A study analysis found that daily vosoritide treatment for two years improves height gain and body proportionality in children with achondroplasia. This is the first robust evidence of a precision therapy for this condition, which typically affects short stature and bone growth.
Researchers investigating COVID-19's impact on the thyroid gland found atypical inflammation in 1/3 of patients after 3 months, raising concerns about potential long-term damage. The study aims to determine if this inflammation triggers permanent thyroid dysfunction.
A novel convolutional neural network, FMNet, was developed to determine the source focal mechanism of earthquakes rapidly using full waveforms. The method proves effective in calculating parameters within one second with minimal computing resources.
Research suggests Spanish as primary language is associated with higher childhood obesity rates among U.S. children, regardless of ethnicity. The prevalence of obesity among Spanish-speaking households was 24.4%, significantly higher than those from English-speaking households.
Hospitalized COVID-19 patients with high blood sugar are more likely to require aggressive therapies and experience kidney injury, according to a new study. Patients with diabetes have a higher risk of ICU admission and in-hospital death when their blood glucose levels exceed certain thresholds.
Researchers found that nudges can reduce socioeconomic disparities by facilitating selection of welfare-enhancing options, particularly for low-SES consumers. The study generalized its findings across multiple types of nudges and decision contexts.
Children with poorly controlled type 1 diabetes have a 10 times higher risk of COVID-19-related complications and death compared to those with well-controlled diabetes, according to a study. The findings will help families make informed decisions about in-person schooling during the pandemic.
The Omnipod 5 System shows significant average improvements in hemoglobin A1c and time spent within the recommended target glucose range. Children also experience improved blood sugar control after using the device.
Four UNIST Central Research Facilities laboratories received 'Excellent Safety Management Laboratory' certification from the Ministry of Science and ICT. The certificate system aims to establish autonomous safety culture and standard model in university labs, following comprehensive evaluation based on 29 items.
Cornell University researchers developed micron-sized shape memory actuators that enable atomically thin materials to fold themselves into 3D configurations. These tiny machines can hold their shape even after voltage is removed, enabling potential applications in nano-robots and smart materials.
A large-scale study found that the introduction of RADLogics' AI-Powered solution into radiology workflow reduced report turnaround time by an average of 30 percent, equivalent to 7 minutes per case. The study also showed a significant improvement in productivity and report accuracy.
Researchers have discovered an enzyme on the surface of Aspergillus fumigatus that breaks down vital molecule NAD, affecting immune cells and weakening the immune system. The discovery may lead to new treatments for fungal infections.
Non-circulating memory T cells play a crucial role in chronic transplant rejection by providing local protection against re-infection and causing prolonged immune responses. Targeting these cells could improve clinical transplant outcomes while preserving the immune system's ability to fight off infections.
Researchers have developed a new imaging technique that allows them to visualize immune T cells in three dimensions, revealing specialized niches that determine their function. The study identifies avenues for therapeutically targeting effector and memory cells, which could lead to improved vaccine strategies.
Researchers used quantum simulations to understand glycerol carbonate, a compound that could improve lithium-ion battery efficiency and reduce environmental impact. The study revealed new details about hydrogen bonding and its effects on solvent properties.
Scientists at Karolinska Institutet have determined the 3D structure and mechanism of MGST2, an enzyme involved in oxidative stress and DNA damage. The study's findings reveal three functional units controlled by sophisticated movements, regulating vital functions and offering insights into future drug development.
A recent study published in Toxicological Research & Application compared the effects of vape aerosol and cigarette smoke on human lung tissue. The research found that exposure to vape aerosol had a minimal impact on gene expression compared to combustible cigarettes.
Researchers found that without battery storage, homeowners only use 30-40% of their solar PV electricity, while the rest is exported to the grid. With a home battery, self-consumption doubles and grid reliance reduces by up to 84%. Innovative energy policies can make PV-batteries profitable, even in low-solar irradiation countries.
A new review published in the Journal of Dairy Science suggests that fermented milks may help reduce hypertension by modulating gut microbiota. The researchers propose the development of tailor-made fermented milks to target this effect, which could have significant implications for cardiovascular health.
Researchers at Vall d'Hebron Institute of Oncology are conducting a first-in-human Phase I trial to evaluate the safety and efficacy of Peptomyc's novel Myc inhibitor Omomyc in treating advanced solid tumors. The trial aims to confirm the compound's therapeutic potential, particularly for patients with progressed disease.
A team of researchers from Pompeu Fabra University has developed a new technology to print cellular devices on paper that can be used outside the laboratory. These devices can detect multiple markers and generate complex responses, making them useful for applications such as detecting mercury, cholera, or preeclampsia.
Researchers used holographic stimulation and calcium imaging to study the effects of acute pain on neuronal network activity. They found that spontaneous activity and synchronization between neurons increased during pain, and that blocking N-type calcium ion channels helped restore pain thresholds.
Researchers attached an omnidirectional camera to a humpback whale to study its resting behavior. The whale was found to be inactive for half the recorded period, with active behavior in the latter half, suggesting it may have been recovering from foraging.
A new Mayo Clinic research found that tumor mutation burden is significantly inflated in Black patients with cancer compared to White patients, affecting therapy selection. The study suggests that accurate tumor mutational burden is crucial for predicting optimal treatment for patients with diverse ancestral backgrounds.
Bioengineers have discovered a way to harness multiple forms of regulation in living cells to strictly control gene expression. This breakthrough enables precise regulation of biochemical processes involved in producing chemicals, medicines, and other products, leading to improved biotechnologies.
Researchers have established theorems that guarantee whether a given machine learning algorithm will work as it scales up on larger computers. This breakthrough solves a key problem of useability for quantum machine learning and takes an important step toward achieving quantum advantage.
Researchers have developed a new dye called MS5 that significantly enhances the efficiency of dye-sensitized solar cells (DSSCs), which are already being manufactured on a large scale. The new dye produces an open-circuit voltage of 1.24 Volts and achieves a power conversion efficiency of 13.5%, surpassing previous records in the field.
A study by University of Tokyo researchers found that writing on physical paper leads to more brain activity when remembering information an hour later. Paper's unique spatial and tactile information enhances memory recall. In contrast, digital tools were slower and scored worse in simple test questions.
A study from the University of Eastern Finland found that adolescent binge drinking is associated with changes in the volume of the cerebellum in young adulthood. Heavy drinkers showed reduced posterior cerebellar lobules compared to light drinkers, affecting motor and cognitive functions.
Researchers at Lancaster University have made a breakthrough in measuring miniscule levels of plutonium pollution in soils to differentiate between local and global sources. This innovation could help inform clean-up operations around nuclear power plants, saving time and money.
A study analyzed over 1,000 medical records from two US hospitals to examine potential disparities in resource allocation under crisis standards of care. The researchers found no evidence of bias against patients based on race or ethnicity.
A University of Pittsburgh-led survey found US hospitals struggled with strain during the 2017-18 flu season, highlighting a need for pandemic planning. The study's findings suggest that lessons from past crises can inform better preparedness strategies.
University of Cincinnati assistant professor Ashley Ross is developing tools to detect and study chemical signals between the brain and immune system using a federal grant. Her research aims to understand how neurons regulate inflammation and develop new therapies.
A research group at Osaka City University has shown that convict cichlid fish display prosocial choice tasks, choosing to share food with a partner rather than an unknown or rival fish. This behavior suggests that these small fish have an altruistic nature and can distinguish between paired females, unknown females, and rival males.
Research reveals that although more stroke patients are receiving mechanical clot removal, racial disparities in treatment persist. The study found a significant difference in short- and long-term outcomes between non-Hispanic white patients and those from other racial and ethnic groups.
Researchers at Ohio State University developed a technology called tissue nanotransfection (TNT) that reprograms skin cells into vascular cells to repair damaged brain tissue. In a mouse study, cells treated with this innovative cell therapy regained 90% of their motor function, showing promise for treating stroke patients.
A nine-month program combining theoretical studies and meditation practices improved life satisfaction, perceived well-being, and emotional regulation. The study suggests that happiness is linked to inner equilibrium and offers a secular approach to develop authentic happiness.
During the COVID-19 pandemic, potentially avoidable hospitalizations for non-COVID conditions dropped more among white patients than Black patients. This UCLA study suggests that existing racial healthcare disparities worsened, with African Americans facing worse access to outpatient care.
A multinational team discovered at least two inactive and three active conformations of the human adenosine A2A receptor, dependent on ligands and G protein interactions. The study sheds new light on GPCR activation and signaling, offering opportunities for drug discovery.
A study by Universitat Oberta de Catalunya found that 80% of Spanish health professionals are willing to receive the COVID-19 vaccine. The main reasons for not wanting vaccination were concerns about safety and side effects. The low acceptance rate among nursing staff is particularly worrying, as they are closely involved with patients.
New research published in CMAJ finds COVID-19 infection during pregnancy associated with increased risks of preeclampsia, stillbirth, and preterm birth. Pregnant individuals with severe COVID-19 symptoms are particularly vulnerable to these complications.
Research reveals COVID-19 patients are at a higher risk of stroke, particularly those with high blood pressure, Type 2 diabetes, or irregular heartbeat. The analysis of over 20,000 patients found that Black Americans may have a higher risk of ischemic stroke after contracting the virus.
A phase III clinical trial showed that reducing steroid use in intermediate-fit older patients with newly diagnosed multiple myeloma yields similar outcomes to standard treatment. The adapted Rd treatment schedule spares steroid use after nine months, resulting in fewer adverse effects and improved event-free survival.
Researchers from Aarhus University have developed an intelligent light trap that can count insects and determine their species, significantly boosting nature monitoring. The invention uses ultraviolet light to attract insects and image recognition to register them, allowing for more precise knowledge about insect populations and habitats.
Sabrina L. Spencer, a CU Boulder researcher, has won two awards to further her research on drug-resistant cancer cells. The grants will help her investigate how these cells acquire DNA damage and activate stress response pathways to evade drugs. Understanding these mechanisms could lead to new treatments for cancer.
A study examined COVID-19 outcomes in patients with multiple sclerosis, finding that certain patient characteristics are linked to worse outcomes. The analysis revealed associations between disease severity and SARS-CoV-2 infection risk factors.
A study co-developed with local stakeholders explores regional water scenarios to facilitate rational water resource planning in the extended Lake Victoria Basin. The analysis suggests that water use and withdrawal will increase significantly due to population and GDP growth, coupled with climate change.
Scientists have developed a novel technology combining 3-D bioelectronic systems with human neural cultures to study brain development and repair. The device can record electrical activity, manipulate neural activity using light pulses, and perform optogenetic experiments.
A recent analysis of climate data from the last millennium reveals that megadroughts in Central Europe were characterised by a weak or negative phase of the Atlantic Multidecadal Oscillation and reduced solar radiation.
The eukaryotic cell nucleus has an organized layout, similar to a superstore, with DNA-packed into compact structures and molecules moving efficiently through channels. The chromatin fibers work like shelves, holding genetic information, while proteins move randomly within the channels according to Brownian motion rules.
Researchers found that virtual reality can reduce types of pain typically seen in patients with nerve injuries, including prickling and touch-related pain. The study also showed that VR can boost the body's natural pain inhibiting process by enhancing conditioned pain modulation.
Researchers have found that disrupting the interaction between cancer cells and certain immune cells is more effective at killing cancer cells than current immunotherapy treatments. The new approach, targeting protein CD6, has shown promise in mice and may also treat autoimmune diseases.
Researchers have developed smart buoys using seawater batteries to monitor various marine data, including salinity, pH, and water temperature. The buoys utilize a naturally-abundant sodium source in seawater to charge and discharge electricity, enabling scalable energy storage.
A five-member team led by Jingqiu Mao at the University of Alaska Fairbanks is working on a tool to provide air quality forecasts for Alaskans and visitors. The team will use satellite data, ground-based instruments, and computer models to create a web-based forecast that can help wildland fire managers deploy resources effectively.
Research by Linköping University finds that foreign-born employees are more likely to experience person-related bullying, which is based on their cultural identity. The study reveals an increased risk of workplace bullying for people born abroad, particularly those from Asia.
A new coating technology has been developed to stabilize Ni-rich cathodes in lithium-ion batteries, improving cycling stability and capacity retention. The technique involves infusing a cobalt boride metallic glass into the grain boundaries of the cathode material, resulting in improved electrochemical performance and safety.
A pilot study found COVID-19 transmission is rare in schools with proper precautions such as masking, distancing and frequent hand-washing. Only two people received positive test results indicating probable school-based SARS-CoV-2 secondary transmission.
Researchers at Ruhr-University Bochum found that flashlight fish use blink patterns resembling Morse code to communicate in schools. The frequency and intensity of these signals affect the animals' behavior, with faster blinking associated with increased attraction to group members.
Researchers at Rensselaer Polytechnic Institute have developed a polymerized estrogen biomaterial that shows promise as a treatment for spinal cord injuries. The study found enhanced neuroprotection in preclinical mouse models with implanted polymerized estrogen, suggesting a potential therapeutic approach.
Research found that high vitamin D levels above traditional sufficient levels are associated with a lower risk of COVID-19, especially in Black individuals. Vitamin D deficiency is linked to an increased risk of testing positive for COVID-19.