A NTU Singapore study found that ageing alters brain cells' communication, leading to weakening connections and poorer memory in middle-aged mice. The research suggests strengthening these connections through memory training may delay age-related working memory decline.
A novel score, the Phoenix Sepsis Score, predicts mortality in children with suspected or confirmed infection. The new criteria outperform existing organ dysfunction scores and International Pediatric Sepsis Consensus Conference criteria
Prolonged endosomal defects lead to cell death, but the effects on cellular signaling were poorly understood. Endosomal stress caused by USP8 depletion induces immune responses and activates NF-kB- and Nrf2-mediated gene expression.
Researchers have developed a novel sequential ultrasound molecular imaging (USMI) approach to identify non-alcoholic steatohepatitis (NASH), offering a potential noninvasive diagnostic tool. The method uses microbubbles targeting CD36 and ICAM-1 to visualize hepatic steatosis and inflammation.
Researchers found Megalodon had an elongated body form more similar to the modern great white shark than previously thought. The study suggests that previous estimates of its length may have been too high, with some fossil vertebrae suggesting a total combined length of 11.1m but estimated total length including head being only 9.2m.
A team at Pohang University of Science & Technology has successfully created the world's first plumber's nightmare structure in block copolymers, a complex configuration where polymer chain ends coalesce inward. This achievement showcases the potential for self-assembly in block copolymers and opens up new possibilities for materializi...
Pediatric sepsis experts have released new diagnostic criteria that will be used worldwide to diagnose life-threatening infections in children. The updated criteria, known as the Phoenix Criteria, include measures of respiratory, cardiovascular, and coagulation dysfunction.
A new study by the University of Technology Sydney suggests that office air conditioning can reduce the risk of harm from wildfire smoke. The researchers found that air conditioning filters in UTS Buildings 4 and 7 captured a significant portion of wildfire smoke, reducing exposure to toxic particles for staff and students.
A new study published in Palaeontologia Electronica shows the Megalodon was more slender than earlier studies suggested, changing our understanding of its behavior and impact on ancient ocean life. The revised model suggests a longer digestive canal, potentially leading to less predation pressure on other marine creatures.
A new set of international criteria has been established to diagnose pediatric sepsis and septic shock in children, aiming to improve clinical care and research globally. The Phoenix Sepsis Score of at least 2 can identify potentially life-threatening organ dysfunction in infected children under 18 years old.
Researchers investigated the co-occurrence of gadolinium and sulfamethoxazole on the fate of antibiotic and heavy metal resistance genes in activated sludge systems. The study found that Gd and SMX affect ARGs, MRGs, and mobile genetic elements, providing new insights into their interactions and removal in wastewater treatment plants.
The new pediatric sepsis criteria, called the Phoenix criteria, define sepsis as severe response to infection involving organ dysfunction. These criteria were developed using data from over 3 million pediatric healthcare encounters worldwide and are better at identifying children with infections at higher risk of poor outcomes.
The study analyzes artificial mountain making in traditional Chinese gardens from a topographical perspective, highlighting the importance of form, space, and time in creating dynamic landscapes. The research contributes to the development of Landscape Architecture in contemporary China.