Researchers identify PIEZO2-expressing fibroblasts as key drivers of keloid formation and recurrence. These cells sense mechanical pressure, leading to excessive collagen production and scarring. The study's findings hold significant implications for future diagnosis and treatment options.
Researchers at Tohoku University developed a rechargeable magnesium battery prototype that can operate stably at room temperature, thanks to a newly designed amorphous oxide cathode. The breakthrough enables fast and reversible Mg-ion diffusion, allowing for efficient energy storage and reducing dependence on limited lithium resources.
A researcher is exploring the hidden functions of vascular-neuronal interfaces to uncover how blood vessels influence brain development and connectivity. The study aims to develop new therapeutic strategies for diseases caused by disrupted communication between blood vessels and neurons.
Researchers identified novel genes, including ADAMTS2, significantly more active in brain tissue from African American donors with Alzheimer's disease. This study provides crucial insights into the genetic architecture of Alzheimer's risk in African Americans.
Research found virtual reality (VR) techniques can help break down barriers to social communication in children. VR provides an accessible interface for young people to practice social skills before applying them in everyday life.
Researchers at Sophia University have discovered 14 compounds secreted by slime molds that repel root-knot nematodes and protect plant roots. The mixture of these organic compounds showed a strong synergistic effect, demonstrating potential for use in non-toxic crop protection.
The American Chemical Society's President Dorothy J. Phillips congratulates Susumu Kitagawa, Richard Robson, and Omar M. Yaghi on their Nobel Prize in Chemistry win for developing metal-organic frameworks. This award highlights the power of chemistry to address global challenges through international collaboration.
Researchers developed a framework for building trust-based partnerships with Indigenous communities to study microbiomes. They worked closely with Matsés leaders and community members, incorporating cultural differences and transparency into their methods.
The Association for Molecular Pathology has created a standardized biomarker report template to simplify complex molecular profiling data presentation to oncologists and healthcare providers. The template includes guidelines for clear formatting, therapeutic guidance, and references to clinical practice guidelines.
Researchers at Universitat Jaume I develop cost-effective, high-performance chiral LEDs with enhanced optical properties. The RADIANT project aims to simplify display architectures and save energy consumption by leveraging scalable chiral metasurfaces.
Researchers found that time-restricted feeding can improve body composition, boost immunity and prevent metabolic disorders in high-performance athletes. Combining HIIT with time-restricted eating may yield greater improvements in performance without significant adverse effects.
Researchers identified KCTD10, a 'traffic controller' protein that shields DNA during cell division, potentially leading to new cancer therapies. The discovery could target cancer cells where DNA replication and transcription processes malfunction.
Researchers have discovered that certain harmful DNA variations become more common in sperm as men age, raising genetic disease risk for offspring. The study found that around 2-5% of sperm from middle-aged and older men carried disease-causing mutations, with a significant increase in the risk of passing on these mutations to children.
A systematic review found little to no benefit from prenatal and postnatal support apps in reducing postnatal depression, anxiety, or improving infant bonding, breastfeeding, or parenting satisfaction. The study also investigated the effects of perinatal mobile apps on psychosocial and parenting outcomes for couples.
A new study found that fire can have varying impacts on global bee populations, with some species thriving in post-fire conditions and others declining or disappearing. The review highlights the need for tailored fire management strategies to support biodiversity, particularly in Australia's unique ecosystems.
Scientists have tracked 1039 dust devils to reveal how they lift dust into the air and sweep around Mars' surface. The study found wind speeds of up to 44 m/s, faster than previously measured with rovers on the ground, and improved our understanding of Martian weather patterns.
A new AI-based system helps researchers design polymers with tailored electronic properties for next-generation bioelectronics. By processing a wide range of experiments, the system reveals the importance of local polymer order and dopant-polymer separation in controlling electronic properties.
Researchers from Eötvös Loránd University review the biological and technological possibilities behind enhancing canine communication. They find that while dogs may not need words to be great communicators, understanding each other requires 'listening' in the right way.
A new study published in PLOS One found that team diversity in personality traits can contribute to greater resilience under extended isolation and operational load. The researchers used agent-based modeling to simulate the impact of team composition on stress, health, performance, and cohesion over a 500-day Mars mission.
Researchers at Flinders University developed a dual-function biomaterial that combats persistent infections and promotes bone regeneration. The new implant material, embedded with silver-gallium liquid metal nanoparticles, offers sustained antimicrobial protection while actively supporting bone healing.
Researchers develop a new nanotechnological device that delivers lithium directly to the brain, targeting glycogen synthase kinase-3 beta enzyme. The treatment achieves similar effects as oral lithium but with lower concentrations and reduced side effects.
A new study found that between 15-20% of Quebecers gambled online in 2021, with many trying it for the first time. Online gambling almost tripled in scope during this period.
A study by PLOS reveals significant differences in gut microbiomes between captive and wild bears and pandas, particularly among giant pandas which have less diverse microbiomes than their wild counterparts.
The M-Cube associated research laboratory combines micron-level visualization tools with precise mineralogical and geochemical analyses to identify new avenues for optimizing the mining cycle. The collaboration aims to reduce the environmental impact of uranium mining sites and better understand the mobility of radioactive descendants.
Researchers have developed an innovative approach combining serial brain biopsies with multi-omics analyses to uncover dynamic changes in recurrent glioblastoma tumors. This breakthrough study reveals that CAN-3110 triggered powerful immune responses deep inside the tumor, which were invisible to standard imaging.
Scientists at St. Jude Children's Research Hospital discovered that protein ASPL regulates stress granule disassembly by facilitating VCP phosphorylation and stabilizes interactions among core stress granule proteins. Additionally, ASPL facilitates stress granule assembly independent of VCP by stabilizing G3BP interactions.
Brassica vegetables are rich in health-promoting compounds like glucosinolates, vitamins, carotenoids, and essential minerals that can reduce risks of cancer, cardiovascular disease, and other chronic conditions. The review highlights strategies to boost their value through breeding, biofortification, and advanced biotechnologies.
A new study suggests that well-managed solar farms with wildflower margins could double bumblebee numbers within themselves. However, their benefits are largely constrained to the local site and have a limited impact on wider landscapes.
A new UTEP study found that postseason NFL officiating from 2015-2023 consistently favored the Kansas City Chiefs, coinciding with their rise as a marketable franchise. This phenomenon, known as regulatory capture, suggests that financial incentives can subtly shape rule enforcement.
Researchers used deep learning to identify dust devils in satellite images, revealing high wind speeds that lift more dust into the atmosphere than previously thought. The study's findings have significant implications for future Mars missions, enabling better modeling of Martian weather and climate.
ACTM-838, a novel bacterial immunotherapy, enriches in solid tumors and delivers IL-15/IL-15Rα and STING payloads to engage innate and adaptive immunity. The therapy shows durable anti-tumor efficacy and synergizes with anti-PD1 drugs, improving outcomes in treatment-resistant tumor models.
Researchers found that Medicaid accountable care organizations (ACOs) can improve some maternal health outcomes if designed thoughtfully. The study highlights the importance of value-based care delivery design within Medicaid programs to support low-income women before, during, and after pregnancy.
Researchers found high rates of depression and anxiety among juvenile prisoners, regardless of the charge. The study suggests that addressing mental health concerns before detention can reduce recidivism, and screening and intervention should be standard practice in all detention settings.
A new book by Peter Turchin analyzing data from over 800 societies reveals that warfare was the central driver of social complexity, leading to the development of institutions for cooperation and prosociality. The Great Holocene Transformation offers insights into the evolution of human societies over 10,000 years.
A study published in Blood Advances found that individuals with sickle cell disease who were triaged appropriately received their first dose of pain medication within 60 minutes, while those triaged at lesser severity levels waited nearly three times as long. The researchers analyzed the impact of emergency severity index (ESI) assignm...
A study found that combining tramadol with certain antidepressants increases the risk of seizures in older nursing home residents. Researchers analyzed 10 years of Medicare data and found a modest but measurable increase in seizure rates when these medications were taken together.
A new study from the University of Vaasa examines how Finnish households are becoming more flexible with their energy consumption, driven by digitalisation and financial incentives. The research finds that material and monetary benefits are the most effective motivators for adopting flexible energy habits.
Joanna Wardwell-Ozgo, a Kennesaw State assistant professor, received a $720,000 NIH grant to investigate the hormonal control of cancer. She aims to understand how hormones affect cellular growth and development, with potential implications for disease mechanisms.
Imperial College London and the University of Sheffield have signed up to eLife's uncapped scheme, promoting greater equity and inclusivity in scientific publishing. The partnerships aim to support researchers in publishing through eLife Model, providing a fairer and more transparent approach to research publishing and assessment.
A recent analysis found that former inmates report worse health than non-incarcerated peers, even years after release. The study, published in the Journal of the American Geriatrics Society, suggests that clinicians consider screening for incarceration history and connecting patients to supportive services.
A new framework models evolution by combining short-term natural selection with species-wide changes over millions of years. This resolves a long-standing debate in biology, allowing researchers to study trait evolution across multiple scales.
A new study uses general-purpose AI to classify real cosmic events and explain its reasoning without complex training. The model achieved approximately 93% accuracy and provided plain-English explanations for every classification.
A Phase 1 clinical trial has successfully tested a new vaccine against typhoid fever and invasive non-typhoidal Salmonella, demonstrating strong immune responses in healthy adults. The vaccine triggered balanced immune defenses and showed potential for whole-body protection against Salmonella.
Researchers analyzed five diets and found that protein foods, livestock farming, and hand-picked fruits were major sources of forced labor risk. The Healthy Mediterranean-Style diet and the Healthy U.S.-Style diet showed greater risks compared to other diets.
Researchers investigated whether cut flowers from Africa could spread livestock viruses through tiny biting midges. While no midges were found in packaging or transport areas, the study highlights potential risks and suggests measures to reduce them.
Researchers developed an environmental quality standard to evaluate reindeer populations, finding most areas rated as poor or medium. The standard aims to inform management efforts and secure long-term conservation of wild reindeer.
A new study reveals that stevioside can effectively promote hair follicles to enter the growth phase when combined with minoxidil. The natural sweetener enhances skin absorption of the drug, leading to new hair development in a mouse model of alopecia.
Researchers at MIT have developed a new way to engineer CAR-NK cells that are less likely to be rejected by the patient's immune system, making them a promising treatment for cancer. The cells can destroy most cancer cells while evading the host immune system, and may offer a better safety profile than traditional CAR-T cells.
Researchers at EPFL have developed a novel 3D printing technique that creates ultra-strong metal and ceramic materials by infusing water-based gel with metal salts. The process results in exceptionally dense and strong constructions, suitable for next-generation energy, biomedical, and sensing technologies.
Researchers optimized lab culture conditions to boost levels of low-abundance chlorinated compounds in slime mold cells, identifying CDF-2 and CDF-3 as potent antibiotics against Gram-positive bacteria. The compounds' similar molecular structure suggests a critical role in protecting against harmful bacteria.
A study by Kobe University discovered that wild orchid seeds require fungi from decaying logs to germinate. The team found a consistent association between young and adult plants with coral-shaped rhizomes and wood-decaying fungi, suggesting an essential role for these fungi in the orchid's nutritional needs.
The Amazon rainforest experienced its most devastating forest fire season in over two decades, releasing 791 million tons of carbon dioxide into the atmosphere. The study highlights the growing ecological fragility of the region, driven by climate change, deforestation, and land-use mismanagement.
Researchers found that specific bacteria, such as Haemophilus parainfluenzae and Fusobacterium species, are associated with AIG-related neuroendocrine tumors. The study suggests that changes in host metabolism occur before alterations in the gastric microbiota, potentially creating a microenvironment that favors tumor growth.
A recent study published in Cancer Discovery found that Medicaid expansion is associated with improved five-year cause-specific and overall survival rates among cancer patients. The research showed significant improvements in survival rates for patients living in rural areas, high-poverty areas, and those with higher-mortality cancers.
Researchers investigated tree swallow bird groups in the US and found no association between chemical exposure and reproductive health outcomes. Despite high concentrations of forever chemicals in their environment, birds were unaffected by exposure levels, indicating resilience to these pollutants.
A new study suggests that hormone therapy within the early postmenopause years can help women with early or surgical menopause remain in the workforce. Women with surgical menopause were found to have an increased risk of labor market exit, especially after age 45.
A new method has been developed to generate induced natural killer cells and CAR-engineered NK cells from cord blood-derived hematopoietic stem and progenitor cells. This approach increases the induction efficiency of NK cells and lowers the cost of CAR engineering, offering a promising avenue for cancer immunotherapy.
A £1.55m study examines the effect of long-term vaping on respiratory health in 200 healthy smokers and non-smokers. The research aims to provide insight into vaping's biological effects on lung cells, immune cells, and airway microbiome.
Researchers at UChicago study the doublesex supergene in swallowtail butterflies, discovering a single genetic switch that controls wing patterns through cis-regulatory elements. The study sheds light on how butterflies develop complex traits and explores the evolution of supergenes.
Scientists have successfully observed altemagnetic domains in bulk samples of MnTe, a candidate altermagnet, using scanning transmission X-ray microscopy. The study provides experimental evidence for the bulk nature of altermagnetism and establishes X-ray nanoimaging as a powerful method for identifying altermagnetic order.