Bacteria have found a way to survive stressful environments by producing microscopic syringes called Streptomyces phage tail-like particles (SLPs) that are located inside the cell. These SLPs interact with cellular systems involved in cell wall synthesis and protein translation, providing resistance against osmotic stress.
Researchers found that participants who were physically active in the afternoon had greater reductions in blood sugar than those most active at other times of day. This study suggests timing of activity may be important for managing blood glucose levels.
A new Yale-led study found that river erosion generates biodiversity of freshwater fish species in the Appalachians. The research suggests that gradual internal dynamics of erosion isolate populations, leading to speciation.
Researchers used AI to identify a compound that kills Acinetobacter baumannii, a bacterium responsible for many drug-resistant infections. The new antibiotic shows promise in combating this growing public health threat.
Researchers found varying microbiome compositions in early-onset (age 45 or younger) and late-onset (age 65 or older) colorectal cancer tumors, with distinct species present in each group. The discovery may help explain the rise in young-onset disease cases without known risk factors.
A study by Florida Atlantic University and CINVESTAV found that long-term running maintains the connectivity of adult-born hippocampal neurons, which contribute to memory function during aging. Exercise may prevent or delay age-related memory decline by increasing the survival and modifying the network of these neurons.
Researchers from Oregon Health & Science University have discovered how stem cell transplantation can kill the virus that causes AIDS. The study, published in the journal Immunity, reveals that two circumstances must co-exist for a cure to occur and documents the order in which HIV is cleared from the body.
Scientists have discovered that increasing expression of the RIT2 gene reduces alpha-synuclein accumulation and protects neurons from cell death in Parkinson's disease. This breakthrough offers hope for developing a simpler intervention to reduce risk of the disease.
Researchers explore ED visits as a continuum of care, evaluating frailty in older adults and deprescribing medications. The studies aim to improve subsequent care through better communication between emergency departments and primary care doctors.
Researchers developed a scalable approach to synthesize ferromagnetic single-atom spin catalysts, which exhibit interatomic quantum spin exchange interaction and induce local magnetic moments. The Ni1/MoS2 SASC demonstrates a dramatic enhancement of OER magnetocurrent by 3,000% under a mild magnetic field.
A study published in Nature Microbiology highlights the need for better monitoring of bat coronaviruses globally. Researchers found substantial differences in coronavirus prevalence across studies, with gaps in South Asia, the Americas and Sub-Saharan Africa, and subfamilies of leaf-nosed bats.
A new combination treatment for brain hemorrhage significantly improves survival rates and reduces disability. The INTERACT3 study shows a Care Bundle of readily available treatments can improve outcomes, particularly in low- and middle-income countries where most cases occur.
Scientists at La Jolla Institute for Immunology found that MAIT cells can be tuned to fight different pathogens via their metabolism, with two distinct subtypes responding to sugar and fat. This discovery may inspire new vaccines and cell therapies to boost the immune response against specific pathogens.
Researchers analyzed 28 samples of curd cheese and mozzarella from Brazil and found aflatoxins in all, with levels below the European Union's upper limit. The study highlights the need for improved production practices throughout the dairy industry to minimize contamination.
Researchers found that communities with collective land rights were more cooperative during forestry and non-forestry activities, such as working on community projects. They scored higher on measurements of cooperation and tended to collaborate more on tasks like maintaining roads or digging wells.
Expert authors suggest a holistic approach to understanding compliance, considering legal and institutional aspects to generate trust among member states. They argue against one-size-fits-all solutions and formal sanctioning power, proposing a more nuanced approach to ensure effective pandemic prevention, preparedness, and response.
Researchers discovered that Trichodesmium filaments form aggregates through a simple behavioural strategy, controlling density and light penetration. This mechanism enables the formation of visible aggregates with unique shapes, providing essential nutrients for other marine organisms.
A new study published by LSU Health New Orleans found that a diet high in fruits, dark-green vegetables, and beans can significantly lower the risk of genital high-risk-HPV infection, which is associated with cervical cancer. The research also showed that women who eat healthily tend to practice other healthy behaviors.
A study by researchers from the University of Tsukuba found a key molecule involved in sleep homeostasis also plays a critical role in circadian behavior. The SIK3-HDAC4 pathway modulates the length of the circadian period through NMS-producing neurons, contributing to the sleep/wake rhythm.
Long-duration energy storage (LDES) is crucial for US states with decarbonization goals to address variable energy generation and customer demands. LDES systems can store renewable energy until needed, providing a reliable solution for a decarbonized grid.
Researchers found that formalin fixation does not significantly alter the polarimetric properties of brain tissue, making it suitable for training machine-learning models. The study suggests that formalin-fixed brain tissue specimens can provide high-quality data for rapid and accurate diagnostic imaging in surgery.
Scientists conducted computational simulations to clarify the origin of life on Earth. The study suggests that chiral asymmetry may have originated in space through CP Lyman-α emission line, influencing the production of biological amino acids.
Children begin considering past choices at age 6, influencing their moral judgments of others. As they grow older, they account for choice in judging character behavior.
Researchers have studied targeting telomeres as a potential therapeutic strategy for non-small cell lung cancer. Telomere dysfunction and telomerase deficiency slowed tumor progression, increasing vulnerability to DNA damage and immune system response.
Researchers identified 12 symptoms that most set apart those with and without long COVID, including post-exertional malaise, fatigue, and brain fog. The study's findings will help identify effective treatment strategies for people with long COVID.
Researchers at Weill Cornell Medicine have successfully converted human stomach stem cells into insulin-secreting cells, offering a promising approach to treating type 1 and severe type 2 diabetes. The transplants reversed disease signs in mouse models, suggesting good durability.
A new study from Tulane University found that eight social determinants of health significantly contribute to the racial mortality gap in the US. The research indicates that addressing these factors can eliminate the disparity in premature deaths among Black and White adults.
A study suggests that river erosion can drive biodiversity in geologically quiet environments, such as the Appalachian Mountains. The research found that changing landscapes pushed a species of fish into different tributaries, leading to distinct genetic lineages.
Researchers developed an experimental drug, 32-134D, that inhibits HIF protein levels, reducing blood vessel production and leakiness in diabetic eyes. The study shows promising results in both human cell models and mice, suggesting a safer therapeutic approach for diabetic eye disease.
Researchers at UC San Diego and Stanford University have developed a roadmap of root chemicals that are critical to plant growth, providing new insights into plant development. The study reveals that key small molecules are clustered in patches across the root, suggesting a purposeful distribution for optimal growth.
Scientists at the University of Michigan have created a structure called 'fire ice' using nanoparticles, which harnesses a strange physical phenomenon to manipulate light. The finding showcases an unusual effect called entropy compartmentalization, where entropic forces stabilize even more complex crystals.
A study by University of Technology Sydney found that plants can remove 97% of toxic compounds, including cancer-causing pollutants, from indoor air in just eight hours. This breakthrough discovery highlights the critical role played by indoor plants and green walls in improving air quality.
Researchers at Aalto University create a new bolometer that can accurately measure microwave power down to the femtowatt level at ultra-low temperatures. This breakthrough device has the potential to significantly advance quantum computing and technology, enabling more precise control over qubits and improving overall performance.
Researchers at UChicago's Pritzker School of Molecular Engineering have developed a method to constantly monitor noise around a quantum system and adjust qubits in real-time. The approach uses spectator qubits to track environmental changes and cancel out noise in vital data-processing qubits, improving the quality of data qubits.
The CALET team, including researchers from Waseda University, found that cosmic ray helium particles follow a Double Broken Power Law, indicating spectral hardening and softening in high-energy ranges. This deviation from expected power-law distribution suggests unique sources or mechanisms accelerating and propagating helium nuclei.
The COMMANDS trial showed improved red blood cell counts and erythroid responses in transfusion-dependent patients with myelodysplastic syndromes, allowing the majority to no longer require regular blood transfusions. Luspatercept demonstrated superior effectiveness over epoetin alfa in this study.
Researchers developed a drug treatment that inhibits YTHDF2, improving results of radiation therapy and preventing progression of distant metastasis. The treatment also prevents the "bad-scopal" effect, where radiation causes distant tumors to metastasize.
Researchers found that distant cancers alter liver function by inducing fat accumulation and inflammation in liver cells. The process involves secretion of extracellular vesicles containing fatty acids, which reprogram the liver to resemble fatty liver disease.
A new study maps French Canadian populations using a unique dataset of over five million records spanning 400 years, revealing the complex relationship between human migration and genetic variation. The research shows that the genetic structure of French Canadians is encoded within its genealogy.
A new gene editing tool exploits a bacterial immune system to target and eliminate antibiotic-resistant genes. The tool has shown early promise in laboratory experiments by protecting host cells from developing resistance and reversing it in resistant hosts.
Researchers at Chalmers University of Technology show that electrifying heavy goods vehicles can be profitable, even for long-distance trips. The study compared two battery sizes and fast charging prices, concluding that electricity is a cheaper alternative to diesel in many cases.
Researchers can reduce stigma in scientific literature by implementing practices such as referencing language guides, updating terminology, and connecting with the community. This change is crucial for promoting non-stigmatizing language and respecting preferred terms used by individuals living with HIV.
Scientists have developed a way to control the microscopic origin of high-efficiency solar cells by applying a sudden electric field spike in the form of terahertz radiation. This precise control over atomic twist motions may contribute to dynamic protection mechanisms and novel non-equilibrium material properties.
A citizen science project in Italy involved 500 Italian students in trapping and identifying ambrosia beetles, resulting in new geographical records for two quarantine pest species. The students gained a greater understanding of the negative effects of invasive alien species and increased awareness of biological invasions.
Researchers uncovered traces of Giardia duodenalis, a common cause of debilitating diarrhoea, in two Jerusalem latrines dating back to the biblical Kingdom of Judah. The study suggests dysentery was endemic in the Kingdom of Judah.
A new study found that canagliflozin, a type 2 diabetes drug, can dampen down T-cell activation, suggesting it could be repurposed to treat certain autoimmune diseases. This discovery provides a potential therapeutic route for patients with autoimmune disorders.
Researchers developed an automated spot assay system using a liquid-dispensing robot to evaluate yeast growth potential on agar media. The new system, which corrects variations in agar height and automatically observes and quantifies yeast growth, showed comparable accuracy to manual experiments.
A recent study led by UCLA researchers has identified a potential new strategy for treating glioblastoma by targeting a specific metabolic process in cancer cells. The study found that disrupting this process could make glioblastoma cells more vulnerable to cell death, offering hope for new treatment options.
A recent study has identified the specific gut bacteria that pose a threat to neonatal babies, particularly those with necrotising enterocolitis. Researchers analyzed genomic similarities in Clostridium perfringens and found a set of strains with lower disease-causing capacity, lacking genes responsible for toxin production.
Researchers analyzed a comprehensive dataset from Catholic parish records and genotype data to reveal how local topographies influenced French Canadian relatedness. They found that geographic features, particularly river networks, shaped Quebec's population structure and contributed significantly to the French Canadian gene pool.
The metaverse has the potential to make scientists more effective by removing barriers, improving teaching and learning, and enabling new experimental environments. Researchers must also plan well and avoid potential pitfalls, such as ownership and privacy issues.
Researchers designed and tested textile fibers that can change shape and generate force like a muscle, showing promise for use as cell scaffolds. The findings suggest the fibers could be used to develop 3D models of living, moving systems in the human body.
UMC Utrecht researchers are conducting two new projects to treat cancer using image-guided interventions. One project uses MRI-guided radiotherapy for locally advanced pancreatic cancer, while the other employs ultrasound techniques for head and neck cancers.
Researchers have identified a novel model and therapy to mitigate the development of REM sleep behavior disorder, which affects over 3 million Americans. Dual orexin receptor antagonists have been shown to significantly reduce dream enactment behaviors, providing a promising new treatment option.
A study suggests that iron-rich particles from meteors and volcanic eruptions could have generated precursors for organic molecules needed for life. The researchers found that these particles promoted the conversion of carbon dioxide into hydrocarbons and other compounds under various conditions.
A new study published in the Journal of the American College of Surgeons predicts a significant increase in cancer cases due to COVID-19 screening delays, with lung, breast, and colorectal cancers most affected. The study found that missed diagnoses during the pandemic may lead to delays in treatment and upstaging of disease.
The US has lost 57.6 billion tons of topsoil due to farming practices, but new research suggests no-till methods can drastically reduce erosion and extend fertility for centuries. No-till farming, currently practiced on 40% of Midwest cropland acres, can modelled to slow down soil loss.
Researchers discovered that knapping is far more dangerous than previously understood, with severe injuries including bone piercings, tourniquet needed ankles, and eye damage. Injuries varied across body parts, including hands, feet, legs, and torso.
Researchers at Penn State discovered that coal can act as a geological hydrogen battery, storing hydrogen for future use. The team found that coal's unique structure and properties make it an ideal material for hydrogen storage, with low-volatile bituminous coal performing best in tests.
Researchers at the Center for One Health Research have found that antiviral drugs can make antifungals work again by blocking efflux pumps in Candida auris. This approach may be a key treatment strategy against the deadly fungal pathogen, which has a 60% mortality rate.