A study published in the Journal of Neuroscience reveals that neutrophils, a type of immune cell, play a significant role in clearing debris from damaged nerves. Without this cellular clearance mechanism, nerves cannot properly regenerate after injury.
Researchers at Case Western Reserve University discovered a protein called ISX that helps balance vitamin A metabolism in the gut. Without this protein, mice develop severe inflammation and become immunocompromised, highlighting the link between diet and inflammatory diseases.
The Youth Enjoy Science (YES) Program at CWRU School of Medicine aims to interest and recruit underrepresented minorities in cancer research careers. The program provides a comprehensive approach to training middle school through college undergraduates, with the goal of increasing diversity in scientific research.
A new molecular pathway controlling lifespan and healthspan has been identified in worms and mammals. Excess levels of proteins called Kruppel-like transcription factors (KLFs) can extend lifespan and improve blood vessel function, highlighting a potential target for age-related diseases.
The Case Center for Synchrotron Biosciences has been awarded the second prize in the 2017 Sharing Research Resources Award by the American Association of Medical Colleges. The center provides access to advanced technology, training, and support to researchers worldwide, enabling them to conduct research on biological macromolecules.
A Case Western Reserve University-led study assessing memantine's cognitive-enhancing effects on adolescents and young adults with Down syndrome has been approved in São Paulo, Brazil. The trial aims to build on previous findings and could lead to a much larger final phase of testing.
Researchers at Case Western Reserve University are developing a new financial product to attract long-term private investors to emerging energy technologies. The goal is to address the 'valley of death' – the gap between seed investment and later rounds of financing when startups have scaled up and are profitable.
Researchers at Case Western Reserve University have developed a soft, flexible origami-inspired robot called TWISTER. The robot uses multiple layers of polygons to bend, contract, extend, and twist, making it suitable for fragile-object manipulation and direct human-robot interaction.
Researchers at Case Western Reserve University have developed a new MRI contrast agent that can pinpoint breast cancers at early stages and distinguish between aggressive and slow-growing types. The agent is more efficient, safer, and easier to flush from the body than traditional agents.
A CWRU researcher led an international team to develop functional materials inspired by nature, including sticky and durable caddisfly silk and sea cucumber skin. The research aims to create materials with wide range of practical uses, such as soft-sided robots for search-and rescue missions.
A new four-year project will collect data on three methods of delivering a self-management course to reduce MS-related fatigue and improve quality of life. The study aims to test online and teleconference-based adaptations of the course, which has shown effective results in reducing fatigue when delivered in-person.
A CWRU researcher has received a five-year, $3.9 million grant from the National Institutes of Health to explore ways to augment the body's immune system after exposure to toxic chemicals, including mustard gas. The goal is to reduce skin swelling and pain while enhancing tissue repair.
A recent grant of $1.8 million will support research on mixed-income community-building, with a focus on promoting social equity and inclusion in US cities. The funding will enable the National Initiative on Mixed-Income Communities (NIMC) to launch an innovation network and profile exemplary initiatives.
Martha Sajatovic, MD, receives international grants to develop and test adherence enhancement programs for chronic psychiatric disorders. The projects also explore patient-centered approaches to diabetes management, including Shared Medical Appointments (SMAs) and targeted training for illness management.
Scientists at Case Western Reserve University have discovered that tiny holes and cracks in materials can control electric charge through friction. The findings could lead to better adhesion for agricultural pesticides, paints, and other applications, while also preventing damage from static electricity.
Case Western Reserve researchers refine an electrical nerve-block implant to treat asthma and heart failure, focusing on blocking unwanted nerve impulses in the autonomic nervous system. The technology aims to provide a reliable, rapid, and reversible nerve block as an alternative to surgery or drugs.
Researchers will study a nanoparticle-based therapeutic that targets the body's own cancer immunity cycle, aiming to prevent tumor progression and metastasis. The therapy shows promise in treating melanomas, ovarian, and breast tumors, with sustainable immune stimulation and prevention of relapse.
A study by Case Western Reserve University researchers has identified long non-coding RNAs that play a critical role in orchestrating sperm development. The lncRNAs help regulate various stages of sperm development and are found exclusively in the testes, suggesting they could be used to develop novel infertility drugs.
The new guidelines offer a series of evidence-based recommendations for pediatricians, including routine blood pressure measurements only at annual wellness visits and using ambulatory blood pressure monitors. The report also removes obese patients from normal blood pressure calculations, replacing them with average-weight kids to prev...
A study from Case Western Reserve University found little evidence of a relationship between women's intelligence and their mindsets. The research challenged the idea of a 'bright girl effect,' which suggests that young females limit their own progress based on their perceived intelligence.
Researchers at Case Western Reserve University have developed a new multicolor MRI method that enables simultaneous detection of two different contrast agents, allowing for immediate comparisons of diseased and healthy tissue. This breakthrough has the potential to transform molecular imaging and aid disease diagnosis.
A new machine learning program developed by researchers at Case Western Reserve University appears to outperform other methods for diagnosing Alzheimer's disease before symptoms begin. The program integrates various indicators of the disease, including mild cognitive impairment, to predict who has Alzheimer's and those with mild cognit...
Researchers recommend reevaluating the need for contrast agents in MRI scans to minimize brain accumulation and potential health risks. Emerging evidence suggests that small amounts of gadolinium deposit in certain brain areas after repeated use, but the scientific community agrees that the current benefits outweigh these risks.
Rodeo Therapeutics aims to develop drugs that promote tissue repair using 15-PGDH inhibitors, which have shown promise in animal models for treating inflammatory diseases and bone marrow transplants. The company plans to focus on increasing prostaglandin E2 levels to support tissue stem cell production.
A new study from Case Western Reserve University School of Medicine suggests that replenishing cytokine molecules could repair diabetic nerve damage. Diabetic mice showed low levels of specific cytokines that hindered activation of reparative genes, leading to poor circulation and muscle weakness.
Alex Huang, MD, PhD, receives funding to continue fighting childhood cancer with a focus on immune system activation and tumor evasion strategies. The award supports breakthrough research at Case Western Reserve University School of Medicine and the National Cancer Institute's 'moonshot' initiative.
Researchers found that Ptbp2 regulates RNA processing during sperm development, controlling over 200 genes involved in movement and communication. Without the protein, sperm development went awry, leading to defects in cellular processes.
A new clinical trial found that high doses of vitamin D can reduce skin redness, swelling, and inflammation after a sunburn. Vitamin D at doses of 50,000-200,000 IU was shown to have long-lasting benefits in reducing skin inflammation and promoting skin barrier repair.
Researchers at Case Western Reserve University have developed a new method to screen brain tumor cells and identify potential drug targets. The team found 57 genes required for cancer cell survival in the brain, but not in traditional laboratory culture, suggesting a new avenue for therapeutic development.
Nicole F. Steinmetz receives two NIH grants to develop microscopic drug-delivery systems for triple negative breast cancer patients and patients at risk of serious blood clots. The funding will enable her team to explore mechanisms behind anti-tumor effects and develop dual-pronged therapeutic approaches.
A recent study by researchers at Case Western Reserve University has discovered that injecting potato virus particles into melanoma tumors activates an anti-tumor immune response, halting tumor progression. Co-administering the nanoparticles with chemotherapy drugs yields the most potent benefit.
Researchers at Case Western Reserve University found that a high fat diet rich in plant-derived 'good' fats reduced bacterial diversity and inflammation in mice with Crohn's-like disease. This discovery could lead to new anti-inflammatory probiotics and provide hope for patients suffering from debilitating intestinal symptoms.
Researchers found that Candida tropicalis infection intensifies Crohn's disease symptoms in mice by modulating gut bacteria and triggering inflammation. The study suggests anti-fungal medications could be beneficial in combating debilitating symptoms of the disease.
Researchers at Case Western Reserve University found a way to store digital data in half the space required by current systems. They developed an optical storage system using polymer films containing two dyes, which can represent information using a quaternary code.
A study conducted by Case Western Reserve University found that 60% of male participants reported being both perpetrators and victims of intimate partner violence. The research highlights the need for behavioral programs that address unresolved trauma from childhood abuse, which can contribute to violent behavior in adulthood.
Recent clinical trials suggest using medications that control blood glucose while reducing cardiovascular risk can improve patient outcomes. This approach may be more effective than current treatments, which prioritize blood sugar maintenance alone.
The university will investigate genetic determinants of Barrett's Esophagus and esophageal adenocarcinoma, developing a new molecular marker for detection. The research aims to improve non-invasive diagnostic approaches and treatment of esophageal cancer.
Biomedical engineers use biological nanoparticles, a plant virus, to deliver pesticide to root level of crops, reducing leaching and runoff, increasing efficacy and safety. The technology has potential for widespread use in agriculture to control parasitic nematodes, which cause significant crop failures worldwide.
Researchers have discovered a previously unknown cell receptor interaction that can safely prevent blood clots. The new mechanism targets the Mac-1-GPIbα receptor duo, which is required for harmful clots, but blocking its interaction with a therapeutic small molecule has no effect on bleeding risk.
Researchers found that using MRI to detect lesions and guide biopsies increased standardized quality-adjusted life years for patients, and was cost-effective in 94.05% of simulations. This approach could change how doctors identify and sample cancer lesions, reducing unnecessary treatments and costs.
Researchers developed a prototype drug that directly activates a tumor suppressor protein, preventing lung cancer tumors in mice. The study's findings suggest the potential for broad applicability to various human cancers, including breast, prostate, and childhood cancers.
A team of researchers from Case Western Reserve University used data science to predict the deterioration of polyethylene terephthalate (PET) films in solar panels. The study, published in PLOS ONE, combines engineering epidemiology and statistical-data analytics to develop predictive models for environmentally exposed applications.
Researchers at Case Western Reserve University have developed a neural stimulation system that improves walking ability for stroke and MS patients. Functional electrical stimulation (FES) significantly helped patients walk more effectively, with one patient covering nearly a mile and another gaining balance and confidence.
A deep-learning network developed through research at Case Western Reserve University was 100% accurate in determining the presence of invasive breast cancer in whole biopsy slides. The network correctly identified cancerous pixels with 97% accuracy, rendering near-exact delineations of tumors.
Researchers at Case Western Reserve University developed a gene-carrying nanoparticle that delivers healthy RPE65 genes to photoreceptor cells, preventing vision loss in mice with Leber congenital amaurosis. The therapy's success indicates promise for treating other inherited visual disorders.
Children exposed to cocaine in the womb are more susceptible to addiction due to trouble controlling behaviors and emotions. Many teens in the study showed poor coping strategies, leading to acting out behaviors like substance use, tobacco, and alcohol abuse.
Case Western Reserve University researcher Martin Basch has been awarded a $300,000 Hartwell Individual Biomedical Research Award to study cell therapies for treating congenital strial deafness. The goal is to restore hearing in children affected by this condition.
Researchers discovered three novel genetic mutations associated with Fuchs endothelial corneal dystrophy, increasing the number of known risk factors fourfold. The study also revealed sex-specific differences in genetics and found that these genes can predict disease risk with approximately 78% accuracy.
The discovery of three new species and insights into a fourth indicates the Palaeothentidae family was diverse and widespread across South America as recently as 13 million years ago. The findings complicate existing theories about their extinction, suggesting it may not have been a slow process.
Case Western Reserve University researchers aim to combat chronic inflammation by targeting oral complications in HIV patients, which can lead to malnourishment and further weaken the immune system. The team will investigate regulatory T-cells and study tissues from HIV-positive patients taking common antiretroviral drugs.