This study analyzed 111 Hispanic CMML patients from Puerto Rico, revealing significantly lower rates of overall cytogenetic abnormalities and trisomy 8. The findings suggest a favorable prognosis in these patients, potentially due to lower mutation rates in ASXL1 and SETBP1.
A Korean research team has developed an innovative treatment method for vesico-vaginal fistulas using a mussel adhesive protein-based bioadhesive. The new method shows promise in sealing fistulas quickly and effectively, with improved outcomes compared to conventional suture methods.
A new study evaluates the economic impact of gene therapy on severe sickle cell disease, suggesting substantial costs and potential cost savings for Medicaid programs. The analysis estimates a high prevalence of sickle cell disease among these programs, which may affect treatment affordability.
A new poll shows that 10% of older adults between 50-80 years old obtained a pet during the pandemic, with 59% of those in this age range being pet owners. Pet ownership was higher among women, whites, and employed individuals, providing companionship and social support.
A team of researchers at the University of Tsukuba demonstrated second-order nonlinear optical effects in diamonds using internal color center defects. This breakthrough may lead to faster internet communications, all-optical computers, and quantum sensing technologies.
Screenings for breast cancer and colon cancer dropped dramatically during the pandemic but returned to near-normal levels by July 2020. Researchers analyzed insurance claims from over 6 million Americans and found that mammography rates among women aged 45-64 declined by 96% in March and April 2020.
The study reveals how neural circuits balance excitation and inhibition, crucial for normal functionality of our brain. The results provide a clearer picture of how this balance is preserved and where it fails in living neural networks.
Researchers found conservatives less willing to participate in medical research due to lower trust in science and ideological differences. The divide could threaten the generalizability of studies, impacting the quality and relevance of medical findings.
A new study by UC San Francisco found that approximately 5 million Americans, or 42% of those with mobility constraints, lacked essential devices such as grab bars and shower seats. The research emphasizes the importance of affordable and accessible assistive devices to improve quality of life for elderly individuals.
Researchers will explore decision-making processes for adopting solar energy systems and electric vehicles, as well as improve the efficiency and manufacturing process for solar panels. The studies aim to identify non-technological barriers to clean-energy adoption and evaluate the effectiveness of low-cost interventions and incentives.
A study by Baylor University researcher Matthew A. Andersson found that US work-family policies are inadequate, leading to significant gaps in children's health between rich and poor families. Cash transfers, while important, do not provide the same benefits as paid parental leave and flexible work hours.
Researchers at NC State University developed a virtual laboratory to determine the most suitable AI tools for addressing various chemical synthesis challenges in flow chemistry systems. By simulating over 600,000 experiments, they found the best AI-guided decision-making strategies, reducing the time and reagents required by 97.5%.
Researchers developed a new type of minimally invasive BMI using functional ultrasound technology, which can accurately map brain activity from precise regions deep within the brain. This breakthrough allows for high-performance, less-invasive brain-machine interfaces that could benefit people with paralysis or neurological injuries.
A comprehensive review of COVID-19's multi-organ effects suggests the need for dedicated clinics with specialists from diverse areas of medicine. Long-haulers experience a range of symptoms including fatigue, shortness of breath, and mental health issues, often persisting weeks or months after initial infection.
A new study published in Geology indicates that Arctic ice melt can trigger methane releases from buried reserves. Researchers measured carbon isotopes in ancient shells and found evidence of violent methane spurts during past sea-ice melt events, suggesting similar releases may occur again. The findings highlight the importance of con...
Researchers discovered a method to modify graphene's shape and properties by exposing it to powerful laser pulses. The process, called optical forging, stiffens the material, increasing its bending stiffness and vibrational frequency. This leads to improved device speed and precision, with record-breaking stiffness achieved.
A new study published in Health Affairs found that COVID-19 mortality rates among nursing home residents declined from March to November 2020. The deadliest period for nursing home residents followed the pandemic's arrival when the virus spiked in spring 2020, and improved PPE use and testing contributed to the decline.
Studies on viral evolution reveal that beneficial mutations often occur at the expense of symptom severity, while genetic novelties can arise from noncoding DNA insertion. Additionally, viruses' codon usage is constrained by host machinery, with some exhibiting unique compositions, and their effects can persist after infection clearance.
A study analyzing tornado wind speed and size data from 120 events found that stronger and wider tornadoes exist than damage-based estimates indicated. The median peak wind speeds were around 60 m/s, sufficient for Enhanced Fujita scale ratings of 2-3.
Researchers from Louisiana State University demonstrated a machine learning approach that corrects distorted quantum information in photon systems. This method outperforms traditional protocols, showcasing the potential for machine learning to enhance quantum sensing and communications technologies on the battlefield.
University of Ottawa researchers discovered a shortage in noradrenaline released to the motor cortex from the locus coeruleus, leading to delayed motor learning in autistic children. This delay can cause social isolation and may be overlooked due to its similarity to social deficits.
Researchers discovered phytol, a chlorophyll constituent, inhibits root invasion by certain nematodes without killing them. Phytol induces host defense mechanisms against nematodes in plant roots.
A new technique called time-extended ΦOTDR (TE-OTDR) allows for strain and/or temperature sensing with resolutions on the cm scale over up to 1 km range, enabling cost-effective DOFS in short-range and high-resolution applications.
An international team of researchers has discovered a new type of basalt beneath the Pacific Ocean, which was formed during large and exceptionally hot volcanic eruptions. The discovery suggests that ocean floor eruptions sourced in the Earth's mantle were even hotter and more voluminous than previously thought.
Recent advancements in metasurfaces for manipulating terahertz waves enable ultra-compact devices with unusual functionalities for applications such as imaging, encryption, and communications. Metasurfaces can locally control wavefronts at subwavelength resolution, making them ideal candidates for THz device miniaturization.
Researchers discovered that ferulic acid primed stem cells can repair bone damage caused by radiation. The study found that FA enhances the bone repair effects of skeletal stem cells by activating specific pathways, making it a potential novel strategy in treating irradiated bone injury.
A study found that adults with type 1 diabetes who require in-hospital treatment of diabetic ketoacidosis have a high readmission rate, with 20.2% returning within 30 days. Factors such as gender, leaving against medical advice, anemia, and chronic kidney disease increase the risk of readmission.
A study of 500,000 participants found that eating 25g of processed meat daily was associated with a 44% increased risk of developing dementia. In contrast, consuming 50g of unprocessed red meat daily was linked to a 19% lower risk of the disease.
A systematic review of research evidence has found a strong association between Covid-19 and auditory problems, including hearing loss, tinnitus, and vertigo. The prevalence rates were estimated to be 7.6%, 14.8%, and 7.2% respectively.
The excavation of shell middens off two sites in the Gulf of Mexico and Northern Europe reveals new insights into the hidden history of submerged landscapes. The study challenges the current understanding of coastal life in these regions by pushing back the inhabitation timeframe by hundreds of years.
A research team has discovered a new type of superconductor by inducing an extended buckled-honeycomb-vacancy (BHV) ordering in Ir16Sb18. The superconductivity emerges when the BHV ordering is suppressed through extra atom squeezing or Rh substitution, competing with the ordered vacancy as a potential superconducting parent phase.
A recent study reveals that droughts over the southwestern Tibetan Plateau are triggered by ocean warming in the eastern Pacific, approximately 18,000 km away. The researchers found that anomalous advection of moist enthalpy and suppressed rainfall contribute to this phenomenon.
A study of UK residents shows that personal values and political worldviews play a significant role in shaping perception of COVID-19 risk, with those who feel government should be less controlling believing the virus poses less risk. This is associated with adoption of fewer protective behaviors.
A new once-weekly basal insulin injection demonstrated similar efficacy and safety to daily basal insulin in patients with type 2 diabetes, achieving comparable blood glucose control and lower rates of hypoglycemia
A recent study found that children and teens with type 1 diabetes experienced better blood glucose levels when confined to home during the COVID-19 pandemic. The researchers noted that remote consultations and school pressures contributed to poorer glucose control in the past.
A small study presented at the Endocrine Society's annual meeting found that 17 out of 26 patients taking teprotumumab reported otologic symptoms, including subjective hearing loss and tinnitus. The authors recommend baseline audiogram testing to better understand this potential side effect.
A new study reveals that higher ghrelin levels in healthy females predict a greater preference for smaller immediate monetary rewards over larger delayed financial rewards. This indicates more impulsive choices, contradicting previous research findings in rodents suggesting a similar effect.
Women with gestational diabetes who prefer evening activity are more likely to experience preeclampsia and have newborns requiring neonatal intensive care. The study suggests that circadian rhythm disturbances may add an additional risk of poor pregnancy outcomes.
A recent study found that hospitalized COVID-19 patients with obesity have a significantly higher rate of ICU admissions and longer duration of ICU stay. Individuals with severe obesity were twice as likely to require ICU care, while the risk of death was not significantly higher in those with obesity.
A study published in ENDO 2021 found that children with adrenal insufficiency are at a significantly higher risk of severe COVID-19 complications due to impaired cortisol production. The researchers analyzed data from over 846 children with the condition, revealing a mortality rate 10 times higher than in children without adrenal disease.
A study finds Black women with PCOS have a poorer cardiometabolic risk profile than white women, including higher insulin levels, more insulin resistance, and increased blood pressure. The research highlights the need to address health disparities in women with PCOS, particularly among young Black women.
Patients hospitalized for COVID-19 with low vitamin D levels who receive vitamin D supplementation may have a lower risk of dying or requiring mechanical ventilation. Over half of these patients do not receive supplements, highlighting the need for clinicians to discuss adding this supplement with their patients.
A study by The Endocrine Society found that transgender youth are 1.8x more likely to have abnormal cholesterol levels and 1.4x more likely to have liver dysfunction compared to cisgender youth. This highlights the need for better management of health in this population.
A mouse study suggests that white button mushroom extract can suppress androgen receptor activity in prostate cancer cells. The study also found that mice treated with the extract experienced reduced prostate tumor growth and decreased levels of PSA in their blood.
Endocrinology clinics see many patients needing long-term close follow-up, with most feeling telehealth visits are comparable in quality to in-person visits. Providers prefer video visits due to lack of physical examination component in phone calls.
Semaglutide treatment leads to reduced excess body fat and increased lean body mass in adults with obesity. The medication has the potential to reduce the risk of heart disease, diabetes, and stroke by improving body composition. The STEP 1 trial found that semaglutide significantly improved body weight loss and reduced visceral fat.
Only 3% of patients with high blood pressure who are at risk for primary aldosteronism receive screening, a condition that can lead to heart and kidney complications. Researchers emphasize the importance of initiatives to encourage screening to prevent cardiovascular and kidney disease.
A study published in The Endocrine Society's annual meeting found that genetic risk factors for PCOS are associated with obesity, diabetes, cardiovascular disease, and male-pattern baldness in men. This suggests that at least some cases of PCOS may be caused by biological mechanisms common to both men and women.
A recent study published by The Endocrine Society has found that commonly used medications for type 2 diabetes and obesity, known as GLP-1 RAs, are not associated with an increased risk of breast cancer. This new research provides relief to concerns arising from previous clinical trials of liraglutide.
Endogenous Cushing's syndrome is associated with a threefold increase in death, primarily due to cardiovascular disease and infections. The study analyzed data from over 19,000 patients and found that mortality rates were lower after 2000, but still unacceptably high.
A lifestyle intervention targeting women with obesity and infertility significantly improves pregnancy rates, especially spontaneous pregnancies. The Fit-For-Fertility program shows promise as a cost-effective alternative to fertility treatments, with a live-birth rate 14.2 percentage points higher than the control group.
Researchers found that combination therapy is equally effective to levothyroxine in treating hypothyroidism, with patients preferring DTE over other treatments. Desiccated thyroid extract (DTE) was shown to improve symptoms and lead to modest weight loss compared to levothyroxine.
A study published in Nature Neuroscience reveals the discrete thalamocortical circuits underlying chronic pain and depressive symptoms. The researchers found that a specific pathway from the parafascicular thalamic nucleus to the anterior cingulate cortex mediates depression-associated pain sensitization.
A mouse study finds that treatment with MCB-613 repairs heart tissue after a severe heart attack, preventing damage and scarring. The molecule decreases inflammation and increases heart function, offering hope for effective treatments to prevent heart failure.
Researchers from Tokyo Metropolitan University have developed a simplified algorithm to convert freely drawn lines into holograms on standard desktop CPUs. The new method reduces computational cost and power consumption, allowing for real-time conversion of writing into holographic images.
Researchers tracked DNA changes in melanoma samples to understand how the disease progresses and develops resistance to treatment. The study revealed chaotic genetic changes that contribute to aggressive disease growth and treatment resistance, offering potential targets for new therapies.
A recent study presented at ENDO 2021 found that women with polycystic ovarian syndrome (PCOS) who are obese have a more than three-fold increased risk of developing type 2 diabetes during their lifetime. The risk was not observed in normal-weight women with PCOS.
Research suggests that sleep disturbances during menopause may contribute to changes in the body that increase the risk of weight gain and related diseases. The study found that poor sleep reduced fat utilization, increasing the likelihood of fat storage and subsequent weight gain.
The partnership aims to drive digital innovation in the region through three major projects: AI Innovation Park, semiconductor industry development, and smart healthcare research. The initiatives are expected to foster education, research, and entrepreneurship based on AI and Big Data.
A study by The Endocrine Society finds oral testosterone therapy undecanoate (TU) is an effective treatment for men with low testosterone levels, with a safety profile consistent with non-oral products. TU has minimal effects on cholesterol levels and no liver toxicity was reported.