A team of researchers used 3D-electron diffraction/micro-crystal diffraction to determine the structure of Levocetirizine dihydrochloride, an over-the-counter oral antihistamine. This breakthrough allows for a better understanding of its properties and potential applications.
A new fossil discovery shows that a tiger-sized, saber-toothed creature called Inostrancevia migrated 7,000 miles to occupy a vacant ecosystem before going extinct. The arrival of this top predator indicates its vulnerability and serves as an analogue for modern apex predators facing extinction due to human activities.
A study by researcher Breno Arsioli Moura investigated the depictions of Benjamin Franklin's famous kite experiment in illustrations published in the 19th century. The study found several inaccuracies, including the incorrect location where the experiment was performed and the method used to harness electricity from the clouds.
Researchers used deep learning to analyze drone images of pine trees, detecting pine processionary moth larvae nests with high accuracy. The method can be applied in various settings to inform tree health managers about potential threats.
A study by WVU researchers highlights the need for improved mental health programs for first responders, citing increased stress and stigma. The study recommends linking responders with culturally competent clinicians, establishing centralized organizations, and expanding research efforts to address these issues.
A new CAR T cell design approach using machine learning and artificial intelligence is being developed to improve cancer treatment. The project aims to create a hybrid knowledge- and data-driven approach to guide the design of immunotherapeutic cells.
A new study reveals faster growth rates of SAR11 bacteria than previously believed, with some groups dividing up to ten times faster. The research also shows that the timing of bacterial proliferation can influence their abundance and survival, challenging previous assumptions about marine microbial life.
A University of Minnesota team creates high-quality metal oxide thin films from historically difficult-to-synthesize metals using a breakthrough method that stretches the metals at the atomic level. This innovation paves the way for scientists to develop better materials for various next-generation applications.
A recent survey of 1,460 US academics found that 19% report witnessing unidentified aerial phenomena (UAP) and 37% are interested in conducting research into the topic. Academics across various disciplines consider UAP research to be important, with many expressing interest or willingness to engage in such studies.
Researchers developed double perovskites with Cs2AgInCl6 composition, doped with Eu3+ and Bi3+, to achieve high photoluminescence efficiency (PLQY) of up to 80.1% in white light emission. The optimal doping concentrations for Bi3+ and Eu3+ ions were found to be 0.5% and 6%, respectively.
A new method for sexing chicken eggs by scent has been developed by researchers at UC Davis, allowing for early identification of male embryos. The technology relies on detecting volatile organic compounds emitted by the developing embryo, which can be analyzed using gas chromatography/mass spectrometry.
A new study suggests that depression is associated with an immune-suppressed type of microglial cells in the brain, rather than neuroinflammation. This finding, published in Biological Psychiatry, may provide a new target for medication and treatment.
A new study proposes a realistic implementation of the Kitaev model in quantum simulators, hosting a chiral spin liquid with non-Abelian anyons. The system's striking properties are revealed through practical methods, including topological heat current measurements.
A research team at Göttingen University has discovered that mobile and stationary cells have different mechanical properties due to their cytoskeleton. The study found that intermediate filaments, which are crucial for cell stability, exhibit metal-like plasticity when stretched, similar to non-biological materials.
Researchers created a novel map of protein assemblies in DNA damage response, capturing canonical repair mechanisms and proposing new DDR-associated proteins linked to stress, transport, and chromatin functions. The study provides new therapeutic opportunities for diseases caused by defects in DNA damage response.
A new study suggests that limiting global warming to 1.5°C could save five times more people from dangerous heat than if warming reaches 2.7°C by 2100. Currently, over 60 million people already live outside the 'climate niche' where humans have thrived.
A new study finds that midwifery care is associated with higher levels of autonomy and respect during childbirth, particularly in community settings. Midwives attended 12% of births, mostly in hospitals, while community births were more common with midwife attendance.
A new study by University of Wyoming researchers found that regular diagnostic testing and self-isolation can deliver higher net benefits than physical distancing strategies in combating infectious diseases. The study took into account the concept of superspreading, which made the testing-isolation approach even more effective.
Researchers investigate Metal-Organic Frameworks (MOFs) and MXene, a two-dimensional material, for enhanced electrochemical properties. The hybrid materials show improved performance in various energy storage and conversion applications.
Current measures to protect grasslands in the Qinghai-Tibetan Plateau are damaging the ecosystem and should be stopped. Small burrowing mammals, like the plateau pika and zokor, play crucial ecological roles in maintaining ecosystem health and biodiversity.
Researchers are harnessing Frontier's exascale capabilities to tackle complex scientific challenges, including nuclear fusion and earthquake forecasting. The system has already demonstrated impressive performance, with updated rankings on the TOP500 list and improved benchmark scores.
A new study suggests that high-sugar diets can exacerbate inflammatory bowel disease (IBD) symptoms by disrupting the colon's lining renewal process. The research found that a high-sugar diet led to impaired cell division and altered metabolic pathways in mice, resulting in faster gut damage.
A Texas A&M team is studying the impact of cryptocurrency mining on the state's power grid, revealing a potential for demand flexibility during times of peak energy usage. The research suggests that when the grid is stressed due to heatwaves or other factors, cryptocurrency miners can shut down, providing a buffer against strain.
Physicists from Würzburg's ToCoTronics CRC have made groundbreaking discoveries in topological materials, including indene and bismuthene. The renewed funding will focus on shaping these materials into nanostructures using lithographic methods.
Research found that drought can increase tree growth in cold, harsh environments due to its impact on energy-limited systems. The study's results provide insights into how different tree species and ecosystems will respond to climate change, particularly in water-limited regions.
A multi-institutional team of experts is studying how to use focused ultrasound to create a temporary gateway through the blood-brain barrier to deliver cancer medicine. Researchers aim to develop a personalized medicine approach in which they can test drugs on patient tumors and predict treatment effectiveness.
Researchers from Aarhus University conducted an online experiment showing that repeated exposure to food images can induce satiety, reducing the desire for more. The study found that participants who viewed pictures of orange M&M's 30 times chose a smaller portion than those who only saw them three times.
A research group led by NCKU professor I-Non Chiu conducted the first cosmological study on galaxy clusters identified by eROSITA, analyzing 550 galaxy clusters. The results suggest that Dark Energy occupies up to 76% of the total energy density in the Universe.
A new study from the University of Colorado Boulder documents more than 60 years of change in snowpack water storage across Western North America. The researchers found that snowpack water storage has significantly declined in over 25% of the Mountain West, leading to earlier water scarcity and impacts on agriculture and wildfire risk.
Weigel will develop HAPI adoption support and create new server reference implementations to facilitate an integrated ecosystem. He will also demonstrate HAPI's capabilities in serving images and evolve its specification for machine learning-based infrastructure.
A recent study analyzing US FDA PATH data found a correlation between current tobacco use and symptom burden among adult cancer survivors. However, symptoms were not related to the desire to quit smoking. The findings suggest that better management of cancer symptoms may help survivors quit smoking.
A special issue of the Journal of Vocational Rehabilitation presents strategies to challenge the status quo that young people with disabilities face in employment. Research highlights the need for verification of evidence-based practices, competitive integrated employment, and increased utilization of vocational rehabilitation services.
A study by Lund University researchers reveals that visual perspective taking, a crucial social skill, originated in the dinosaur lineage around 60 million years ago. This finding challenges the prevailing view that mammals drove the evolution of complex cognition.
A year-long immunotherapy through a skin patch safely desensitized toddlers with peanut allergy, lowering the risk of a severe allergic reaction from accidental exposure. Children who originally reacted to small amounts of peanuts were able to tolerate larger quantities after completing treatment.
Survivors of firearm injury experience chronic PTSD symptoms and poor health-related quality of life, emphasizing the need for comprehensive care. Screening for chronic kidney disease could be cost-effective for US adults starting at age 35.
A growing number of people worldwide will be affected by low back pain by 2050, with Australia facing a nearly 50% increase. The study highlights the need for effective prevention and management strategies to address this growing burden.
A study of nearly 67,200 postmenopausal women found that the Fracture Risk Assessment Tool (FRAX) was inadequate for identifying osteoporotic fracture risk across racial/ethnic categories. However, the Osteoporosis Self-Assessment Tool (OST) was excellent for detecting osteoporosis within each category.
New research highlights the benefits of family-based care for children exposed to early psychosocial deprivation, improving cognitive function, emotional well-being, and social development. The study found that high-quality foster care had a lasting impact on children's brain development and risk of psychopathology.
Despite years of research, few salt-tolerant crops have been released commercially. KAUST researchers argue that increasing crop salinity tolerance is essential due to climate change impacts. New genetic tools and approaches like grafting or domesticating wild species can help develop more resilient crops.
A new study has identified the preferred flower species of Midwest bumble bees, revealing that these social bees have more discerning dietary preferences than expected. The research found that common flower species like milkweed and thistles are favored by bumble bees, while others, such as alsike clover and black-eyed Susan, are ignored.
Researchers have discovered that a previously unknown strategy is used by the foodborne bacterium Listeria monocytogenes to invade and infect humans and animals. A housekeeping enzyme called LAP plays a crucial role in this process, and its attachment to the bacterial surface is essential for pathogenesis.
Researchers found that introducing financial trading in California's wholesale electricity market led to reduced volatility in prices, production costs, and carbon emissions. The study also showed improved physical market outcomes, including lower fuel costs and reduced complexity in real-time markets.
Established as international standards at the International Organization for Standardization (ISO) meeting in Vienna, Austria, ETRI's 'Unmanned Aircraft Area Network' technology prevents collision risks between drones and supports simultaneous operation of hundreds of drones. The standards cover four detailed technologies: unmanned aer...
Coral cells use a molecule called LePin to mark friendly algae for ingestion, a mutually beneficial relationship that helps corals survive. This discovery could inform strategies to prevent coral bleaching and promote coral resilience.
A new study found that neurons in a key brain region have different functions based on their genetic identity, which could lead to better understanding of the brain's computational flexibility and memory capacity. The diversity of neurons in the CA1 region of the hippocampus was previously unknown and is crucial for memory development.
In Estonia, approximately one in three ticks carry bacteria that cause borreliosis. Researchers are exploring the potential of local medicinal plants to combat Lyme disease. Studies have shown that extracts from certain plant species, such as Galium verum and Galium aparine, possess significant antioxidant properties.
Researchers developed a new method combining palmitoleic acid, gentamicin, and non-invasive ultrasound to improve drug delivery in chronic wounds infected with S. aureus. The strategy reduced bacterial burden by 94% and successfully sterilized wounds in diabetic mice.
Scientists have found that siblings with autism spectrum disorder (ASD) share more of their father's genome than initially thought. In many cases, it is the father who may play a bigger genetic role in ASD. This discovery offers new potential sources for understanding and treating the disorder.
Researchers found that consumers prefer sitting together in the front row of a movie theater than taking seats with better views, even if it means sacrificing some experience quality. This preference is more pronounced when they are with someone they feel close to.
A recent study by UC Davis researchers found that humans exhibit reproductive inequality similar to other mammals, challenging the notion of human exceptionalism. The study also revealed greater reproductive egalitarianism in societies allowing polygynous marriages, where women have equal access to resources and parenting help.
A study of over 12,000 UK children found that low self-esteem and body image were strong predictors of poor mental health outcomes, including depression and anxiety. Increasing children's satisfaction with their appearance and self-esteem from early adolescence may help protect against these negative impacts.
Researchers have developed a novel computational approach to design protein-peptide ligand binding complexes that can trigger complex cellular responses. The new biosensors can sense flexible compounds and provide optimal sensing of molecular signals, potentially leading to improved therapeutic applications.
A study of 1,050 pregnant women found frequent detection of HPV, with infrequent perinatal transmission. The authors note challenges in distinguishing contamination from true infection, particularly in placentas.
Researchers found that GPR141 enhances cell migration and proliferation in breast cancer by activating the p-mTOR/p53 signaling pathway. Silencing GPR141 restores p53 expression and attenuates tumor growth, suggesting its role in regulating breast cancer progression and metastasis.
A new method called 5PSeq has been developed to quickly assess bacterial response to antibiotics, with potential implications for treating antibiotic-resistant infections. The method measures mRNA translation and decay, revealing how bacteria interact with environmental factors and stressors.
AI enhances drug discovery by analyzing abundant data, identifying new targets and designing effective treatments, significantly reducing cycle time and costs. AI also improves clinical trial design and post-market surveillance, leading to safer and more personalized medications.
Coastal ecosystems worldwide are found to be a net sink for carbon dioxide and methane emissions, counteracting their own uptake. Fjords in North America and Southeast Asia take up significant amounts of CO2, while mangrove forests release more CH4 than estuaries.
A new study reveals that microorganisms can adapt to temperature changes and even benefit from them. The organisms differ in their sensitivity to temperature changes, with bacteria being more sensitive than fungi. This adaptation allows them to store carbon in soil, slowing down global warming.
Scientists from the Institute of Industrial Science, The University of Tokyo, have used in situ confocal microscopy to study colloidal gels. They found that different local particle arrangements uniquely modulated the properties of the gel, with tetrahedra arresting motion and pentagonal bipyramid clusters imparting solidity.
A research team has developed a method to identify genetic variations responsible for differences in plant traits. The study found thousands of variations associated with traits like yield and pest resistance in maize. These regions can be targeted for plant breeding, leading to improved crop varieties.
A study found that measuring three potential biomarkers on day three after a stem cell transplant can identify patients at risk of sinusoidal obstruction syndrome (SOS). Patients with positive scores were 9.3 times more likely to develop SOS and more likely to die within 100 days.
A new study suggests that modular production techniques can minimize construction delays caused by weather, resulting in cost savings for builders. The research estimates that using modular construction can reduce costs by approximately AUD$40,000 on a $6.4 million project.
Scientists found ceramic artefacts with wine residues from a Spanish olive jar dated between 1490-1520 AD on Isla de Mona, Puerto Rico. This discovery suggests that European wine was consumed by both Europeans and indigenous people shortly after the arrival of Spanish colonists.
Hanna Kokko, a renowned theoretical evolutionary biologist, has been awarded the Alexander von Humboldt Professorship for her groundbreaking research on the interplay between evolutionary and ecological factors. She will receive EUR 3.5 million to establish her research team and obtain necessary equipment and facilities.
A new study shows that the Montreal Protocol is delaying the occurrence of the first ice-free Arctic summer by as much as 15 years. The treaty's implementation has postponed the melting of Arctic sea ice at this very moment, yielding measurable results within a few decades of its implementation.
A new study by Potsdam Institute for Climate Impact Research and Mercator Research Institute finds that the current difference between savings and lending rates results in additional global heating of 0.2 degrees Celsius. Governments can effectively counteract high interest rates on loans by subsidising investment, leading to more foss...
Research reveals that age-dependent changes in germinal centres lead to reduced vaccine response in older people. The study demonstrates that reversing these changes can be achieved through interventions.
Women who experience adverse pregnancy outcomes are at a higher risk of developing stroke, with those having recurrent issues facing a twofold increase. Lifestyle interventions and sharing pregnancy history with doctors may help reduce this risk, according to the study published in the journal Stroke.
New research shows that the Montreal Protocol is delaying the first ice-free Arctic summer by up to 15 years. The treaty's regulation of ozone-depleting substances has slowed global warming and preserved the ozone layer.
A University of Gothenburg study found that individuals who engaged in regular physical activity had smaller hemorrhages upon arrival at the hospital. Physically active patients experienced 50% less bleeding volume compared to inactive ones.
A recent study published in JAMA Pediatrics monitored the safety of Pfizer-BioNTech COVID-19 vaccine in over 3 million children, identifying only rare cases of myocarditis or pericarditis, consistent with previous reports. The results provide additional evidence supporting the safety of COVID-19 vaccines in children ages 5 to 17.
Cell death is a crucial process in organisms, preventing tumor development and pathogen spread. Researchers at the University of Basel have now elucidated the exact mechanism of cell death, revealing that a specific protein called ninjurin-1 assembles into filaments that open the cell membrane, leading to its disintegration.
The study found a significant increase in mental health diagnoses among female youth, especially adolescents, during the COVID-19 pandemic. This trend was most pronounced for eating disorders, with vulnerable populations showing marked increases.
A new study suggests that curbside recycling can compensate for greenhouse gas emissions from landfills, providing a return on investment similar to or better than electric vehicles. The authors recommend restructuring programs to target high-value materials and implementing policies to relieve cost burdens on local governments.
Researchers identified TAp63 as a key protein in rheumatoid arthritis, which is targeted by methotrexate. Lowering TAp63 expression improves autoimmune arthritis in mice.
Researchers have found that craniospinal radiation can control metastasis in diffuse midline gliomas, leading to improved treatment options for patients. The study suggests that this approach may lead to long-term survival and potentially curative effects for these children.
Research finds that piecemeal feedback increases consumer impatience when provided at a fixed pace after specific behaviors. This association strengthens the connection between actions and outcomes, motivating consumers to pursue prompt results and leading to increased frustration.
Researchers aim to understand and utilize quasiparticles called excitons, which can transport energy without a net electric charge. The goal is to design energy-efficient systems that detect and emit light across a wide range of frequencies.
A comprehensive review of consumer research journals reveals growth in non-marketing journals focusing on consumer research, particularly since 2019. Emerging topics such as food waste, technology, and sustainability reflect contemporary issues pertinent to consumers.
Researchers discover a molecule that destroys aged cells without affecting healthy ones, paving the way for delaying tissue ageing. Testing with animal models will now begin to explore its potential anti-cancer effects and improve life expectancy.
A study by NIST and University of Colorado Boulder collected breath samples from participants before and after smoking high-THC cannabis, revealing that distinguishing between recent use and past use remains challenging. The research aimed to develop a reproducible protocol for breath measurements, which will help answer key questions ...
Victims of sexual assault are often blamed for not fighting back, but neuroscientific research suggests this may be due to involuntary immobility. Thirty per cent of women experience sexual assault or rape in their lifetime, and 70% report being 'frozen' during the ordeal.
New research suggests that fine particulate matter catalyzes oxidative stress in the lungs by converting peroxides into highly reactive hydroxyl radicals. This study challenges current paradigms for assessing air pollution's differential toxicity.
Researchers have cloned the wheat rust resistance genes Lr9 and Sr43, revealing that they encode unusual kinase fusion proteins. This breakthrough enables new options for addressing disease resistance in bread wheat and could lead to heat-resistant versions of the Sr43 gene to adapt to climate change.
An international consortium led by Amsterdam UMC has developed an improved version of the wireless pacemaker, enabling placement in both the atrium and ventricle of the heart. This innovation expands treatment options for patients with slow heart rhythms, improving contraction and reducing the need for multiple mini pacemakers.
Researchers developed a mathematical model that accounts for variables such as helicopter resources and operational range to optimize air movement tasks. The model can perform planning functions in under an hour, saving commanders three to five hours compared to traditional methods.
A new study reveals that increased sugar intake and elevated blood glucose levels can cause amyloid plaque buildup in the brain, increasing the risk of Alzheimer's disease. Researchers identified a metabolic sensor on neurons linked to this process, suggesting potential therapeutic benefits for diabetic patients.
Researchers from the UCLA Jonsson Comprehensive Cancer Center are presenting findings on combination therapies for breast cancer and a potential new treatment for patients with recurrent glioma. A phase 3 study evaluating vorasidenib versus placebo in patients with residual or recurrent grade 2 glioma with an IDH1/2 mutation is also be...
Brackish groundwater has the potential to replace fresh water for cooling coal- and natural gas-fired power plants, but treatment can be energy intensive. The study found that retrofitting power plants to use brackish water could nearly eliminate fresh water usage, but increase electricity generation costs by 8-10%.
Researchers at Duke University have discovered a class of compounds called argyrodites that could lead to the development of safer and more efficient solid-state batteries. The materials' unique crystalline structures allow for fast ion conduction, making them promising candidates for energy storage applications.
Researchers discovered that students working with a social robot featuring a charismatic voice produced more original and elaborate ideas compared to those who interacted with an identical robot using a flat voice. The study found that the charismatic robot's engaging tone increased team positivity, perceived effectiveness, and creativ...
New research published in Social Psychological and Personality Science found that guilt-prone people are less likely to accept bribes, especially when the act would cause obvious harm to other people. The study highlights the importance of assessing candidates' guilt proneness in personnel selection, particularly for leadership positions.
An international team found that volcanic eruptions can produce equatorial plasma bubbles in the ionosphere, disrupting satellite-based communications. The Tonga eruption triggered an irregular structure of electron density across the equator, delaying radio waves and degrading GPS performance.
Research suggests that brain's electrical activity tunes sub-cellular components to optimize network stability and efficiency. This 'Cytoelectric Coupling' hypothesis proposes that electric fields influence neurons' physical configuration to fine-tune information processing.
Researchers at Heidelberg University have identified a molecular mechanism controlling root branching in plants, which involves the activity of the target of rapamycin (TOR) protein. The study found that glucose plays a crucial role in forming lateral roots, and TOR acts as a gatekeeper to regulate this process.
Researchers at HSE MIEM develop mathematical model to enhance supercapacitor electrical capacitance by utilizing polymers with large pore sizes. This enables storing more energy and preventing potential adverse effects.
The researchers developed a Revealed Preference Argumentation framework and an Integrated Preference Argumentation framework, which unify two main approaches to RPT. They also created comprehensive algorithms for IPA frameworks and tested the tool on RPT-based consumer behavior analysis.
Researchers found that hydrocortisone was associated with a decrease in the need for vasopressor drugs and improvement in survival when used in combination with other corticosteroids. The study also suggests that combining fludrocortisone with hydrocortisone may provide a greater benefit in terms of survival.
Researchers comprehensively reviewed recent discoveries in 2D material mechanics, highlighting elastic properties, failure, and interfacial behaviors. Computational advancements are crucial for understanding dynamic behaviors and practical applications.
A new paper analyzes the olive shrub Phillyrea angustifolia's mating system using Kuhn's paradigm shift framework. The discovery of diallelic self-incompatibility resolves a long-standing paradox, demonstrating how science can undergo significant changes in response to emerging data.
A new research project, LC-H2, will develop next-generation electrodes to boost energy efficiency in electrolysis. This will help reduce grey hydrogen's carbon footprint and increase the share of green hydrogen in European energy systems.
A new AI method accurately predicts enzyme-substrate pairs, opening doors for efficient drug discovery and biotechnology. The ESP model, developed by a team of researchers, can work with any combination of an enzyme and over 1,000 substrates.
A new study shows public acceptance of phage therapy is moderately high and can be increased through education. The study found that describing phage therapy in a more positive light increases its acceptance, while exposure to information about antibiotic resistance also plays a role.
Researchers used a multiomics approach to analyze changes in transposable elements after influenza A virus infection, identifying transcription factors contributing to individual responses. The study provides insights into the variable severity of illness among individuals infected with the same virus.
Researchers have recorded pain-related data from inside the brains of individuals with chronic pain disorders, identifying an area associated with chronic pain and objective biomarkers. The findings, published in Nature Neuroscience, represent a step towards developing novel methods for tracking and treating chronic pain.
A team of researchers developed a deep-learning model called WearNet that uses Fitbit data to detect depression and anxiety. The study found that WearNet performed better than state-of-the-art machine learning models in detecting these conditions, producing individual-level predictions.
A recently discovered protein domain, MOTH, has been found to regulate collagen transport between cells and organelles. This domain, which evolved over several hundred million years, is responsible for identifying and transporting the collagen protein.
Researchers discovered that marsupial brains exhibit region-specific patterns of cortical activity during early development. This finding provides valuable information about human brain development and may inform strategies for improving cognitive function in humans.
A team of researchers at NYU College of Dentistry has successfully modified an existing anti-nausea drug to target the endosomes within cells, thereby providing a more prolonged analgesic effect. The modified netupitant showed improved pain-relieving properties compared to its original form and other drugs targeting similar receptors.
Researchers have found that honokiol, a compound from magnolia tree bark, inhibits SARS-CoV-2 replication in several cell types, reducing infectious particle production. The compound also shows broad-spectrum activity against other highly pathogenic coronaviruses.
Researchers have developed a new method to study ant brain chemistry, revealing differences in neuropeptide distribution between two species. The approach integrates 3D chemical data with high-definition anatomical models, providing unbiased visualization of neurochemistry.
Researchers at UC San Diego have created a wearable ultrasound system that can monitor deep tissue vital signs continuously, even in subjects on the go. The device uses machine learning to track movement and adjust its focus, providing real-time cardiovascular data.
Necrotizing Enterocolitis (NEC) Awareness Day is now recognized by California, thanks to advocacy efforts led by the NEC Society. The state's declaration aims to accelerate prevention and treatment options for this devastating disease affecting medically fragile infants.
A large population-based randomized controlled trial found that providing better opportunities for exercise and group training can prevent falls and fall-related injuries among older women. The study showed a significant reduction in recurrent falls, fall-related injuries, and fractures caused by falls.
A recent study published in Archives of Sexual Behavior found that married individuals who cheat report high levels of sexual and emotional satisfaction, but low levels of regret. The survey of over 2,000 Ashley Madison users revealed that fundamental problems with the relationship are often less cited as motivations for infidelity.