Researchers have identified an unusual hepatitis B virus in shrews, which lacks a key protein essential for chronic infection. This discovery offers new insights into the disease's pathogenesis and may lead to the development of effective treatments.
The European Society of Cardiology and European Atherosclerosis Society Guidelines recommend lowering LDL cholesterol levels to prevent cardiovascular disease. Lowering LDL cholesterol reduces risk regardless of the baseline concentration, making it effective even in people at very high risk of heart attack or stroke.
The new guidelines clarify the diagnosis and treatment of acute pulmonary embolism, emphasizing the importance of quick and reliable diagnosis to prevent death. The guidance also provides recommendations on the use of anticoagulant drugs and clot busters, as well as distinguishing between fresh thrombi and chronic obstructions.
Research finds that patients experiencing internal bleeding after a heart attack may be at higher risk of developing cancer. The study suggests that early detection of bleeding can lead to improved cancer prognosis.
Procizumab shows high therapeutic potential in treating acute heart failure and cardiogenic shock by targeting the DPP3 enzyme. The company is setting up GMP process for Procizumab manufacturing and expects to enter regulatory non-clinical safety studies next year.
A study of nearly half a million people found that those with heart or blood vessel problems benefited more from having a physically active lifestyle than healthy people without cardiovascular disease. Increased physical activity reduced the risk of dying during a six-year follow-up period for people with and without CVD.
A new study suggests that a diabetes medication called empagliflozin can protect against heart disease by regulating circulating progenitor cells and reducing inflammation. The findings from the EMPA-HEART CardioLink-6 Trial may provide the basis for new therapies for patients with heart disease complicated by diabetes.
A new study by New York University researchers finds that the presence of refugees in local communities has no effect on residents' voting behavior or attitudes towards immigration. Despite widespread anti-immigrant sentiments after 2015, attitudes and voting patterns remain unchanged.
Researchers developed a tiny wearable camera to track heart failure patients' daily activities, providing valuable data for fine-tuning self-management. The study found that the cameras could identify areas for improvement in diet, exercise, and medication adherence, with potential applications for guiding newly diagnosed patients.
A novel disease mechanism links circulating DPP3 to cardiac and renal dysfunction, with sustained high DPP3 levels associated with reduced cardiac function, impaired kidney function, and increased mortality. The DPP3 biomarker has high potential utility in diagnosing organ dysfunction and predicting outcomes in cardiogenic shock patients.
The European Society of Cardiology recommends reducing air pollution and environmental noise to minimize heart attack and stroke risk. Lifestyle changes, such as quitting smoking, eating a balanced diet, and exercising regularly, are also emphasized.
A study found that bacteria in coronary plaques were pro-inflammatory, whereas gut bacteria were diverse and varied. Patients with acute coronary syndrome had different gut microbiota compared to those with stable angina. The research suggests a possible role for microbes in plaque destabilization and heart attack onset.
A recent study found that eating nuts at least twice a week is associated with a lower risk of death from cardiovascular disease. The researchers analyzed data from 5,432 Iranian adults and found that nut consumption was linked to a 17% reduced risk of fatal heart attack and stroke.
A sub-group analysis from the ASPREE trial found that daily low-dose aspirin did not prolong disability-free survival in healthy people over 70, even in those at high cardiovascular disease risk. The study suggests that improved risk prediction methods are needed to identify those who could benefit from aspirin therapy.
The guidelines emphasize healthy behaviors, such as physical activity and a Mediterranean diet, to prevent cardiovascular disease. They also recommend specific medications, including GLP-1 receptor agonists and PCSK9 inhibitors, for patients with diabetes at high risk of cardiovascular disease.
A 22-year analysis of physical activity levels found that inactivity was linked to a two-fold increased risk of all-cause death and a 2.7-fold greater risk of cardiovascular disease mortality compared to high activity levels. The study suggests that even small amounts of exercise can provide health benefits.
A low-cost text-messaging programme improves blood sugar control in patients with diabetes and coronary heart disease. The programme, which consisted of six messages per week, resulted in a significant reduction in HbA1c levels and an increase in participants achieving the target level of less than 7%.
The European Society of Cardiology has published new guidelines for the management of fast heartbeat, highlighting the benefits of catheter ablation in treating supraventricular tachycardia. The guidelines recommend invasive methods for eradicating arrhythmias and provide specific recommendations for pregnant women.
A USF-led team studied geological formations in a coastal cave to understand past sea level rise. They found that 3-4 million years ago, global mean sea level was 16 meters higher than present, with potential implications for current-day sea level rise.
Researchers have found a novel approach to limit excessive immune responses in chronic diseases like psoriasis, asthma, and HIV by targeting the IL-1 family. The study identifies IL-1R3 as a potential target for effective treatment, offering a new direction for research and therapy.
Researchers found that older men who never exercised before could build muscle at a similar rate as master athletes, highlighting the benefits of starting exercise later in life. The study suggests that regular physical activity can help delay age-related decline and improve overall health.
A new paper by researchers at the University of Colorado Denver calls for a fundamental shift in how we approach wildfires, from basic recovery to transformation. The study highlights the need for communities to adopt more resilient strategies, such as reducing flammability and promoting prescribed burns.
A new study found that NFL players who experienced concussions had elevated risk for serious cognitive problems, depression, and anxiety, persisting even 20 years after injury. Players in high-impact positions like running backs, linebackers, and special teams faced greater risks compared to those in lower-risk positions.
Researchers used a newly developed algorithm to study mixed x-ray images of the Ghent Altarpiece, separating features from the front and back of the painting's double-sided panels. The analysis improved our understanding of art masterpieces and provided new opportunities for art investigation, conservation, and presentation.
New research shows that particle transport in crowded cells can be faster than in non-crowded environments, especially when moving from densely crowded areas to less crowded ones. The study used microfluidics and tracer colloids to investigate the effects of non-uniformly distributed crowding molecules on particle movement.
A team of scientists discovered geologic evidence in a Mallorcan cave showing sea levels were 16 meters higher than present day 4 million years ago. The findings provide insights into past global sea level rise and implications for predicting current-day rise amid a warming climate.
The guideline covers the diagnosis of invasive pulmonary aspergillosis, invasive candidiasis, and three common endemic mycoses. Effective treatment depends on rapid and accurate diagnosis, with recommendations for laboratory tests such as galactomannan testing and polymerase chain reaction approaches.
Researchers at the University of Queensland have found that human-induced landcover change was globally extensive by 2000BC, four millennia ago. The study used crowdsourcing-from-experts approach to gather archaeological data and found long-term cumulative changes caused by early food producers.
Primary care physicians tend to prescribe opioids more for pain issues later in the day and if appointments are running late. The likelihood of an opioid prescription increased from 4% to 5.3% as appointments progressed, with a notable increase for appointments over 60 minutes behind schedule.
Researchers have developed a way to remove ice and frost from surfaces efficiently using less than 1% of the energy needed for traditional methods. The technique works by melting the interfacial layer directly, allowing the ice to slide off the surface.
The HOT SHOT program has revealed a way to improve tests, providing an earlier indicator of technology success and saving taxpayer money. The analysis of sounding rocket data has produced more complete vibration pictures, used to create accurate simulations and ground tests.
Hurricane Dorian has strengthened to near 110 mph with higher gusts, threatening the Bahamas and southeastern US with life-threatening storm surge and heavy rainfall. The storm is expected to produce 6-12 inches of rain and cause life-threatening flash floods.
Researchers have successfully stored and released mechanical waves without losing energy, paving the way for improved technology in structural integrity monitoring, energy harvesting, and quantum computing. This breakthrough has significant implications for efficient wave propagation and control.
The ArchaeoGLOBE project provides the first global assessment of land use changes since the last ice age, driven by humans over the past 10,000 years. This study reveals profound implications for understanding contemporary global changes in land use, climate, and biodiversity.
A study compared phenolic profiles of 'Brown Snout' juice and cider apples harvested by hand or machine, finding similar quality at reduced labor costs. The results suggest that over-the-row machine harvesting offers a cost-effective option for commercial sustainability in cider apple operations.
Researchers reconstructed the Anak Krakatau flank collapse using satellite remote sensing data, finding it was triggered by a relatively small landslide. The study shows that the collapse changed the eruption style, leading to a more explosive and destructive event.
Preoperative chewing gum use does not affect gastric emptying, while postoperative gum may aid recovery. Chewing gum can be a useful tool to aid recovery and reduce complications after certain types of surgery.
A new study published in Frontiers found that Amazon deforestation causes local climates to warm, particularly in areas with severe tree cover loss. Intact forests maintained more climate stability, while disturbed forests experienced larger temperature increases during dry periods.
Researchers identified cone snails' hydraulically propelled feeding structure as the quickest movement among mollusks by an order of magnitude. The radular harpoon can propel into prey within 100 microseconds with extreme speeds similar to a fired bullet.
Researchers found that tortoises cannot distinguish the lower petal surfaces of daisies with closed flowers, which are camouflaged to avoid herbivores. This novel defense mechanism does not negatively impact pollination interactions.
A unique Victorian databank that profiles children with hearing loss will help researchers globally understand why some children adapt and thrive, while others struggle. The study found that language development and speech in hearing-impaired children lags behind other children despite advancements in earlier detection and intervention.
Researchers found evidence of earlier Arctic sea-ice decline starting at the beginning of the 20th century using a new proxy from coralline algae. The study provides insight into past sea-ice variability and may help reduce uncertainties in ocean model simulations.
The National Institutes of Health has granted $2.23 million in funding to develop statistical and computational methods for genome-wide CRISPR/Cas9 screening. The goal is to improve functional gene identification, analyze non-coding elements, and study genetic interactions, with potential applications in cancer research.
A team of international researchers has developed a financial mechanism to support the protection of the world's natural heritage. The socio-ecological design option proved most efficient in incentivizing additional conservation action, particularly for countries lacking in global conservation goals.
Researchers have found that Saccharomyces boulardii, a probiotic yeast, produces uniquely excessive amounts of acetic acid. This discovery may pave the path towards improved treatments for intestinal diseases. The study also showed that modifying the yeast's genetic basis could enhance its probiotic effects.
Rice University researchers have developed a new fluid dynamic model that allows scientists to predict when an eruption will transition from spattering to flowing lava. This tool could help emergency officials prepare for potential hazards by providing early warnings of changing behavior.
University of Illinois researcher Kyle Smith has made significant progress in water desalination with a new publication and research project. His work involves deionization devices that can reversibly store and release cations using intercalation materials, resulting in a nearly 10-fold increase in salt removal rates.
A 420 million-year-old mass extinction event, one of the most dramatic ever recorded, was caused by rapid and widespread depletion of oxygen in global oceans. The study provides a mechanism for the step-wise extinction event, driven in part by sulfidic ocean conditions.
Researchers at Scripps Research Institute have discovered a potential biological marker for early detection of type 1 diabetes using single-cell analysis of immune cells. The discovery could lead to earlier intervention and prevention of the disease, which affects over 1.25 million Americans.
Research at Hokkaido University reveals that deeper Arctic snow cover can trigger wave train-like temperature distributions in Eurasia. This phenomenon causes surrounding regions to experience high temperatures due to altered westerly wind patterns.
Researchers have found stone tools and other artifacts at Cooper's Ferry site in Idaho dating back to 15,000-16,000 years ago, contradicting the 'Clovis First' theory of early human migration. The discovery supports the hypothesis that people entered North America via a Pacific coastal route.
The new concrete mixture has a compressive strength increase of 2.7-3.3 times compared to traditional concrete, while reducing frost-resistance issues and increasing water-resistance. The eco-friendly concrete technology is cost-effective and can be implemented with minimal spending.
Research reveals that diet can alter the effectiveness of metformin, a type-2 diabetes drug, by influencing gut bacteria. The study found that specific nutrients can either enhance or suppress these effects, highlighting the importance of dietary guidance for improved treatment outcomes.
A new study from the University of Pennsylvania School of Medicine found that providing patients with more testing choices, such as home fecal immunochemical testing (FIT), does not increase participation in colorectal cancer screening. However, framing choice did impact patient decision-making, leading to a decrease in colonoscopy rates.
NASA's fleet of satellites is gathering data on Hurricane Dorian, helping scientists understand its structure and predict its path. The storms maximum sustained winds are currently at 115 mph with higher gusts, posing a significant threat to Florida and the northwestern Bahamas.
A team of engineers and psychologists at UC San Diego discovered clever tricks to design materials that replicate different levels of perceived softness. The findings provide fundamental insights into designing tactile materials and haptic interfaces that can recreate realistic touch sensations.
A new machine learning-based model evaluates immunohistochemical characteristics in patients with suspected thyroid nodules, achieving excellent performance for individualized noninvasive prediction. The model improves thyroid nodule diagnoses and helps identify papillary thyroid cancers earlier.
Researchers found that Helicobacter pylori is attracted to bleach, relying on a protein called TlpD to navigate to sites of inflammation in the stomach. This attraction enables the bacterium to turn the body's defenses against it and colonize inflamed tissue.
A new study found that nearly one-third of kidney transplant candidates die or are removed from the list without receiving a transplant, with many having had multiple organ offers declined. The research highlights concerns about the allocation system and suggests better communication between patients and transplant centers could improv...
A new study suggests transplanting Hepatitis C-infected kidneys to uninfected recipients is safe and can be implemented as a standard of care. This approach could greatly expand the number of available kidneys and reduce waiting times for donors, saving thousands of lives annually.