Aalto University researchers have developed a natural wax coating that makes garments water-resistant and breathable, using carnauba wax and a cheaper, cationic starch alternative. The coating retains breathability and natural feel while being environmentally friendly.
The BEACON CRC Phase III clinical trial found that the three-drug combination of encorafenib, binimetinib, and cetuximab significantly improved overall survival in patients with BRAF-mutated metastatic colorectal cancer. Median OS for the triplet-targeted therapy was 9 months compared to 5.4 months for standard therapy.
Research reveals that subsequent terrorist attacks are more likely to occur within a 20km radius of the initial attack, suggesting a localized pattern. The study also finds that group alliances and rivalries play a crucial role in shaping terror activity, with mutually reinforcing effects between terror attacks and state intervention.
A study of 79,000 gun purchasers found that those with prior DUI convictions were at increased risk of arrest for violent crimes. Gun purchasers with DUI convictions were 8.8% more likely to be arrested for violent crimes compared to those without a criminal history.
Tetravinylallene, a highly unsaturated molecule with two adjacent double bonds, has been synthesized for the first time, offering a new approach to constructing complex molecular frameworks. Its symmetry enables chemists to perform multiple reactions in one step, making it a potent tool for synthesizing natural products and drugs.
A new method uses neutron beams to establish facts about warheads, physically encrypting information to prevent disclosure of military secrets. The system balances verification with secrecy for countries involved in arms reduction pacts.
Research reveals how CBD inhibits emotional processing in rats exposed to THC, reducing anxiety behaviors. The study proposes a bi-directional control of ERK1-2 phosphorylation as the key mechanism behind these findings.
Researchers found that women with asthma are more likely to have lower levels of free testosterone and estradiol compared to those without asthma. Elevated sex hormone levels were associated with reduced odds of asthma in both men and women, particularly obese individuals.
Scientists have successfully implanted an electronic device into tobacco plants, allowing them to deliver a stress hormone called ABA. This enables the plant to close its small pores and conserve water.
A UC Davis study found that handgun purchasers with a prior DUI conviction are at a higher risk of future arrests for violent crimes, including murder and assault. The research used California crime data from 2001 to 2013 to identify purchases made by individuals with at least one DUI conviction.
Researchers developed a new approach to diagnosing melanoma using microRNA biomarkers, achieving high sensitivity and specificity rates. The method overcomes challenges of tumor heterogeneity and improves diagnostic accuracy, potentially leading to earlier detection and better patient outcomes.
A phase III trial found that olaparib significantly delayed disease progression by about four months compared to enzalutamide and abiraterone, resulting in a 66 per cent greater delay. The study highlighted the importance of genomic testing in prostate cancer patients.
A recent study has shown that targeting faulty DNA repair mechanisms can slow the progression of advanced prostate cancer and improve survival rates. The PROfound trial demonstrated a significant delay in cancer progression with olaparib, compared to new hormonal agents, in patients with metastatic, pre-treated prostate cancer.
Tropical Storm Narda is expected to produce heavy rainfall along Mexico's west coast, with potential accumulations ranging from 1-6 inches. NASA's Aqua satellite captured images of the storm, revealing deep convection and cloud tops colder than minus 80 degrees Celsius.
A study of nearly 9,700 Medicare beneficiaries found that food insecurity was common among older adults (1 in 10) and individuals with long-term disabilities (4 in 10). Lower incomes and reporting multiple chronic conditions were associated with increased risk of food insecurity.
New research finds that climate change may exacerbate species conflicts, driving extinctions, and highlights the importance of landscape connectivity. High movement rates can reduce conflict, emphasizing the need for well-connected landscapes.
Scientists developed computational models of word meanings and tested them against real-time brain activity in volunteers, revealing how the brain combines words to make sense in context. The study shows how word constraints directly affect meaning interpretation, highlighting the neural mechanisms behind spoken language understanding.
UT Dallas researchers have shown that hyperspectral imaging and AI can predict the presence of cancer cells with 80-90% accuracy in 293 tissue specimens. This technology, called a smart surgical microscope, aims to reduce operating time, lower medical costs, and save lives.
A new study published in Health and Place found that living close to the coast supports better mental health in England's poorest urban areas. The research analyzed data from nearly 26,000 respondents and revealed a link between coastal proximity and reduced symptoms of mental health disorders among low-income households.
Researchers developed a machine learning method to enhance optoacoustic imaging quality without sacrificing it. The approach uses sparse data, allowing for reduced sensor numbers and improved diagnosis accuracy, facilitating clinical decision-making.
Researchers found polyethylene terephthalate (PET) drinking bottles are the most abundant type of debris, increasing at 14.7% annually since the 1980s. The majority of recent bottles were manufactured in Asia, with China being a primary source.
Researchers at Kyoto University have developed a method to selectively amplify the effect of X-ray radiation on cancer cells. The technique uses specially designed silica nanoparticles loaded with gadolinium, which releases low-energy electrons when hit by precisely tuned X-rays, damaging cancer cell vital components and killing them.
A Waseda University-led research reveals that SET/TAF1, a proto-oncogene, functions as a tension sensor to regulate Aurora B kinase activity and maintain even chromosome distribution. This discovery sheds light on the molecular mechanism of cancer-causing oncogenes and their role in leukemia development.
Typhoon Mitag continues to produce strong thunderstorms around its cloud-filled eye, affecting Taiwan and forecasted to graze China's east coast. The storm is at peak intensity, moving northwards with maximum sustained winds near 75 knots.
The US National Institutes of Health (NIH) has awarded a grant to Sydney-based company Kinoxis Therapeutics to develop a potential treatment for opioid withdrawal. KNX100, a small molecule therapeutic drug candidate, is being developed to treat opioid-use disorder and other substance use disorders.
A two-year study in Sydney's urban coastal environments reveals that some beaches have elevated levels of antibiotic-resistant bacteria following rainfall. The research highlights the exchange between human wastewater streams and natural ecosystems, posing a risk to human exposure to antibiotic-resistance bacteria.
Researchers discovered that supernatural beings are attractive due to mind-based abilities, ambiguity, and the potential for eliciting both love and fear. This finding has implications for understanding the psychology of belief and devotion in religious contexts.
A study by UCLA researchers found that adding ribociclib to standard hormone therapy significantly improves overall survival in postmenopausal women with advanced hormone-receptor positive/HER2- breast cancer. The combination treatment demonstrated a 28% reduction in risk of death and improved progression-free survival.
Researchers at Intermountain Medical Center found that wrist-worn step trackers can estimate exercise capacity and determine health status of patients with pulmonary disease. This technology allows for more frequent monitoring of patient progress and disease management, enabling early interventions to improve outcomes.
New research from the University of Oxford suggests that poorly reported placebos can influence treatment outcomes, leading to incorrect inferences about a new treatment's effects or harms. The study highlights the need for more transparent reporting of placebo components in clinical trials.
An international study used human retinal cells to demonstrate how the Toxoplasma parasite creates a distinctive eye lesion. Researchers identified proteins produced from infected cells that push neighboring uninfected cells to overgrow and create a characteristic lesion.
The Antarctic ozone hole's decline has indirectly helped increase sea ice due to altered atmospheric and oceanic circulations. Ozone-induced changes impact sea surface temperatures and dynamics of sea ice.
A recent study published in the New England Journal of Medicine found that nintedanib slows the progression of a broad range of scarring lung diseases. The medication was shown to be effective in patients with progressive fibrosing interstitial lung disease, regardless of the underlying cause or pattern of lung fibrosis.
Two studies show that CDK4/6 inhibitors plus fulvestrant significantly improve overall survival in hormone receptor-positive advanced breast cancer. The combination is recommended as a standard of care for patients with metastatic disease.
A new phase III trial found that immune therapy added to chemotherapy improved pathological complete response in patients with early triple negative breast cancer, leading to a clinically meaningful benefit and potential cure for more patients. The study also indicated an improvement in event-free survival.
A smart shirt has proven to be accurate in measuring breathing, with results similar to traditional equipment, according to European Respiratory Society research. The Hexoskin senses chest movements and records air volume, heart rate, and movement, making it a practical alternative for monitoring lung function.
A survey of 905 Italian truck drivers found that nearly half suffer from at least one sleep-related breathing problem, with a significant risk of OSA due to lifestyle factors such as poor diet and physical inactivity. The study highlights the importance of compulsory testing for sleep-related breathing problems among haulage companies.
A new study presents promising results from the CheckMate 358 trial, a phase I/II investigational immune-therapy trial combining nivolumab and ipilimumab for recurrent and metastatic cervical cancer. The combination showed higher clinical benefit rates compared to single-agent treatments.
A Rutgers study reveals that new risk factors have emerged for heart valve infections, which can be deadly and affect patients with heart disease or artificial valves. The study found a significant increase in hospital-acquired cases, attributed to staphylococcus bacteria, highlighting the need for tailored prevention strategies.
Researchers developed a more efficient statistical model to analyze extreme weather events globally, identifying regions with high precipitation levels and predicting their frequency. The model can handle vast amounts of data from multiple locations, providing valuable insights for disaster planning.
Researchers discovered mechanically delivered projectile weapons in Europe dating back 45,000-40,000 years, indicating modern humans had a hunting advantage over Neanderthals. The spearthrower and bow-and-arrow technologies allowed for higher impact energy hunting strategies, leading to the replacement of Neanderthals.
Scientists at the University of Hong Kong and Hunan Normal University have realized a giant magnetic field through moiré pattern engineering. The magnetic flux per supercell is quantized, and the field magnitude scales inversely with the square of the moiré period.
A recent international trial showed that patients requiring emergency heart attack treatment also benefit from further intervention to reduce the risk of future heart attacks. The study found that additional stenting for significant narrowings in other untreated arteries significantly reduces the risk of future heart attacks and death.
A new trial shows that adding a PARP inhibitor to bevacizumab improves ovarian cancer patients' chances of responding to chemotherapy. The study found median progression-free survival of 22.1 months in the olaparib arm, compared to 16.6 months in the placebo group.
A combination of ipilimumab and nivolumab has stopped or reversed melanoma progression for five years in nearly half of patients, offering new hope for advanced melanoma patients. The Checkmate 067 trial found a 52% five-year overall survival rate, with 74% treatment-free after five years.
First-line osimertinib significantly lengthens overall survival compared to older generation EGFR-TKIs in patients with Ex19del/L858R EGFR mutated advanced non-small cell lung cancer. The median overall survival with osimertinib was 38.6 months, with over half of patients alive at three years.
A new blood test has been developed to detect multiple types of cancer, including hormone receptor-negative breast, colorectal, and pancreatic cancer, with a high degree of accuracy. The test uses next-generation sequencing technology to probe DNA for methylation patterns associated with cancer.
Professional drivers, including taxi drivers, experience high levels of black carbon exposure while working in congested cities. Research found that taxi drivers are exposed to an average of 6.5 micrograms of black carbon per cubic meter of air, compared to office workers at home who experience similar levels.
The CheckMate-227 trial found that the combination of nivolumab and low-dose ipilimumab improves overall survival in patients with advanced non-small cell lung cancer compared to chemotherapy. The treatment was well-tolerated, with a low rate of discontinuation and treatment-related toxicities.
A Phase III trial validates the benefit of veliparib for patients with newly diagnosed, metastatic high-grade serous ovarian cancer. The combination therapy achieved a PFS of 23.5 months, compared to 17.3 months for the control arm.
A new treatment using niraparib after conventional chemotherapy improves progression-free survival and reduces risk of relapse or death in patients with advanced ovarian cancer. The study, led by Dr. Antonio González Martín, found a significant reduction in risk of relapse, especially in patients with homologous recombination deficiency.
A liquid biopsy test can predict which patients with colorectal cancer are likely to relapse after surgery, and guide treatment. The test identified patients who were more or less likely to remain disease-free two years after chemotherapy.
Researchers found that combination immunotherapy increases the 5-year overall survival rate to 52%, compared to 26% for ipilimumab monotherapy, and preserves quality of life. The therapy has a high cure rate and is effective even in patients who stop treatment due to side effects.
A team of LSU researchers has successfully demonstrated a method to generate groups of photons with manipulable quantum properties, known as multiphoton states. By subtracting out some photons, they can reshape the form of the wavepacket and artificially increase the number of photons in it.
The new SCAPE 2.0 system allows for faster and more detailed imaging of living tissues, revealing previously unseen details of biological systems. This technology has the potential to impact various fields such as genetics, cardiology, and neuroscience.
Rice University chemist Han Xiao is developing a custom-designed 21st amino acid to make life-saving substances and produce novel proteins for therapies. The goal is to create 'unnatural organisms' that can produce multiple designer amino acids, leading to breakthroughs in immunotherapy and cancer treatment.
Researchers have discovered that a lipid produced by brown adipose tissue, called 12-HEPE, helps reduce blood sugar levels in obese mice. The study found that 12-HEPE promotes glucose uptake into both skeletal muscle and brown adipose tissue, leading to improved glucose tolerance.
The Morris Animal Foundation has awarded over $1 million in wildlife health research grants to support studies on low fertility in elephants, rabies in bats and amphibian fungal disease. These studies aim to address critical health challenges in various species and promote conservation strategies.
Scientists at Hokkaido University detected nucleobases in a simulated interstellar cloud environment, essential building blocks of DNA. The findings suggest that the processes could lead to the formation of molecular precursors of life.
A new model simulates fluid dynamics in arteriovenous grafts, finding that vein flexibility can reduce disrupted blood flow. The study suggests several options for improving AVG designs to prevent thrombosis and extend their lifespan.