A novel treatment has been successfully used to treat patients with a rare disorder that causes kidney failure, allowing targeted elimination of abnormal proteins and improving kidney function. The treatment, Daratumumab, targets plasma cell clones in the bone marrow, offering a new way to specifically treat the problem.
Researchers have discovered that excessive DNA replication can lead to cell malignancy but also offers a potential approach against cancer. By exploiting the cooperation of proteins CDC6 and CDT1, scientists aim to induce lethal DNA re-replication selectively in cancer cells.
The VISTA survey has imaged millions of stars in the Small Magellanic Cloud, revealing surprising results about star formation history and structure. Most SMC stars formed relatively recently, unlike those in larger galaxies.
The Weng'an Biota fossils, once thought to be among the world's oldest evidence of animal life, may actually belong to other groups like algae. Researchers have found that characteristics previously used to define animals are not unique to them, leaving room for alternative identifications.
New research suggests UK health spending must increase at a rate faster than GDP to meet growing demand for healthcare services. The J-value model, developed by Professor Philip Thomas, indicates that developed countries like France and Germany are already prioritizing health care as a fraction of their income.
The first result from Jefferson Lab's upgraded CEBAF demonstrates the feasibility of detecting a potential new form of matter, studying quark structure, and exploring universal glue. The experiment produced two ordinary mesons and studied their production mechanisms.
A new review suggests calorie restriction prolongs life by increasing ketone bodies, which decrease malignancies and insulin resistance in mice. Calorie restriction also reduces muscular weakness and blood glucose levels, supporting the theory's potential longevity benefits.
A UK study found that building modelling professionals often fail to predict a building's actual energy efficiency, leading to significant financial and environmental implications. The researchers attribute this to the 'modelling illiteracy' caused by separation from the construction process and lack of feedback.
Researchers have identified four damaged genes associated with Tourette syndrome, a neurological disorder characterized by vocal and physical tics. These findings suggest that multiple gene mutations contribute to the development of the disorder, offering new hope for personalized treatments.
Scientists create an input system called WatchSense that tracks the movement of fingers on and above the back of the hand using a depth sensor. This allows for more expressive interactions with smartphones and smart TVs, and has been successfully tested in various scenarios, including virtual and augmented reality.
Researchers analyzed high-speed endoscopic videos of vibrating vocal folds and audio recordings to study register changes in professional sopranos. They found distinct vocal fold vibratory patterns, including abrupt transitions and temporary loss of contact, which correlate with audible register breaks.
Scientists have developed a water-repellent material that molts like a snake's skin when damaged, revealing another hydrophobic layer beneath. This material has the potential to be used in various applications such as rain gear, medical instruments and self-cleaning car windows.
Researchers studied 240 children with autism between 15-71 months old, finding that IQ, communication skills, and speech ability explained less than 3% of their tantrums. Children with clear speech and high intelligence had the same number of tantrums as those with lower speech skills.
The compilation presents state-of-the-art reviews on the pathogenesis, pathophysiology, and therapy of obesity, with a focus on the gastrointestinal tract. Key findings highlight the importance of diet composition, lifestyle interventions, and pharmacotherapy in weight management and metabolic health.
A Finnish study found that childhood exposure to high blood pressure, smoking, and elevated LDL-cholesterol is associated with poorer cognitive performance in middle age. The study suggests that regulating these risk factors through healthy lifestyle choices can promote brain health in adulthood.
Researchers create technique to observe mRNA at ribosome sites, revealing protein synthesis and cellular responses to iron. The method is applicable to any type of RNA and could be modified for other interactions.
Giant larvaceans play a significant role in moving carbon from the upper to deep sea through their 'houses,' which filter tiny particles. Laser technology enables researchers to visualize chambers and passageways inside these structures, revealing higher filtration rates than previously estimated.
Patients with advanced NSCLC who received pre-treated checkpoint inhibitors had a 27% partial response rate to salvage chemotherapy, compared to 7% in those without pre-treatment. The study's findings suggest that checkpoint inhibitors may render tumor cells more sensitive to chemotherapy.
A recent survey of 14,000 internet users in seven nations found that concerns about fake news undermining democratic processes are unwarranted. In fact, internet users use search to check facts and validity of information, and encounter diverse information across multiple media sources.
Scientists at the Center for BrainHealth propose a systematic model for drug addiction research, focusing on craving as an intense urge to use drugs. They plan to reanalyze brain scans to quantify craving and its effects, potentially leading to targeted treatments.
The Microbicide Trials Network (MTN) starts a Phase I study to test a vaginal ring containing dapivirine and levonorgestrel, aiming to provide protection against HIV and unintended pregnancy. The trial aims to evaluate the safety and effectiveness of the dual-purpose ring.
A new study develops a tool to catalog police and law enforcement interactions with black men, finding that discrimination is associated with depression symptoms. The Police and Law Enforcement Scale can help document bias and provide greater insight into how institutionalized racism shapes the health of people in black communities.
Research by Sayuri Naruse and Dr Mark Moss from Northumbria University found that couples' physical and mental wellbeing improved after a three-week massage course. The study involved 38 participants who reported significant benefits to their wellbeing, stress coping, and relationship satisfaction.
The University of Alabama at Birmingham has been awarded a five-year, $11.2 million Program Project Grant to study the renal control of sodium and salt balance. The research aims to understand how the body regulates salt intake and its impact on blood pressure regulation.
Research by Ulster University found that mothers taking folic acid supplements throughout pregnancy had children with higher levels of emotional intelligence and resilience. The study also showed a correlation between the level of folic acid in mothers' blood and their child's resilience.
A new study published in Environmental Science & Technology shows that air conditioning increases air pollution by hundreds to thousands of metric tons, particularly sulfur dioxide, nitrogen oxides, and carbon dioxide, with a 3-4% increase per degree Celsius rise in temperature
A new paper in Science Advances challenges the approach of using metadata to validate community detection algorithms, showing that this method introduces biases and limits algorithm diversity. Researchers propose two new statistical approaches to explore deeper patterns within network data.
Asian elephants are carriers of virus types 1, 4 and 5, while African elephants carry types 2, 3 and 6. The transmission of Elephant Herpes has been largely unknown until now.
A recent study found that even small daily stressors increase illegal drug use among those on parole or probation who have a history of substance use. The researchers also discovered that treatment helps limit substance use over time, and that prevention programs may be more effective with consideration of treatment history.
A study has identified four brain-expressed genes as likely risk factors for Tourette disorder, including WWC1, FN1, CELSR3, and NIPBL. De novo variants in these genes were found to have a significant association with the disorder, suggesting a potential target for effective treatments.
Researchers have developed a method that enables computers to infer psychologically plausible models of individuals from limited data, improving understanding of human behavior. This breakthrough could lead to more accurate predictions and adaptations in human-robot interaction and adaptive interfaces.
A year-long weight loss programme helped participants lose more weight and prevent diseases like hypertension, diabetes, and heart disease compared to a 12-week programme. The study found that the longer programme was cost-effective in the long-term due to reduced future healthcare expenditure.
Researchers found that wild dolphins have chronically activated immune systems due to exposure to pathogens, parasites, and pollutants. This could lead to immunologic dysregulation and increased vulnerability to disease in both humans and animals. In contrast, dolphins in managed care environments have less activated immune systems.
A comprehensive study of mesophotic coral reefs on Hawaii island has revealed the presence of a diverse range of fish species, with many found nowhere else. The research highlights the importance of these deep reefs in conserving reef fish biodiversity and providing critical habitat for shallow reef fishes.
Researchers have identified a unique pheromone in Indian jumping ant larvae that signals which larvae are likely to become queens. The discovery reveals how the colony ensures proper caste differentiation and highlights the importance of pheromones in social insect behaviors.
Researchers find Lgl1 controls neural stem cell proliferation, producing neurons and glia cells in the developing cortex. The study reveals two mechanisms of Lgl1 function: one for embryonic development and another for postnatal brain growth.
Mayo Clinic's new imaging technologies use computerized tomography scans to measure the firmness of brain tumors and how attached they are to normal brain tissue. This information helps surgeons plan the safest method for extraction, potentially reducing complications and improving patient outcomes.
A computational analysis led by Johns Hopkins Bloomberg School of Public Health researchers estimates that even a mild Zika outbreak in the US could result in $183 million in medical costs and productivity losses. A more severe outbreak could cost over $1 billion, with increased risks of birth defects and Guillain-Barré syndrome.
A new analysis reveals that people with indigenous backgrounds are less likely to be identified after death due to inadequate family involvement and trust issues with government institutions. Non-governmental organizations can serve as bridges between families and authorities to improve identification rates.
Researchers found that activating or deactivating a hormone in roundworms stimulates or stunts growth, mirroring human TRH regulation. This discovery offers new possibilities for research into human growth mechanisms.
Researchers found that mice lacking Bax/Bak genes failed to develop sophisticated neural circuits, leading to impaired skilled movements. The study suggests testing individuals with motor development disabilities for mutant forms of the same genes.
A study found substantial differences in accuracy between commercially available heart rate apps, with some apps performing up to 20 beats per minute off from the clinical gold standard. Non-contact apps performed less well than contact apps, particularly at higher heart rates and lower body temperatures.
Studies in mice funded by NIH reveal thalamus sustains ability to distinguish categories and hold thoughts in mind. The structure boosts synchronous activity of PFC neurons to sustain memory of category, improving working memory performance.
A study published in the Canadian Journal of Cardiology found that women with atrial fibrillation/flutter experienced higher death rates than men 30 and 90 days after discharge from emergency departments. The study analyzed data from 21,062 patients and identified differences in outcomes between male and female patients.
An analysis of 27 US states found that summer temperature increases lead to higher electricity-related emissions of sulfur dioxide (SO2), nitrogen oxides (NOx) and carbon dioxide (CO2). States with more coal power plants, such as Ohio and Pennsylvania, released the most SO2 emissions.
A new blood test can detect multiple copies of the androgen receptor gene in men with advanced prostate cancer, indicating a lower likelihood of responding to targeted treatments. The test could help doctors personalize treatment options for patients.
A team of biophysicists used experiment and mathematical theory to study the changing composition of a mixed bacterial population. They found that in some cases, a strain with a toxin can outcompete another strain, but this depends on various factors such as the environment and initial inoculum size. The results suggest a complex inter...
A new detection test for Zika virus distinguishes between African and Asian strains, improving tracking efforts. The low-cost LAMP test is faster than current gold-standard methods, with minimal processing requirements.
Researchers analyzed FDA Adverse Effect Reporting System data to find that ketamine alleviates depression symptoms in patients taking pain medication. The study also identified three other drugs with previously under-appreciated antidepressant effects: Botox, diclofenac, and minocycline.
Researchers at North Carolina State University developed a new method for manipulating cells using light, creating an effective tool for bioelectronics. Persistent photoconductivity allows the material to become more conductive when exposed to light, increasing surface charge and directing cells to adhere.
A new study found that 53% of NHS patients who recovered from depression and anxiety experienced relapses within a year after treatment. Patients with residual depression symptoms were twice as likely to relapse, highlighting the need for long-term monitoring and support.
A new study shows that displaying FIT Game episodes in school cafeterias can increase vegetable consumption by 99.9%, surpassing previous classroom-based games. The low-cost approach offers promise for influencing children's health and behavior.
Researchers at the University of Kansas conducted a study suggesting that explicit racial prejudice is a reliable predictor of the free speech defense of racist expression. The study found that people with high levels of prejudice were sensitive to their own freedom of expression and used the 'free speech' argument to justify their pre...
Researchers develop process to mix chicken droppings with Mexican sunflower to produce biogas, which can power generators and used as fertilizer. The method produces more than 3 kg of biogas from 8 kg of poultry waste and sunflowers, reducing environmental pollution.
A large randomized controlled trial found that acupuncture significantly improved the quality of life and physical and mental health of patients with allergic asthma. The study involved 1445 participants who received on average 15 acupuncture sessions over three months, with benefits maintained for up to six months.
A population-based study found associations between maternal smoking and severe mental illness in offspring, but weakened when considering family-related factors. The study analyzed nearly 1.7 million people born in Sweden, suggesting that environmental influences shared by siblings may be more important than causal teratogenic effects.
A study by Christian König and Ayse Yarali found that fruit flies generalize their memories of an electric shock to a range of similar scents, mirroring the behavior of PTSD sufferers. This ability can be beneficial but also detrimental if overgeneralized.
A study by University of Michigan researchers found that preschoolers who recognize food brand logos are more likely to be overweight. The study showed that children with higher BMI percentiles recognized unhealthy foods like M&M's and Coca-Cola more often than healthy-weight peers.
A team of researchers has discovered that parasitic fig wasps use odour sensors to find their host larvae within the fruit. The study, published in Journal of Experimental Biology, found that the wasp's ovipositor can detect carbon dioxide and other gases emitted by developing larvae.
The American Sleep Medicine Foundation has selected three researchers to receive Strategic Research Awards for their projects on telemedicine and cognitive behavioral therapy for insomnia (CBT-I). The studies aim to compare the effectiveness of CBT-I delivered through telemedicine versus in-person sessions. One project will evaluate th...
A study published in Annals of Emergency Medicine found that prednisone did not provide additional relief for emergency patients with hives. Antihistamine levocetirizine alone achieved full itching relief within 2 days for 76% of patients.
A study by Australian National University reveals the world's biggest volcanoes in Hawaii formed along twin tracks due to a shift in the Pacific Plate's direction three million years ago. The discovery helps reconstruct Earth's history and understand volcanic activity away from tectonic plate boundaries.
A study conducted by Ohio State University researchers found that over half of breast cancer patients undergoing mastectomy lack necessary medical knowledge to make informed decisions about reconstructive surgery. Only 43% of patients demonstrated adequate understanding of reconstruction facts and made choices aligned with their prefer...
Phagocytosis not only eliminates useless cells, but also 'educates' macrophages, the immune cells that carry it out. This process helps maintain tissues in a clean and healthy state. Researchers identified specific molecular toolkits for eliminating unwanted cells in each tissue.
Scientists analyzed DNA samples from 97 western spotted skunks and found three genetic sub-groups corresponding to different climate refugia created by Ice Age climate change. This discovery suggests that climate change played a more important role in the evolution of spotted skunks than geographical barriers.
Researchers at Hokkaido University developed a novel method combining p53 and BMPep to control nanostructure of inorganic materials. The method successfully created hexagonal silver nanoplates with enhanced specificity and crystal growth regulation.
A Portland State University study found that affluent neighborhoods with lawns use up to 10 times more water than densely populated areas. The research highlights the importance of water-saving measures in urban planning, suggesting that hardscaping and native plants can reduce water usage.
A new study published in Nature finds that the thalamus strengthens connections within the prefrontal cortex, enabling it to focus attention and make decisions. This discovery has implications for understanding cognitive deficits in diseases such as schizophrenia and improving cognition by adjusting thalamic function.
Researchers at Florida State University have developed a statistical model that ranks chemotherapy treatment options for patients based on the gene expression profile of their tumor. The model takes into account both effectiveness and potential side effects, predicting a higher complete response rate for some subtypes of breast cancer.
A new study calls for a global code of conduct for marine conservation, considering social justice and accountability practices. The code could ensure fair governance and respect for fishers' livelihoods, food sovereignty and dignity.
Research from Ohio State University found a surprising relationship between blood sugar and brain tumors. While diabetes increases cancer risk at other sites, it lowers the risk of gliomas, the most common type of malignant brain tumor.
Researchers found higher rates of brain abnormalities in children with single-ventricle disease as staged surgeries progressed. Cerebral blood flow measurements showed a potential link to brain lesions, but more investigation is needed to confirm causality.
A newly published study documents an orchid fossil trapped in Baltic amber, shedding light on the family's evolutionary history. The discovery, published in Botanical Journal of the Linnean Society, pushes the record for oldest orchid fossil to over 45 million years.
A new study from Duke University found that adolescents already at risk for mental health issues face increased attention, behavior, and self-regulation problems when using technology. However, excessive digital device use was also linked to fewer symptoms of depression and anxiety.
Researchers found that phthalate exposure during pregnancy and breastfeeding can lead to epigenetic modifications in children, increasing the risk of developing allergic asthma. The study also showed that the effects are not limited to the child, as the offspring of exposed mothers continued to be affected even after birth.
Scientists at the University of Bonn have created a realistic 3D model of a fish's lateral line system, allowing them to simulate precise current conditions. The results show that anatomical adaptations minimize background noise, enabling fishes to navigate and identify prey with high accuracy.
Researchers have characterized the unusual cell death process triggered by starvation, where the endoplasmic reticulum plays a key role. This discovery may shed new light on tumor progression and ischemia-related cell death in cancer and other diseases.
A large study of over 39,000 participants found that social smokers face the same high blood pressure and cholesterol risks as everyday smokers. The researchers advise clinicians to ask about social smoking in different ways to identify and help these individuals quit.
Children exposed to cocaine in the womb are more susceptible to addiction due to trouble controlling behaviors and emotions. Many teens in the study showed poor coping strategies, leading to acting out behaviors like substance use, tobacco, and alcohol abuse.
In a study published in PLOS ONE, researchers found that female Drosophila buzzatii fruit flies use courtship songs to pick mates of their own species. The study suggests that this preference may have driven speciation in the cluster. Female preferences for specific songs varied among individuals.
Researchers at Columbia University have obtained detailed images of AMPA receptor interactions with regulatory proteins, revealing the structural changes that occur during desensitization. This knowledge may aid in designing targeted therapies for conditions like Alzheimer's, Parkinson's, epilepsy, and schizophrenia.
Tropical Cyclone Donna formed in the South Pacific and is now threatening Vanuatu. The storm intensified under favorable atmospheric conditions, including strong poleward outflow and warm water, before tracking westward at 5 knots per hour.
A new study from Sanford Burnham Prebys Medical Discovery Institute uncovers the role of non-coding RNA SPRIGHTLY in tumor growth and metastasis, suggesting it as a potential therapeutic target or diagnostic marker for skin cancer. The molecule binds to over 115 RNA partners, including genes implicated in various cancers.
Researchers propose new solution to alleviate poverty by incorporating culture and nature, classifying three types of solutions: Big Push, lowering the barrier, and transforming the system. This new approach aims to break the cycle of poverty and environmental degradation.
Researchers have identified multipotent stem cells in the human brain following a stroke, which can differentiate into neurons and help repair damage. These cells, called iSCs, express multiple stem cell markers and demonstrate high proliferative potential.
Researchers have discovered that FES, a protein previously linked to cancer development, actually acts as a tumor suppressor in melanoma. The study found that restoring FES expression through epigenetic drugs may provide a novel therapeutic strategy against melanoma.
Researchers discovered that oxytocin and isotocin signaling molecules play a crucial role in regulating anemonefish paternal behavior. Blocking these hormones led to decreased aggression but increased attention from the dads towards their offspring.
A new pilot study reports that Mexican-American stroke survivors are less likely to receive inpatient rehabilitation than non-Hispanic whites. The research team found that only 30% of Mexican-Americans received inpatient rehab while 73% of non-Hispanic whites did.
A team of researchers discovered that the Western Amazon sank twice, with ocean water from the Caribbean flooding the region for less than a million years. The study found distinct layers of marine pollen separated by non-marine types, as well as shark teeth and mantis shrimp fossils.
A clinical trial found that the drug teprotumumab significantly reduces eye bulging, pain, and swelling in patients with moderate-to-severe active thyroid eye disease. The treatment, which blocks an autoimmune attack on muscles around the eyes, showed rapid therapeutic benefits within six weeks of infusions.
A new generation of prosthetic limbs with built-in cameras can now automatically pick up objects, eliminating the need for manual control. Researchers at Newcastle University have developed a 'hand that sees' using computer vision and neural networks, which can assess object shape and size in real-time to trigger precise movements.
Researchers have engineered soybeans to withstand increased temperature and carbon dioxide levels, resulting in higher yields in future climate conditions. The modified crops outperformed conventional soybeans in field studies conducted at SoyFACE, a facility emulating future atmospheric conditions.
University of New Mexico researchers have discovered a method to optimize network processes, reducing energy consumption and effort required to achieve desired results. By focusing on key elements rather than monitoring all elements, the effort can be reduced dramatically, leading to significant cost savings and improved performance.
A new study by Colorado State University researchers demonstrates a method to quickly detect Zika virus in mosquito populations, informing decision-making on disease-prevention methods. The use of loop-mediated isothermal amplification (LAMP) allows for easy detection in human and mosquito samples from the US, Brazil, and Nicaragua.
Research found that meerkat calls vary with factors such as sex and social status, providing cues about the producer. Call rates were higher in dominant females and one-year-old males during foraging, but not linked to stress hormones.
A study has mapped nearly two square kilometers of seafloor around the leeward side of Bonaire, revealing new details about mesophotic reefs. The data can help local conservation efforts by identifying areas worthy of further investigation and providing insights into reef dynamics.
Researchers found that migratory mule deer closely time their movements to track the timing of early spring green-up, allowing them to access high-quality forage. The study's findings highlight the importance of habitat corridors in enabling animals to move between winter and summer ranges.
A gene mutation called the Met allele may accelerate memory and thinking skills decline in people at risk for Alzheimer's disease, according to a study published in Neurology. Researchers found that individuals with the mutation lost cognitive skills more rapidly than those without it.
A new study from ANU found that sagittal crest size in male gorillas and orangutans is linked to their social behavior. Females prefer larger crests, indicating a possible form of social signalling related to sexual selection.
Researchers have discovered a new conducting additive, Super P carbon black (SPCB), that exhibits high capacity and cycling stability for reversible lithium and sodium ion storage. SPCB shows a higher capacity for lithium ion storage than sodium ion storage due to its reaction mechanism.
Researchers have found that giant larvaceans, tiny plankton that live in the upper 400 meters of the ocean, filter carbon particles at higher rates than any other zooplankton. These structures sink to the sea floor, significantly contributing to moving organic materials into deeper water.
The March for Science drew hundreds of thousands of participants worldwide to show support for scientific research and demand continued government funding. The event highlighted the importance of collaborative initiatives in advancing scientific progress.
Researchers found that wine-derived human gut metabolites are protective against neuronal death in human cells under stress conditions. The exact composition of these metabolites depends on the individual's gut microbiota, highlighting the importance of personalized nutrition in preventing neurodegenerative diseases.
Researchers at McGill University have discovered how specific bacterial enzymes, known as kinases, confer resistance to macrolide antibiotics. The study provides a detailed atomic view of the kinases and their interaction with different macrolide antibiotics, paving the way for the design of next-generation antibiotics.
A new study conducted at The Ohio State University Comprehensive Cancer Center found that more than half of breast cancer patients undergoing mastectomy lack necessary medical knowledge for high-quality decision-making about reconstructive surgery. Researchers emphasize the need for shared decision-making tools and patient-doctor commu...
A study led by the University of Bath discovered a distinct dinosaur fauna in Africa at the end of the Cretaceous period. The newly discovered species, Chenanisaurus barbaricus, was found in phosphate deposits in Morocco and is considered one of the last dinosaurs on Earth before its extinction.
A new report by RTI International highlights the significant treatment burden faced by younger women with breast cancer, who often receive more aggressive treatments and incur substantially higher costs. The study estimates that younger women cost $97,000 to treat annually, compared to $76,000 for older women.
The Plant-Biotic Interactions program aims to provide a deeper understanding of complex relationships between plants, microbes, and other organisms. Research funded through this program may lead to novel cropping systems that help plants thrive in extreme environments.
Researchers have designed a nickel catalyst that transforms unrefined hydrocarbons and CO2 into pure fatty acids at room temperature and atmospheric pressure. This sustainable process has significant implications for the environment and could alleviate economic concerns in the production of fatty acids.
A new theory published in the journal Human Development proposes that adults can learn new skills and combat cognitive aging by adopting broad learning strategies similar to those used in infancy. By embracing open-minded learning, individualized scaffolding, growth mindset, forgiving environment, serious commitment to learning, and le...
A 35-year study of a protected alligator population has found that male and female alligators exhibit 'determinate growth,' stopping at some point after reaching sexual maturity. Females are reproductive far longer than previously thought, with one case reaching 46 years past onset of sexual maturity.
A training program on aging-related health improved police officers' empathy and skills to interact with older adults. Participants reported increased knowledge scores, including how to identify safety concerns during police interactions.
Researchers found that minimizing soil disturbance, ensuring permanent organic cover crops, and diversifying crops through crop rotation improved soil properties. These techniques created a beneficial environment for microorganisms, fungi, and earthworms, ultimately leading to increased crop productivity and reduced erosion.
Wild mice have highly-activated immune systems due to exposure to infections, with more activated myeloid cells compared to laboratory mice. The study's findings emphasize the importance of considering natural variability when interpreting research results.
Researchers found that CA2 maintains inhibition in connected networks, suppressing signaling and preventing hyperexcitability. Without CA2, mice experience epilepsy-like activity and seizures, highlighting the region's role in regulating brain balance.
A new special collection in Disease Models & Mechanisms (DMM) explores the intersection of models and mechanisms to therapies for neurodegenerative disorders. The collection includes articles on induced pluripotent stem cell models, antisense oligonucleotide therapy for spinal muscular atrophy, and more.
Researchers have discovered that doxycycline can reduce α-synuclein aggregation and improve symptoms in animal models of Parkinson's disease. This could lead to a potential treatment option for the degenerative condition.
A Johns Hopkins Medicine research team successfully flew a specialist to a stroke patient, improving outcomes and reducing costs. The study demonstrates the feasibility of helicopter-based care for time-sensitive procedures like catheter-based treatment.
Researchers found that in areas with high predation risk, fish differentiate into leaders and followers, leading to increased shoal cohesion. The study suggests that decision-making in social groups can adapt depending on ecological factors.
A Finnish study finds that moderate cardiorespiratory fitness protects against fatty liver, a significant public health concern linked to metabolic disturbances and cardiovascular disease. Achieving cardiorespiratory fitness can help mitigate the risk of fatty liver, regardless of weight status.
A new computer model assesses real-time Zika epidemic risk in US cities by combining population dynamics, historical infection rates, socioeconomics, and mosquito density. The model predicts that certain counties in Texas have the highest risk of Zika transmission, while others have nearly no risk.