Researchers at the University of Helsinki discovered a potential treatment for Alzheimer's disease and frontotemporal dementia using a PREP inhibitor. The PREP inhibitor reduced Tau accumulation and toxicity in cellular models and mice with tauopathy, improving cognitive skills.
Researchers tracked the evolution of Staphylococcus aureus in patients with eczema, discovering rapid mutations in a gene that enables the bacteria to grow faster on the skin. These findings could lead to targeted treatments by targeting variants of S. aureus associated with eczema symptoms.
A team of researchers has discovered that chromium(III) supplementation can regulate glucose metabolism in type 2 diabetic mice by targeting ATP synthase activity. This process improves mitochondrial deformation caused by high glucose levels and boosts glucose metabolism.
A new study finds that childhood symptoms of disordered eating are predictive of symptoms in adulthood for both Black and white women. Black women's symptoms were predicted by earlier ages compared to white women, suggesting cultural and psychological factors may influence symptom presentation.
A recent study published in the New England Journal of Medicine found that tranexamic acid did not reduce the need for blood transfusions or prevent maternal death in patients with increased risk for excessive bleeding after cesarean delivery. However, patients who received tranexamic acid had less need for additional medical intervent...
Researchers at University of California - San Diego found that vertebrates acquired a special protein from bacteria more than 500 million years ago. This discovery reveals a new piece of genetic material introduced from foreign bacterial genes, leading to unique functionality in vertebrate eyes.
Researchers developed ProTac, a soft robotic link with multimodal perception to improve human-robot interactions. The device incorporates tactile and proximity sensing capabilities, enabling robots to react safely and predictably to physical contact.
A novel clinical trial demonstrated that open-label placebo increased patient retention rates by 78% compared to methadone-only treatment. Participants also reported better sleep quality, with no significant differences found in other outcome measures. The study suggests that deception-free placebo treatment can provide valuable benefits.
Experts warn that the UK's free trade deal with CPTPP will make it harder to regulate tobacco and alcohol, ban products containing harmful pesticides, and enact policies to cut consumption of unhealthy food and drinks. A health impact assessment is needed to evaluate the potential benefits and harms of this deal.
Researchers at Salk Institute discover that dysfunctional mitochondria at synapses fail to meet energetic demand, supplying either too much or too little power and potentially causing working memory impairment with age. Adherence to the ultrastructural size principle is essential for avoiding cognitive decline in aging brains.
Scientists create B cell organoids to screen conjugate vaccine candidates, identifying antigen-specific antibodies with potential applications. The platform accelerates testing throughput, offering insights into the immune response to vaccines.
Researchers have developed an organoid-based method to assess the potency of glycoconjugate vaccines, speeding up the vaccine development process. This method uses tissue from a single mouse to create hundreds of immune organoids, allowing for the assessment of dozens or even hundreds of vaccine candidates in just four days.
A study analyzed Google Trends data to assess the impact of immunization and the COVID-19 pandemic on varicella cases in Europe. The research found a significant decrease in chickenpox cases across the region, suggesting suppressed transmission during the pandemic.
Researchers discovered a novel function of Claspin in the nutrition-induced signaling pathway, essential for activation of PI3K-PDK1-mTOR pathway and cell survival. This finding provides new targets for therapeutic interventions of metabolic disorders such as obesity, diabetes, and cancers.
A new study found that snowshoe hares' seasonal color swap is being disrupted by global warming, leaving them vulnerable to predators. Hares that wait too long to turn white may not survive the winter, highlighting the importance of timing in their survival.
A new study suggests that US food insecurity rates may be significantly higher than previously reported, with some areas experiencing rates over twice as high as national averages. The researchers recommend conducting surveys more frequently and asking about recent experiences to improve accuracy.
Scientists discovered that deleting a protein called sphingosine kinase 2 (SphK2) reprograms the tumor microenvironment, decreasing S1P levels and increasing p53 tumor suppressor gene accumulation. This creates an inhospitable environment for aggressive breast tumors.
A randomized clinical trial found that using smartphone apps for home monitoring after oncologic surgery leads to improved quality of recovery and equal patient satisfaction. The study compared this approach with conventional in-person follow-up, revealing no significant differences in these outcomes.
A new study found that Mexican American people who spoke only Spanish had worse neurologic outcomes three months after a stroke compared to those who spoke English or were bilingual. The study involved 1,096 participants and controlled for factors such as education and blood pressure.
Researchers found a partial response in a patient with pancreatic acinar cell carcinoma, as well as stable disease in 11 patients, when combining riluzole with sorafenib in a phase I trial. The combination was safe and tolerable, and further exploration of its potential is warranted.
Researchers found a 14.4% decline in new cancer diagnoses in 2020 compared to prior years, correlating with stay-at-home orders during the COVID-19 pandemic. The study estimates that around 200,000 people may have had undiagnosed or untreated cancer cases during this time.
Researchers at Vanderbilt University Medical Center have discovered a new way to measure the growth rate of precancerous clones of blood stem cells using a technique called PACER. The findings suggest that drugs targeting the gene TCL1A may be able to suppress clonal growth and associated cancers.
A Danish study has validated a dried blood spot test that can detect HIV, hepatitis B, and hepatitis C from a single drop of blood. The test uses existing hospital equipment and is suitable for places where needle-based testing is not practical or feasible.
New research suggests that disconnecting from work at home can boost a leader's energy and effectiveness the next day. Managers who ignored their work email at home felt more refreshed and were rated as effective leaders by their employees.
A new study found that the COVID-19 pandemic resulted in a significant increase in weekday screen time among school-aged children, with boosts of up to 1.35 hours per day. This finding suggests that children used screens to fill time previously spent at school or participating in extra-curricular activities.
A study found that cell competition between neural progenitor cells regulates brain size in mice, with top performers producing 30%-40% of neurons and losers producing only 1%-2%. The researchers identified Axin2 and p53 as key drivers of this process.
Researchers found that membership-based free shipping (MFS) can increase net customer revenue by up to 12.75%, as heavy buyers consolidate their spending after enrollment. Light buyers contribute the highest percentage change in revenue contribution, while heavy buyers may exploit free shipping benefits and lose money for retailers.
A Yale School of Public Health study found that older persons with mild cognitive impairment (MCI) who adopted positive age beliefs were 30% more likely to regain normal cognition compared to those with negative beliefs. These positive beliefs also enabled participants to recover their cognition up to two years earlier.
Dr. Roland Martin is honored for his work on immune mechanisms underlying multiple sclerosis, identifying key genes and nerve-insulating components targeted by immune attacks. His experimental therapy aims to make the immune system ignore those targets while preserving protective immunity.
Researchers identified a technique to detect abnormal protein deposits linked to Parkinson's disease, confirming its accuracy for early detection and characterisation. The α-synuclein seed amplification assay (αSyn-SAA) can identify people with Parkinson's disease and at-risk individuals prior to diagnosis.
Researchers confirmed a new protoplanet, HD 169142 b, orbiting a star 374 light years away. The planet is estimated to be about 37 astronomical units from its star and has carved an annular gap in the surrounding gas and dust disk.
Researchers at the University of Gothenburg have developed a new epoxy resin monomer based on isosorbide, a substance produced from glucose, to reduce contact allergies. The new monomer is far less allergenic and not based on Bisphenol A (BPA), a known endocrine disruptor.
Researchers found that a protein associated with liver cancer, ATF4, protects the liver by promoting the expression of SLC7A11, which suppresses ferroptosis and slows liver cancer progression. This unexpected result could inspire new treatments for preventing liver disease and cancer.
A simple blood test for ALS has been developed using microRNA analysis, which can accurately identify patients with the disease. The test uses a unique protein called L1CAM to concentrate diagnostic particles from extracellular vesicles in the bloodstream.
As organisms age, gene transcription speed increases but accuracy decreases, leading to lower-quality proteins. However, researchers found that dietary restrictions and certain interventions can reverse this process, revealing a potential molecular mechanism for healthy aging.
A randomized clinical trial found that patients who knowingly took placebos were more likely to stay on methadone and had improved sleep quality. After three months of follow-up, 78% of the placebo-treated group remained on methadone compared to 61% of the control group.
A nationwide study found that poor family cohesion among bereaved youth is strongly associated with negative psychological effects years after the loss. The research highlights the importance of supporting families during parental illness and immediately after the loss to improve long-term health and well-being.
Researchers found that dairy pastoralism began on the highland plateau by about 3500 years ago, supported by palaeoproteomic analysis of ancient milk proteins. This early adoption enabled expansion into the region's vast, non-arable highlands, facilitating long-term human occupation.
A large clinical trial of over 8,700 patients found that the sex of a donor has no effect on the survival of recipients of red blood cell transfusions. The study used a pragmatic approach to answer the question definitively and was conducted at a lower cost than typical trials.
A new training program has been shown to increase the accuracy of autism diagnoses in young children by primary care physicians, reducing wait times for specialist care. The ECHO Autism STAT model leverages video-conferencing technology and case-based learning to build capacity among community clinicians.
Memorial Sloan Kettering Cancer Center experts to present significant advances in cancer research at the American Association for Cancer Research Annual Meeting. MSK faculty will also receive prestigious awards and lectureships, highlighting their contributions to precision medicine and tumor biology.
The HERA team has improved the sensitivity of a radio telescope, allowing them to detect radio waves from the cosmic dawn era. The data suggests that early galaxies contained few elements besides hydrogen and helium, unlike modern galaxies.
The study reveals that the stability of Dion-Jacobson 2D perovskites is determined by the rigidity of organic diammonium cations. This mechanism allows for intercoordination between organic and inorganic components, enabling a stabilized state. The findings may provide guidance for manipulating the stability of DJ 2D perovskites.
This technology uses light and sound to create images of the inside of the body. The research team developed a novel method that eliminates the need for ultrasonic transducers, allowing for non-contact photoacoustic signal detection and improved sensitivity. The technique has great application potential in various biomedical research.
A team of chemists at the University of Basel has successfully synthesized organic light-emitting diodes by creating compounds with the exact three-dimensional structure desired. This breakthrough enables the development of more efficient and longer-lasting OLEDs.
The NCCN 2023 Annual Conference emphasized the importance of fostering welcoming environments for patients and staff, ensuring care meets latest standards, and rejecting a one-size-fits-all approach. Key findings included the need to address systemic bias, social determinants of health, and staffing issues in cancer care.
A new study found that sedentary time increases cardiac mass by 3.8g/m2.7, while moderate-to-vigorous physical activity results in a smaller increase of 1.2g/m2.7. Light physical activity shows no effect on cardiac mass but improves cardiac function.
A new study published in The Lancet found that higher dose corticosteroids are associated with a 60% increased risk of death in hypoxic COVID-19 patients requiring only non-invasive oxygen therapy. The RECOVERY trial also identified an excess of pneumonia and hyperglycaemia in the higher-dose corticosteroid group.
Researchers discovered that skates' remarkable fins result from changes in their genome's non-coding regions and three-dimensional complexes called topologically associated domains (TADs). These alterations drove the evolution of unique gene-expression patterns, enabling the development of exceptionally wide fins.
Researchers have developed a new detection method using carbon nanotubes to measure the duration of dopamine release in the brain. This allows for more robust detection and monitoring of neurotransmitters, which is crucial for understanding neurological disorders such as Parkinson's disease.
A new study by MIT and Michigan State University found that altering job descriptions to make them more gender-neutral has little impact on applicant behavior. Despite efforts to appeal equally to women and men, the research reveals no practical effects of 'degendering' job listing language.
A growing number of European countries have experienced diphtheria outbreaks primarily associated with recently arrived migrants. Key findings indicate that whole genome sequencing and phylogenetic analysis reveal that the toxin-producing bacteria were acquired during migration rather than in their home country or Germany.
Researchers propose that early interactions between the magma ocean and a molecular hydrogen proto-atmosphere could have given rise to Earth's signature features, including its abundant water. The study suggests that even dry rocky material collisions would generate large quantities of water through these atmospheric-magma interactions.
Researchers have developed a new class of materials that can efficiently remove glyphosate from groundwater. The new metal-organic frameworks (MOFs) have a large surface area and can be customized depending on the application.
Researchers found that dopamine availability in the brain affects people's self-assessment of physical effort and willingness to undertake future exertions. The study, which involved Parkinson's disease patients, suggests that dopamine level is a critical factor in helping people accurately assess how much effort a physical task requires.
Researchers at UCLA Health discovered that astrocytes, traditionally considered the brain's support system, are involved in obsessive-compulsive disorder-related behaviors. The study suggests that targeting both neurons and astrocytes may be effective for OCD treatment.
Researchers at UIUC use 4D-STEM to resolve magnetic behavior on angstrom scale, breaking record for atomic resolution. They achieve this by combining electron microscopy with simulations using software package Magnstem.
A new study has identified disrupted levels of molecular compounds in maternal blood and cord blood linked to later diagnosis of autism spectrum disorder. The findings shed light on the biological processes that give rise to ASD and could open the door to early diagnosis and treatment.
Researchers have created a new material that responds to substantially lower electrical charges, making it suitable for use in medical devices. The material, made of bottlebrush polymers, was found to expand and contract over 10,000 times before degrading when stimulated by voltages as low as 1,000 V.
A machine learning model has been developed to predict a patient's risk for a sleep disorder using demographic, lifestyle, physical exam results, and laboratory values. The model identified depression, weight, age, and waist circumference as the greatest predictors of a sleep disorder diagnosis.