A Phase 1 study demonstrated early promising antitumor activity and few adverse side effects in patients with advanced non-small cell lung cancer harboring KRAS G12C mutation. The therapy, AMG 510, showed encouraging anti-tumor activity with no dose-limiting toxicities or adverse events leading to discontinuation.
The MYSTIC trial found that patients with STK11 or KEAP1 mutations had poorer outcomes to anti-PD-L1 and anti-CTLA-4 immunotherapies compared to those without these mutations. ARID1A mutations were associated with improved survival in the durvalumab + tremelimumab arm.
Researchers found that psychiatric medications like antidepressants can alter gut bacteria in rats, sparking questions about specificity of psychoactive drug action and potential benefits or drawbacks for human patients. The study aims to explore these findings further through a large-scale human observational study.
The MYSTIC trial found that patients with STK11 or KEAP1 gene mutations in metastatic non-small cell lung cancer experienced poorer overall survival compared to those without these mutations. Additionally, patients with ARID1A mutations in the durvalumab + tremelimumab arm had longer median overall survival rates.
Researchers have developed all-polymer photodetectors with single carrier transport property, exhibiting high external quantum efficiency and low dark current density. The photomultiplication type PPDs demonstrate improved performance and versatility for applications in biological detection and image sensing.
Research presented at the IASLC 2019 World Conference on Lung Cancer found that combining nivolumab with ipilimumab showed improved efficacy in patients with advanced non-small cell lung cancer (NSCLC), particularly those with high TMB or higher tumor PD-L1 expression. The safety profile of this combination therapy was also consistent ...
A recent study published in The American Journal of Clinical Nutrition has found that vitamin E absorption does not require concurrent consumption with fat. After 12 hours without eating, subjects who consumed a fat-containing meal showed significant absorption of vitamin E.
Researchers discovered that providing native foods to captive rodents preserves their gut microbiome diversity, whereas artificial diets lead to significant changes. The study found that feeding woodrats with prickly pear cactus maintained around 90% of their original microbiome diversity.
Researchers studied the relationship between tumor mutational burden and response to immunotherapy with pembrolizumab. The study found that high or low TMB levels did not significantly impact overall survival, progression-free survival, or objective response rates for patients with metastatic nonsquamous non-small cell lung cancer.
The bioMILD trial demonstrated that combining low-dose CT screening with a microRNA blood test reduces lung cancer mortality and incidence in high-risk individuals. The study found that participants with positive LDCT and/or miRNA at baseline had a significantly higher lung cancer incidence and overall mortality.
A new report by The Lancet Commission on malaria eradication suggests that malaria can be eradicated by 2050 with the right tools, strategies, and sufficient funding. The report analyzes existing evidence with new epidemiological and financial analyses to demonstrate the feasibility of eradication.
A large study found that children of anxious mothers are more likely to develop hyperactivity symptoms in adolescence, with a link seen between maternal anxiety and child behavior. Researchers tracked over 3,000 children and found that children from high-anxiety mothers were twice as likely to show signs of hyperactivity
Researchers found no significant correlation between tumor mutational burden and response rates, progression-free survival, or overall survival in patients treated with pembrolizumab plus carboplatin and pemetrexed. High objective response rates were observed in both TMB low and high subgroups.