Scientists discovered that enterocytes play a significant role in absorbing relatively large particles, challenging conventional wisdom and offering new avenues for increasing the absorption of medicines taken by mouth. The study found that between 10-50% of spheres were absorbed via endocytosis in cells called enterocytes.
A collaborative research project between ASU and Mayo Clinic aims to improve carpal tunnel syndrome diagnosis through the use of novel grasp testing methods. The new approach seeks to provide a more precise measure of functional recovery, enabling early detection of non-recovery after surgery.
A study by Weill Cornell Medicine found that patients and health organizations favor electronic communications, but physicians face barriers such as lack of compensation and increased workload. The study identified successful examples of medical groups using electronic communication to improve access to care and communication with pati...
New study links aluminum accumulation to neuronal cell death and identifies necrostatin-1 as a substance that counteracts aluminum's neurotoxic effects. In mice treated with aluminum, Nec-1 demonstrated strong protection against cell death and improved cognitive function.
A new non-invasive test may be more effective in promoting colorectal cancer screening among uninsured patients than a traditional colonoscopy. The test, fecal immunochemical test (FIT), was shown to triple participation rates compared to usual care strategies.
Researchers found that cilostazol decreases hypoxia-inducible factor-1α and heme oxygenase-1 expression levels, protecting against cognitive impairment induced by chronic cerebral ischemic injury. Cilostazol treatment also exhibits an anti-apoptotic mechanism in the context of chronic cerebral ischemia.
A recent study found that eating a large breakfast reduces the risk of obesity, diabetes, hypertension, and cardiovascular disease. Participants who ate a larger breakfast had significantly lower levels of insulin, glucose, and triglycerides throughout the day.
Researchers at Berkeley Lab and University of Wisconsin have developed a non-destructive 3D imaging technique that provides molecular-level chemical information. The technique, FTIR spectro-microtomography, combines Fourier Transform Infrared spectroscopy with computed tomography to create full-color 3D images with unprecedented detail.
Researchers at Brown University propose that double-layered ejecta craters on Mars were formed when impacts blasted through ancient glacial ice, creating a two-layered appearance. The model explains distinct features of the craters, including radial striations and their locations at middle or high latitudes.
Researchers found that economic conditions worsen only for mothers carrying the T allele, leading to increased harsh parenting. The study suggests that anticipation of adversity, rather than actual economic hardship, drives this response.
A randomized trial found that universal HIV screening in emergency departments detected nearly as many cases as targeted screening, despite requiring fewer tests. The study suggests that broad criteria and sufficient resources can detect most cases with reduced testing numbers.
A new study found that mindfulness meditation, known as Integrative Body-Mind Training (IBMT), significantly reduced smoking in smokers by 60 percent. The training improved self-control pathways related to addiction, leading to increased activity in areas such as the anterior cingulate cortex and medial prefrontal cortex.
Scientists successfully reproduce protein recycling process, tracing Rab's extraction from lipid membrane. The study reveals GDI protein's active role in recycling Rab proteins, shedding light on disease-relevant interactions.
Researchers at Mayo Clinic have made a breakthrough discovery about the origin of inflammation-driven pancreatic cancer. They found that chronic inflammation in the pancreas can push acinar cells to transform into duct-like cells, which can then acquire mutations leading to further progression of pancreatic cancer. The study identified...
Researchers at the Salk Institute have developed a new tool for protein engineering by adding strong, unbreakable bonds between two points in a protein or between two proteins. This technique enables the design of novel drugs, imaging agents, and molecules that aid basic research.
A study published in Health Affairs found that nursing home consumer satisfaction scores are a valuable tool for informing consumer choice and rewarding homes for quality care. The study also found correlations between higher satisfaction scores and better staffing levels, fewer citations, and improved care.
A USGS report identifies crucial factors influencing public-supply well vulnerability to contamination, including geochemical conditions, groundwater age, and human-induced changes in aquifer conditions. Understanding these factors can help anticipate future water quality issues and inform water management strategies.
A study found that patients with Celiac disease and persistent intestinal damage have a higher risk for lymphoproliferative malignancy. Prioritizing USPSTF recommendations based on patient characteristics can improve life-expectancy by identifying the most beneficial interventions for each individual.
A study by Purdue University researchers found that pigs thrive on lipids from soybean oil, leading to improved growth performance. The study's results suggest that using concentrated energy sources like soybean oil can help counteract issues limiting growth in nursery pigs.
A mathematical model helps clinicians prioritize recommended preventive care methods, leading to enhanced care and potential lifesaving outcomes. The model, developed by NYU Langone researchers, takes into account individual patient needs and provides personalized recommendations.
Researchers analyzed data from over 30,000 patients to determine if Parkinson's disease and Alzheimer's disease share a common genetic risk factor. The study found no evidence of such overlap.
University of Illinois scientists have found that lifelong exposure to genistein, a bioactive component in soy foods, protects against colon cancer. The study suggests that a diet rich in soy genistein represses signals through epigenetic modifications, reducing the number of pre-cancerous lesions and abnormal cell growth.
Researchers found that older adults showed less day-to-day variability in cognitive performance compared to younger adults. The study suggests that learned strategies, motivation levels, and daily routines contribute to the consistency of older adults' cognitive abilities. This finding has implications for workplace productivity and ag...
NYU Langone researchers have identified the type of inhibitory interneurons responsible for oxytocin's effects on brain function. The study found that oxytocin increases the reliability of stimulated impulses, improving brain function and potentially relevant to autism-spectrum disorder.
Scientists develop a new approach to eliminate mutated DNA in mitochondria using TALEN technology inspired by plant-infecting bacteria. The method shows promise for treating mitochondrial diseases, including Leber hereditary optic neuropathy, and could lead to effective treatments for various eye diseases.
Researchers find that small, disordered crystals in plastic materials improve charge mobility, enabling faster electron movement and higher performance. This discovery could lead to the development of low-cost, commercially available plastic solar cells.
A new study from MIT suggests that dopamine signaling plays a crucial role in maintaining focus on long-term goals. The research reveals that the level of dopamine increases steadily throughout each trial, peaking as the animal approaches its goal, reflecting its distance from the reward.
A study published in PLOS ONE found that listeners' brain reactions differ depending on the speaker's perceived ability to act upon their words. Researchers used EEG recordings to compare reactions to statements made by influential and non-influential speakers, revealing a significant impact of social status on neural responses.
A research team identified a new type of cell in the brain that helps people navigate unfamiliar environments through path integration. Grid cells allow the brain to keep track of navigational cues and maintain a sense of location.
A global meta-analysis reveals that climate change is driving changes in marine species' breeding, feeding, and migration timing, as well as shifting their geographic distribution toward the poles. The study found that warming oceans are causing marine species to move at an average of 72 kilometers per decade.
A rare genetic deletion of the TOP3B gene has been identified as a common biological pathway for both schizophrenia and a learning disorder associated with autism, increasing susceptibility by two-fold. The study uncovers an important biological process underlying these brain disorders, potentially leading to new drug targets.
A new global study reveals widespread systemic shifts in marine species distribution and phenology, comparable to those observed on land. The research found that 81% of changes were consistent with climate change, with some species shifting up to 11 days earlier in spring.
EPFL researchers dismantled a bacterial nano-machine that kills host cells by piercing membranes. The discovery opens new therapeutic perspectives, including coating catheters with substitute peptides to prevent infection.
Researchers at St. Jude Children's Research Hospital discovered a way to target the immune system to shrink or eliminate tumors in mice without causing autoimmune problems. The mechanism focuses on regulatory T cells and proteins semaphorin-4a (Sema4a) and neuropilin-1 (Nrp1).
Scientists have developed a new material that can strengthen itself in response to stress, similar to how muscles build strength through exercise. The material, inspired by weightlifting and Silly Putty, can transform from a liquid to a solid state, becoming stronger with each cycle of stress.
The researchers determined the structure of NatA, a protein complex modifying nearly 85% of human proteins, and found it essential for cancer cell proliferation. The team believes their findings will allow them to create an inhibitor that can knock out NatA, potentially curbing cancer growth.
Researchers have developed substrate-selective COX-2 inhibitors that relieve anxiety behaviors in mice by activating natural endocannabinoids without gastrointestinal side effects. The findings suggest a new approach to treating mood and anxiety disorders, potentially paving the way for clinical trials and new treatments.
Researchers found that practice reduces metabolic activity in primary motor cortex for internally generated movements, but not visually guided tasks. The study suggests the motor cortex is plastic and can store motor skills.
Researchers found that rats fed high-fat or high-sugar diets during pregnancy weighed more as adults, drank more alcohol, and had stronger responses to abused drugs. Exposure to sugar-rich diets before birth or nursing increased sensitivity to amphetamine and hyperactivity.
Research from the University of Copenhagen reveals that flexible wage systems have led to a 5% increase in average wages for private sector employees in Denmark. Companies can now better retain key personnel under these systems, leading to increased productivity.
Researchers at Harvard University have developed a new coating that makes ordinary glass tough, self-cleaning and incredibly slippery. The coating, inspired by the slippery leaves of carnivorous pitcher plants, repels a variety of liquids and maintains its mechanical stability even after scratches or damage.
Recent studies demonstrate that ethanol directly induces apoptotic cell death of neurons, leading to brain damage and cognitive deficits. The researchers found that ethanol activates the p53-related cell cycle arrest pathway, resulting in neuronal apoptosis.
Researchers at Scripps Research Institute identified a promising new compound, 6'-guanidinonaltrindole (6'-GNTI), which targets the kappa opioid receptor (KOR) to reduce dopamine release and potential side effects. The study's findings suggest a potential breakthrough in developing effective drugs for addiction with fewer side effects.
Researchers at the University of Basel have successfully replaced iodine in copper-based dye-sensitized solar cells with cobalt, increasing sustainability and improving long-term stability. This breakthrough uses a systems chemistry approach to optimize molecular components, paving the way for environmentally friendly energy production.
Children's perceptions of living with asthma may differ significantly from those of their caregivers, a new study shows. The study found that both children and caregivers should be interviewed during doctor visits to ensure accurate understanding of the child's condition.
Researchers have developed a technique to pattern and actuate hydrogel materials, enabling the creation of soft robotic devices with potential biomedical applications. The devices can manipulate objects using electrically assisted ionoprinting, opening new possibilities for drug delivery and tissue scaffolding.
Researchers developed an inertial sensor-based monitoring system to track upper limb movements in patients with impairment. The system was validated using a commercial optoelectronic system and showed promise in assessing functional rehabilitation of the upper limbs.
Patricia Resick, PhD, ABPP, received the American Psychological Association's Division of Trauma Psychology Award for Lifetime Achievement in trauma psychology. She has made outstanding contributions to science, practice, advocacy, and education, developing Cognitive Processing Therapy (CPT) for PTSD treatment.
Terence M. Keane, a renowned expert on posttraumatic stress disorder (PTSD), has received the Distinguished Scientific Contributions to Clinical Psychology Award from the American Psychological Association. His work focuses on developing new therapies and treatments for PTSD, which affects approximately 7.7 million adults in the US.
Researchers aim to develop innovative ways to enhance smokers' ability to abstain from nicotine cravings. The study will recruit hundreds of smokers and use behavioral exercises to build resistance to tobacco withdrawal cues.
Research reveals that burning incense generates indoor air pollutants that cause inflammation in human lung cells, similar to cigarette smoke. The study recommends improving ventilation and using alternative combustion devices to mitigate this health risk.
Research found that multiracial people are more likely to be misidentified as white rather than black and value being accurately identified. Multiracial participants were more interested in meeting partners who had accurately identified them, while single-race people had similar negative reactions to being misidentified.
New research finds that playing violent video games boosts visual skills but impairs proactive executive control, leading to increased aggression. This reduction in impulse control is linked to increased attention problems and aggression.
Prothrombin complex concentrates (PCCs) are recommended as the first line of defense for reversing warfarin-associated hemorrhage in emergency departments. PCCs can reverse anticoagulation three to five times faster than fresh frozen plasma, making them a life-saving treatment option.
Researchers discovered baby owls spend large amounts of time in REM sleep, similar to human infants, and this changes as they age. The team also found a link between the expression of a melanism-related gene and sleep patterns, suggesting that brain development may influence adult traits.
Researchers at GEOMAR found that about one third of oxygen supply in tropical oxygen minimum zones is provided by vertical turbulent mixing, surprising previous assumptions. High-precision measurements confirmed this finding, using a tracer and profiling current meters.
Researchers found that intimate partner violence increases risk for property crimes, drug offending, and commercial sex work. Witnessing violence also contributes to property crimes, fighting, and use of weapons. Women who experienced caregiver violence are more likely to run away as teens.
Researchers used high-resolution imaging technology to locate the 1906 fault trace, resolving decades of confusion caused by human error. The primary rupture occurred along a single western trace of the San Andreas Fault, with no step-over within the town.
Flavia Tauro, a graduate student at NYU-Poly, has won the AGU Hydrology Section's Horton Research Grant to develop novel tracer particles for hydrological monitoring. Her technique aims to improve the efficiency and feasibility of traditional tracing methods while reducing environmental impact.
Dr. Lu Zhou has been awarded the Children's Tumor Foundation Young Investigator Award to develop therapies based on existing drugs for NF tumours, aiming to improve quality of life and survival rates for children with this condition.