The new Keck website demonstrates advances in digital mapping by providing a customizable interface for users to access various data sets. The site combines ArcGIS Server and Google maps, offering an intuitive way to access data, and is significantly faster than comparable searches, returning results five to six times faster.
Researchers developed multicolor quantum dot staining to identify Reed-Sternberg cells, characteristic of Hodgkin's lymphoma. This method allows for rapid detection and identification of rare malignant cells from heterogeneous tissue specimens.
SourceEmory Health Sciences·JournalAnalytical Chemistry·DateJul 6, 2010
A randomized controlled trial found that patients with chronic low-back pain and degenerative lumbar osteoarthritis who took glucosamine for six months showed no significant difference in pain-related disability, pain, or quality of life compared to those who received a placebo. The study suggests that further research is needed to det...
Researchers found diverse marine life on the Mid-Atlantic Ridge, including a missing evolutionary link between backboned and invertebrate animals. The team discovered three new species with different colors and shapes, as well as sea cucumbers with unique swimming abilities.
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
New research reveals that cellular changes in fat tissue, rather than the immune system, contribute to glucose intolerance and type 2 diabetes. The study found that a specific gene, protein kinase C-zeta, promotes inflammation in fat cells, leading to insulin resistance.
SourceUniversity of Cincinnati·JournalCell Metabolism·DateJul 6, 2010
A study published in the World Journal of Gastroenterology found that patients with the X+ allele of the APOB gene have a higher incidence of gallstone formation after radical gastrectomy. This is due to increased levels of TC and LDL, leading to bile cholesterol saturation and an increased risk of gallstones.
SourceWorld Journal of Gastroenterology·JournalWorld Journal of Gastroenterology·DateJul 6, 2010
A study by the US Department of Agriculture's Agricultural Research Service found that rotational grazing and checking a lamb's eye color can minimize deworming. The researchers tested 71 lambs with the barber pole worm, finding that gel capsules filled with copper oxide wire particles eliminated the need for conventional dewormers in ...
SourceUnited States Department of Agriculture - Research, Education and Economics·JournalVeterinary Parasitology·DateJul 6, 2010
A molecule that binds toll-like receptors doubles the early antibody response to an antigen and shifts it to a more effective IgG form. The findings support bridge immunity, which links innate and adaptive arms of the immune response.
SourceNational Jewish Health·JournalJournal of Experimental Medicine·DateJul 6, 2010
The article discusses a new approach to breast cancer detection using microwave tomography, which is cheaper and less invasive than traditional X-ray mammography. The method uses mathematical models to reconstruct images of the breast based on electrical conductivity properties.
SourceSociety for Industrial and Applied Mathematics·JournalSIAM Journal on Applied Mathematics·DateJul 6, 2010
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
A recent study published in the World Journal of Gastroenterology found that stapled transanal rectal resection (STARR) is a safe and beneficial surgical procedure for patients with obstructed defecation syndrome. The procedure significantly improved symptoms of constipation, quality of life, and patient satisfaction.
SourceWorld Journal of Gastroenterology·JournalWorld Journal of Gastroenterology·DateJul 6, 2010
A recent study by UNC researchers provides evidence that a specific gene, MAGE-11, interacts with proteins to promote androgen receptor activity in advanced prostate cancer cells. This finding opens the door to additional targets for new therapies and broader clinical applications of new drugs.
SourceUniversity of North Carolina Health Care·JournalJournal of Biological Chemistry·DateJul 6, 2010
Researchers identify a protein released by neural stem cells that induces signaling in glioblastoma cells, causing them to differentiate. This discovery could lead to new therapy concepts targeting tumor stem cells and potentially destroying the aggressive brain tumors.
SourceHelmholtz Association·JournalBrain·DateJul 6, 2010
Researchers have successfully visualized lipid ordering in a whole, living vertebrate organism for the first time. The study reveals that membrane lipid order plays an important role in cellular processes and may be linked to human pathologies.
SourceCell Press·JournalBiophysical Journal·DateJul 6, 2010
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers at NUI Galway have discovered a protein that enables cancer cells to withstand intense stress. Understanding this interaction could lead to the development of more effective anticancer drugs by blocking its function and encouraging tumor cell death.
The American Institute of Aeronautics and Astronautics (AIAA) will present several awards at the 46th Joint Propulsion Conference & Exhibit. These include the AIAA Air Breathing Propulsion Award to Bobby Berrier for his contributions to propulsion airframe integration, and the AIAA Propellants and Combustion Award to David G. Lilley fo...
SourceAmerican Institute of Aeronautics and Astronautics·DateJul 6, 2010
A new study found that depressed patients who receive more competent therapy show significant symptom improvement. Therapist competence was particularly important for patients with anxiety and early onset depression. While competence predicted better outcomes in the short-term, its impact waned over time.
SourceOhio State University·JournalJournal of Consulting and Clinical Psychology·DateJul 6, 2010
Researchers found that anxious conditions cause participants to become more engaged in their ideals and extreme in their religious convictions. The findings suggest that bold but vulnerable people gravitate to idealistic and religious extremes for relief from anxiety.
SourceYork University·JournalJournal of Personality and Social Psychology·DateJul 6, 2010
Researchers at the University of Adelaide are exploring ultrasound to combat blue-green algae blooms in water supplies, a significant global problem. They aim to develop an environmentally friendly and cost-effective method using low-amplitude ultrasound to immobilize the algae without releasing toxins.
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Researchers create nanoparticle that effectively delivers genetic material into cells, outperforming existing methods. The device, a vector, is between 2 ½ and 10 times more effective than other experimental materials, according to the research.
SourceOhio State University·JournalInternational Journal of Pharmaceutics·DateJul 6, 2010
A study by ISU researcher Diane Debinski found that drought conditions could lead to a shift from flowering plants to shrubs in montane meadows. This change could impact wildlife populations, including elk, bison, and pollinators like butterflies. Medium-moisture meadows may be particularly vulnerable to climate change.
SourceIowa State University·JournalEcology·DateJul 6, 2010
A study published in the Journal of Neurophysiology found that rejection by a romantic partner activates brain areas associated with motivation, reward, and addiction. This can lead to extreme behaviors like stalking, homicide, and suicide during break-ups.
SourceAlbert Einstein College of Medicine·JournalJournal of Neurophysiology·DateJul 6, 2010
Researchers achieved unprecedented pressures, temperatures, and time scales to study metastable states of argon under ultra-high pressure. This technique allows for direct comparison with molecular dynamics simulations and expands our understanding of planetary interiors and exotic behavior.
SourceDOE/Lawrence Livermore National Laboratory·JournalJournal of Applied Physics·DateJul 6, 2010
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Anthropologists analyze farmers branch texas revealing that immigrants are perceived as a threat to American identity, not just race but also class status. The study shows how immigrants changing their communities make whites react with anti-immigrant legislation.
SourceSouthern Methodist University·JournalInternational Migration·DateJul 6, 2010
The Framingham Heart Study has had a profound impact on the understanding and prevention of cardiovascular disease. The study's findings have led to significant reductions in cardiovascular mortality rates worldwide, particularly in the United States. Its legacy continues to shape public health initiatives globally.
SourceElsevier Health Sciences·JournalProgress in Cardiovascular Diseases·DateJul 6, 2010
Rutgers researchers have discovered the genetic basis for a hard kernel in quality protein maize (QPM) corn, which is essential for economical and nutritious food crops. The findings could lead to better hybrids and increase the supply of this nutritional staple in developing countries.
SourceRutgers University·JournalProceedings of the National Academy of Sciences·DateJul 6, 2010
A study at a small private high school in Rhode Island found that delaying school start time by 30 minutes improved adolescent alertness, mood, and health. The researchers observed significant increases in sleep duration, decreases in daytime sleepiness, and improvements in motivation.
SourceLifespan·JournalArchives of Pediatrics and Adolescent Medicine·DateJul 6, 2010
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Research suggests that small and isolated reefs are more susceptible to local species extinctions due to variable fish populations. Larger, connected habitats see fewer fluctuations in population sizes, making them more resilient to changes.
SourceUniversity of Adelaide·JournalEcology·DateJul 6, 2010
A study using fMRI found that looking at photos of a former partner stimulated key brain areas involved in motivation, reward and addiction. The brain's attachment system showed signs of recovery over time, suggesting hope for those coping with rejection.
SourceAmerican Physiological Society·JournalJournal of Neurophysiology·DateJul 6, 2010
A new Policy paper argues that the estimated $30 billion needed to improve maternal, neonatal and child health is insufficient due to overlooked service delivery costs. Donors need a more realistic understanding of the funding required to achieve MDG targets for child and maternal health.
Researchers at Vanderbilt University Medical Center have discovered that water increases the activity of the sympathetic nervous system, raising alertness, blood pressure, and energy expenditure. Drinking water may also reduce fainting responses in blood donors by 20 percent, according to the study.
SourceVanderbilt University Medical Center·JournalHYPERTENSION·DateJul 6, 2010
A 50-year study on Isle Royale has discovered a significant link between osteoarthritis in moose and early malnutrition, which also affects humans. The research found that moose experiencing malnutrition as young adults are more likely to develop arthritis later in life.
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
A case report describes a rare instance of intrahepatic clear cell cholangiocarcinoma, highlighting its distinct characteristics and low risk of metastasis. The cancer's unique cell structure and lack of mucin production set it apart from conventional HCCs.
SourceWorld Journal of Gastroenterology·JournalWorld Journal of Gastroenterology·DateJul 6, 2010
A team of researchers from North Carolina State University has developed a new method for determining the sex of skeletal human remains with high accuracy. The technique uses three-dimensional imaging technology to analyze the shape and size of the pelvis, identifying over 20 key anatomical landmarks that can help determine a body's sex.
SourceNorth Carolina State University·JournalJournal of Forensic Sciences·DateJul 6, 2010
Avello Bioenergy Inc., founded by Iowa State students Jared Brown, Cody Ellens, and Anthony Pollard, utilizes fast pyrolysis technology to produce bio-oils for various industrial applications. The company's goal is to replace petroleum-based materials with renewable alternatives.
Researchers studied the bacterial community structure in four environments of the Tablas de Daimiel National Park, revealing similarities and differences between them. The study found 265 new phylum groups, including those related to Proteobacteria, which are abundant in the superficial sediment sample.
SourceSpanish Foundation for Science and Technology·JournalAquatic Microbial Ecology·DateJul 6, 2010
African children suffer from an estimated 656 million fevers annually, with many cases likely due to non-malarial causes. A new study estimates that only 60-103 million of these fevers are caused by the most dangerous form of malaria.
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
A new study published in Genetics found that mutations in 10 different genes of worms can extend lifespan without reducing oxidative stress. This discovery challenges the long-held notion that oxidative stress is responsible for aging and suggests a slow rate of metabolism may be key to increasing longevity.
SourceGenetics Society of America·JournalGenetics·DateJul 6, 2010
ATV accidents result in severe head and spine trauma, costing $3.24 billion annually, with children under 20 years old accounting for 42% of these injuries. The study highlights the need for improved ATV stability, increased helmet use, and rider training to reduce the risk of such accidents.
SourceUniversity of Utah Health·JournalNeurosurgery·DateJul 6, 2010
Researchers have created a nano-sized light mill motor that can control rotational speed and direction by tuning incident light waves. The motor's power density is high, and it can be used to drive micro-scale objects, enabling new applications in nanotechnology and biology.
SourceDOE/Lawrence Berkeley National Laboratory·JournalNature Nanotechnology·DateJul 6, 2010
A study by Dr. David Hibbard and Dr. Duane Buhrmester found that competing to win is detrimental to teenage girls' social relationships and well-being, while competing to excel has no gender differences in its effects. Competing to excel benefits both genders, improving self-esteem and reducing depression.
A multi-institutional study found that extended use of anti-clotting drug enoxaparin significantly reduced the chances of blood clots in bedridden patients, especially those over 75 and female. The treatment also increased bleeding risk slightly.
SourceWashU Medicine·JournalAnnals of Internal Medicine·DateJul 6, 2010
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
AquaLux 3D uses precisely controlled water droplets to create 3D images in water, allowing for unique effects like video games on falling water. The technology can also enable physical interaction with the display.
Studies found higher and lower levels of genes regulating spine plasticity in individuals with schizophrenia. These alterations may contribute to layer-specific deficits in dendritic spines, a structural abnormality relevant to the disorder. Further research aims to develop new treatments targeting these disturbances.
SourceElsevier·JournalBiological Psychiatry·DateJul 6, 2010
Researchers used computer simulations to study the possible spread of the Deepwater Horizon oil spill in the Atlantic over a year. The study found that about 20% of the initial particles had been transported through the Straits of Florida and into the open Atlantic by October 2010.
A new study reveals that shorter leukocyte telomere length is associated with a significantly increased risk of developing cancer and dying from cancer. Participants with the shortest telomere lengths had approximately three times the risk of cancer compared to those in the longest group.
A study found significant variability in 5-year patient survival rates for lung transplantation centers in the US, with risks of death ranging from 30% lower to 70% higher. Despite controlling for procedural volume, center performance remained significant, suggesting true differences in quality of care.
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
The Genomic SQueeZ (G-SQZ) compression technique developed by TGen can compress genomic sequencing data by up to 80 percent, reducing storage needs and costs. This technology allows for selective content access and maintaining the relative order of the data.
SourceThe Translational Genomics Research Institute·JournalBioinformatics·DateJul 6, 2010
Researchers at TGen have found a way to revive chemotherapy in ovarian cancer patients who no longer respond to conventional treatment. By inhibiting the CHEK1 protein, they were able to make these cells sensitive again to cisplatin, a widely used platinum-based chemotherapy drug.
SourceThe Translational Genomics Research Institute·JournalGynecologic Oncology·DateJul 6, 2010
Actin capping protein (CP) regulates filament elongation by capping the dynamic end of the filament. Two regulators, V-1 and CARMIL, modulate CP activity in different manners. The new study reveals that CARMIL uncaps filaments by suppressing twisting movement required for tight-barbed end capping.
A multidisciplinary team observes single-molecule interactions of bistable rotaxanes functioning in their native environment, enabling detailed studies of molecular machines. This breakthrough enables greater understanding of how they interact with their neighbors and might work together in nanoelectromechanical devices.
SourceUniversity of California - Los Angeles·JournalACS Nano·DateJul 6, 2010
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
A new study published in Marine Ecology Progress Series found that cleaner water improves the resilience of coral reefs to climate change in the Florida Keys. Corals living in cleaner waters with fewer nutrients were shown to be more resistant to warming and bleaching, while those in dirtier water became sick.
SourceFlorida Institute of Technology·JournalMarine Ecology Progress Series·DateJul 6, 2010
Researchers at the University of Montreal have identified three proteins that regulate blood cell production and one protein that inhibits it. Understanding these factors is crucial for developing novel therapies to treat diseases caused by abnormal blood-making stem cells.
SourceUniversity of Montreal·JournalCell Stem Cell·DateJul 6, 2010
Research reveals that North American right whales adjust their calls in response to increased ocean noise levels, maintaining signal-to-noise ratio while incurring costs. This adaptation is crucial for successful communication in a noisy ocean, but its long-term effects on whale behavior and population health remain uncertain.
SourcePenn State·JournalBiology Letters·DateJul 6, 2010
Strong health research systems are needed to address bottlenecks in implementing effective interventions for maternal, newborn, and child health in sub-Saharan Africa. Investing in African scientists, institutions, and systems is crucial to deliver solutions tailored to local problems.
Children who exceeded two hours of recommended screen time were 1.5 to 2 times more likely to have attention problems. The study found that both TV viewing and video games contribute to increased attention problems in youths.
SourceIowa State University·JournalPEDIATRICS·DateJul 6, 2010
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
Researchers have developed a diagnostic blood test that can identify lymphangioleiomyomatosis (LAM), a rare but serious lung disease affecting women. The test analyzes serum VEGF-D levels, showing high accuracy in diagnosing LAM, and may help screen for the disease in women with Tuberous Sclerosis Complex.
Research highlights potential problems with breathing system filters, which allow substantial passage of bacteria and yeast when wet. Commonly available filters cannot be relied upon to prevent bacterial transfer, posing a risk to patients.
A recent study by UT Southwestern researchers suggests that the brain enzyme PI3 kinase plays a key role in regulating body heat and calorie burn after consuming high-fat meals. Mice with reduced PI3 kinase activity gained weight due to impaired thermogenic response, highlighting potential new targets for combating obesity.
SourceUT Southwestern Medical Center·JournalCell Metabolism·DateJul 6, 2010
Researchers at University at Buffalo have developed a method to remotely control ion channels, neurons and animal behavior using heated magnetic nanoparticles. The approach could lead to innovative cancer treatments and therapies for neurological disorders.
SourceUniversity at Buffalo·JournalNature Nanotechnology·DateJul 6, 2010
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
A new study suggests that a protein called SIRT1, found in specific neurons of the brain, is essential for maintaining normal body weight. Without this protein, mice on high-calorie diets gain more weight and are more susceptible to obesity.
SourceUT Southwestern Medical Center·JournalCell Metabolism·DateJul 6, 2010
Scientists have mapped the herpes virus protein complex that allows it to invade cells, revealing a new target for antiviral drugs. This breakthrough could lead to the development of new therapeutics to restrict herpes virus access to mammalian cells.
SourceTufts University, Health Sciences Campus·JournalNature Structural & Molecular Biology·DateJul 6, 2010
Researchers investigated the potential therapeutic effects of local anesthetics on experimental inflammatory bowel disease in rats. They found some improvement in macroscopic inflammation at the application site, but not supported by microscopic findings.
SourceWorld Journal of Gastroenterology·JournalWorld Journal of Gastroenterology·DateJul 6, 2010
Research suggests that a pregnant mother's diet can interact with her child's genetic predispositions to affect the type or severity of birth defects, including congenital heart disease. A high-fat diet has been shown to increase the risk of this condition in mice offspring, highlighting the importance of a balanced diet during pregnancy.
SourceWellcome Trust·JournalHuman Molecular Genetics·DateJul 6, 2010
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
Researchers developed a reversible watermarking system to verify the authenticity of digital images without modifying them. The system uses a Hash Message Authentication Code (HMAC) to embed and extract watermark bits, allowing for lossless data integrity verification.
SourceInderscience Publishers·JournalInternational Journal of Signal and Imaging Systems Engineering·DateJul 6, 2010
Drivers tend to look at a specific point on the lane marking when negotiating curves, with more time spent looking at the tangent point in shorter sight distances. A new study may lead to the development of an in-car warning system to prevent drivers from unintentionally departing from their lane.
SourceAssociation for Research in Vision and Ophthalmology·JournalJournal of Vision·DateJul 6, 2010
Researchers warn that rising CO2 levels could dramatically change the behavior of baby fish, making them more susceptible to predators and decreasing their chances of survival. This shift is expected to have serious implications for the sustainability of fish populations, threatening food security as a result.
SourceARC Centre of Excellence for Coral Reef Studies·JournalProceedings of the National Academy of Sciences·DateJul 6, 2010
The new edition of Infectious Diseases provides comprehensive guidance on overcoming the latest clinical infectious disease challenges, including updates on H1N1 and avian influenza viruses. The book's editorial team offers regular content updates, case studies, and an interactive disease outbreak map.
SourceElsevier·JournalInfectious Diseases·DateJul 6, 2010
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
A new study from the University of Sheffield found that social and psychological factors have a bigger impact on women's sex lives during menopause than previously thought. The research suggests that individual experiences vary greatly, with external factors like relationships and care-giving playing a significant role.
SourceUniversity of Sheffield·JournalJournal of Health Psychology·DateJul 6, 2010
Patients with hypertension, diabetes, and coronary artery disease who maintained systolic blood pressure at less than 130 mm Hg did not have improved cardiovascular outcomes compared to usual blood pressure control. Tight blood pressure control was actually associated with increased risk of all-cause mortality.
Researchers found a persistent gender gap in math and science performance among the most talented seventh graders, with boys outnumbering girls by 3-to-1 at extremely high levels. However, the gap has narrowed considerably over time, and girls slightly outnumber boys at higher levels of verbal reasoning and writing ability.
SourceDuke University·JournalIntelligence·DateJul 6, 2010
Researchers from Berkeley Lab and UC Berkeley have developed a novel approach to transformation optics, allowing for the manipulation of near-field optical waves on uneven surfaces. This breakthrough enables the design of plasmonic devices such as beam splitters, shifters, and directional light emitters.
SourceDOE/Lawrence Berkeley National Laboratory·JournalNano Letters·DateJul 6, 2010
A Cochrane Systematic Review found that music therapy, specifically rhythmic auditory stimulation (RAS), can improve walking speed and arm movements in stroke patients. RAS therapy was shown to be more effective than standard movement therapy, with an average improvement of 14 metres per minute.
SourceWiley·JournalCochrane Database of Systematic Reviews·DateJul 6, 2010
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
A systematic review by Cochrane Researchers concludes that alpha-1 antitrypsin replacement therapy has no clinically important effect on lung function, may cause modest harm, and is extremely expensive. The treatment should not be recommended due to the lack of evidence and potential adverse effects.
SourceWiley·JournalCochrane Database of Systematic Reviews·DateJul 6, 2010
The University of Haifa's Sagy Center has received an IBM Open Collaborative Research grant to develop a 'crowd computing' application enhancing online databases with user participation. The project aims to harness human intelligence beyond computation, exploring social dynamics and motivations behind user contributions.
The Cedars-Sinai Heart Institute has received a $1.66 million grant to develop a measurement system predicting patient vulnerability to sudden cardiac arrest. The study aims to identify patients at high risk of sudden cardiac arrest by analyzing electrocardiogram data.
Researchers found that bacterial communication promotes persistence and resistance to antibiotics in ear infections caused by multiple bacteria species, particularly Haemophilus influenzae and Moraxella catarrhalis. Disrupting this communication could lead to effective treatments for chronic ear infections.
SourceAmerican Society for Microbiology·JournalmBio·DateJul 6, 2010
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.