A retrospective study found that cases of metabolic dysfunction-associated fatty liver disease increased since before the COVID-19 pandemic. Late-night meals and higher alcohol intake were identified as independent predictors of developing MAFLD, especially among working-age individuals.
Researchers at Osaka City University found that globin family members can suppress liver inflammation and fibrosis in mice. The proteins' antioxidant capacity was greater than glutathione and vitamin C, suggesting a potential therapy for liver fibrosis.
Researchers identified peripheral tissues as source of blood amyloid beta, which regulates blood glucose levels and suppresses insulin secretion. The study suggests a possible mechanism linking type 2 diabetes to Alzheimer's disease development.
A new genetic-labeling method developed by Osaka City University researchers uses a single gene to reveal neuronal circuits from multiple upstream regions. The 'intersectional, anterograde transsynaptic targeting system' demonstrates enhanced synaptic specificity in two different mouse brain circuits.
Researchers at Osaka City University have developed a new technique for controlling the luminescence color of materials using optical tweezers and nanotextured black silicon. The system can change the color of a material in response to changes in light pressure, allowing for fully reversible remote control.
Researchers provide additional evidence that cleaner fish Labroides dimidiatus have Mirror Self-Recognition (MSR), passing the mark test with 94% positive result. The study addresses criticisms by using ecologically relevant marks and testing visual recognition of mirror images.
A study of 31 patients with peripheral arterial disease (PAD) reveals a high correlation between ulcerated plaque in the femoropopliteal artery and poor angiographic runoff scores, suggesting a possible origin for arterial embolism. This discovery could lead to improved treatment methods for PAD.
Scientists have discovered a new type of skyrmion with half-integer topological numbers in a ferromagnetic superfluid, challenging the current understanding of these phase defects. This discovery could lead to a major breakthrough in skyrmion research and its applications in particle physics and spintronics.
A new combination therapy using rifampicin and resveratrol administered intranasally has shown to improve cognitive function in mouse models of Alzheimer's disease, frontotemporal dementia, and Lewy bodies. The treatment effectively reduces oligomer accumulation and restores brain-derived neurotrophic factor expression.
A study by Osaka City University found that the Kihon Checklist is a useful tool in assessing frailty in patients undergoing transcatheter aortic valve replacement. The checklist, originally developed for Japan's long-term care insurance system, correlated with clinical scores to identify patients at high risk of mortality.
Researchers at Osaka City University developed a new quantum algorithm that calculates potential energy curves of molecules without controlled time evolutions. This addresses issues with conventional quantum phase estimation algorithms, enabling parallel processing and efficient full-CI calculations.
A cohort study of 165 patients with hepatitis C-related hepatocellular carcinoma found that treating the virus with direct-acting antivirals reduces tumor progression and metastasis. The study showed a 72% reduction in tumor progression and an 88% reduction in risk of death from HCC.
Scientists sequenced Plasmodium falciparum genomes to understand malaria parasite populations and track drug resistance biomarkers. The study identified population-specific SNPs that can be used to determine transmission routes and monitor drug resistance.
Researchers from Osaka City University found that non-thermal atmospheric pressure plasma (NTAPP) accelerates cell growth and promotes bone regeneration in animal models with critical bone defects. Micro-CT images showed a 1.51 times larger bone volume after 10-minute treatment, while histological analysis confirmed new bone formation ...
A new study reveals that certain strains of Cutibacterium acnes (C. acnes) found on healthy skin can prolong the lifespan of Caenorhabditis elegans and help its innate immune system fight against Staphylococcus aureus. RNA sequencing analysis also shows these beneficial strains activate genes related to innate immunity.
A new study published in Nutrients found that consuming fermented soy product ImmuBalance reduces eosinophilic-related inflammation in the bronchi of asthma model mice. The researchers also discovered a suppression of proteins that induce eosinophilic inflammation, suggesting beneficial effects for allergic asthma.
A new study found that para-athletes have lower nutritional knowledge compared to university student athletes, with 40% needing help with meal procurement and cooking. This highlights the need for targeted nutrition support and education for para-athletes.
Researchers discovered a two-cell color detection system in lampreys, which they propose could be the evolutionary ancestor of single-cell systems in fish and reptiles. The study found that this ancient system produces similar responses to UV and visible light as modern single-cell systems.
Researchers have successfully bonded gallium nitride and diamond without intermediate layers using surface-activated bonding. The resulting GaN-on-diamond material demonstrates stability even at extreme temperatures of up to 1,000℃, enabling the development of highly conductive semiconductors for high-power devices.
Research from Osaka City University reveals that hepatocellular carcinoma survival decreases as poorly differentiated tumor size increases. Tumors over 5cm have a significantly higher risk of early recurrence and spreading to other parts of the body.
Researchers from Osaka City University have developed a Bayesian phase difference estimation (BPDE) algorithm that directly calculates the energy difference between two relevant quantum states. This breakthrough enables precise accuracy in chemistry problems and overcomes limitations of conventional full-CI calculations.
Researchers found that high levels of complement protein Ba are a reliable indicator of transplant-associated thrombotic microangiopathy development, contrary to previous reports. The study's findings provide hope for developing prophylactic treatments to prevent the disease.
Researchers at Osaka City University have successfully stored electricity using ferromagnetic resonance (FMR) in ultra-thin magnetic films. The team found that two alloys, Ni80Fe20 and Co50Fe50, generated varying amounts of electricity under FMR, with Co50Fe50 showing a steady increase in energy storage over time.
A study by Osaka City University reveals that urban lighting and heat delay insect hibernation, allowing insects to enter hibernation up to 3 weeks later than in rural areas. The findings suggest that increased nighttime light and heat from urban areas interfere with the natural photoperiodism of insects.
A recent study published in European Heart Journal: ESC heart failure shows that increased oxidative stress during exercise adversely affects heart failure prognosis. Tailoring exercise therapy to individual patients based on their level of oxidative stress may be more effective than conventional exercise therapies.
A study published in the Journal of Materials Science: Materials in Medicine found that alginic acid improves artificial bones by increasing porosity, compressive strength, and setting time. The addition of alginic acid to calcium phosphate cement enhances its mechanical properties, allowing for more effective bone replacement.
A team of researchers has successfully synthesized polycarbonate diols from carbon dioxide and diol at atmospheric pressure using a CeO2 catalyst. This process eliminates the need for dehydrating agents, producing only water as a by-product, making it an attractive alternative to existing methods.
Researchers have discovered a twin motor modified from ATP synthase in Mycoplasma mobile, which facilitates its gliding movement. The discovery has brought closer understanding of the evolution of cells and proteins, and may lead to development of nanoscale devices and pharmaceuticals.
Researchers captured the internal motor structure of Mycoplasma mobile, revealing an internal chain structure causing the external appendage structure to move in a specific direction. The study provides insight into the gliding motion mechanism and could lead to understanding human replications of it.
Researchers at Osaka City University have developed a method to exfoliate materials using UV light, achieving the world's fastest rate of 260 microseconds. This breakthrough has the potential to revolutionize photoactuator production and enable precise manipulation in areas inaccessible to traditional power sources.
A systematic review of literature found that only 17% of quality improvement articles in PICUs met high standards, highlighting a need for better reporting practices. The study suggests that bringing the KAIZEN philosophy to kid healthcare can improve the timely delivery of medical care.
A study published in International Journal of Molecular Sciences suggests a link between corticotropin-releasing hormone (CRH) and increased expression of mast cells in the nasal cavity, exacerbating allergic reactions. The research offers promising therapeutic potential with CRHR1 inhibitors and SCF neutralizing antibodies.
A research group at Osaka City University has shown that convict cichlid fish display prosocial choice tasks, choosing to share food with a partner rather than an unknown or rival fish. This behavior suggests that these small fish have an altruistic nature and can distinguish between paired females, unknown females, and rival males.
Researchers at Osaka City University have developed a new quantum algorithm, BxB, which calculates energy differences directly to predict electronic states of atoms and molecules with chemical precision. The algorithm achieves this with half the number of qubits required by the existing Quantum Phase Estimation (QPE) method.
A team at Osaka City University has found that the subiculum sorts and routes spatial information from the hippocampus to specific regions of the brain, enabling smooth navigation. This discovery could shed light on disorders such as dementia and improve our understanding of brain function.
Researchers found that conventional diagnostic methods for liver fibrosis do not accurately track the disease in patients who underwent Fontan surgery. The study revealed a unique regional development of fibrosis, which was not observed with hepatitis C and B, highlighting the need for new biomarkers and imaging techniques.
Researchers at Osaka City University discover sesaminol protects against neuronal damage and increases dopamine levels in Parkinson's disease models. The study suggests sesaminol may be the first-ever medicine for Parkinson's disease, potentially derived from industrial waste.
Cytoglobin has been identified as a key player in delaying liver fibrosis progression in mice. The enhancement of CYGB on hepatic stellate cells or intravenous injection of recombinant CYGB suppresses liver damage and cirrhosis. This discovery holds promise for developing new anti-fibrotic therapy for human chronic liver diseases.
Researchers at Osaka City University demonstrated the mechanism behind FMT, showing how FMT can restore human intestinal flora by replacing damaged microflora with a healthy one. The study reveals the crucial role of bacteriophages and their host bacteria in the pathogenesis of rCDI and its recovery.
A team from Osaka City University developed a quantum algorithm that can accurately calculate energy differences between the electronic ground and excited spin states of open-shell molecular systems. This breakthrough enables efficient calculations for complex molecules, potentially revolutionizing chemical and industrial applications.
Researchers from Osaka City University have successfully recycled a type of plastic found in everyday items into liquid fuels and wax using a novel catalyst process. The process, which requires temperatures as low as 473 degrees Kelvin, produces a 92% yield of useful materials.
Researchers describe a physical phenomenon in quantum dots and nanoscale materials using new mathematical formulas. The theories predict electrons interact through two different ways, contributing to the Kondo effect.
Researchers at Osaka City University discovered that metolazone, a drug used to treat hypertension, activates a mitochondrial stress response that prolongs lifespan in the roundworm Caenorhabditis elegans. The study suggests that repurposing existing drugs for aging control may be possible.
Researchers found that Ninjin'yoeito enhanced PGC-1α expression in skeletal muscle, improving muscle mass loss in aging mice. This study suggests a potential treatment for COPD patients with severe sarcopenia frailty.
Researchers at Osaka City University have found a way to fine-tune quantum resonance in layered structures of quantum dots, leading to improved charge transport and potential applications in solar cells. The breakthrough involves controlling the distance between quantum dot layers using short ligands and polyelectrolytes.
Researchers have developed a new diagnostic tool that can detect cancer cells in small blood samples and connect them to their original tumor. This method has shown significant correlations between circulating tumor cells and tumor expression levels, allowing for targeted therapeutic agents to be used more accurately.
The 'nap' protein complex, essential for M. pneumoniae's attachment, movement, and transformation, has been clarified at the atomic level. The study reveals that P40/P90 proteins bind to sialic acid substance on cell surfaces, contrary to popular belief.
Researchers at Osaka City University have discovered metal ions as a key component to produce malic acid, a molecule with 4 carbon atoms, through artificial photosynthesis. This innovation enables the exploration of CO2 as a raw material for producing complex materials.
Researchers at Osaka City University have developed a quantum algorithm that removes pesky spin contaminants from chemical calculations on quantum computers. This breakthrough enables precise and accurate predictions of atomic and molecular behavior, which is crucial for applications such as pharmaceuticals and materials research.
Researchers from Osaka City University developed a microscope-based thermometer that uses quantum technology to detect temperature changes in live, microscopic animals. The thermometry algorithm successfully tracked temperature fluctuations in C. elegans nematode worms after inducing a fever by stimulating their mitochondria.