Researchers found that HER2-positive breast cancer patients with high levels of tumour infiltrating lymphocytes in residual disease have significantly shorter overall survival. High levels of TILs are associated with poorer outcomes, while lower levels are linked to improved survival rates.
The ESMO Asia Congress 2022 will focus on the latest scientific and clinical advances in oncology, with a special emphasis on the Asia-Pacific region. Media representatives can register for coverage through the official media registration form.
Researchers found that summer rainfall and autumn-winter dry days are increasing, leading to fluvial discharge and sediment load in rainy seasons and water deficits in dry seasons. The Pantanal's complex geomorphology, including mega-fans and self-affine landforms, makes it susceptible to anthropic interference.
Researchers found that genetic copy-number alterations drive HPV-negative head and neck cancers, providing new insights for immune checkpoint inhibitors. The study identified key determinants of resistance and suggests a novel diagnostic biomarker test, potentially leading to improved treatment outcomes.
Albert Almada's laboratory will explore the role of Nicotinamide Adenine Dinucleotide (NAD+) in muscle repair and regeneration. Lower levels of NAD+ may be inactivating stem cell repair, and re-activating it could promote better muscle healing in older animals.
Researchers discovered trapped seawater sealed in North American rock for 390 million years, shedding light on ancient oceans' chemistry and potential for storing carbon-free fuel. The study's findings could inform geologic studies and help identify subsurface locations to safely store hydrogen.
A student-based contact-tracing program at the University of Illinois Chicago reduced COVID-19 exposures and infections by 96% among campus members. The program, which trained students as case investigators and contact tracers, effectively quarantined over 120 cases and prevented an estimated 132 downstream exposures.
Researchers used genetic lineage tracing to study the origin of cardiac adipocytes in an arrhythmogenic cardiomyopathy (ACM) model. SOX9+, PDGFRa+ and PDGFRb+ mesenchymal cell populations gave rise to cardiac adipocytes, while Bmp4 was found to promote cardiac mesenchymal-to-adipose transition.
A recent study found that science misinformation about genetically modified crops reached a quarter of a billion people globally. The majority of articles containing GMO-related keywords contained false information, especially on human health concerns, which had the highest readership.
A new study by Indiana University researchers found that nearly half of non-psychiatric ER patients have mental health and substance use problems. The study used a digital screening tool to identify these issues, which could help reduce future visits and improve patient care.
Scientists at the University of Illinois Urbana-Champaign have created alginate hydrogels that can endure the growth of bacteria, allowing them to synthesize essential enzymes. The modified hydrogels provided a stable platform for bacterial colonies to form and grow, producing important compounds like nisin.
Researchers developed a method to quantify filamentous fungal promoters at single-cell resolution, identifying strong promoters like PzipA and PsltA. These promoters were used to activate a silent gene from Aspergillus fumigatus, producing new cyclic tetrapeptide derivatives.
A Ludwig Cancer Research study found that cancer cells express high levels of the protein FMRP, which shields tumors from immune detection and destruction. The study reveals a signature of gene expression induced by FMRP that predicts poor patient survival across multiple types of cancer.
Researchers studied bamboo nodes using multiscale imaging techniques, revealing a hierarchically organized fiber structure. The findings suggest optimal allocation of limited resources for responding to environmental challenges.
Researchers developed a non-invasive device to measure cervical nerve activity, which could potentially improve treatments for patients with sepsis and PTSD. The device recorded electrical activity across different nerves, grouping patients into distinct biotype groups based on their response to stressors.
The USC+CHLA Alpha Clinic will advance clinical trials of new cell and gene therapies, engaging underserved communities and training the workforce that conducts them. This program complements existing efforts to translate discoveries into new therapies for better health outcomes.
A novel framework uses remote-controlled, internet-connected microscopes to bring project-based STEM education to students worldwide. Users in Latinx communities and multinational students successfully conducted tissue culture experiments, exploring the scientific method in a scalable and affordable approach.
A study published in Scientific Reports found that feeding cats and dogs dry food can significantly reduce the environmental impact of their diets compared to wet food. The research evaluated the environmental impacts of different pet diets, including greenhouse gas emissions, land use, and water usage.
A new study found that long-term exposure to air pollution can increase the risk of high blood pressure and heart disease in teenagers. The review of eight studies involving over 15,000 adolescents aged 12 and above found a significant association between air pollution and rising diastolic blood pressure.
A study of 3,110 US counties found that residential segregation is associated with increased cancer mortality. The findings highlight opportunities for targeted cancer prevention and control efforts at the county level.
A study of 315 women found moderate physical activity to be associated with a 60% lower risk of death. Physical activity levels may play a crucial role in extending survival and improving quality of life for breast cancer survivors.
A new IIASA-led study estimates that global climate goals can be met in a cost-effective manner with fair financial flows, but current pledged funding is insufficient. The researchers recommend increasing financing from rich countries to poorer regions to meet the Paris Agreement targets under most equity considerations.
Researchers have characterized the functional significance of DDX41 in molecular processes underlying cancer. The study reveals that DDX41 serves crucial functions in transcriptional processes, RNA splicing, and genomic integrity maintenance, which may hold significance in treating hematopoietic malignancies.
Researchers at UC San Diego have shown that vibrational polaritons alter molecular dynamics, leading to changes in chemical reactions. The study uses 2D infrared spectroscopy to separately excite and follow polariton modes and dark modes, revealing a new way to control reactions.
Researchers developed a technique to 'see' fine structure and chemical composition of human cells with high resolution. The new method uses infrared light to reveal chemical signatures without fluorescent labeling.
A new study by UBC researchers emphasizes the need for public urban greenspaces to be designed with the needs of young adults between 15 and 24 in mind. The research found that such spaces can promote social interactions, physical exercise, and psychological restoration, leading to improved mental health outcomes.
Women entrepreneurs tend to be more flexible and resourceful in their decision-making, leading to greater business success. This study found that women are more likely to use 'effectual logic,' which involves creatively using available resources to achieve success.
Researchers developed IsoNet, a software package solving intrinsic 'missing-wedge' problem and low signal-to-noise ratio issues in cryoET. IsoNet uses iterative self-supervised deep learning to perform missing-edge correction and denoise tomographic data.
A new study from Mount Sinai Hospital finds a strong association between age-related macular degeneration and severe forms of heart disease, including heart failure, heart attacks, and stroke. The study highlights the importance of increased screening for eye disorders to diagnose undetected heart disease.
Researchers at Oak Ridge National Laboratory have discovered genetic markers for autism, developed recyclable composites to drive the net-zero goal, and created a tool for real-time building evaluation. Additionally, they have made significant progress in growing hydrogen-storage crystals using a novel nano-reactor material.
A new study suggests that ray-finned fish diversified earlier than previously thought, accumulating small changes before the Carboniferous period. The fossil specimen Palaeoneiros clackorum shows features typical of younger species, indicating a more complex picture of species diversification.
A research team has developed a method to easily synthesize a self-healing polymer gel made of ultrahigh molecular weight (UHMW) polymers and non-volatile ionic liquids. The gel exhibits superior mechanical properties, high self-healing capabilities, and can be recycled via thermal processing.
Researchers developed SDCBench, a benchmark suite that evaluates workload co-location in datacenters, enabling cloud tenants to understand performance isolation ability and choose their best-fitted cloud services. The tool also helps cloud providers improve service quality to increase revenue.
Researchers from Ludwig-Maximilians-Universität München have identified a new, endemic species of crown-of-thorns seastar in the Red Sea. The species, Acanthaster benziei, differs from other species in the genus by its smaller arms and thinner spines.
Research reveals significant regional disparities in parental incarceration rates, with children of color and those living in impoverished households more likely to experience it. The study also highlights the need for tailored strategies to address health inequities in remote or under-resourced communities.
Researchers found that individuals with CYP8B1 loss-of-function mutations have improved insulin sensitivity and better glucose regulation, reducing the risk of developing Type 2 diabetes. The study suggests a potential new treatment approach using bile acid modulators to target this gene.
A study published in PLOS ONE found that adults with type 2 diabetes taking metformin had a 45% lower risk of needing a breathing machine or dying from COVID-19 compared to those not taking the medication. The research team analyzed data from a large database and suggested metformin may be an effective treatment option for reducing COV...
Researchers created synthetic knee x-ray images to complement real images in osteoarthritis classification. Medical experts were unable to distinguish between authentic and synthetic images, highlighting the potential of synthetic data for collaboration and testing.
A new species of ancient turtle, Leviathanochelys aenigmatica, has been discovered in Spain with an estimated body length of up to 3.74 meters. This specimen represents the largest marine turtle ever found in Europe and one of the largest worldwide, challenging previous records held by the extinct genus Archelon.
A new study found that schools with more students of color and those who receive free or reduced-price lunches have higher concentrations of pollutants, exacerbating health issues such as asthma and heart disease. Long-term exposure to these pollutants can result in increased risk of hospitalization or death.
Researchers at NIST created grids of quantum dots to study electron behavior in complex materials. The grids provided ideal conditions for electrons to behave like waves or get trapped in individual dots.
A study reveals that porcini mushrooms have evolved in different ways across the globe, with local ecological factors playing a stronger role in maintaining genetic distinctiveness than genetic flow. The findings challenge traditional notions of species development and suggest multiple evolutionary strategies for this organism.
A recent study by UCF Associate Professor Varadraj Gurupur created an algorithm to predict and measure the incompleteness of electronic health records. The analysis found that missing information is a significant issue, with varying levels of incompleteness per year and no clear pattern of where it occurs.
This study employs machine learning to analyze existing experimental results and predict the device performance of metal halide perovskite solar cells. The authors applied shapley additive explanations (SHAP) analysis to understand the correlations between fabrication processes, composition, and device performance.
Researchers identified five genetic variants that progressively increase the risk of becoming nearsighted with more schooling, especially for university-level education. These findings provide new insights into biological pathways causing nearsightedness and its interaction with lifestyle factors.
Researchers discovered a new signalling pathway using enzyme FAAH to dilate bronchial tubes, which may lead to new treatment options for lung diseases. Asthma patients have lower levels of anandamide and other endocannabinoids in their bronchial system.
Researchers used weather radar to track bird movements and found peak roosting stages shifting earlier due to warmer temperatures. This shift may lead to a shortened pre-migratory season, impacting birds' survival during migration.
A nationwide study found that hundreds of residents in neurological surgery trained on a first-of-its-kind simulator, mirroring real-life catastrophe scenarios. The simulation model was deemed feasible and cost-effective, similar to pre-flight simulators used by pilots.
A Rice-led team developed molecular simulations that reveal distinct differences in how inner and outer shells of water molecules around gadolinium respond to thermal excitation. Temperature affects the self-diffusivity of molecules, influencing relaxation rates in MRI scans.
Scientists have discovered that plants can rapidly adapt to environmental changes and pass on these adaptations to future generations through epigenetics. Plants use somatic memory to recognize previous environmental conditions and react promptly in the face of similar challenges.
A new study published in the journal Nature has identified medin as a key player in Alzheimer's therapies. Medin, a protein that accumulates in the blood vessels of the brain, promotes vascular pathology and cognitive decline. The researchers hope to develop a treatment targeting medin to prevent vascular damage and cognitive decline.
Researchers demonstrate a new way to deliver medication to malignant brain tumors in mice, using a modified peptide that can penetrate the blood-brain barrier. The study shows promising results, with a 50% increase in survival rate for treated mice, and offers hope for future treatment breakthroughs.
A new study published in Nature Scientific Reports reveals that social media engagement with climate policy events can increase the focus of the building sector on environmental justice. The researchers found a strong environmental justice discourse among public concerns, which can foster positive sentiments and inspire innovative emis...
Researchers identified key risk factors for intimate partner violence in pregnant women, including head injuries, multiple contusions, and certain injury patterns. The study highlights the importance of screening for IPV in pregnant trauma patients to prevent poor outcomes such as premature birth and low birth weight.
A study by University of Minnesota researchers found that personalized federated learning may offer an opportunity to develop both internal and externally validated algorithms. This technique enables multiple parties to train AI models collaboratively without exchanging or centralizing data sets, protecting sensitive medical informatio...
Inducing a hibernation-like state in mice using Q neuron activation has been shown to protect kidneys from oxygen deprivation and avoid harmful side effects. This technique could lead to new methods of performing heart surgery with reduced organ damage.
Researchers at Singapore University of Technology and Design (SUTD) have developed a novel phase-change key for new hardware security. The device, known as the physical unclonable function (PUF), is scalable, energy-efficient, and secure against AI attacks compared to traditional silicon PUFs.
Researchers identified specific immune cells driving deadly heart inflammation in cancer immunotherapy patients, and found that CD8 T cells target the heart muscle. The study's findings have led to investigations into preventing or treating this form of myocarditis, a common but fatal side effect of ICIs.
Research reveals mitochondria play crucial role in NF-κB signaling pathway regulation. Mitochondria assemble signaling platform at outer membrane, amplifying signal through large surface area.
Researchers at HKUST have developed a novel integration scheme using lateral aspect ratio trapping (LART) to efficiently couple III-V lasers and photodetectors with silicon on silicon photonics platform. This breakthrough enables the integration of energy-efficient photonics with cost-effective electronics.