Research has led to biomarker-directed treatment options for patients with advanced NSCLC featuring specific driver mutations. Targeted therapies have improved patient survival but also raised the need to understand resistance mechanisms.
Researchers from Tsinghua University propose a novel process to convert cutting chips into unique microstructures, transforming waste into valuable materials. The finding has potential applications in enhanced heat transfer, anti-icing, and antibacterial properties.
Researchers at VUB discovered that targeting the xCT protein can reduce tumour growth while regulating inflammation and improving mood. This finding holds promise for a comprehensive approach to treating pancreatic cancer, a highly malignant form of the disease.
A brief intervention based in an emergency department, comprising advice and e-cigarette starter kit, can help smokers quit. After 6 months, the intervention group showed a 76% higher rate of continuous abstinence compared to those signposted to smoking cessation services.
Researchers developed a new triplex real-time PCR test to detect the emerging Powassan virus in deer ticks, improving sensitivity and accuracy. The method reduced false negative results, providing assurance that negative test results are true negatives.
A cluster randomized controlled trial found that patient education about flu shots during a non-life threatening emergency department visit increases vaccination rates, particularly in patients without regular primary care. The study showed that participants who received video education materials were more likely to get vaccinated, wit...
A study published in Critical Care identified eight different trauma phenotypes associated with lower in-hospital mortality when treated with tranexamic acid. The researchers used a machine learning model to analyze data from over 50,000 patients and found subgroups of patients who received no benefit from treatment.
A semiconductor device called a Z-source inverter can rapidly reduce voltage and current in the case of a short-circuit or open-circuit fault, protecting against power surges and fires. This innovation can be used to retrofit existing infrastructure and create a safer energy grid.
A UK trial found that giving e-cigarette starter packs to smokers in emergency departments led to a significant increase in quitting, with nearly one-quarter of participants successful after six months. The intervention also helped those who didn't quit reduce their cigarette smoking.
A tandem approach for better solar cells involves combining perovskite-based photovoltaics with traditional silicon to minimize losses and increase efficiency. The technology has shown promise in laboratory settings but faces significant practical challenges, including reliability and scalability issues.
The Lunar Environment Monitoring System, developed by UMD researchers, will track seismic activity on the moon's surface during the upcoming Artemis III mission. The system's data will help prepare NASA for a long-term presence on other planetary bodies.
A new study from the University of Georgia reveals that young Black men are experiencing suicidal thoughts at alarming rates, with one in three rural Black men reporting ideation or death thoughts. Childhood adversity and racism are major contributing factors, leading to feelings of mistrust and isolation.
A new plan published in Nature Communications advocates for conserving natural areas and promoting biodiversity to prevent pandemic outbreaks. The roadmap aims to prevent pathogens from spilling over into humans by preserving habitats and ensuring animals have adequate food sources and safe havens.
Engineers have developed a modular artificial reef structure made of concrete voxels that can dissipate wave energy more effectively than natural coral reefs. The design, optimized through hydrodynamic modeling and experimental testing, has been confirmed by tests at the MIT Towing Tank.
Molecular quantum computing may connect quantum biology and cognitive science through shared concepts like quantum degrees of freedom. Researchers explore potential links between charge movement, spin states, and biological processes in neurons and photosynthesis.
Researchers from IOCB Prague have developed a molecule that can switch between three distinct states, enabling the storage of complex information. This achievement opens the door to the development of molecular chips with unprecedented capabilities.
Scientists at UC Davis discovered specific strains of soil bacteria that induce resistance to witchweed, a parasitic plant that affects 20% of Africa's sorghum crop. The bacteria alter root anatomy and degrade chemical cues, making it harder for witchweed to latch on, and have great promise as soil additives to improve yields.
Researchers at Yokohama National University found that cinnamic acid activates oxytocin receptor expression, increasing hair growth gene expression in human dermal papilla cells. The compound showed a similar hair growth effect to oxytocin, with a 1.25-fold increase in hair shaft-like structures.
Researchers propose geometry-adaptive electrocatalysis to overcome oxygen electrocatalysis limitations and accelerate the transition to a hydrogen economy. This approach utilises catalysts that dynamically adjust their geometry during a reaction.
Researchers from Tohoku University have developed a new signal processing technique that improves particle motion analysis in the time and frequency domain. This approach enables the detection and identification of various polarized seismic waveforms, including S-waves and P-waves, with improved accuracy.
A study by Marshall University Joan C. Edwards School of Medicine reveals that collaborative EHR optimization efforts can significantly improve departmental productivity. The research found notable enhancements in monthly charges and payments, with improvements attributed to accommodations, creations, discoveries, and modifications.
Researchers develop innovative treatment to alleviate deleterious effects of hyperkalemia, a disease affecting 350 million people worldwide. The new mineral-based therapy uses ion transfer to flush excess potassium from the body, offering a safer alternative to existing treatments.
Researchers have designed iron-based nanocomposite materials that combine galvanic reactions and nanoconfinement effects to efficiently remove trace Cr(VI) from acidic or alkaline water. The CnZVI/Cu composites show great promise for practical applications in heavy metal pollution remediation.
Researchers found that nontraditional stroke risk factors like migraines are as important as traditional risk factors like high blood pressure for adults younger than ages 35-45. The association between stroke and nontraditional stroke risk factors was stronger in adults younger than 35 years old.
Researchers discovered changes to blood vessels in the brain that can increase stroke and dementia risk are common in people with heart conditions. The study confirms heart disease as a main cause of these changes, highlighting the importance of imaging tests to guide safer treatment choices.
A genetic variant reducing IKZF1 expression increases B-cell ALL risk in Hispanic/Latino kids, with ancient DNA tracing its emergence ~13,000 years ago from Indigenous American ancestors.
A new nanofluidic implant has been shown to deliver an HIV drug with increased potency compared to existing oral medications, providing a potential breakthrough in addressing treatment nonadherence. The device is intended for long-term controlled release and avoids repeated systemic treatment, which can lead to adverse side effects.
Researchers found that MAFB inhibits the expression of inflammatory cytokine IL-6, reducing sympathetic nerve fiber density and impairing thermogenic capacity. This regulation plays a key role in maintaining body temperature in cold environments.
A new study by Clark University and partners provides global analysis of tree cover restoration's climate benefits, considering albedo changes. The research identifies locations with greatest climate-cooling potential and tools for practitioners to assess albedo impacts.
A new study found that increased childhood sedentary time accelerates vascular damage, while light physical activity reverses it. Arterial stiffness is a key factor in this process, with moderate-to-vigorous physical activity slightly increasing stiffness.
A new study predicts that Australia's soil will become a net emitter of carbon dioxide, releasing more CO2 into the air than it absorbs. This could account for 8.3% of current emissions and worsen climate change unless farming methods are improved.
Beneficial LOF mutations have been identified as potential targets for disease prevention, with drugs like PCSK9 inhibitors and ANGPTL3 monoclonal antibodies already approved or in clinical trials. New targets like ASGR1 and KHK are also being explored for lipid-lowering and fructose metabolism therapies.
Researchers found that forests in Japan's Quercus serrata trees trap approximately 420 trillion airborne microplastics per year, acting as a terrestrial sink. The study used alkaline extraction to detect microplastics adhering to leaf surfaces, revealing a higher number than previously estimated.
The nTIDE March 2024 deeper dive reveals a reduction in the gender employment gap among individuals with disabilities, but women with disabilities still face lower wages and undervalued positions. The data suggests that women are more likely to be disabled due to COVID-19, which may explain the trend.
Researchers used intracortical recordings to study the neural mechanisms behind exogenous attention, identifying three cortical networks activated in sequence as attention was captured by visual stimuli. The findings suggest a continuum of activity in the cortex, with attention emerging as a bridge between perception and action.
Researchers found that chlorogenic acid enhances osteoblast proliferation and differentiation, while inhibiting RANKL-induced osteoclastogenesis. Administration of chlorogenic acid antagonizes ovariectomized-induced bone loss in rats.
Two Micrurus mipartitus coral snakes have been observed battling for a caecilian in the dense rainforests of western Colombia, showcasing a rare example of kleptoparasitism among Elapidae family members. The study highlights the elusive nature of these reptiles and challenges of observing them in their natural habitats.
A study from USC Keck School of Medicine reveals a genetic variant on the IKZF1 gene contributing to increased risk of acute lymphoblastic leukemia among Hispanic/Latino children. The variant increases ALL risk by around 1.4 times and may be linked to Indigenous American ancestry, according to researchers.
The MIT-designed 'architected' reef could dissipate more than 95% of incoming wave energy using a fraction of the material needed, reducing erosion and flooding. The cylindrical structure's unique design leverages turbulence to efficiently break waves, making it a potential solution for coastal protection in various water conditions.
A team from the University of Copenhagen contributed to an Antarctic experiment studying neutrinos, which may hold the answer to whether gravity also exists at the quantum level. The study found no conclusive changes in neutrino properties, but the results do not exclude the possibility of quantum gravity.
A recent Johns Hopkins Children's Center study reveals a significant negative impact of the COVID-19 pandemic on youth minority mental health. The research found increased rates of depression, anxiety, and suicidal thoughts among adolescents in racial and ethnic minorities, with Black females showing a 90.2% increase in suicidal thoughts.
A Finnish study reveals that bone-strengthening physical activity levels decrease during adolescence, especially among the least fit youth. Regular exercise during childhood and adolescence is essential for maintaining strong bones and preventing osteoporosis later in life.
A new therapy combines gene-modified dendritic cells with immunotherapy to promote a stronger immune response against lung cancer. The treatment slows down tumor growth and activates T cells to attack cancer cells systemically.
Researchers have experimentally verified the parity anomaly in a topological insulator, which leads to spectral asymmetry and an unusual change in electrical resistance. This finding is generic for any topological insulator and opens up new avenues for exploring topological insulator physics.
A recent study by University of Colorado Boulder researchers sheds light on the interactions between genetic variants and their impact on smoking behaviors. The study found that certain gene variants can interact with each other and with Mr. Big, a widely replicated genetic variant associated with smoking behaviors.
Recent research reveals that social factors control ant queens' specialization in egg-laying and maintain it in established colonies. Founding queens assume multiple tasks before becoming specialized.
A global map tracks changes in climate change impacts on wine production, highlighting regions at risk of excessive drought and heatwaves. Adaptation strategies, such as using drought-resistant grape varieties and management methods, can help preserve economic viability.
Researchers developed an Integrated Classifier Pipeline (ICP) tool to analyze CRISPR edit outcomes and track unintended 'bystander' edits. The ICP system provides a genetic fingerprint of how material is being inherited, helping scientists untangle complex biological issues.
The University of Cincinnati Cancer Center team has opened a Phase 2 clinical trial to test a new combination treatment for glioblastomas, a deadly form of brain tumors. The treatment uses letrozole, a drug that targets an enzyme present in breast cancer cells, and temozolomide, a chemotherapy drug already approved as a GBM treatment.
Italian speakers gesture more frequently than Swedes when retelling a story, using pragmatic gestures to present new parts of the narrative. Swedes instead rely on representational gestures to convey events and actions, indicating differing rhetorical styles and ways of conceptualizing narratives.
Researchers have solved the high-resolution structures of porcine megacomplex-I2III2IV2, showing a plausible regulatory mechanism for its activation/deactivation process. The complex shifts from active to deactive states through conformational changes, with key interactions between CI and CIII playing a critical role in electron transfer.
Five Triceratops dinosaurs lived and died together, according to new research. The team's findings suggest that these prehistoric creatures formed a migratory group, with one researcher hoping to receive his PhD title soon.
Scientists discovered a fast and reproducible strategy to control the oxidation of spiro-OMeTAD, improving its conductivity and energy level position. The approach resulted in a high photoelectric conversion efficiency of 24.5% with stable performance under various conditions.
Researchers uncover how EBV infects host genome, leading to tumor formation and finding novel therapeutic targets. EBV-host interactions reveal epigenomic rewiring, dysregulated gene expression, and potential cancer treatment.
Experts recommend using handheld solar viewers with a solar filter to safely view the eclipse. The American Academy of Ophthalmology also warns against using home-made filters or pinholes to view the eclipse.
Early bilingualism may protect theory of mind abilities against normal age-related declines. The research team found that early bilingualism was associated with higher gray matter volume, greater cortical thickness, and larger surface area in brain regions involved in mental state inferences and language processes.
New data suggest that blood-based colorectal cancer screening tests could lead to more cases and deaths than established methods, despite improving outcomes for unscreened individuals. The tests are predicted to be less effective and more costly, making them unsuitable replacements for current screening programs.
The article discusses the biological functions of heat shock protein 90 (HSP90) and its implications in various diseases. HSP90's regulatory mechanisms governed by heat shock factor-1 (HSF-1) play a crucial role in modulating its activity.
Researchers have found an effective and affordable targeted treatment strategy for an HIV cure, using a virus-like particle that can 'shock and kill' latent HIV reservoirs. The study demonstrates the therapy is 100 times more effective than other candidate HIV cure therapeutics.
The study found that Streptococcus and Pedobacter bacteria species were present in healthy eyes, while more Acinetobacter species were found in dry eye samples. This knowledge could lead to improved treatments for various eye problems and diseases affecting the gut microbiome.