Researchers at UT Southwestern Medical Center have made a major breakthrough in understanding the biology of neurofibromatosis type 1 (NF1) skin tumors. They identified Hox-B7 as a marker for cell origin and found that modifying the Hippo pathway can slow tumor development.
Researchers from Empa and re-fer AG have developed a new building material called memory-steel, which uses shape-memory alloys to permanently prestress concrete structures. The material eliminates the need for hydraulic prestressing, reducing space requirements and making it suitable for confined spaces.
A UCSF special issue of Tobacco Control debunks the tobacco industry's claims that heated tobacco products are safer than conventional cigarettes. The research, led by Stanton A. Glantz, PhD, finds no statistically detectable difference between IQOS and conventional cigarettes in terms of harmful chemicals released.
A recent study reveals that employee anxiety, self-esteem, and leadership behavior perception can impact a leader's influence on organizational functioning. Followers and leaders can buffer against undesirable effects of dark-side traits like dishonesty, disagreeableness, and carelessness.
The EPFL-developed nerve-on-a-chip platform enables rapid recording of hundreds of nerve responses with a high signal-to-noise ratio. The platform can also record individual nerve cell activity, enabling the development of more effective neuroprosthetics for treating chronic pain and regenerating peripheral nerves.
A new technology, Sprocket, enables fast video processing by breaking down files into small pieces and processing them on thousands of servers. This reduces processing time to seconds, making it ideal for image searches within videos.
A University of Iowa study found that women in India who fetch water daily are more likely to give birth prematurely or with low birth weight. Harassment and lack of private toilets also increase the risk of adverse birth outcomes.
The atlas uses state-of-the-art data and cartography to visualize the finely choreographed movements of migratory big-game species. The maps reveal how animals have perfectly tuned their movements to landscapes and seasons, highlighting the challenges faced by conservation efforts.
SIRVA is an uncommon phenomenon where vaccines are administered too high in the arm, causing pain that doesn't improve with over-the-counter medications. Proper vaccination landmarking techniques can help avoid SIRVA by targeting the deltoid muscle instead of the shoulder capsule.
A new study by Meredith G. F. Worthen explores the relationship between social contact, social distancing, and attitudes towards lesbian, gay, and transgender individuals globally. The research reveals that simple measures of knowing LGT people no longer correlate with supportive attitudes in liberal cultural climates.
Researchers applied polydopamine as an infiltrate binder to achieve high mechanical and electrical properties in graphene-based liquid crystalline fibers. The bio-inspired defect engineering overcomes the limitations of conventional graphene fibers, making it suitable for flexible electronics, textiles, and wearable sensors.
A study published in EPJ Data Science found that algorithms predicting crimes more accurately than existing models, with significant improvements in predictions for assaults and drug offences. The system used location and activity data from Foursquare users to make predictions.
The partnership aims to find new cancer drugs and attract diverse researchers to focus on cancers with increased risk of incidence and mortality among African-Americans, Hispanics, and Native Americans. The program will also enhance current researchers' awareness and knowledge of cancer health disparities.
A new study found that fasting hyperglucagonemia in type 2 diabetes is associated with higher waist-to-hip ratio, poor glycemic control, and increased insulin concentrations. Visceral fat deposition may play a role in the development of this condition.
Researchers at Case Western Reserve University have developed a 'transistor' laser that can be manipulated at the nanoscale using an external voltage. This technology could lead to more accurate medical procedures and re-routing of fiber optic communication lines.
Researchers discovered that 80% of adult remains showed evidence of tooth decay and over half were missing teeth. The study found pipe smoking marks on many of the skeletons, suggesting that smoking was a major contributing factor to poor oral health in this population.
Researchers have found evidence for a large number of double supermassive black holes, precursors to massive galaxy mergers. The discovery was made by studying radio maps of powerful jet sources, which showed signs of periodic changes in jet direction, indicative of binary black hole mergers.
MIT researchers have developed a method to control the fracturing process of atomically-thin, brittle materials, directing it to produce miniscule pockets of predictable size and shape. Embedded inside these pockets are electronic circuits and materials that can collect, record, and output data.
Researchers found that using priming can lead to significant changes in competitive behavior among both men and women. The study revealed that when men were primed to exert influence, they became more cautious, while women became more confident. This breakthrough has implications for education and professional training.
The ReNature project aims to establish a nature-based solutions research strategy for innovation, economic growth and human well-being in Malta. The three-year collaboration will increase research capacity, develop practical solutions through international collaboration, and promote evidence-based environmental decision-making.
A team of researchers has discovered a noble metal-free catalyst system that is as active as platinum, thanks to the high entropy effect. The alloy, made up of five elements, forms new active centers that offer entirely new properties and are relevant for catalysis.
The University of Texas at San Antonio (UTSA) has developed ArcCI, a web-based repository that combines thousands of images taken along the years of the Arctic Ocean. This database allows researchers to extract detailed information on ice properties and conduct research in a digital modality.
Researchers found that patients with a non-functional IDO2 gene had more favorable outcomes when receiving radiotherapy, living cancer-free for almost twice as long. The discovery could lead to personalized treatment recommendations and improve patient survival rates.
Researchers are developing an automated virtual health coach using data from human health coaches to help participants set SMART goals and stay on track. The system will learn to automate interactions and notify human health coaches when needed, aiming to improve health behaviors among underserved populations.
A study published in Nature Neuroscience has uncovered a link between gene activity and Alzheimer's disease, identifying genes involved in the pathology of the condition. The research found changes in histone acetylation across the genome, providing a framework for studying histone modification studies in other brain diseases.
A research group led by Professor Sanna Lehtonen found that metformin directly binds to the lipid phosphatase SHIP2, increasing glucose uptake in muscle cells and protecting kidneys from damage. This discovery highlights SHIP2 as a drug target for regulating glucose metabolism and cell death.
Oncologists require more education on the use of biosimilars, which could increase patient access to innovative therapies due to economic constraints. ESMO supports their use as cheaper alternatives to reference biologics, promoting sustainable and widely accessible cancer care.
A new analysis of genetic data and clinical trial results suggests that African-American men may have comparatively higher cure rates when treated with radiation therapy. The study found that tumors from African-American men were more likely to have indicators of increased sensitivity to radiation, leading to improved outcomes.
Researchers have found that intensive blood pressure lowering does not necessarily lead to true kidney disease, but rather benign reductions in kidney blood flow. This major advancement challenges current clinical standards for diagnosing and monitoring chronic kidney disease.
A new approach to treating advanced anal cancer is safer and more effective than current treatment, according to a randomised clinical trial. The study found that a chemotherapy combination of Carboplatin and Paclitaxel performed better in terms of survival rates and safety compared to Cisplatin and 5-fluorouracil.
Scientists have created a comprehensive map of individual human liver cells, identifying 20 distinct cell populations and new aspects of the liver's immunobiology. The study, published in Nature Communications, reveals new insights into the liver's cellular landscape and its impact on disease.
A new report highlights sex differences in cell biology in the female and male lower urinary tract, which may help stimulate breakthroughs in diagnosing and managing urinary dysfunction. Recent evidence suggests that differential expression of immune cells in the bladder amplifies UTI rates in women.
Researchers developed a new approach to measure freshwater environments and found New Jersey's current nutrient levels are likely too high. The team suggests a lower threshold of 50 micrograms per liter to maintain healthy ecosystems.
Researchers found cranial shape variation within species reflects genetic diversity. Genetic drift and mutation processes underlying genetic diversity are likely drivers of this variation.
Researchers at Joslin Diabetes Center found that paternal exercise improves glucose metabolism, reduces body weight, and decreases fat mass in offspring. Exercise also alters genetic expression in sperm, potentially transmitting beneficial effects to next-generation offspring.
Researchers developed a targeted strategy to treat chemotherapy-resistant AML by targeting the MTF2-MDM2 axis, resulting in complete remission in all mouse models treated with the new combination. The findings hold promise for treating AML patients who would otherwise die from their disease.
A phase II/III study found that a high concentration of multi-strain probiotic helped reduce mild to moderate episodes of chemotherapy-induced diarrhoea (CID) in cancer patients. The probiotic also reduced levels of inflammatory markers, although it did not meet its primary endpoint.
African protected areas with lions require approximately $1,000-$2,000/km2 in funding for effective conservation. The total annual funding deficit is estimated to be $0.9-2.1 billion, with 88-94% of individual PAs being underfunded.
The revised guidelines have led to a significant increase in hemithyroidectomy procedures, with benefits including lower complication rates, reduced hospital stays, and lower costs. The procedure is now considered an equal option to total thyroidectomy for many patients, offering improved outcomes and more personalized care.
Researchers report a significant link between upper ocean temperatures and September tropical cyclone activity in the North Atlantic. Considering subsurface temperatures enhances hurricane prediction accuracy up to three months in advance.
MIT engineers have created a new technique to detect electromagnetic signals in the brain using minimally invasive MRI sensors, enabling spatially accurate pinpointing of electrical activity. The sensors can also detect light produced by luminescent proteins, expanding their potential applications in neuroscience and beyond.
Researchers have unraveled the complex process of how black widow spiders transform proteins into steel-strength fibers. They found that spider silk proteins form hierarchical nano-assemblies, potentially required for creating strong fibers.
Researchers have developed an optoelectronic interface that uses fiber-optic channels to transmit signals from artificial neurons to live ones, providing galvanic isolation and adaptive stimulation capabilities. This system has been demonstrated effective in stimulating electrophysiological activity of neurons in a surviving section of...
A recent study found that liver transplant survival rates have improved significantly among older adults, with a notable increase in recipients aged 65-69 and those aged 80 or over. The one-year acute rejection rate decreased by 30%, and the risk of death was 57% lower compared to earlier years.
Researchers have found a way to grow human stem cells destined to become mature sperm, providing fertility options for males diagnosed with childhood cancer. The breakthrough could help patients who are infertile due to chemotherapy and radiation treatments.
Researchers have developed a new tool to study genetic switches in glioblastoma tumors, which drive cancer growth and survival. The new technique uses ChRO-seq data to classify tumors into subtypes based on active switches, with potential applications in predicting patient outcomes and developing new therapies.
Tropical Storm Vicente formed in the Eastern Pacific Ocean and moved west-northwest, bringing heavy rains to El Salvador, Guatemala, and southeastern Mexico. The storm is expected to weaken and dissipate near the southwestern coast of Mexico by Wednesday.
Newly developed systems will gather information from a wealth of sources, including radar, drones, and social media, to create an information advantage for the modern military. The £4 million project aims to give military personnel access to the most useful information with minimal overheads.
Research finds that states with poor access to a comprehensive trauma center have more deaths occurring before injured patients arrive at a hospital. Improving access to care and reducing prehospital deaths can lead to lower overall trauma-related mortality.
A global analysis by Columbia Engineers reveals a significant increase in storm runoff extremes driven by both climate change and human-induced changes. The study suggests that projected responses of storm runoff extremes will dramatically increase, threatening ecosystem resilience and infrastructure systems.
A yearlong program for adolescent refugee girls in Sub-Saharan Africa successfully promoted healthy transitions to adulthood, reducing reports of sexual and physical violence. The COMPASS program taught life skills geared to build girls' knowledge of violence risk factors and empower them to advocate for their rights and physical safety.
Researchers developed an AI Clinician system that predicts and recommends optimal treatment strategies for patients with sepsis, showing a higher chance of survival compared to human doctors. The system analyzed 100,000 hospital records and made more reliable treatment decisions than humans.
Researchers from the University of Queensland recreated 450-million-year-old enzymes to accelerate chemical reactions, offering a cheaper alternative to current processes. The ancient enzymes showed improved performance at high temperatures, lasting about 100 times longer than natural enzymes.
A deep neural network trained on annotated radiographs from senior orthopedic surgeons helps reduce misinterpretation of fractures in emergency department clinicians. The system demonstrated the transfer of expertise from specialists to generalist clinicians, leading to improved accuracy.
A team of CU researchers has identified a genetic connection between rheumatoid arthritis-associated interstitial lung disease and idiopathic pulmonary fibrosis. The study found that patients with RA are at risk of developing progressive pulmonary fibrosis, enabling potential interventions to prevent this condition.
A QUT research study reveals that female journalists report more emotional investment and management strategies compared to their male counterparts. Visual journalists often suppress or enhance their emotional displays while dealing with editorial decisions, and only a few participants have access to formal support.
The DOE has funded Argonne's high-efficiency latent heat thermal energy storage system (TESS) for use in building applications and process/manufacturing industries. TESS can store waste heat, reducing costs and increasing energy efficiency, especially during periods of high electricity pricing.
A recent study found that plants with strong defense capabilities against insects exhibit slower growth rates and compromised reproductive success. The research suggests a trade-off between defense and growth in plant biology, where investing more energy in defense reduces resources available for growth and reproduction.
The long-term effects of smoked cannabis on lung health are unclear due to conflicting research findings. The authors emphasize the need for well-designed studies to address pressing gaps in knowledge and resolve lingering myths.
A new protein sequencing method has been developed, enabling the identification of individual protein molecules with high sensitivity and throughput. This advance has the potential to reveal new biomarkers for cancer diagnosis and enhance understanding of healthy cell function.