their sedentary counterparts, with similar characteristics when plaque forms. In contrast, male marathon runners tend to develop more plaque volume and stenosis.
Patients with recurrent inflammatory spinal cord diseases have significantly lower vitamin D levels compared to those with monophasic disease. The study suggests a common link between low vitamin D levels and immunologic dysregulation in these conditions.
Researchers found that increased wave reflections are predictive of cardiovascular events and congestive heart failure, even with small increases in magnitude. This measure surpassed established risk factors like hypertension in predicting heart failure risk.
A study by Baylor College of Medicine reveals the benefits of genetic evaluation in managing retinoblastoma, a childhood eye cancer. The research showed that genetic analysis helped identify hereditary cases and determined at-risk relatives, reducing unnecessary screening.
Scientists at University of Oregon and Caltech discovered a 22,500-year-old landslide dammed the upper reaches of the Eel River, forming a 30-mile-long lake that disappeared over time. The lake's presence may explain genetic similarity among steelhead trout found in the river today.
A University of Miami study reveals that the Southern Oscillation plays a bigger role in the climate system than previously thought. The research finds that atmospheric pressure, surface temperature, and precipitation are similar across two climate scenarios with static and dynamic oceans.
A lower glycemic index diet has been shown to delay the development of age-related retinal lesions in mice, which are similar to those seen in Age-Related Macular Degeneration. The study found that mice on a lower GI diet had fewer and less-severe lesions than those on a higher GI diet.
A study in twins found a significant association between trichloroethylene exposure and an increased risk of Parkinson's disease, with a more than 6-fold increased risk. The study also suggested a lag time of up to 40 years between exposure and symptom onset.
A team of MSU researchers is working on a project to link climate change to coping strategies and impacts on food production, security, and incomes for farm families in Zambia and Kenya. The study will provide new information on how climate change affects farming households and their responses.
A recent NIH-funded twin study found a significant link between occupational chemical exposure and the development of Parkinson's disease. The study, published in Annals of Neurology, suggests that two common solvents, trichloroethylene (TCE) and perchloroethylene (PERC), may increase Parkinson's risk sixfold and ninefold, respectively...
Researchers found that photos taken by police and fashion agents share similar characteristics, highlighting the universality of image-making processes. The study suggests that both fields use documentary portraits to fix identities motivated by transformation, with similar lighting, poses, branding, and record-keeping.
A new study found a significant association between adolescent alcohol consumption and increased risk of benign breast disease among girls with a family history of breast cancer. Consuming more alcohol was linked to a higher risk, particularly in those with rapid height growth spurts.
Scientists at Oregon Health & Science University have identified a definitive role for the brain in regulating involuntary muscle mass loss associated with chronic illnesses. The process is driven by a signaling system that controls stress responses and cortisol release.
A new study finds that air pollution increases precipitation in wet regions while decreasing it in dry regions, exacerbating severe storms. The research provides clear evidence of aerosols' impact on weather and climate, with significant implications for water resource management.
Researchers propose a new explanation for electrical conductivity at polar-nonpolar oxides, suggesting that atomic mixing and rearrangement occurs at the interface. They found that lanthanum and chromium crossed over to the nonpolar side in equal amounts, making conduction impossible.
Researchers found a gene, Prox1, essential for normal development of the lymphatic system and proper formation of one-way valves controlling fluid movement between systems. The study provides new insights into valve defects affecting children and adults.
Researchers have developed a new technique that can identify protein structures in just hours, revolutionizing the pharmaceutical industry. The enhanced NMR spectroscopy method using dynamic nuclear polarisation (DNP) enables significant structural data to be gained from small biological samples.
A recent study published in Ophthalmology found that astronauts who spent long durations in space experienced swollen optic nerves, distorted eyeball shapes, and retinal changes. The study also revealed that many astronauts experienced worsening of distance or near visual acuity after flight.
Research demonstrates that life experiences can be transmitted from one generation to the next through epigenetics, affecting brain plasticity and behavior. This new knowledge has implications for understanding the cognitive benefits of motherhood and how environmental factors influence brain development in offspring.
Researchers found that carotid artery stenting following prior same-side carotid artery revascularization results in lower incidences of in-hospital death, stroke, and heart attack. The study's findings have the potential to change how carotid artery stenosis is assessed and treated.
Scientists engineer mice to express human enzyme IKKbeta in fat tissue, significantly slowing weight gain and improving metabolism. The study suggests obesity is worse than inflammation for insulin resistance, offering new clues about the connections among obesity, inflammation, and type 2 diabetes.
Researchers discovered a molecular pathway driven by PDGFR-alpha that promotes the aggressive nature of a significant proportion of glioblastomas. Overexpressed in GBMs, this pathway triggers signaling cascades leading to tumor growth and invasion. Manipulating Dock180 phosphorylation disrupts this pathway, resulting in failed tumor pr...
Research by University of Cincinnati professor Leila Rodriguez examines business strategies and networking patterns among Nigerian immigrants in New York City. The study reveals that these entrepreneurs adapt African business models to Western strategies, maintaining social distance with suppliers, customers, and employees.
Researchers are investigating a novel gene therapy approach using LG631 to improve tolerance and effectiveness of chemotherapy for glioblastoma, a devastating brain cancer. The study aims to prevent damage to bone marrow, enabling patients to receive higher doses with fewer side effects.
A new study by Johns Hopkins researchers found that nearly 30 million Americans have severe hearing loss, with prevalence doubling every decade. The finding suggests that many more people than previously thought are affected by this condition, which has significant consequences for cognitive decline and physical functioning.
A new study from the University of Toronto's Rotman School of Management finds that smart managers engage in earnings manipulation and insider trading due to limited capacity and ethical weaknesses. The study suggests that choosing less ethical managers may be in the best interests of current shareholders but not future ones.
A new Harvard study found that dynamic social networks encourage cooperation and friendliness, while selfish behavior can lead to exclusion from the group. Players who re-wired their social connections were more willing to form new relationships with generous individuals.
A new University of Minnesota study reveals that even treated municipal wastewater can contribute significantly to antibiotic-resistant bacteria in surface waters. Researchers found that quantities of these bacteria were typically 20-fold higher near the site where treated wastewater was released into Duluth-Superior Harbor.
Researchers have successfully differentiated mouse ES cells into a tissue resembling the adenohypophysis, the hormone-secreting component of the pituitary gland. The self-organized tissue exhibits functional hormone secretion and can compensate for pituitary function in mice.
The exhibit features research images that capture the exquisite harmony of natural systems, including a field rabbit regulating its body temperature and a simulation of galaxy birth. The competition aimed to reframe the concept of intelligent design, focusing on the beauty of both nature and engineered designs.
A vaccine seroepidemiology surveillance system would help track vaccine coverage, identify trends, and predict outbreaks in Canada. This system is crucial for informing vaccine policy and improving the country's immunization programs.
Research found a strong link between high childhood IQ and subsequent illicit drug use, particularly among women. High IQ scores at age 5 or 10 were associated with increased use of cannabis, cocaine, and other drugs by age 30.
The natural health products industry lacks robust regulation, putting consumers at risk. The authors argue that uniform regulations can protect consumers while allowing choice.
Researchers at Mount Sinai School of Medicine discovered fetal stem cells in the placenta can migrate to and repair damaged maternal hearts after a heart attack. The study found that these cells reprogram into beating heart cells, providing a potential therapeutic agent for cardiac regeneration.
Research found that higher CHADS2 scores are associated with increased risks of stroke, systemic embolism, and major bleeding in A-Fib patients taking oral anticoagulants. Additionally, a study on warfarin patients suggests a 12-week monitoring interval is non-inferior to the current four-week schedule.
Research published in BMJ Open found a significant association between contraceptive pill use and increased rates of new prostate cancer cases and deaths globally. The study suggests that environmental oestrogen exposure from oral contraceptive metabolism may contribute to this risk.
The new journal will publish groundbreaking research in bimonthly installments, featuring innovations in science and engineering that can improve society. It aims to accelerate the development of enabling science and engineering to drive disruptive innovation.
A multidisciplinary team approach to genetic testing in retinoblastoma patients ensures timely evaluation and appropriate counseling, improving risk prediction for patients and family members. Genetic testing also prevents overutilization of clinical screening tests, reducing potential morbidity for relatives.
Researchers used adult stem cells to treat patients with heart failure after a myocardial infarction. The trial showed an average improvement of 12% in left ventricular ejection fraction (LVEF) and a decrease in scarred regions, suggesting that heart tissue can regenerate.
Researchers at Scripps Research Institute have determined the atomic structure of a protein used by the Lassa fever virus to replicate within infected cells. The study reveals an unexpected molecular crevice where the viral protein grips viral genes, making it a target for potential antiviral drugs.
A new study found that therapeutic hypothermia confers similar neurologic and survival benefits in cardiac arrest patients with preexisting cardiomyopathy as those without the condition. However, cardiogenic shock was more prevalent in patients with cardiomyopathy, leading to lower survival rates with favorable neurologic outcomes.
A study published at the American Heart Association scientific sessions found that delays in therapeutic hypothermia and return of spontaneous circulation significantly worsen neurologic outcomes. Caregivers with a thorough understanding of post-cardiac arrest neurologic states can better manage patients at discharge.