Researchers at CWRU are using big data methods to understand the mechanisms of Alzheimer's disease. They're developing large-scale knowledge bases that will identify ways to develop new or reuse existing drugs, with a focus on identifying possible new genes and pathways.
A CWRU-led study shows a single dose of the new triple-drug therapy is significantly more effective at killing microscopic larval worms in people diagnosed with lymphatic filariasis. This finding has led to changes in WHO treatment guidelines, offering promise for eliminating this disease from global health threats.
Dr. Alex Huang is awarded a three-year, $1.35 million grant to develop new ways to treat osteosarcoma, a rare cancer that begins in the bone. His research team aims to create immune-based clinical trials to improve treatment outcomes for pediatric and young adult patients.
Researchers aim to understand KLF2's role in vascular health and disease, targeting inflammation and narrowing of arteries. The team seeks to develop novel strategies to sustain KLF2 levels and treat cardiovascular disorders.
The CanSUR summer program at Case Western Reserve University School of Medicine will support 32 undergraduates annually in cancer-focused research. The five-year NIH grant will provide a solid foundation in cancer science and laboratory experience.
Researchers at Case Western Reserve University School of Medicine used high-tech microscopes to view serotonin activating its receptor for the first time. The study highlights distinct conformations of the receptor that could lead to more precise drugs targeting specific regions or functions of serotonin receptors.
A new study has discovered a single protein called Dazl that regulates a network of genes essential for developing sperm to replicate and survive. This finding could lay the groundwork for future research into therapies for infertile men, offering insights into molecular events that ensure survival of germ cells.
Researchers aim to improve guidelines for human-animal chimera research, considering moral status and animal welfare. The project will address conceptual, ethical, and procedural limitations in existing ethics guidance.
Researchers at Case Western Reserve University have developed a 'transistor' laser that can be manipulated at the nanoscale using an external voltage. This technology could lead to more accurate medical procedures and re-routing of fiber optic communication lines.
A new multi-national database will help researchers address questions about bipolar disorder throughout the adult lifespan. The database will aggregate data from over 1,000 patients worldwide, enabling scientists to uncover patterns of and predictors for the condition.
The Case Comprehensive Cancer Center has received a $3 million NIH grant to investigate racial disparities in colorectal and breast cancer. The research program aims to identify genetic biomarkers for cancer specific to high-risk populations and promote medical and social policies that benefit communities.
Case Western Reserve researchers discover small molecules that block toxin formation in bacteria, allowing infected mice to survive. The breakthrough could lead to a solution for the global threat of antibiotic resistance.
The Brainstorm Project aims to develop a philosophical framework for government policy and regulations on brain organoid research. The two-year project, led by CWRU researcher Insoo Hyun, will bring together neuroscientists and bioethicists to explore emerging ethical issues in this rapidly advancing field.
Researchers at Case Western Reserve University have identified a previously uncharacterized structure within the human estrogen receptor that could serve as a valuable new drug target. By disrupting this interface, drugs may be able to inhibit receptor function and prevent metastasis.
A team of nurses and physicians has received a four-year, $3 million grant to extend traditional HIV treatment protocols to improve cardiovascular health. The project aims to address the rising prevalence of cardiovascular disease among HIV patients.
Case Western Reserve researchers are investigating skin prions as a potential diagnostic biomarker for Creutzfeldt-Jakob disease. The study aims to determine if skin prions can serve as a pre-mortem and post-mortem diagnostic tool, as well as explore their role in transmission between humans.
Researchers at Case Western Reserve University developed a new method to generate brain stem cells, paving the way for greater understanding of myelin disease. The findings also provide new insights and therapeutic strategies for Pelizaeus-Merzbacher disease, a rare genetic disorder affecting male children.
A study published in the Journal of Endodontics found that smoking damages the pulp inside teeth, reducing their ability to fight illness and disease. This increases the risk of gum disease and delayed healing, with smokers nearly twice as likely to require a root canal as non-smokers.
A new study found significant disparities in the use of outpatient dermatology services among different ethnic groups and socioeconomic statuses. Patients with lower incomes and education levels were less likely to receive care, while those with higher incomes and education levels had better access to specialized services.
Researchers found that antibiotics kill beneficial bacteria, preventing them from controlling infection and inflammation in the mouth. The study suggests that overuse of antibiotics can have devastating effects on overall health, including oral conditions.
Case Western Reserve University researchers have discovered a way to predict which lung cancer patients will benefit from chemotherapy based on the arrangement of immune cells. This information may aid in decision-making for routine tissue-slide images, potentially sparing patients from invasive treatments.
Researchers at CWRU School of Medicine are exploring the role of long noncoding RNAs in colon cancer. They have identified potential targets for treatment, including lincDUSP, and found that depleting its levels can slow tumor growth.
Researchers aim to develop and evaluate non-contrast based imaging methods to diagnose peripheral arterial disease without relying on gadolinium-based contrast agents. The proposed techniques have high applicability to other medical procedures, including venography and vessel wall imaging.
Dr. Lan Zhou's research focuses on the impact of gut microbiome imbalance, immune response, and genetics on colorectal cancer development through the serrated pathway. Her team will use mouse models and human tissue to study carcinogenic transformation and inflammation-related pathways.
Case Western Reserve scientist Burcu Gurkan receives $600,000 grant to create more efficient carbon dioxide capture and conversion systems for space travel. The technology uses ionic liquids to filter CO2 and convert it into oxygen, reducing the need for stored oxygen and making long-distance space travel possible.
A team of researchers from Case Western Reserve University discovered a way to stop immune cell death associated with multiple diseases, including sepsis, IBD, and arthritis. They identified a chemical, necrosulfonamide, that potently inhibits inflammatory cell death by preventing pyroptosis, a type of cell suicide.
Chris Carr, an Ohio undergraduate, discovered a new galaxy 37 million lightyears away using deep sky images from the Burrell Schmidt telescope. The detection is part of the Leo I galaxy group and is considered the lowest surface brightness object ever detected via integrated light.
The university's School of Medicine has received a $936,000 grant to develop strategies for more equitable food systems in Cleveland. The project aims to sequence and integrate efforts like supermarket expansion, social marketing campaigns, and emergency food assistance programs to achieve maximum community benefit.
Researchers have identified a genetic mutation and faulty development process that causes a debilitating brain-based disorder in children. The mutation, in the alpha-N-catenin gene (CTNNA2), leads to abnormal cell adhesion and impaired neuronal migration, resulting in severe intellectual impairment and limited life expectancy.
Case Western Reserve University researchers developed an automatic alert system using wearable sensors and smartphone apps to help people quit smoking. The system tracks specific arm and body motions associated with smoking and sends personalized text messages or videos to motivate users.
Researchers have successfully generated brain tissue with all major cell types using organoid technology, providing a more accurate representation of human brain development. This breakthrough enables the study of neurological diseases such as multiple sclerosis and Pelizaeus-Merzbacher disease in laboratory-dish models.
Researchers at Case Western Reserve University School of Medicine have identified dozens of drug candidates that share a common mechanism to repair damaged brain cells in multiple sclerosis. These new targets and potent early-stage drug candidates could lead to regenerative medicines for the debilitating disease.
Scientists have found a mechanism that explains how the protein-making machinery chooses which alternative start sites to use for protein synthesis. The discovery reveals that RNA structure plays a crucial role in determining these start sites, and could lead to new therapies or medications for diseases such as cancer.
Researchers found that supplementing mitofusion 2 protein could prevent nerve degeneration, muscle atrophy, and paralysis in a mouse model of Lou Gehrig's disease. The study suggests this approach may be a novel therapeutic strategy for the disease.
Researchers discovered a llama-derived nanobody that specifically targets G beta-gamma signaling, preventing it from activating several other signaling proteins. This approach may provide control over multiple GPCRs and avoid undesired cellular events.
Researchers found that amputees who used sensory-enabled prostheses reported greater psychosocial well-being and confidence in using their hands for daily tasks. The study, led by Case Western Reserve University, demonstrates the significant positive impact of sensory feedback on improving amputees' quality of life.
A recent international study has identified three regions in the genome with significant genetic differences between men and women for developing glioma. These differences vary by sex and type of tumor, suggesting a potential path to assessing patient risk for brain cancer through genetic tests.
Researchers at Case Western Reserve University and other universities have discovered two new species of extinct hoofed mammals known as litopterns from a site in Bolivia. The animals, dating back to the late Miocene epoch, provide insights into South America's rich diversity of living mammals.
A recent study published in Psychiatric Services journal found nearly 24% of behavioral-related admissions in children and adolescents are complicated by suicidality or self-harm. The study emphasizes the importance of considering both physical and mental health needs for vulnerable youth.
Researchers have discovered 63 new genetic variations associated with higher risk of prostate cancer, enabling early and regular screening for men at increased risk. The findings represent the largest increase in genetic markers since their first identification in 2006.
A new atlas maps out comprehensive information on glioblastoma at the cellular and molecular levels, aiming to improve diagnosis and treatment. The atlas, created by an international team led by Jill S. Barnholtz-Sloan, provides a road map of different cells and potential molecular changes in glioblastoma tumors.
CWRU School of Medicine researchers synthesized the first artificial human prion, offering hope for treatment and cure of brain-wasting diseases. The discovery provides a basis for understanding how mis-folded protein structure affects prion transmissibility and manifestation in humans.
Case Western Reserve University astronomers detected a massive cloud of ionized hydrogen gas spewed from a nearby galaxy and consumed by its central black hole. The discovery provides an unprecedented opportunity to study the behavior of a black hole and associated galaxy as it consumes and 'recycles' hydrogen gas.
Researchers discovered that colon cancer cells rely on unusually long RNA strands, called lincRNAs, to evade cell death and promote unregulated growth. Targeting these molecules could lead to effective treatments.
Researchers found that nitric oxide deficiencies can underlie heart failure, while low levels may cause GPCRs to activate harmful pathways. Managing nitric oxide could help improve heart function and reduce side effects of existing medications.
Researchers found that immune cells in the bloodstream can worsen heart disease when they migrate to the heart. Blocking their migration improved symptoms in mouse models of heart disease, offering a novel therapeutic approach for non-ischemic cardiomyopathy.
Recent studies by Case Western Reserve University's Anant Madabhushi show that his diagnostic imaging lab's 'deep learning' computers can accurately diagnose heart failure and detect various cancers. The machines offer valuable tools for pathologists and radiologists, helping them become more efficient in their work.
A groundbreaking study by Case Western Reserve University estimates that exposure to domestic violence carries significant long-term consequences for children and society. The research found that the average cost to the national economy over a child's lifetime is nearly $50,000, including increased medical costs, violent crimes, and pr...
A new study from Case Western Reserve University found that certain PTSD therapies can effectively reduce symptoms for civilians and military veterans long-term. The study analyzed 32 PTSD-related studies and found that patients displayed less intense symptoms up to two years after treatment ended compared to six months post-therapy.
A recent study published in Families in Society The Journal of Contemporary Social Services found that social workers have the capability to mitigate impending financial calamity before it happens. Further training could strengthen their abilities to stave off foreclosure, supporting families in connecting with resources.