Researchers at Case Western Reserve University have developed an electrochemical CRISPR platform that can detect specific viruses, such as HPV and parvo, in a single droplet of blood. This innovative device has the potential to provide accurate results in under an hour, compared to existing tests which take three to five days.
A new AI-powered analysis has improved understanding of stage 0 breast cancer, identifying which patients are most likely to progress to invasive cancer. The research suggests that some patients may not need radiation therapy, contrary to current prevailing wisdom.
Researchers will study immune responses needed to prevent initial infection, establish latent infection, and transition to active TB, with a global footprint.
A study by Case Western Reserve University found that spending more on transitional housing for teens aging out of foster care can prevent homelessness, incarceration, substance abuse, and early childbirth. States that spend above average on housing support have lower rates of negative outcomes among these youth.
A study from Case Western Reserve University found that entrepreneurs who pitch their startup ideas with passion are more likely to entice investors. The researchers used functional Magnetic Resonance Imaging (fMRI) to examine the neural responses of investors' brains, revealing a causal relationship between passion and interest. As a ...
A novel swallowable balloon device has been cleared by the FDA for clinical use, allowing for early detection of Barrett's esophagus and reducing the risk of esophageal adenocarcinoma. The test is more than 90% sensitive and non-invasive, making it a promising tool for screening and prevention.
A new study reveals a shift in obesity-associated cancers towards younger individuals, with significant increases in certain types of cancers among non-Hispanic Black and Hispanic women and men. The study found that the number of cases of these cancers increased by 25% to 400% in specific populations between 2000 and 2016.
The study aims to improve caregiver physical and emotional well-being, increase confidence for caregiving, and enhance patient outcomes. Researchers will use simulation-based learning to train 180 family caregivers, comparing results to a control group.
A new pathway has been identified as a potential treatment target for Crohn's disease, a form of inflammatory bowel disease that affects millions in the US. The study suggests that blocking a specific protein receptor may ameliorate inflammation and fibrosis in CD patients.
A new skin test using ultrasensitive technology may provide an early diagnosis of Alzheimer's and Parkinson's diseases, detecting misfolded proteins in skin samples. The RT-QuIC test is highly sensitive and specific, offering a promising tool for diagnosing and characterizing these neurodegenerative diseases.
A new combination treatment regimen enhances the immune system's ability to kill leukemias that do not respond to standard treatments. The regimen includes a therapeutic antibody designed to attract natural killer immune cells to cancer cells, resulting in increased killing of acute lymphoblastic leukemia cells by up to 35%.
A recent grant from the National Institutes of Health will support a study investigating the interaction between gut bacteria and fungi in Crohn's disease. The research aims to identify genetic mechanisms underlying these interactions and develop novel antifungal and probiotic strategies to decrease symptoms.
A new study using a cryo-electron microscope provides critical information for developing anti-nausea drugs that are effective against cancer patients' vomiting side effects. The high-resolution images reveal the attachment site of widely-used setron drugs on serotonin receptors, offering insights into how their design might be improved.
A recent study published in PLoS Neglected Tropical Diseases reveals that female Anopheles mosquitoes bite more often and have varied diets than previously assumed. The study also found that certain species of Anopheles mosquitoes, typically considered less important for malaria transmission, are infected with the Plasmodium parasite.
A CWRU team will provide regulatory guidelines for non-traditional gene editing experiments, aiming to protect the public while encouraging creativity and innovation. The researchers will explore options such as licensure requirements, experiment reporting, and equipment restrictions.
Researchers successfully combined ceftazidime-avibactam and fosfomycin to fight P. aeruginosa in mouse models, outperforming individual antibiotics. The combination reduced the presence of the bacterium significantly, offering a potential therapeutic strategy against superbugs.
Researchers call for better diagnosis and treatment protocols due to misdiagnosis, resource waste, and patient discomfort associated with BMS. The condition's symptoms can be easily treated if underlying causes are identified.
A researcher at Case Western Reserve University has developed a data-driven algorithm that uses electronic medical records and computer science to identify which patients would benefit from air transfer. The study aims to reduce unnecessary helicopter transfers, saving patients and healthcare costs.
Researchers found that an anti-malarial drug called artemisinin can help sensory cells of the inner ear recognize and transport essential proteins to specialized membranes. This could lead to new therapeutic options for people with Usher syndrome, a common genetic cause of hearing loss.
Researchers found that mountain streams retain sediment for thousands of years, revealing a waterway's history. Climate-induced threats like wildfires and increased precipitation will alter the dynamics of other rivers, including the Cuyahoga River.
A physics professor at Case Western Reserve University has developed a theory that explains how basic ordered patterns emerge in music using statistical mechanics. The theory reveals that the same principles guiding physical systems also govern musical harmony, shedding new light on the fundamental structure of music.
Researchers outline detailed sequence of events where a GPCR encounters its downstream signaling partner, providing insights into fundamental mechanisms of drug-induced signaling. The new analysis technique can identify precise amino acids most central to GPCR function, enabling potential sites for precision drug targeting.
The Case Comprehensive Cancer Center has been selected as a Lead Academic Participating Site by the National Cancer Institute for a six-year grant worth $8.9 million. This renewal grant enables the center to provide patients with additional access to clinical trials through the National Clinical Trials Network.
Researchers at Case Western Reserve University have made breakthroughs in identifying who will benefit from chemotherapy using artificial intelligence and radiomics. The studies focused on markers outside the tumor that can indicate treatment response, providing hope for personalized medicine and improved patient outcomes.
Researchers from Case Western Reserve University have developed an open-source quality-control tool to assess the quality of digital tissue slides. The tool, called Histo-QC, incorporates measurements and classifiers to flag corrupted images and retain high-quality slides for analysis by computers.
A groundbreaking experiment has successfully restored some functions and structures in donated pig brains for up to four hours after they were butchered. The result challenges the notion that mammalian brains are fully and irreversibly damaged by a lack of oxygen, raising questions about when to save patients and organs.
A study led by Case Western Reserve University aims to identify genetic biomarkers for corneal ulcer infections, which can lead to blindness. The research focuses on contact lens wearers and will explore the genetic profile of those who contract infections versus those who don't.
Researchers at Case Western Reserve University have identified a novel probiotic mix that can weaken and break apart stubborn microbial biofilm communities in the gut, which are often resistant to antibiotics. The study suggests this probiotic could help patients with gastrointestinal diseases avoid harmful biofilms that worsen symptoms.
A new study published in the Journal of Human Evolution provides evidence for a more robust adaptation to bipedalism in the human ancestor Ardipithecus ramidus. The research shows that Ardipithecus used its big toe as a propulsive lever when walking, marking a key transitional phase in human evolution.
LeVar Burton receives the Inamori Ethics Prize for his decades-long dedication to promoting children's literacy and supporting AIDS research. The award recognizes his tireless advocacy and impact on the human condition.
A new study from Case Western Reserve University finds that low- to middle-income individuals with subsidized health-exchange insurance are more likely to experience problems with access and affordability. They are 2.5 times more likely to have difficulty paying medical bills and skip needed care, compared to Medicaid recipients.
Researchers at Case Western Reserve University have identified two molecular pathways that could lead to new treatments for esophageal cancer. By blocking the JNK and TGF-beta pathways, tumors can be slowed in growth and even regressed in mice. The study's findings suggest a new targeted therapeutic avenue for this deadly form of cancer.
Researchers at Case Western Reserve University discovered that gut bacteria secrete nitric oxide to communicate with mammalian hosts, controlling gene expression and influencing human health. This 'interspecies communication' strategy has implications for diseases such as Alzheimer's, Parkinson's, and cancer.
A $3.34M NIH grant will aid in understanding how bacteria resist antibiotics by targeting cell-wall strengthening machinery in B. multivorans and identifying peptide-based inhibitors to block this process. Novel peptides may enhance the immune response and synergize with existing antibiotics to treat drug-resistant infections.
A four-year, $1.3 million grant from the National Institutes of Health will support the development of a decision-making tool to help care providers tailor treatments for intimate partner violence (IPV). The project aims to reduce inequalities in current treatment methods and improve outcomes for victims and perpetrators.
Researchers found blood cells retain intrinsic age nearly two decades after transplant, using epigenetic patterns to calculate cellular age. The study suggests blood cells could be the master clock of human aging, with implications for understanding age-associated diseases and developing new therapies.
A new method, developed by Case Western Reserve University researchers, identifies effective second-line antibiotics for treating germs resistant to first-line antibiotics. The approach could help clinicians choose the best treatment for patients and overcome antibiotic resistance.
Researchers found that dragonflies with darker wings absorb more heat, leading to stronger flight and successful territorial battles. However, at extremely high temperatures, dark-colored wings cause overheating and poor flight, potentially leading to reproductive difficulties.
The Internet of Things Collaborative has received an additional $2.2 million grant from the Cleveland Foundation to build on its early successes and position Cleveland as a leader in digital innovation. The collaborative aims to harness IoT's vast potential across four sectors: manufacturing, health, energy, and municipal infrastructure.
Researchers developed a new skin test to detect prion infections before symptoms appear, using RT-QuIC and sPMCA methods. The study demonstrates the preclinical utility of skin samples in detecting prions, which could serve as a biomarker for early diagnosis.
Researchers Julie Renner and Mohan Sankaran have developed an electrolytic process with a plasma to create ammonia from nitrogen and water at low temperature and pressure. This process could lead to smaller, more localized ammonia plants powered by alternative energy.
John Tilton will receive funding to develop a nanoPOD platform to deliver therapies to specific tissues in mice affected by genetic disease. The project aims to address the challenge of delivering nanoscale therapeutics to the right location inside the body.
Case Western Reserve University researcher Sanjay Gupta has been awarded nearly $1 million to investigate drug resistance mechanisms in prostate cancer. He will test two promising medications, simvastatin and metformin, to overcome drug resistance and halt metastasis.
Researchers at Case Western Reserve University have developed a novel computerized approach to detect lung cancer using routine CAT scans. The method analyzes patterns of heterogeneity within and outside the tumor, distinguishing benign from malignant nodules with high accuracy.
A CWRU researcher has secured a $14.6 million grant to study Alzheimer's disease in diverse populations, including African-Americans and Hispanics. The project aims to identify new genetic factors and improve understanding of the disease's impact on these communities.
HIV-infected patients have a higher risk of developing cancer due to the presence of fewer T-cells in their bodies. Researchers found that exosomes play a key role in supporting cancer growth and spread in these patients, who are 500 times more likely to be diagnosed with Kaposi sarcoma.
Researchers have developed two new mouse models to study schizophrenia and found that restoring ErbB4 receptors alleviates symptoms regardless of brain development. The study suggests a therapeutic approach focused on improving brain cell signaling associated with the ErbB4 receptor.
Researchers discovered a new pathway to enhance kidney self-repair by reprogramming the body's metabolism. The 'lift and push' process involves shifting glucose from energy production to repair damaged cells, resulting in improved lifespan for injured animals.
A breakthrough study has demonstrated that long-term effects of spinal cord trauma on breathing and limb function may be reversible. Rats treated with a new therapy regimen regained complete diaphragm and partial forelimb function, with full recovery maintained six months after treatment.
Researchers at Case Western Reserve University are developing a new system that uses changes in vibrations, sound, and electrical fields to improve energy consumption and monitor occupants' movements. The system has the potential to provide energy savings, track structural integrity, and enhance building safety.