The latest issue of Cardiovascular Innovations and Applications features a wide range of papers on various cardiovascular topics. These include studies on selective coronary angiography following cardiac arrest and systemic vasculitis as an underestimated cause of malignant hypertension. The journal also covers reviews on epicardial co...
A recent study by University of Edinburgh researchers found that nearly 20% of people waiting for hip replacements suffer from extreme pain or discomfort. The study also revealed that knee replacement patients face similar struggles, with 12% reporting severe health issues.
Researchers have identified a specific rice immune receptor that can trigger immune reactions in response to multiple fungal proteins, paving the way for disease-resistant rice crops. Gene-editing technologies could be used to precisely insert genes into rice plants, overcoming issues with linkage drag and enhancing disease resistance.
A study by Massachusetts General Hospital researchers has found a mutation in the RABL3 gene linked to hereditary forms of pancreatic cancer. The discovery may lead to earlier diagnoses and improved treatments for patients with strong family histories.
Researchers discover that sticky meshworks of DNA and proteins extruded by neutrophils act as the glue that binds together calcium and cholesterol crystals during gallstone formation. Inhibiting NETs reduces gallstone growth in mice, offering new strategies for treating gallstone disease.
A study by Washington University researchers found that people ascribe an inflated weight to their country's contribution to WWII. Russians view the war differently, listing D-Day as a 'relief' for Soviet forces rather than a pivotal moment.
Researchers suggest that reaching an 80% reduction in building CO2 emissions by 2050 requires highly energy-efficient technologies, new operational approaches, and electrification of fossil fuel-based systems. The study identifies two promising avenues for reducing emissions: energy-saving retrofits and smart software optimization.
Researchers found that mixing glyphosate with dicamba formulations consistently lowered the pH of the spray solution below 5.0, a critical value according to dicamba application labels. The study suggests that glyphosate in tank mixes could be a culprit behind dicamba drift and volatility issues.
Researchers create BodyNet, a wearable technology that detects physiological signals from the skin using RFID technology. The system tracks heart rate, respiration, and muscle movements, providing accurate readings without interfering with daily behavior.
Research from the University of York suggests that climate change is disrupting local plant communities, leading to increases in species richness in certain areas. The study analyzed over 200 studies and found that rapid changes in rainfall are driving these local diversity increases.
Scientists are simulating nuclear waste disposal in the Grimsel rock laboratory to explore the stability of the geotechnical barrier bentonite. The research team inserted a small barrier system into a natural flow system and observed its behavior over four years, finding that the radionuclides moved but remained near the barrier.
A soft robotic exosuit can assist both walking and running by detecting the wearer's gait and providing appropriate assistance, reducing metabolic costs of walking and running by 9.3% and 4.0%, respectively. The device weighs only 11 pounds and enables a near-seamless transition between gaits.
A new approach developed at Penn State's Center for Advanced Data Assimilation and Predictability Techniques can accurately forecast the intensity and trajectory of Hurricane Harvey. The method uses data from the GOES-16 satellite and Penn State's all-sky radiance technique, which more accurately models hurricanes.
Researchers discovered tetraaminobenzene-based linear polymers of nickel and copper that can be used as anode materials for fast-charging batteries. These materials retain up to 79% of their capacity after 20,000 charging-discharging cycles.
The new self-calibrating endoscope produces 3D images of objects smaller than a single cell, opening new opportunities for medicine and research. The device measures just 200 microns across and enables minimally invasive access and high-contrast imaging.
A recent study found that fewer than eight per cent of cancer drug trials included participation from all four major races in the US between 2008 and 2018. Black and Hispanic patients were particularly underrepresented, with rates of 22 per cent and 44 per cent respectively.
A team of researchers led by Brittany Dugger will study donated post-mortem brain tissues from diverse individuals with Mexican, Cuban, Puerto Rican, and Dominican heritage to define the neuropathology of Alzheimer's disease in Hispanic cohorts. The goal is to develop specific disease profiles and improve prevention and treatment.
Researchers at UCSF and NIH create a new CRISPR technique that allows them to systematically alter gene activity in human neurons, enabling the study of neurological diseases. They discovered that housekeeping genes behave differently in neurons and stem cells, suggesting that these differences may play important roles in disease.
A new study found that off-service patient placement contributes to a 23% longer hospital stay and a higher chance of being readmitted within 30 days. The research also reveals that this practice leads to nearly 4,000 additional patient-days per year.
A nationwide HIV prevention study led by Dr. Christian Grov has been extended due to its success in achieving stringent transition milestones. The study aims to improve HIV prevention and care for gay and bisexual men using technology-mediated epidemiological cohort studies.
Researchers analyzed helium isotopes in super-deep diamonds to find evidence of pristine reservoirs of primordial rock material beneath the upper mantle. The study suggests that these reservoirs occasionally infiltrate the transition zone and mix with subducting material, creating diverse isotopic compositions.
Research in flies reveals potential drug targets for gout, metabolic syndrome, diabetes, and kidney stones by manipulating insulin-like signaling pathway. Elevated uric acid levels increase risk of these diseases, emphasizing the importance of routine screenings in humans.
Researchers found that HIV integrase inhibitor dolutegravir is not a clinical inhibitor of folate transport pathways, reducing concerns about its impact on maternal and fetal health. The study's results suggest that these drugs may be safer for pregnant women than previously thought.
A new prospective study of over 4,000 children found that screening for cervical spine risk factors can significantly reduce the number of unnecessary CT scans. The study identified seven key risk factors that can aid clinicians in deciding which children need imaging, with the potential to spare hundreds of children from cancer annually.
A University of Illinois study finds that designers who focus on how a product makes consumers feel create more innovative products. By incorporating feelings into the design process, designers experience greater empathy and cognitive flexibility, leading to higher levels of outcome originality.
Geriatric patients with ST segment elevation myocardial infarction who undergo primary percutaneous coronary intervention have higher in-hospital mortality rates if they have a high mean platelet volume. This is also associated with higher Gensini scores, creatinine concentrations, and lower HDL cholesterol levels.
Researchers at Karolinska Institutet have discovered a new sensory organ in the skin that detects painful mechanical damage, such as pricks and pressure. This discovery changes our understanding of the cellular mechanisms of physical sensation and may be significant in the understanding of chronic pain.
A University at Buffalo-led study found that a vegetable-rich diet can improve fatigue in multiple sclerosis patients by increasing good cholesterol levels. The results suggest that lipid metabolism plays a crucial role in fatigue and may provide new treatment options for this debilitating symptom.
A Dartmouth-led research team has identified a non-verbal neural marker of autism, which shows individuals with autism are slower to dampen neural activity in response to visual signals. The findings offer an objective way to potentially diagnose autism and were found to be independent of intelligence.
A recent study found that people living with HIV have a significantly elevated risk of Chronic Obstructive Pulmonary Disease (COPD) and coughs, heart disease, pregnancy mortality and sepsis, anemia, and bone fractures. The review combined data from 20 observational studies to examine 55 different illnesses.
Researchers at Northwestern University discovered that mixing strong and weak graphene oxide flakes can create stronger paper, improving the material's durability. The finding sheds light on a general problem in materials engineering and has implications for other two-dimensional materials.
Recent research highlights the importance of treating epicardial coronary artery abnormalities that do not result in myocardial ischemia. Aggressive risk factor modification and drug use are recommended for individuals with such conditions.
Researchers have developed a drug that speeds up blood stem cell regeneration after exposure to radiation, accelerating the recovery of cancer patients. The new compound, DJ009, lifts molecular 'brakes' on blood stem cells, enabling them to recover faster and reducing the risk of infections.
A study of 1,400 elementary and junior high school students in Tokyo estimated the rate of nearsightedness. Nearsightedness was found to be relatively common among Japanese schoolchildren.
A study of hundreds of basketball half-time speeches found that negative coaches' emotions at halftime led to higher scores in the second half. While expressing positive emotions can motivate, negative emotions can also drive performance, but only up to a point.
The study introduced macrocyclic rigid structures that improve polymer properties, allowing for the creation of hybrids with biopolymers and self-assembling capabilities. These hybrids were applied in prototypes of chemical and biochemical sensors, offering good prospects for creating new smart drugs and systems.
A new study found no harm to newborns from opioid maintenance treatment (OMT) during pregnancy compared with no treatment. The growth parameters of newborns were similar in the OMT and comparison groups, supporting the prescription of OMT drugs to pregnant women with opioid use disorders.
A new study at the University of Hawaii found that a tropical marine sponge obtains essential nutrients from its symbiotic bacteria, not from filtering seawater. This discovery provides insight into the biology of sponges and highlights the importance of marine microbes in their diet.
New analysis reveals Europe's onshore wind farms could supply enough energy for the world until 2050, producing 497 EJ of power. The study identifies Turkey, Russia, and Norway as having the greatest potential for future wind power density.
Researchers from the University of California, Davis and the University of Wisconsin-Madison identified neurotrophin-3 as a key molecule in anxiety models. Boosting this molecule reduced anxiety-related behaviors in nonhuman primates.
A new study published in PLOS ONE reveals that women and men perform equally when required to switch attention between tasks or perform two tasks simultaneously. Multitasking imposes a substantial cost on both speed and accuracy for both men and women, with no difference between the two groups in the magnitude of the cost.
Researchers have developed a new 'ubiquitin clipping' technique to study protein modifications, revealing branched ubiquitin chains are common and could impact diseases like cancer and neurodegenerative disorders. The technique enables detailed experimentation, providing insights into disease mechanisms and potential drug targets.
A two-step gene therapy treatment has shown promise in treating recurrent glioblastoma by boosting IL-12 production and enhancing antitumor immune cell infiltration. The treatment has also been found to be safe, with serious side effects easily reversible after discontinuing treatment.
Researchers at ETH Zurich developed a new CRISPR-Cas method that can modify up to 25 target sites within genes in a single step. This technology enables targeted, large-scale cell reprogramming by systematically modifying entire gene networks, with potential applications in basic research and cell replacement therapy.
The All of Us Research Program has made strong progress in advancing precision medicine by collecting diverse participant data. The program aims to include 1 million or more people from diverse communities, with over 230,000 participants enrolled and 80% from underrepresented groups.
Researchers are creating a database to catalog teacher misconduct cases in Texas, aiming to inform policymakers with empirical data on educator sexual misconduct. The database will include employment and certification data, shedding light on patterns among offender educators.
A phase 1 clinical trial found that combining AZD1775, a Wee1 inhibitor, with radiation and gemcitabine resulted in better-than-expected overall survival in patients with locally advanced pancreatic cancer. The median overall survival was 22 months, surpassing previous results for the same treatment combination.
Stroke survivors who completed group-based aerobic exercise programs showed significant improvements in aerobic endurance and walking speed. Participants with mild movement impairments benefited the most, with average distances walked during a six-minute test being almost half the size of a football field.
A new study has gained insights into the mechanism of vaccine-induced T cell immunity, shedding light on the regulation, gene expression, and metabolic pathways of T cells. The discovery of a marker, TfR1, suggests that T cell immunity depends on specific metabolites.
A new study reveals that up to 47.5% of patients who face life-threatening risks, such as domestic violence or depression, do not disclose this information to care providers. This phenomenon is linked to discomfort and a lack of trust between patients and providers.
Researchers developed an app called Bluetana that uses Bluetooth signature detection to identify gas pump skimmers. It has been shown to discover more skimmers and have a lower false positive rate than existing apps, allowing inspectors to quickly locate the devices without manual inspections.
Researchers at UNC School of Medicine find that adding rhamnolipids enhances the potency of aminoglycoside antibiotics against Staph infections, including MRSA. The study suggests a new strategy to overcome antibiotic resistance and has implications for treating various bacterial species.
Researchers at the University of Warwick have discovered a way to make patterned films of silver and copper without using toxic chemicals or expensive methods. The new method uses an extremely thin printed layer of organofluorine to prevent metal deposition, making it more sustainable and potentially cheaper.
A new small molecule drug, DYR219, targets the early instigator of Alzheimer's disease by inhibiting DYRK1 kinase. This approach delays amyloid plaque formation and improves cognitive performance in hybrid mice bred to develop AD-like symptoms.
Martin Nyffeler's study calculates the significant ecological role of insectivorous birds in consuming herbivorous insects and other arthropods. The research reveals that forest birds are major consumers of arthropod biomass, with an estimated 400-500 million tons of prey consumed annually.
The newly discovered Clevosaurus hadroprodon is the oldest known fossil of its kind in Gondwana, dating back to around 237-228 million years ago. Its unique dentition features a mix of primitive and derived teeth, challenging current understanding of sphenodontian evolution.
Researchers found that adding compost and cover crops to organic-certified systems increased soil carbon content by 12.6% over a 19-year period, outperforming the international '4 per 1000' initiative. This approach stores more carbon than previously calculated, highlighting the importance of balancing diet for microorganisms in soils.
Researchers studied skulls of New World leaf-nosed bats to understand the evolution of specialized diets and faces. They found that heterochrony influenced development, leading to primate-like faces for fruit-eating bats and wolf-like faces for bird- and rodent-eating bats.
The study reveals that non-cognitive skills such as conscientiousness and self-esteem play a significant role in determining graduate earnings. Graduates from STEM subjects tend to earn more than those from Arts subjects, while those from elite institutions also have higher earning potential. The research emphasizes the importance of c...
A new nanoparticle delivery tool targets metastatic cancer cells in lymph nodes, leading to improved survival rates and reduced tumor growth. The therapy, called iCluster, effectively treats cancer at primary tumor sites as well as distant lymph node metastases.