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Science News for May 18, 2021


Study shows racial differences in personal care product use, may lead to health inequities

A large survey of women in California found significant racial and ethnic differences in personal care product use, with Black women more heavily exposed to endocrine-disrupting chemicals. The study aims to fill the gap in data on products used by women of color and informs guidance for self-protection and policy development.

SourceSilent Spring Institute·JournalJournal of Exposure Science & Environmental Epidemiology·DateMay 18, 2021

A randomised trial comparing imaging-guided PCI with Orsiro vs Xience

The CASTLE study investigated the role of imaging-guided percutaneous cardiac intervention (PCI) in clinical outcomes difference between ultra-thin strut biodegradable polymer sirolimus-eluting stent (Orsiro) and durable polymer everolimus-eluting stents (Xience). The results show no significant differences in target lesion failure rat...

SourcePCR·DateMay 18, 2021

Study of Utah cancer care-at-home model demonstrates lower costs, better outcomes

A new study published in the Journal of Clinical Oncology reports findings on Huntsman at Home, a cancer hospital-at-home model that demonstrates lower costs and better outcomes for patients. The study found that participants had 55% fewer hospitalizations and 47% lower healthcare costs compared to those who did not participate.

SourceHuntsman Cancer Institute·JournalJournal of Clinical Oncology·DateMay 18, 2021

Experts call for better design of early drug trials for Alzheimer's and related dementias

The Alzheimer's Drug Discovery Foundation and The Association for Frontotemporal Degeneration recommend adopting best practices in designing exploratory trials, including rigorous statistical analyses and biomarker selection. These recommendations aim to reduce costs and improve patient engagement in clinical trials.

SourceAlzheimer's Drug Discovery Foundation·JournalJournal of Neurology·DateMay 18, 2021

Black, Hispanic and Asian populations saw greatest rise in cardiac deaths during pandemic

A new study characterized heart disease and cerebrovascular deaths by race and ethnicity during the US COVID-19 pandemic, revealing that Black, Hispanic and Asian populations experienced significantly higher relative increases in heart disease deaths, with a 19% rise compared to non-Hispanic whites. The study suggests that disruptions ...

SourceBeth Israel Deaconess Medical Center·JournalCirculation·DateMay 18, 2021

Getting "wind" of the future: Making wind turbines low-maintenance and more resilient

A team of researchers developed a method to detect simultaneous sensor and actuator faults in wind turbines, eliminating the need for redundant hardware components. The approach uses a state observer model to identify discrepancies between the original system and its duplicate, enabling real-time fault detection and correction.

SourceChinese Association of Automation·JournalIEEE/CAA Journal of Automatica Sinica·DateMay 18, 2021

Mapping the Midwest's soil topography

Researchers at Iowa State University are developing new models to predict soil erosion and topography changes in Iowa. The models use big-data technology and validate soil measurements from real-world LiDAR data, enabling more accurate predictions of environmental conditions.

Toward overcoming solubility issues in organic chemistry

A team of four scientists from Hokkaido University developed a rapid and efficient protocol for cross-coupling reactions using ball milling, expanding the pool of chemicals usable in organic synthesis. They successfully applied this method to mostly-insoluble aryl halides, yielding desired products.

SourceHokkaido University·JournalJournal of the American Chemical Society·DateMay 18, 2021

How to become 'ant-i-social'

Researchers sequenced the genomes of three socially parasitic ant species, finding evidence of widespread genomic rearrangements and gene losses. The study sheds light on the evolutionary consequences of transitioning from social to parasitic behavior, with significant impacts on sensory capabilities and behavioral repertoire.

SourceArizona State University·JournalNature Communications·DateMay 18, 2021

Combining immunotherapies against cancer

Researchers developed a microparticle-based cancer vaccine that kickstarts an immune response, increasing the proportion of mice cured of tumors to 75%. Combining the vaccine with immune checkpoint inhibitors greatly improves treatment success, offering a promising approach to improving cancer treatment.

SourceUniversity of Konstanz·JournalNature Communications·DateMay 18, 2021

Modular photoswitch cpLOV2 developed for optogenetic engineering

Researchers designed cpLOV2 using circular permutation to simplify optogenetic device design. The new photoswitch maintained structural integrity and function, providing more choices for optogenetic application developments. It was successfully used to gate ORAI1 Ca2+ channel and control cell activities in a mouse model.

Study reveals huge pressures on anaesthesia and critical care workforce and hospitals during winter wave of COVID-19 pandemic, and devastating drop in surgical activity

During the winter wave of COVID-19, anaesthetic and critical care staff in the UK faced immense pressure due to a surge in newly admitted infected patients. Surgery rates plummeted by one quarter compared to previous years, with many hospitals expanding ICUs to accommodate the influx.

SourceAAGBI·JournalAnaesthesia·DateMay 18, 2021

Icing muscle injuries may delay recovery

A study using a mouse model of eccentric contraction revealed that icing injured muscles delays muscle regeneration. The phenomenon is linked to pro-inflammatory macrophages' ability to infiltrate damaged cells, delaying the healing process.

SourceKobe University·JournalJournal of Applied Physiology·DateMay 18, 2021

Study shows optimized multi-scale structure and chemical gradients in exoskeletons of mantis shrimps

Researchers discovered a four-layered exoskeleton with distinctive micro-structure and chemical characteristics that restrict crack propagation and maximize strain energy release during deformation. Bio-mimetic structures fabricated via 3D printing demonstrated improved toughness and strength, guiding high-performance composites fabric...

SourceUniversity of Science and Technology of China·JournalACS Applied Materials & Interfaces·DateMay 18, 2021

Maintaining self-control -- The careful balance of the immune system

A new study by University of Tsukuba researchers reveals how two receptors, DNAM-1 and TIGIT, maintain the necessary balance between immune activation and suppression to prevent autoimmune diseases. The findings suggest that an imbalance in this mechanism may contribute to autoimmunity, providing potential targets for treatment.

SourceUniversity of Tsukuba·JournalProceedings of the National Academy of Sciences·DateMay 18, 2021

One-year results from the FUTURE-II trial

A randomized trial comparing a new, thin-strut bioresorbable scaffold with a metallic stent showed non-inferiority of the bioresorbable scaffold in terms of late lumen loss and covered struts. The trial's results may revitalize the concept of bioresorbable scaffolds.

SourcePCR·DateMay 18, 2021

Gut check

Researchers at Harvard Medical School analyze the genetic makeup of gut bacteria and find links to various diseases including coronary artery disease, inflammatory bowel disease, and liver cirrhosis. The study identifies groups of bacterial genes that can predict disease risk or identify presence, paving the way for developing tests.

SourceHarvard Medical School·JournalNature Communications·DateMay 18, 2021

In search of drought-tolerant holm oaks

A study by the University of Córdoba has identified holm oak trees that exhibit greater resistance and tolerance to drought stress, root rot, and high temperatures. These 'elite' specimens may be used as molecular markers for drought-tolerant trees in reforestation programs.

SourceUniversity of Córdoba·JournalInternational Journal of Molecular Sciences·DateMay 18, 2021

Disabled researcher calls for better support for faculty

Academic institutions must improve support for disabled faculty members, including those with visible and invisible disabilities. The commentary highlights the challenges created by high demands for grant money and frequent research publications, which can lead to reduced funding and staff retention.

SourceCell Press·JournalTrends in Neurosciences·DateMay 18, 2021

Novel method of labeling DNA bases for sequencing

Researchers developed a novel method for labeling DNA bases using electrochemical detection and redox labels. This approach allows for the identification of individual nucleotides in a single strand of DNA, enabling faster and more affordable DNA sequencing and diagnostic applications.

New model helps predict heart attacks in high-risk patients

Researchers have developed a new approach to analysing the forces at play behind diseased heart vessels, which could help cardiologists predict heart attacks in patients. The study used optical coherence tomography images to generate patient-specific reconstructions of coronary plaques and analyse stress concentrations.

SourceeLife·DateMay 18, 2021

Epigenetics study draws link between hatchery conditions and steelhead trout fitness

A Washington State University study links alterations in hatchery-raised steelhead trout's epigenetic programming to reduced fertility and abnormal health. The research suggests that faster growth practices and environmental factors can lead to epigenetic changes passed down through generations, impacting wild fish populations.

SourceWashington State University·JournalEnvironmental Epigenetics·DateMay 18, 2021

Evidence suggests bubonic plague had long-term effect on human immunity genes

Researchers discovered innate immune markers increased in frequency in modern people from a region that experienced the plague, suggesting these markers might have evolved to resist the disease. The study also found changes in allele distribution for immune-related genes, which could be evidence of past Yersinia pestis exposure.

SourceUniversity of Colorado Anschutz Medical Campus·JournalMolecular Biology and Evolution·DateMay 18, 2021

Few women in sub-Saharan Africa undergo cervical cancer screenings

A recent study found that only 19% of women in sub-Saharan Africa underwent cervical cancer screenings between 2011 and 2018. The rates varied greatly by country, with some countries having nearly 46% of women screened versus less than 1%. Increasing screenings is crucial to detect the disease early and improve treatment outcomes.

SourcePenn State·JournalCancer Epidemiology·DateMay 18, 2021

Adding antibodies to enhance photodynamic therapy for viral and bacterial disease

Photodynamic therapy has shown promising results in treating respiratory tract infections and some types of cancer. Adding antibodies to the treatment can increase its efficacy, making it an attractive option for rapid responses to pandemics. The new approach uses viral antibodies attached to light-absorbing molecules to target viruses...

SourceAmerican Institute of Physics·JournalApplied Physics Reviews·DateMay 18, 2021

New peanut has a wild past and domesticated present

Researchers at the University of Georgia have developed new peanut varieties that combine the genetic diversity of wild relatives with the desirable traits of modern peanuts. The new lines are resistant to diseases such as leaf spot and root-knot nematode, and offer improved sustainability for farmers.

SourceUniversity of Georgia·JournalJournal of Plant Registrations·DateMay 18, 2021