A new study has shown that an individualized approach to nutritional ketosis combined with remote monitoring via a mobile application can sustainably and safely reverse Type 2 diabetes. The treatment resulted in significant improvements, including a 12% weight loss and a reversal of diabetes progression in 94% of patients.
A study found that few dermatologists prescribe opioids, but those who do concentrate in Southern states and surgical practices. Higher rates of opioid prescribing were also observed among dermatologists in these areas.
A recent study published in BioScience found that knowing more about evolutionary theory is key to accepting it, even when considering religious and political beliefs. In a representative sample of over 1,100 people, researchers discovered that those with better knowledge of evolution were more likely to accept it.
Researchers at UMass Amherst and University of Missouri found that prenatal exposure to a mixture of fracking chemicals affects mouse mammary gland development, leading to potential pre-cancerous lesions. Further studies are needed to evaluate the effects on long-term health and lactational capacity.
After Robin Williams' suicide in 2014, researchers found a 10% increase in overall suicides, particularly among men aged 30-44. Suffocation suicides also increased by 32% compared to other methods.
Somayeh Moazzeni, a UTA doctoral student in public policy and transportation, has been recognized as the 2017 outstanding student of the year by the U.S. Department of Transportation for C-TEDD. She will receive a $1,500 cash prize and contribute to research on access to opportunities, public transit, and decent roads.
Researchers found that female mice exposed to fracking chemicals during prenatal development developed abnormal mammary glands and pre-cancerous lesions in adulthood. The study suggests that the mammary gland is sensitive to mixtures of fracking chemicals, increasing concerns about potential health effects in humans.
A study by Dr. Patric Diriwaechter and Dr. Elena Shvartsman found that wage increases temporarily boost job satisfaction due to expectations and social comparisons, but this effect fades out within four years as individuals adapt to their new salary levels.
A $5-million gift will help develop a new CASA Research Chair in Child and Adolescent Mental Health at the University of Alberta. This initiative aims to improve front-line care for children and youth with mental health and addictions issues, and will focus on community-focused research and evidence-based findings.
Researchers have developed a new method to grow patient-derived xenografts (PDX) liver cancer cells in culture, which maintains their proper shape and function and grows as organoids. The success of the engineered organoids has the potential to revolutionize the screening and development of liver cancer drugs.
Researchers compared termites' genetic features to those of ants and bees, discovering similar molecular mechanisms for eusocial lifestyles. They found evidence of convergent evolution in chemoreceptor families and genes involved in pheromone recognition.
A six-year study found that cognitive enhancement therapy (CET) significantly improved neurocognitive function in adults with autism, particularly in attention and social understanding. In contrast, enriched supportive therapy (EST) showed slower but still significant improvements in social cognition.
Researchers from Rothamsted Research introduce a rice gene that regulates sucrose accumulation in kernels, leading to increased productivity in maize even under drought conditions. The transgenic maize also improves rates of photosynthesis, resulting in more sucrose production for additional kernels.
A new study found that age at sexual maturity and average rainfall significantly correlated with cranial shape in carnivores. Skulls of species living in regions with higher precipitation showed elongated features, while those with narrower diets exhibited stiffer lower elements.
Researchers at Hong Kong Baptist University have designed and synthesized a smart globular macromolecular machine vehicle for actively controlled cancer drug delivery, enhancing the efficacy of targeted therapy drugs. The breakthrough offers insights into targeted therapies such as Chlorambucil in leukemia treatment.
Researchers discovered a specific protein that reduces lung inflammation and improves survival in mice with the flu. The study found that administering this protein after infection improved survival rates by 40% compared to untreated mice.
A new study led by Yale University found that positive beliefs about old age can significantly reduce the risk of developing dementia. Among APOE ε4 carriers, who are at high risk of dementia, those with positive attitudes had a nearly 50% lower risk of developing the disease.
Researchers at the University of Maryland have created a new type of wood that is 10-12 times stronger than natural wood, making it a potential competitor to steel. The wood's mechanical properties are comparable to those of titanium alloys, but with improved toughness and reduced weight.
Scientists have successfully observed radiation reaction in a lab experiment, where an ultra-intense laser slows down electrons. This phenomenon is thought to occur near black holes and quasars, and provides insights into quantum effects beyond classical physics.
Researchers identified protective structures at the end of chromosomes called telomeres that don't shorten with age in longest-lived bat species. The study found two genes ATM and SETX drive this process, potentially leading to new solutions to slow down aging and extend human lifespan.
Researchers at Case Western Reserve University question long-held understanding of Earth's solid center formation, citing energy barriers and supercooling issues. The team proposes alternative solutions, including the possibility of a nucleation-enhancing solid metal affecting the core's crystallization process.
A team of researchers has discovered 31 species of plants known only from caves in China, highlighting the importance of cave flora for species conservation. The study also found that plants can photosynthesize at much lower light levels than previously thought.
Researchers developed a new framework to analyze the effects of crosstalk on cooperation dynamics in groups. The model shows that crosstalk hinders the evolution of cooperation and requires strategies with the correct level of forgiveness. This has significant implications for understanding human behavior in social dilemmas.
Researchers found a significant link between acne and major depression, with a 63% higher risk within the first year of diagnosis. The study highlights the importance of monitoring mood symptoms in patients with acne and initiating prompt treatment for depression.
The low FODMAP diet shows promise in treating irritable bowel syndrome (IBS) by avoiding common trigger foods like wheat, onions, and apples. Clinical trials indicate that 50-80% of subjects respond positively to the diet.
Researchers have identified a method to prevent posttraumatic osteoarthritis (PTOA) by reducing oxidative stress after fractures in an animal model. By inhibiting mitochondrial metabolism or boosting antioxidants, they demonstrated that PTOA can be significantly blunted.
A study published in PLOS ONE found that Zimbabwe's Savé Valley lion population has low genetic diversity due to inbreeding, which could impact its health. The authors suggest introducing new unrelated lions to enhance the population's genetic diversity and ensure its long-term future.
Scientists at USC have discovered a new molecule, RCGD 423, that enhances cartilage regeneration and decreases inflammation. The molecule amplifies the body's natural signals to stimulate cartilage development while blocking inflammatory signals.
Researchers develop polymers that can change colors like structural color in nature, enabling smart decorations and anti-counterfeiting measures. The new materials use inkjet printing technology to produce a wide range of colors, including blue, green, orange, and red.
Scientists identified a confining 'cage' in which a magnetic rope forms, causing solar eruptions. The resistance of this cage determines the power and type of flare. A new model predicts maximum energy release during solar flares, potentially devastating for Earth's systems.
Middle-aged white Americans and rural communities are disproportionately affected by the alarming drop in US life expectancy. Experts attribute this decline to factors such as social mobility decline, economic hardship, and distress over losing stability, highlighting the need for policymakers to address these conditions.
The Sicilian mafia arose from high demand for citrus fruits following physician James Lind's discovery that they could prevent scurvy. Citrus cultivation dominated Sicily's economy, creating a lucrative market that attracted mafia affiliation and protection.
The SLAS Journal Achievement Awards recognized outstanding contributions to the advancement of life sciences discovery and technology. Honorees included researchers who demonstrated exceptional review quality, timeliness, and volunteer service.
New research reveals that removing fossil fuel subsidies will only slightly slow the growth of CO2 emissions, with smaller effects in developing economies. The largest emissions savings would come from oil and gas exporting countries, but removal could have a detrimental impact on poor households, who may struggle to afford modern fuels.
A study found that older adults with positive beliefs about aging have a lower risk of developing dementia compared to those with negative views. The protective effect was even observed among individuals carrying the high-risk APOE E4 gene variant.
Researchers found that individual great spotted woodpeckers can be distinguished by unique drumming patterns, including stroke speed and roll duration. Drumming also signals the quality of potential mates, as it requires well-developed back and neck muscles.
Migratory birds use a light-dependent protein called cryptochrome 4 to navigate, which is specifically expressed in the outer segment of double-cone photoreceptor cells. This discovery provides new insights into magnetoreception and could help protect wildlife from human disturbances.
Researchers re-created a Titan ocean in a laboratory and studied the freezing temperatures of methane and ethane lakes. They discovered that nitrogen in the liquid causes lakes to freeze at lower temperatures than expected, which could be beneficial for the submarine's operation.
Researchers from North Carolina State University have developed a new technique that can detect potential airborne radiological materials in hours, instead of days. This approach uses existing technologies to provide quality information to first responders, allowing them to make informed decisions about evacuating the area.
Researchers create biomechanical models to test how ecological factors like age at sexual maturity and average precipitation influence skull shape in carnivoran species. The study reveals that nondietary factors significantly impact both skull form and function, surpassing dietary influences.
Pine trees become temporarily sterile when exposed to intense UV radiation, similar to what scientists believe the Earth experienced 252 million years ago. The effect suggests caution in introducing chemicals that deplete the ozone layer.
A new analysis of dozens of studies confirms protein supplements boost muscle mass and strength in weightlifters. However, their effectiveness decreases with age, highlighting the need for greater supplementation as people get older.
Researchers found that silencing astrocytes in the brain's breathing center caused rats to breathe at a lower rate and tire out on a treadmill earlier. Astrocytes were shown to use adenosine triphosphate (ATP) to communicate with other cells, and their modulation was linked to changes in oxygen levels.
A recent study analyzing pediatric drug dosage guidelines found inconsistencies in recommended doses, with varying results from allometric scaling and prior patterns of use. The analysis suggests a need for more precise treatment approaches to address the complexities of pediatric dosing.
Researchers at Shinshu University have successfully tested a new, safer titanium plate for bone tissue repair, eliminating the need for plate extraction and associated surgical risks. The titanium fiber plates share a similar measurement of stiffness with natural bone, reducing the risk of embrittlement.
A Phase 3 clinical trial demonstrates the safety and efficacy of IMVAMUNE, a non-replicating smallpox vaccine. The study showed twofold higher neutralizing antibodies compared to ACAM2000, a statistically superior immune response.
Researchers found that restricting asparagine production in mice greatly reduced breast cancer's ability to spread, suggesting a potential new treatment approach. The study also suggests that dietary changes may help stop cancer from spreading and improve outcomes for patients.
Researchers identified a new treatment that relaxes muscles and opens airways in asthma, preventing pulmonary resistance. The treatment, TSG12, is non-toxic and more effective than current treatments, providing relief for millions with asthma.
Researchers at UC Riverside have solved the crystal structure of an enzyme that plays a key role in DNA methylation, a process linked to various diseases including cancer. The breakthrough provides important information for understanding de novo DNA methylation and its implications for gene expression and cell differentiation.
Researchers at NYU Tandon School of Engineering have created a bioinspired robotic replica that can interact in three dimensions with live zebrafish. The system allows the robot to watch and mimic the behavior of live fish in real-time, promoting social interactions.
A new study suggests adapting the WHO eradication strategy for yaws by implementing multiple rounds of mass drug administration and targeting a broader geographic area. The research found that this approach can capture those not present during the first round and prevent the spread of antibiotic-resistant strains.
A new patient questionnaire developed by Hospital for Special Surgery measures the physical and emotional impact of brachial plexus injury, assessing patients' expectations and treatment outcomes. The survey has the potential to improve patient care by aligning surgical alternatives with patient needs and expectations.
Tropical Cyclone Cebile in the Southern Pacific Ocean is experiencing strong vertical wind shear, causing rainfall to be pushed away from its center. The heaviest precipitation was found southeast of Cebile's center, with powerful storms on the southern side still dropping rain at high rates.
Biomedical engineers developed a miniaturized system mimicking blood vessel injury, allowing for the study of bleeding and clotting. The device replicates all aspects of blood vessel injury, including clot formation and repair, and responds to drugs and other alterations.
Researchers have discovered a genetic trigger that can increase plant branching, leading to improved crop yields. The newly identified chemical, DL1, has shown promise in both flower and rice plants, paving the way for potential commercial applications in agriculture.
A team of researchers developed a fluorescent sensor, TiY, that selectively stains tumor initiating cells (TICs) in various cancer tissues. The sensor can distinguish TICs from non-TICs and inhibit sphere formation, leading to suppressed tumor growth in mice xenograft models.
Researchers have developed a fast gluten detector that can detect and quantify different sources of gluten than current tests, providing more accurate results. The new test is faster, taking only 45 minutes, and can sense less than 20 parts per million of gluten, meeting the FDA's limit for 'gluten-free' designation.
Researchers at Carnegie Mellon University have created a conversational agent, Evorus, that can answer a wide range of questions using a human/machine hybrid system. The system, which combines crowd workers and AI, allows the agent to learn and improve over time, making it more accurate and effective in its responses.
A study found that obese men have higher levels of inflammatory markers in their seminal fluid and lower sperm quality, correlating with body mass index (BMI). Chronic inflammation in the male reproductive organs may explain the link between obesity and reduced fertility.
A new study reveals that the WHO strategy to eradicate yaws is inadequate due to high rates of antibiotic resistance and relapse of latent infections. The research found that even with high coverage rates, mass treatment alone may not be sufficient to achieve elimination, highlighting the need for adapted strategies.
Two studies found that women with MS who stop taking natalizumab before or after pregnancy experience increased disease activity and relapse rates compared to those who continue treatment. The risk of miscarriage is also higher in the first trimester, but this rate is small and within the general population range.
Researchers found that androgens increase cell spread and prevent death, potentially predisposing boys to autism. The study identified key genes regulated by testosterone that contribute to the risk of autism.
Researchers from Martin Luther University Halle-Wittenberg have developed a cost-effective method to break down pollutants in water, using a green LED light, catalyst, and vitamin C. The new process produces hydrated electrons that can react with stable substances and break them down into harmless components.
Back pain is common in highly active older adults, impacting nearly half of well-functioning individuals. The condition was linked to less efficient walking and poorer endurance, which can lead to mobility issues. Better back pain management may help maintain independence and prevent future loss of mobility.
A new interaction between proteins could provide a breakthrough in the prevention of healthy blood vessel damage. The study found that stabilizing caveolae regions prevents damage by binding protein SOCS3 with Cavin-1, maintaining healthy vascular function.
A new study found that school-based healthy lifestyle interventions did not lead to significant changes in pupils' weight. The WAVES study intervention aimed to support children in keeping their weight at a healthy level by promoting physical activity and healthy eating.
A Florida Atlantic University study found that 70% of loggerhead sea turtle nests and hatchlings had different fathers, with no repeat males detected. This research provides insight into the reproductive behavior of male sea turtles and suggests a breeding sex ratio of approximately 1 female for every 2.5 males.
A study found that marketing messages for lower strength wines and beers are often associated with healthier habits, despite containing less alcohol. This can paradoxically lead to increased consumption, as consumers mistakenly believe these products are suitable for all occasions.
A review of clinical data from trials and observational studies suggests that prasugrel and ticagrelor reduce major adverse cardiac events compared to clopidogrel, but with increased bleeding risk. Prasugrel shows superior benefits in STEMI patients
A multinational research team led by Army scientists successfully induced a controlled release of stored isotopic energy using a physical effect involving atomic electrons. This achievement marks a step in the Army's quest for alternative energy sources for new types of batteries.
Researchers developed a mathematical approach to predict crease formation in soft solids, enabling on-demand control of adaptive surface morphology. This breakthrough enables the design and fabrication of morphable materials for stretchable electronics, self-foldable machines, and lab-on-a-chip devices.
A new study suggests an association between overactive and cytosolic BRCA1 and neurons death in Alzheimer's disease, linked to aberrant DNA damage response and presenilin 1 dysfunction. The findings support the hypothesis that genotoxic stress manifests in neuronal death.
Researchers review hypothetical uses of biosurfactants, safe and affordable molecules that can produce effective detergents at low temperatures. They have potential applications in industries such as biodiesel production and natural gas harvesting from ice crystals.
Research suggests that e-cigarette vapour can increase susceptibility to lung infection with pneumococcal bacteria, similar to traditional cigarette smoke or particulate matter from fossil-fuel pollution. Long-term vaping may raise the risk of bacterial lung infection.
In a groundbreaking study, male white-spotted bush frogs have been found to dedicatedly guard their fertilized eggs from other male frogs and predators. This unique parental care behavior significantly enhances offspring survival rates, with up to 70% of 'fatherless' egg clutches perishing.
Scientists have identified a new family of peptides in wasp venom that can control insect behavior, which may also help develop Parkinson's disease treatments. The peptides, called ampulexins, were found to immobilize cockroaches, and further research aims to identify cellular targets for potential treatment applications.
A recent study published in Science Advances found that CO2 leakage from storage sites can drastically alter seabed ecosystems, leading to the disappearance of animals and disruption of the food chain. The researchers also discovered that some microorganisms can adapt to increased CO2 levels, but most species struggle to cope.
Researchers found that near-infrared spectroscopy (NIRS) values correlate with vital signs and birth weight in critically ill babies. The study suggests that NIRS can provide a more complete picture of babies' health, particularly for those with abnormal brain scans.
A new study suggests that a re-evaluation of fosfomycin's dosing regimen may be effective in treating systemic multi-drug-resistant bacterial infections. Researchers found that a higher dosage schedule is required to combat these infections, offering a potential alternative to developing new antibiotics.
Researchers found evidence of extensive biomass burning at the Younger Dryas Boundary, coinciding with a cometary cloud impact that triggered an 'impact winter', causing widespread extinctions. The study suggests that this event may have contributed to the collapse of the Clovis people and the extinction of megafauna.
Scientists found wild Australian magpies from larger groups showed increased intelligence and produced more offspring. The research suggests that living in complex social groups may drive the evolution of intelligence.
A recent study found that yoga exercise decreases pro-inflammatory adipokines and increases an anti-inflammatory adipokine in adults with metabolic syndrome. This suggests that regular exercise, such as yoga, can help manage aspects of the condition by reducing chronic inflammation.
A pilot study by Brigham and Women's Hospital found that a home hospital model reduced direct costs up to half compared to traditional hospital care. The model also decreased hospital utilization and improved patient physical activity, with no significant impact on quality or safety.
International experts discuss six fetal growth size standards, their strengths and limitations. The INTERGROWTH-21st standard assumes uniform fetal growth rates across ethnic groups, while the customized GROW standard considers maternal and fetal characteristics.
The study found high-quality care for ordering brain imaging and administering antithrombotic agents, but gaps in care for processes like statin prescriptions, carotid artery imaging, and electrocardiography. Patients discharged from the Emergency Department without admission to a VA hospital had lower quality care.
A study published in Psychological Science found that exposure to air pollution, whether physical or mental, is linked with transgressive behavior through increased levels of anxiety. Participants who imagined experiencing air pollution engaged in more unethical behavior than those who thought about clean environments.
Researchers found that Egyptian fruit bats use a technique similar to frequency-scanning sonar, pointing different frequencies of sound at slightly different angles to create fine-grained acoustic images. This discovery could lead to the development of cheap sensors with sensing capability.
Researchers have successfully palliated kidney disease in mice by removing protein tyrosine phosphatase 1B from renal podocytes. Mice with this modification displayed improved glucose tolerance and insulin sensitivity, alleviating some consequences of diabetes.
Researchers found that prenatal stress can promote developmental plasticity in babies, making them more likely to benefit from good parenting. However, this effect only manifests when they are reared in supportive environments.
A new study has found that the immune system uses a specific balance of T cell types to tolerate beneficial bacteria, while triggering inflammation in pathogenic species. The discovery could lead to new treatments for inflammatory bowel diseases like Crohn's and ulcerative colitis.
University of Oregon geologists discovered unusual seafloor structures indicating heightened worldwide magmatic activity 66 million years ago after the Chicxulub meteor struck. The research suggests seismic waves from the impact triggered accelerated volcanism globally, contributing to a mass extinction event.
A new trial shows that family-integrated care in neonatal intensive care units leads to improved weight gain, breastfeeding rates, and reduced parental stress among preterm infants. The program also may have long-term benefits for neurodevelopmental outcomes.
Mobile health units offer a portable approach to bringing healthcare to communities, with over 2,000 units in service nationwide. Adolescents surveyed expressed interest in learning about sexual health through MHUs, with high rates of willingness to obtain birth control and recommend the service to friends.
Researchers are investigating genome elimination in organisms, a process crucial for survival and evolution. Studies aim to uncover the mechanisms of this complex phenomenon, which could lead to the treatment of hereditary diseases.
A randomized controlled trial found no significant difference in weight status among children taking part in a school-based lifestyle and healthy eating program compared to those not participating. The study suggests that wider influences from families, communities, and the food industry may have a greater impact on childhood obesity t...
A University of Iowa biologist discovered a virus family whose set of genes is similar to that of eukaryotes, helping clarify the evolution of eukaryotes after branching from prokaryotes. Giant viruses like Marseilleviridae may have been the source of these genes.
A recent study found that giving individuals a sense of freedom leads to increased feelings of responsibility. The research, involving Russian and American participants, showed that autonomy is a basic human need and that people are more likely to take responsibility when they have the freedom to choose their actions.
Researchers at Boston University School of Medicine have found that individual BET bromodomain proteins work independently, reducing the effectiveness of pan-BET inhibitors. This discovery paves the way for more fine-tuned experiments and treatments in breast cancer patients with varying levels of protein expression.
Researchers found that adding volcanic ash to traditional cement reduces the overall energy needed to manufacture concrete, with a 16% decrease in energy required. The optimal particle size of volcanic ash affects the strength and energy efficiency of the concrete.
GlycoNet has awarded $3.5 million to researchers across Canada to explore glycomics and its impact on human health. The grants will support research into Parkinson's disease, Alzheimer's, drug-resistant fungal infections, and other areas.
Researchers at MIT developed a mathematical model to describe the relationship between hairy surface dimensions, dipping speed, and fluid properties. The model predicts optimal fluid entrainment for hairy-tongued nectar feeders like bats, honeybees, and possums.
The American College of Rheumatology now supports the use of biosimilars in treating patients with rheumatic diseases, citing rigorously acquired data. Communication between providers and patients is crucial to alleviate anxiety around newly available agents.
Most UK doctors (79%) and 80% of the public support legislation for assisted dying. A series of articles explores the debate around assisted dying, with personal accounts and expert opinions. The proposed legislation aims to provide safeguards for terminally ill patients who want to end their lives.
Researchers use a compound called amobarbital to protect joints from cartilage loss after injury, showing promise in preventing post-traumatic osteoarthritis. The study's findings suggest that targeting mitochondria after joint fractures could substantially improve quality of life for PTOA patients.
The Rice lab demonstrates energetic properties of colloids in spinning magnetic fields, gathering into disorganized aggregated clusters and then forming crystal-like regimes as the field strength increases. The researchers explore ways to model novel two-dimensional materials like tunable catalysts or colloids with changing surface areas.
Researchers have identified a pheromone from the Asian citrus psyllid that transmits citrus greening disease. The discovery enables the synthesis of the substance and use in traps to lure and kill the insect, reducing HLB incidence.
Researchers discovered that limiting an amino acid called asparagine can dramatically reduce breast cancer's ability to travel, suggesting a potential strategy to prevent its spread. Foods high in asparagine include dairy and meat products, while fruits and vegetables are low in this compound.
Scientists at the University of Freiburg discovered RNase E as a crucial enzyme in CRISPR/Cas systems, enabling correct gene expression and immune defense. The findings suggest stronger interaction between CRISPR/Cas systems and host organisms, increasing potential for its applications.
Many epilepsy patients receive antiepileptic and non-epilepsy drugs that can interact, altering the effectiveness of one or both types of medications. The study found over 1 in 5 patients taking such combinations may experience reduced efficacy or increased toxicity.
NYU Tandon researchers have developed a new method for manufacturing lightweight syntactic foams using 3D printing. The breakthrough could enable the creation of complex parts that can withstand stresses at greater depths, benefiting submarines. The filaments were made with recycled fly ash and high-density polyethylene plastic.
A new study challenges the long-held assumption that amyloid beta buildup in brain cells is the origin of Alzheimer's disease. Researchers found that standard diagnostic tools fail to detect future AD in many patients under age 70, and that a decline in cerebrospinal fluid clearance may be the early feature of AD.
One hundred high school students from 28 states have been named winners in the third year of PBS' and Stand Up To Cancer's Emperor Science Award program. The recipients will work with a university scientist on a multi-week cancer research project, receive a Google Chromebook computer, and a $1,500 stipend.
Researchers are re-examining old antibiotics to find new ones, applying modern science and technology to test their potential. A compound identified in the 1940s is now being considered as a realistic contender for a new antibiotic drug, with the potential to combat certain types of bacterial infections.
A new study published in The Lancet suggests that the current WHO strategy for yaws eradication is insufficient and may not be effective against antibiotic-resistant strains. Researchers recommend treating every individual living in an endemic zone to cure latent infections and achieve elimination.
A new study finds that nostalgia for America's past can buffer collective guilt and create group coherence. Those who glorify the US tend to be more nostalgic, which alleviates feelings of guilt about historical wrongs.
A global study found that treating multiple chronic diseases is putting a significant financial burden on countries' health systems and individuals. Patients with multimorbidity often face high out-of-pocket costs, leading to non-adherence to prescribed medicines.
Researchers at UPMC Hillman Cancer Center have identified a new genetic change in the estrogen receptor that contributes to therapy resistance in ER-positive breast cancer. The presence of ESR1 fusion proteins in treatment-resistant breast cancer may lead to improved treatments for this form of the disease.
CU researchers found that givinostat improved the heart's ability to relax, holding promise for treating patients with diastolic dysfunction and heart failure with preserved ejection fraction. Fibrosis is not the sole cause of diastolic dysfunction; a defect in muscle cell relaxation contributes.
A study published in Neurology suggests that strokes can compromise the blood-ocular barrier, causing gadolinium to leak into the eye. This phenomenon could potentially provide valuable information about stroke severity and guide treatment.
Researchers at University of Cincinnati are developing cutting-edge methods to overcome the barrier of human skin for biometric sensors. The devices can measure things optically, chemically, electrically, and mechanically without compromising the skin's ability to prevent infection and dehydration.
Researchers at Cornell University developed a novel analytical technique to visualize polymer chain growth in real-time. By combining magnetic tweezers, optical microscopy, and spectroscopic techniques, they discovered that individual polymer chains undergo consecutive wait-and-jump steps.
Researchers at Tokyo Institute of Technology have discovered a highly efficient ammonia synthesis catalyst that functions at low temperatures, exceeding the efficiency of conventional ruthenium and iron catalysts. The catalyst's unique structure expands surface area to improve performance.
Experts emphasize need for standardized quality review, transparent data sharing and greater stakeholder involvement in risk assessment. Workshop participants agree on importance of harmonized system for efficient regulation.
Researchers develop risk assessment framework to incorporate three common failure modes into a comprehensive strategy. The analysis finds that any risk assessment must consider all pertinent failure modes of a structure.
A recent study in Oregon revealed that more than half of the public consider alcohol to be more harmful than marijuana. The study found a significant correlation between age and perceived harm, with younger people substantially more likely to view alcohol as more harmful.
A new study reveals that genetic factors causing autism spectrum disorders diminish brain cognitive functions, leading to lower non-verbal IQ. Motor skills also correlate with de novo mutations in ASD, making them a sensitive indicator of damage.
Women who underwent mastectomy without reconstruction underestimated their future quality of life, while those with immediate reconstruction overestimated it. The study highlights the importance of decision support for breast reconstruction, taking into account patients' expectations about well-being.