Alison Marsden's Y-Graft computer models can optimize Fontan procedures, predicting patient outcomes and exercise tolerance. The technology enables zero-risk testing of new surgery designs before patients undergo surgery.
Researchers found that mice missing the AT1A protein lived significantly longer due to reduced oxidative damage and increased cell survival genes. The study suggests that antagonizing this receptor may also promote human longevity.
A study mapping epigenetic marks in three oncogenic viruses found that viral genomes become progressively methylated in patients who developed cancer. This modification may help viruses evade the immune system and is a promising target for new prevention, diagnosis, and treatment methods.
Researchers have identified a network of genes that control tooth number and patterning in cichlids, shedding light on the evolutionary origins of teeth. This discovery has significant implications for understanding tooth development and regeneration, potentially leading to new treatments for dental diseases.
A study published in Archives of Internal Medicine found that multivitamin use was not associated with an increased risk of breast, colorectal, or cardiovascular diseases in postmenopausal women. No significant associations were found between multivitamin use and cancer or cardiovascular disease mortality rates.
Primary care physicians working in clinics with a high proportion of minority patients report less access to resources and higher levels of burnout. These challenges contribute to the complexities of providing quality care to complex, underserved patient populations.
Researchers discovered that Oncostatin M improves interferon's antiviral effect, increasing immune response to viruses. This combination may be useful for treating chronic viral hepatitis and other tumors that don't respond to conventional therapy.
Biologist Professor H. Allen Orr has been awarded the Darwin-Wallace Medal for his groundbreaking research on speciation and reproductive isolation between species. His work has significantly advanced our understanding of evolution, particularly in the context of gene function and dominance theory.
Researchers discovered that iron spewed out of hydrothermal vents remains protected and usable by ocean organisms due to a complex matrix of carbon compounds. This finding challenges current paradigms about the iron cycle and opens up new research directions.
A new study by University of California, Berkeley biologists reveals that many common salamander species have plummeted in Central America, contradicting previous attributions to habitat destruction and pesticides. Instead, researchers believe global warming is driving these species to higher elevations where habitats become inhospitable.
Researchers developed a new 3-D microscope to visualize cells, which could improve early cancer detection. The technique bridges the gap between research and clinical practices, allowing for more accurate diagnoses.
Scientists at Fermilab will present talks on the proposed Project X accelerator, the latest Higgs search results from the Tevatron collider experiments, and an update on the search for dark matter using a bubble chamber. The conference features expert discussions on high-intensity accelerators and their applications in particle physics.
Researchers have found a way to increase sensitivity of solid-state nuclear magnetic resonance (SSNMR) by doping samples with paramagnetic copper-acid solution, reducing the waiting period from up to three seconds to 20 times.
Population immunity to measles was insufficient to interrupt transmission three years after a mass vaccination campaign in Zambia. Repeated mass vaccination campaigns are necessary to achieve high routine vaccine coverage and reduce measles deaths and illness.
Researchers at Rice University have created hybrid carbon nanotube metal oxide arrays as electrode material that may improve the performance of lithium-ion batteries. The new design could lead to longer-lasting electric cars and gadgets, as well as enhanced capabilities for electrochemical capacitors and fuel cells.
Researchers found that clinics serving higher proportions of minority patients tend to have more challenging work environments and organizational characteristics. This can lead to unfavorable patient and physician outcomes, including lower job satisfaction, increased stress, and burnout.
A study found that smokers are more likely to quit for their pet's health than their own. Secondhand tobacco smoke poses a significant risk to pets, causing various health issues.
Researchers developed a 50-gene set to identify the four known types of breast cancer, allowing for personalized treatment. The test was found to be highly sensitive and predictive for chemotherapy response, particularly for poor-prognosis tumor types.
A study by researchers at Fred Hutchinson Cancer Center found that frequent and/or long-term marijuana use is associated with a 70% increased risk of testicular cancer. The risk was particularly elevated among men who used marijuana at least weekly and/or had long-term exposure to the substance beginning in adolescence.
A new study compared recent avian strain H5N1 with genetic ressortants of the 1918 virus, showing that H5N1 replicates rapidly and induces a lethal cytokine storm. The results highlight the threat of an avian flu pandemic and emphasize the need for improved emergency preparedness.
A Johns Hopkins study reveals that volunteering in grade schools increases physical activity in older black women, which remains high for at least three years. The study suggests that volunteer programs can be a win-win for both the elderly and the community, promoting intergenerational social connections.
A recent study published in PLoS ONE found that women who drink two or more cans of soda per day are nearly twice as likely to show early signs of kidney disease. The study also did not find an elevated risk for men or diet soda consumption.
A new mathematical model predicts that pre-exposure prophylaxis (PrEP) could substantially reduce the lifetime risk of HIV infection, but its cost-effectiveness varies depending on target population and drug costs. With modest improvements, PrEP might be as effective as other public health interventions.
A genome-wide expression analysis identified 3,005 differentially expressed genes, including a ribosome and T-cell receptor signaling pathway. The study provides critical insight into the differences between leukemic stem cells and normal blood stem cells, potentially leading to targeted therapies.
A new study published in Cancer found that pregnancy does not affect breast cancer severity or survival rates, but can delay diagnosis and treatment. Women who develop breast cancer while pregnant or shortly after have similar outcomes to those without a history of pregnancy.
A recent clinical trial found that the investigational vaginal gel PRO 2000 showed encouraging signs of success, with a 30% effectiveness rate in preventing HIV infection. The Phase II/IIb trial enrolled over 3,000 women and tested two candidate microbicides, one of which boosted the natural acidity of the vagina to inactivate pathogens.
A new pediatric study suggests that involving adolescents in end-of-life medical decisions can improve communication between children, families, and care providers. The study found that early planning and discussions can lead to increased agreement between parents and children on medical decisions, as well as better communication overall.
The University of Miami's Rosenstiel School of Marine, Atmospheric, and Earth Science has received a $3.75 million grant from the Office of Naval Research to support satellite-based research in the Western Pacific Ocean. The project aims to better understand typhoons, internal waves, and coastal processes using satellite data.
A large study of postmenopausal women found no evidence that multivitamins reduce the risk of common cancers or cardiovascular disease. Researchers analyzed data from 161,808 women and found no association between multivitamin use and breast, colorectal, endometrial, kidney, bladder, stomach, ovary, or lung cancer.
A new study published by the American Cancer Society found that black women with uterine cancer are more likely to die from the disease than their white counterparts. The researchers discovered that black patients were diagnosed at younger ages and had more advanced and aggressive tumors, which contributed to the survival disparity.
Two studies tracked 31,000 runners for seven years and found that running reduced the risk of cataracts and age-related macular degeneration. Vigorous exercise may be a key factor in preventing eye disease, particularly among men who ran more than 5.7 miles per day.
A large study of nearly 162,000 postmenopausal women found that multivitamin use had no significant impact on the risk of common cancers and cardiovascular disease. The Women's Health Initiative study provides definitive evidence that dietary supplements do not offer long-term health benefits.
A wireless Java-enabled system can automatically call emergency services after a rollover accident, potentially saving lives. The system uses inexpensive sensors to detect the type of accident and provides crucial information for response specialists.
A new study from the University of Cincinnati finds that cigarette smoke can activate specific immune system receptors, leading to worsening of chronic obstructive pulmonary disorder (COPD) symptoms. The research identified a key cellular receptor, NKG2D, involved in this process.
New research finds that long-term use of inhaled corticosteroid drugs increases the risk of pneumonia in patients with Chronic Obstructive Pulmonary Disease (COPD). Analysis of 18 randomized clinical trials showed a significant association between corticosteroid inhaler use and pneumonia, with nearly one in every 47 patients developing...
Research shows Irish children's average weight has increased by 24 kilos since 1948, with growth rates accelerating in the 1970s. The study, published in Journal of Epidemiology and Community Health, suggests current economic downturn may exacerbate obesity trends.
A recent study found that individuals with new diagnoses are more likely to adopt healthier habits than those without recent new diagnoses. Smokers who received at least one diagnosis had 3.2 times the odds of quitting compared to those without a diagnosis.
Researchers mapped every neuron in a small muscle of mice, finding unique neural circuitry even within mirror-image tissues on the same animal. The study suggests that the mammalian nervous system may be more primitive and flexible than previously thought.
A Mediterranean diet has been associated with a lower risk of mild cognitive impairment, as well as the transition from mild cognitive impairment to Alzheimer's disease. Participants who adhered to the highest scores for Mediterranean diet adherence had a 28% and 48% reduced risk, respectively.
A molecule that promotes brain development may serve as a possible treatment for Rett syndrome, reversing some of its symptoms in mice. Researchers found that injecting the molecule into mice with faulty brain cells helped them develop normally and reduced symptoms.
Continuing statin therapy is associated with a reduced risk of death over four to five years, even among those without diagnosed heart disease. Patients who took statins for at least 90% of the follow-up period showed a 45% lower risk of death compared to those who did not adhere to treatment.
A study published in PLoS Medicine found that first-time mothers are at a higher risk of developing psychosis in the month following childbirth. Women with higher infant birth weight and maternal diabetes had lower risks, while smoking and living without their partner did not significantly impact psychosis risk.
A study published in Hypertension: Journal of the American Heart Association shows that high blood pressure control increased significantly in England between 2003 and 2006. In 2006, 53% of women and 52% of men achieved control, with awareness and treatment rates also increasing.
Researchers found that elevated CO2 levels stimulate plant respiration, increasing energy production and potentially supporting greater crop yields. The study used microarrays to detect changes in gene activity, revealing over 600 genes altered by high CO2 conditions.
Researchers at M.D. Anderson Cancer Center found no difference in breast cancer survival rates for pregnant women compared to non-pregnant women, but those with Pregnancy Associated Breast Cancer (PABC) were more likely to be diagnosed late with advanced stages of the disease, leading to delayed treatment.
A study by American Academy of Neurology found that drivers with Alzheimer's disease commit 27% more safety errors than those without the condition. The research used off-road tests to measure thinking, movement, and visual skills, predicting driving safety.
A new University of Florida study analyzing DNA from living flowering plants shows that the ancestors of modern trees diversified rapidly 90 million years ago. This event led to the formation of forests that supported similar evolutionary bursts in animals and other plants.
Scientists at the German Cancer Research Center have discovered that reduced production of LSR in the liver leads to elevated blood fat levels in obese mice. Restoring LSR production with leptin therapy reverses this effect, reducing blood fat levels and promoting fat breakdown.
Researchers have identified a manganese protein essential for Lyme disease bacteria to become virulent. The study found that manganese is crucial for the bacterium's growth and survival, raising questions about its role in pathogenicity.
Researchers at MIT's Picower Institute for Learning and Memory found that two genes cause autism-like symptoms in mice, suggesting multiple genetic risk factors influence autistic symptoms' severity. The study may lead to drugs targeting signaling mechanisms between the two genes and a diagnostic target or biomarker.
Researchers found that microRNA 182 is over-expressed in metastatic melanoma cell lines and tissues, leading to increased invasive capacity and metastatic potential. Inhibiting miRNA 182 may be an effective therapeutic strategy for metastatic melanoma.
Researchers found a significant correlation between low absolute humidity and increased influenza virus survival and transmission. The study, published in PNAS, suggests that absolute humidity is the key control for seasonal flu outbreaks.
A new UNC study finds that chronic low-back pain has more than doubled in North Carolina since the early 1990s, with a significant increase in prevalence across all ages and racial groups. The study suggests that increased healthcare costs for back problems may be due to rising prevalence rather than increased service use.
Scientists at the University of California, San Francisco, have created a new drug that blocks cancer's main source of growth and has proven effective in mice. The drug succeeds where similar compounds fail by blocking both mTOR signal pathways, making it a major advance over existing rapamycin-based drugs.
Research found that bar workers' symptoms improved after a smoking ban in Scotland, with significant reductions in respiratory and sensory symptoms. The study also showed benefits for smokers themselves, highlighting the importance of addressing environmental tobacco smoke exposure at home.
A study found that exercise boosts physical and mental well-being in postmenopausal women, improving aspects such as bodily pain, general health perception, and social functioning. The research suggests that the benefits of exercise are dose-dependent and independent of weight loss.
Researchers analyzed MRI test results of 109 ischemic stroke patients and found that up to 9 hours after symptom onset, a diffusion-perfusion mismatch may still benefit from thrombolytic therapy. This extends the traditional treatment window, potentially saving more lives.
A hardy Antarctic worm produces antifreeze to withstand cold temperatures and can survive in a dormant state until water becomes available. The study provides insight into the genetic response of the worm to its environment and its potential implications for understanding climate change's impact on complex ecosystems.
The James Webb Space Telescope's Backplane, a critical component supporting the 21-foot primary mirror, is being assembled with unprecedented thermal stability performance. This structure will maintain motionlessness to enable precise focusing of telescope optics and instruments, crucial for discovering the first stars and galaxies.
A topical cyclosporine emulsion has been found to improve quality of life by 4.3 percent and reduce net cost by $598 per patient, making it a cost-effective treatment option for moderate to severe dry eye syndrome that does not respond to conventional therapy.
Research suggests mice without AT1A protein have a significantly prolonged lifespan. This is attributed to reduced cellular oxidation, contributing to aging. Additionally, studies investigate the role of MT1-MMP in regulating hematopoietic progenitor cells' release from bone marrow.
New research published in JACC found that patients have a better chance of survival when both their hospital and physician have a strong track record in treating heart attacks with angioplasty and stenting. High-volume hospitals and physicians performed significantly better, with lower risks of in-hospital death.
A novel blood test for hepatitis C virus has been developed by researchers at Bonn University and the Bernhard-Nocht Institute for Tropical Medicine. The test is significantly cheaper than existing commercial tests, while maintaining equal sensitivity, and can be used to monitor blood banks in poorer countries.
A dramatic rise in sea level occurred about 400,000 years ago, exceeding 21 meters above current levels. This finding has significant implications for understanding the impact of future climate change on coastal ecosystems and biodiversity.
A new test can predict which women with breast cancer are likely to respond to chemotherapy and which type of chemotherapy will work best for them. The test, known as the Breast Bioclassifier, has been validated on thousands of women and can help doctors prescribe targeted treatments that may not require chemotherapy.
Researchers from Northwestern Polytechnical University discovered novel microstructural transitions in the Al80.4Cu13.6Si6 ternary eutectic alloy upon substantial undercooling. The study highlights the importance of understanding rapid solidification mechanisms and microstructure formation for this widely used material.
Researchers at Whitehead Institute found that combining an antifungal agent with Hsp90 inhibition is effective against multiple types of resistant fungal infections. The treatment could lead to development of novel therapies for patients with compromised immune systems, who suffer high mortality rates from these infections.
A new study reveals that robots struggle to traverse sandy terrain due to rotational motion of their limbs. To overcome this, researchers recommend slowing down leg movement, especially when the sand is loosely packed, and adjusting parameters such as limb rotation frequency and angle.
Researchers have found a common genetic circuit controlling the formation of teeth in both jaws and throats of vertebrates. This discovery suggests that a core set of genes governs tooth development, regardless of location, and may also be involved in other patterned structures like hair and feathers.
The Autism Consortium has published a groundbreaking study defining the mechanism behind Rett syndrome, a neurodevelopmental disorder primarily affecting girls and a leading cause of autism. The research discovered that targeting the IGF1 signaling axis could be a promising therapeutic strategy for treating or reversing Rett Syndrome.
Carbon nanotube researchers at University of Illinois demonstrate remarkable increase in current-carrying capacity using avalanche process. The process creates multiple electron-hole pairs, leading to rapid increases in current until the nanotube breaks down.
Scientists at Whitehead Institute and MIT's Picower Institute have successfully treated a mouse model of Rett syndrome with daily injections of an active fragment of IGF-1, significantly reducing movement and respiratory irregularities. The treatment promotes nerve cell maturation and increases brain levels of IGF-1.
Scientists at Lawrence Berkeley National Laboratory create a novel technique to precisely modify recombinant proteins by introducing aldehyde tags. This breakthrough enables the labeling of therapeutic proteins in mammalian cells, paving the way for targeted treatments and improved pharmaceuticals.
A laboratory experiment has successfully modeled stellar jets, revealing that magnetic forces shape these objects in a non-linear way. The findings suggest that the jets are fired out like bullets or buckshot, rather than breaking into pieces as previously thought.
The discovery of new mammalian species since 1993 reveals a significant reduction in biodiversity, with many species having small populations or limited geographic ranges. This loss can have severe consequences, including increased disease risk and reduced ecosystem services that support human life.