Researchers found that every person has two to four hidden genetic defects, which can lead to diseases if inherited from both parents. Consanguineous couples are at high risk, with 20% of cases showing increased risks for serious disorders in offspring.
Researchers at Pennington Biomedical Research Center found that maintaining a stable body weight does not guarantee muscle mass and increases the risk of premature death among colorectal cancer survivors. Women are particularly vulnerable to losing muscle mass, with one in five women experiencing significant changes.
A new study found that microplastics in wastewater treatment plants can host antibiotic-resistant bacteria and pathogens, leading to a significant increase in resistance by up to 30 times. The microplastics form a biofilm that allows the bacteria to attach and exchange genes, posing risks to human health.
A new study published in the Journal of the American College of Surgeons found that patients undergoing elective esophagectomy, gastrectomy, or pancreatectomy for malignancies at top-ranked hospitals had significantly lower in-hospital death rates compared to those at unranked hospitals. The average annual case volume for these high-ri...
A new antibiotic compound targets a molecular pathway found in bacteria but not humans, clearing infection of multi-drug resistant gonorrhea in mice with a single oral dose. The research team developed the compound through iterative optimization and testing, demonstrating its potential as a single-dose therapy for gonorrhea.
Scientists have discovered that sugars called mannoses play a crucial role in the immune system's response to malaria and sickle cell disease. This breakthrough could lead to new therapeutic approaches for treating these diseases.
The LSU Veterinary School has received a $11 million grant from the National Institutes of Health to create a Center for Pre-Clinical Cancer Research, which aims to develop more effective anti-cancer treatments. The new center will provide specialized core facilities and training opportunities for researchers.
Researchers have identified a small molecule drug candidate that targets the uptake of glutamine in cancer cells, slowing the growth of melanoma and other cancers. The study, published in Molecular Cancer Therapeutics, offers an exciting new therapeutic approach for treating tumors addicted to glutamine.
As US winters warm, tropical plants and animals are expanding their ranges northward, altering ecosystems and posing risks to human health. The study found that insects, fish, reptiles, and mammals are among the species adapting to warmer temperatures, while others may be less welcome, such as invasive Burmese pythons.
A recent study at the Paul Scherrer Institute has revealed that airborne particulate matter can generate additional oxygen radicals, which can cause oxidative stress and damage lung tissue. The formation of these radicals is triggered by the interaction of iron and organic compounds under typical weather conditions.
A study conducted at Beth Israel Deaconess Medical Center found that COVID-19 cases resulted in significantly more hospitalizations, mechanical ventilation, and mortality rates than influenza cases, highlighting the severity of COVID-19 on patients and hospitals.
A new study suggests that people who report no stress experience better daily well-being and fewer chronic health conditions. However, they also perform lower on cognitive function tests and are less likely to engage in social activities.
Researchers have discovered that ADAR1 can bind to multiple forms of RNA, leading to the misregulation of the immune response in cancer. This finding has implications for the development of new therapies targeting ADAR1's role in cancer regulation and other diseases.
Scientists at Tomsk Polytechnic University have discovered a way to synthesize cyclic carbonates from atmospheric CO2 using sunlight and gold nanoparticles. This method is more efficient and environmentally friendly than traditional methods, which require high temperatures and pressure.
Nearly two-thirds of Canadian adults aged 45-85 reported adverse childhood experiences, including physical abuse, intimate partner violence, and emotional abuse. The research found that exposure to these experiences varied by demographic factors, such as age, sex, education, and socioeconomic status.
The Systems Biology of Early Atopy study aims to integrate biological, environmental, and genetic data to better understand the origins of allergic diseases in children. The 2,500-family study will examine prenatal and early childhood markers of high risk for food allergy and eczema.
Researchers at Oregon State University found that even one session of moderate aerobic exercise increases the cells' ability to burn off fuels. Post-exercise, mitochondria burned 12-13% more fat-based fuel and 14-17% more sugar-based fuel.
Researchers found that men exposed to endocrine disruptors in utero are twice as likely to have low semen volume and sperm count. Exposure to pesticides, phthalates, and heavy metals is associated with poorer sperm quality.
Researchers found that climate change and human disturbances like fire can slow down forest regrowth in the Amazon. The study suggests that protecting these forests is crucial to mitigate climate change.
Researchers developed a non-invasive methodology using artificial intelligence to analyze crop seed quality. The technique uses light-based technology and machine learning to identify immature or poor-quality seeds, avoiding the need for destructive germination tests and providing more accurate results in less time.
Researchers Adam Overvig and Andrea Alù show that strict periodicity is not required for Fano resonances, enabling novel properties in metasurfaces. They demonstrate a nonperiodic metasurface with perfect reflection and phase conjugation, opening up new applications in optics and beyond.
Columbia Engineers use DNA nanotechnology to design nanoparticle-based 3D materials that can withstand extreme conditions. The new fabrication process results in robust and fully engineered nanoscale frameworks with a broad range of applications.
Researchers surveyed 9,911 people in Germany and the US, finding that emphasizing urgency alone doesn't increase support for high-cost climate plans. However, giving context and communicating effective near-term solutions can boost support, particularly when politicians are transparent, engaging, and authentic.
Researchers have identified a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient, suppressing Lou Gehrig's Disease. The LSM12-EPAC1 pathway normalizes abnormal RAN concentration differences, restoring cellular function.
MIT researchers develop a vaccination strategy that creates an army of T cells ready at the respiratory tract's mucosal surfaces, boosting immune responses. The approach uses albumin proteins to ferry vaccines across mucosal barriers, offering a quicker response to viral invaders and potential treatment for lung cancer.
Recent generations show a worrying decline in health compared to previous generations, with poorer physical health, higher levels of unhealthy behaviors, and more depression and anxiety. The researchers found that measures of physical health have worsened from the Baby Boomer generation through Gen X and Gen Y.
A new gene therapy approach using zinc finger proteins has shown long-lasting effects in reducing tau protein levels and reversing brain damage in an animal model of Alzheimer's disease. The treatment involves a single injection and could potentially lead to a new treatment for patients with this devastating illness.
Researchers found associations between vitamin D levels and COVID-19 test results in White and Black individuals, with higher levels linked to positive test results. The study suggests that racial differences in vitamin D levels may play a role in varying COVID-19 outcomes.
Research from Cranfield University reveals that organisations can tap into the unique skills of neurodiverse employees, but fear of stereotyping holds them back. The study found that stereotype threat is a major barrier to hiring and retaining neurodiverse staff, highlighting the need for companies to create more inclusive workplaces.
Researchers at Aalto University used neuroimaging to identify where the brain activates among children identified as having a high risk of dyslexia. The study found that difficulties in processing sounds and learning new words are linked to the left auditory cortex, making reading more difficult.
The European Society of Cardiology's ESC Preventive Cardiology 2021 conference explores the latest research and strategies for preventing heart disease. Experts discuss the role of diet, exercise, and lifestyle habits in maintaining cardiovascular health and identify the most effective ways to promote physical activity and healthy eating.
Researchers have developed a new extraction method to isolate monomeric photosystem I (PSI), revealing its atomic structure and providing insights into the energy transfer process. The discovery may enable uphill energy transfer and improve our understanding of photosynthesis.
Researchers have developed a new animal model of early-stage Alzheimer's disease in rhesus macaques, which could enable better testing of new treatments. The model replicates the spread of misfolded tau proteins through brain circuits, similar to human disease progression.
A new study by Massachusetts General Hospital highlights rumination syndrome, a behavioral problem where patients regurgitate food into their mouths while eating. The condition is often confused with other gastrointestinal disorders, leading to delayed diagnosis and treatment.
The National Eye Institute's Data Commons now offers access to AREDS2 data, including thousands of participants with age-related macular degeneration. Researchers can analyze genomic and phenotypic data, as well as retinal images, to better understand the disease and develop new therapies.
Researchers found that ice loss near Glacier Bay National Park has influenced earthquake timing and location with a magnitude of 5.0 or greater since the past century. This study links expanding mantle movement with large earthquakes across Southeast Alaska, where glaciers have been melting for over 200 years.
A new species of manta-like planktivorous shark, Aquilolamna milarcae, was discovered in northern Mexico, revealing an unexpectedly early evolutionary experimentation with underwater flight. The ancient shark's unique features included long, slender pectoral fins and a wide mouth adapted for filter-feeding.
The discovery of Aquilolamna milarcae sheds light on the evolution of oceanic animals and reveals a new facet of sharks' evolutionary history. The species is characterized by extremely long pectoral fins reminiscent of wings, feeding on plankton.
Researchers discover that organic molecules, commonly found in aerosols, can facilitate ice crystal formation in clouds. They also investigate a memory effect where second-round ice formation is more effective than the first, revealing crevices in the nucleant surface can hold onto small amounts of ice.
A study found that Australian fires created a spreading stratospheric haze, peaking in January to March and persisting through July. The particles were transported by mid-latitude cyclone belts and weather patterns, eventually settling around the entire hemisphere.
Scientists have isolated a genetic clue in the form of an RNA polymerase enzyme that offers new insights into the origins of life. The discovery provides evidence for the RNA World Hypothesis, suggesting that self-replicating RNA molecules were capable of driving chemical reactions essential for life.
A recent study from Tokyo Medical and Dental University found that children who experienced housing loss during the 2011 Great East Japan Earthquake are more likely to prioritize short-term gratification over long-term rewards. The study analyzed data collected in 2012-2014 on 3- to 5-year-old survivors of the disaster.
Researchers estimate SARS-CoV-2 was circulating in China as early as mid-October 2019. The virus likely dies out naturally more than three-quarters of the time without causing an epidemic.
Researchers analyzed citizen science data and found massive by-the-wind sailor jellyfish strandings occurred in warmer winters, with beach cover spanning over 620 miles. The study suggests a tipping point in the ecosystem towards these jellies as climate change warms oceans.
Researchers analyzed ankylosaurid skeleton from Mongolia's Baruungoyot Formation, finding evidence of adaptations for digging. The discovery sheds light on the behavior and habits of these ancient creatures.
The study found that a large majority of U.S. adults support COVID-19 mitigation measures, including mask wearing, social distancing, and contact tracing. Support varied across ages, political party affiliation, and levels of trust in science, highlighting the challenges of reaching key groups during the pandemic.
A UNIST research team has developed a novel electrolyte additive that enables long lifespan and fast chargeability of high-energy-density lithium-ion batteries. The additive tackles the shortcomings of conventional materials, such as poor mechanical strength and chemical stability.
Statisticians have calculated the probability of ships becoming beset in ice along the Northern Sea Route, supporting safer maritime transport planning and oil spill prevention. The study's results also benefit authorities regulating maritime traffic by providing a foundation for statutes and legislation.
A Delphi survey conducted by City University reveals that experts prioritize protecting personal privacy online due to risks like cyberbullying and financial loss. The study identifies key areas for further research into online privacy, including social networks and regulation.
Researchers found that stegosaurs ate tough food, likely plant-based, and had complex jaw movements, including a longitudinal phase. They also discovered that their teeth formed quickly, suggesting they may not have suffered from caries.
Research using fMRI scans reveals that babies under a year old use areas of their frontal cortex to focus attention, previously thought to be immature. This discovery sheds light on the neural origins of attention in infants, potentially informing early childhood education and neurodevelopmental disorder research.
Researchers at Universidad Complutense de Madrid developed new image processing methods to enhance the analysis and three-dimensional reconstruction of biological macromolecules. The methods, published in Nature Communications, improved the visualization and quality of cryogenic electron microscopy-derived 3D reconstructions.
A new study from Finland reveals that undocumented women receive inadequate pregnancy care, with delayed access to prenatal care and lower rates of infection screening. The study highlights the need for better healthcare systems to cater to the unique needs of these vulnerable populations.
Researchers found that dogs infected with Leishmania parasites have a more attractive odor to female sand flies than uninfected dogs. This increased attractiveness could lead to enhanced infection and transmission opportunities for the parasite.
Researchers estimate SARS-CoV-2 was circulating in Hubei province at low levels in early-November 2019, possibly as early as mid-October 2019. The virus had established itself in Wuhan by the time COVID-19 was first identified.
A new study from the University of Bath found that the sugar tax in Catalonia, Spain led to a modest reduction in calorie intake, with households cutting purchases of high-sugar beverages and increasing lower-sugar options. The average reduction was only 2.2% and spread out over 3.7 calories per month.
A modelling study suggests that vaccination alone may not prevent the spread of COVID-19 infection in the UK, even with high vaccine uptake and gradual reopening. Gradual easing of measures and high vaccine protection can minimize future waves of infection.
Research on E. coli bacteria reveals that higher translation error rates lead to increased phenotypic variability at the single-cell level, affecting cell length and division time. However, population-level growth parameters show inconsistent correlations with mistranslation levels, highlighting the need for further investigation.
Researchers found that a synthetic cannabinoid activates astrocytes, which release adenosine to reduce nerve activity and tremors. This new approach may offer targeted treatment with fewer side effects for patients suffering from essential tremor.
Researchers at Tohoku University have developed a nanosecond operation technology for the spintronics-based probabilistic bit, enabling faster computation speeds and accuracy. The device, with an in-plane magnetic easy axis, achieves 100 times faster relaxation times than previous records.