The study found that PPAR-gamma activation inhibits pancreatic carcinoma growth by suppressing tumor angiogenesis. In a xenograft model, Rosiglitazone reduced microvascular density and VEGF expression, leading to significant tumor growth inhibition.
Researchers discuss the potential of nanotechnology in improving food nutrition and safety. Dutch scientist Frans Kampers presents his work on creating nanostructures in food to deliver nutrients efficiently. However, concerns about nanoparticles' migration into human cells and potential health risks are also raised.
Renowned biologist Ursula Goodenough explores the connection between science, ethics, and a culture of sustainability. Her work proposes an 'ecomorality,' prioritizing stewardship of the environment, in response to humanity's impact on the planet.
Scientists should think locally to better understand science and communicate with the public. A metropolitan science council model is needed to create dialogue within the scientific community about science policy.
Scientists at Albert Einstein College of Medicine have developed radioimmunotherapy to target and destroy HIV-infected cells. The treatment, which uses antibodies attached to radioactive payloads, shows promise in laboratory and animal studies, and is currently being tested in pre-clinical trials.
Research found capecitabine and irinotecan with bevacizumab to have comparable tumor response rates of 29% and 35%, similar overall survival at 15 months and 24 months. Toxicity was generally well-tolerated in a small patient population.
Researchers at the University of California, Santa Cruz, have found evidence that mobile repetitive elements, or 'jumping genes,' significantly impact the evolution of gene regulatory networks. At least five percent of the human genome has been under negative selection during most of mammalian evolution, indicating functional importance.
A study analyzed histologic features of liver biopsies from 86 infants with intrahepatic neonatal cholestasis (IHNC) and found no significant differences among different etiologies. However, a significant difference was observed in IHNC of infectious etiology, presenting with more severe erythropoiesis.
A panel of scientists at Michigan State University discussed using the World Wide Web as a tool for research, with topics including survey research, measuring social networks, and creating virtual worlds. Researchers are leveraging the Internet to inform social science applications in the real world.
Researchers analyzed nearly 60 terabytes of data from EverQuest II, a fantasy massive multiplayer online role-playing game, to study social network configurations. They found that players tend to stick close to home, forming groups with people they already know, and women are often the most dedicated and satisfied players.
The IPCC Fifth Assessment will incorporate new studies predicting more severe changes than previous assessments. Tropical forests could become carbon sources due to wildfires and warming temperatures.
A study using African Americans with West African and European ancestry found a strong statistical correlation between genetic admixture and facial traits. The researchers measured distances between specific face landmarks to compare genetically determined admixture with facial feature differences.
Climate change is altering malaria patterns due to daily temperature fluctuations, which can affect the incubation period of malaria parasites in mosquitoes. This can lead to changes in transmission rates, with warmer temperatures potentially increasing the risk of infection.
Researchers are exploring petascale computing to model complex systems like severe storms, enabling better prediction and potentially saving lives. The technology will also facilitate the analysis of large datasets in fields such as high-energy physics.
A six-year vitamin E supplementation study found that high dietary vitamin C intake significantly influenced the effect of vitamin E on mortality in male smokers. Vitamin E decreased mortality by 41% in elderly smokers with high vitamin C intake, while increasing mortality by 19% in middle-aged smokers with similar intake levels.
Scientists develop novel materials for stem cell therapy by combining peptide amphiphiles with hyaluronic acid, resulting in self-assembling sacs that can encapsulate human stem cells and deliver growth factors. The structures also exhibit unique physical properties and can be tailored to release cells at specific injury sites.
Recent studies suggest that global warming could accelerate at a faster pace, leading to more environmental damage and releasing billions of tons of greenhouse gas. IPCC scientist Chris Field warns of the potential for catastrophic consequences, including devastating wildfires in tropical forests and permafrost thawing.
A new study by Holly Gibbs at Stanford's Woods Institute for the Environment suggests that biofuel crops may contribute to climate change by burning tropical forests. The research found that agricultural subsidies and policies favoring biofuel crop production can lead to deforestation, releasing stored carbon into the atmosphere.
The US has a century-long history of dependence on oil, which remade human life's ecology. A shift to alternative energy sources may require reevaluating petroleum use and government involvement in the transition.
Scientists will discuss new techniques to understand planetary formation, habitability, and potential for life. Experts will share insights on the probability of finding Earth-like planets within a few dozen light years of the sun.
The Iowa students' innovative device can sanitize water for a mere $5, making it an accessible solution for developing countries. The project has already received a US EPA first-place award and plans to expand its reach globally.
Paul Davies, a renowned cosmologist, questions the conventional notion that there's only one form of life on Earth. He suggests that life might exist in unexpected places, such as extreme environments, and could be undetected due to our limited detection methods.
Researchers found that nanoparticle size doesn't affect biological responses for most genes, as measured by total surface area. The study suggests a better understanding of nanoscale effects on cells and tissues.
Scientists develop a simple model for complex cell structure by creating artificial cells with molecular crowding and heterogeneity. The system mimics the behavior of proteins and nucleic acids in living cells, allowing researchers to study the effects of macromolecular crowding on chemical reactions.
Researchers have found hundreds of new planets beyond our solar system, with evidence for all three classes of planets detected in extra-solar systems. Carnegie Institution scientists predict that many planets will be habitable, potentially inhabited by life.