Researchers at Case Western Reserve University discovered a self-renewing mechanism to help retina sense light using biochemically manipulated vitamin A. This mechanism could lead to improved therapeutics for treating people with vision impairment and other nerve cell disorders.
Researchers at Case Western Reserve University have identified a new target for improving cardiac output in heart failure patients by modifying a specific protein. Modifying the serine 302 amino acid on myosin binding protein-C (MyBP-C) can significantly enhance cardiac function, providing a promising therapeutic approach.
Researchers used supercomputers to simulate the behavior of K-Ras protein in cell membranes, discovering that certain lipids can turn the protein 'off' by changing its orientation. This finding suggests limiting concentrations of PIP2 in cell membranes could help prevent cancer progression.
The Case Comprehensive Cancer Center has been named to a new national colorectal cancer dream team, comprising scientists and clinicians from top institutions. The team will test a promising new therapy for the first time in human patients, combining glutaminase inhibitor CB-839 with chemotherapy medication capecitabine.
Researchers at Case Western Reserve University have discovered non-antibiotic antivirulence compounds that prevent disease-causing toxins from forming in gram-positive bacteria. These compounds, such as F19, have shown effectiveness against various types of superbugs and may enable the use of existing antibiotics in combination therapy.
Researchers grew stem cells from children with Pelizaeus-Merzbacher Disease to understand the genetic causes of common symptoms. The study identified defects in brain cell function linked to patient genetics, suggesting distinct subgroups requiring different clinical approaches.
A massive meta-analysis of brain tumor data has identified 13 new genetic risk factors for glioma, doubling known risk factors. The study provides a better understanding of the disease and may help doctors diagnose high-risk patients early.
A man with quadriplegia has regained arm movements using a brain-computer interface and functional electrical stimulation system. The technology allowed him to perform simple functions like grasping and eating, marking a significant milestone in the restoration of motor function for individuals with paralysis.
Case Western Reserve University researchers have developed a breakthrough technique to create durable stem cells directly from urine, providing an ethically sound and clinically relevant model for studying Down syndrome. The new method represents a significant improvement in induced pluripotent stem cell technology.
Case Western Reserve University awards Marian Wright Edelman the 2017 Inamori Ethics Prize for her life's work as a fierce advocate for children's rights, poverty alleviation, and access to education. The founder of the Children's Defense Fund has championed policies to protect vulnerable populations and ensure their well-being.
A novel combination of two antibiotics, ceftazidime/avibactam and aztreonam, has been shown to be effective against a high percentage of carbapenem-resistant enterobacteriaceae (CRE) specimens. The therapy works by blocking different types of enzymes that bacteria use to destroy antibiotics.
Researchers at Case Western Reserve University School of Medicine have identified the CD40 receptor on Mueller cells as the primary driver of diabetic retinopathy. The study reveals that this receptor initiates inflammation in the retina, leading to vision impairment.
Researchers at Case Western Reserve University discovered changes in specific regions of DNA that 'enhance' harmful gene expression to promote tumor growth. These recurrent changes in DNA activate genes involved in colorectal cancer progression.
A new study found that acorn ants can evolve quickly enough to endure city temperatures, with some species adapting within 100 years. The ants' ability to adjust suggests they may be able to cope with other sources of warming, such as climate change.
Researchers identified an enzyme called CYP46A1 that eliminates both cholesterol and cholestanol from the brain, reducing the formation of debilitating brain lesions. The discovery could inform clinical trials to test the enzyme's potential as a therapeutic target for these diseases.
A new national study found a 700-percent surge in antibiotic-resistant infections among children in the US, with more than 75 percent already present when admitted to hospital. The study also shows that infected children stayed 20% longer in hospital and faced greater risk of death.
The study provides evidence that a new investigational drug (SCY-078) may help to cure Candida auris infections. The fungus is multidrug-resistant and has been linked to invasive infections with high death rates globally.
A team led by Case Western Reserve University researchers found a tight correlation between observed acceleration and gravitational acceleration from visible mass in various galaxy types. This discovery suggests a universal law governing galactic systems, similar to Kepler's planetary law. The findings require rethinking dark matter an...
A Case Western Reserve University researcher discovered that the Cuatro Ciénegas cichlid, a rare fish species, employs a unique sneaking behavior to fertilize eggs, outpacing dominant males. This unusual strategy is found in only a few dozen of approximately 34,000 fish species worldwide.
Researchers at CWRU are testing a portable blood-adhesion monitor for sickle cell disease patients. The device aims to predict vaso-occlusive crises and help patients better manage their condition, potentially reducing physical and financial costs.
A new four-year study, funded by a $2 million NIH grant, will test a web-based program designed to help grandmothers manage the stresses of caring for their grandchildren. The program aims to improve coping skills and reduce emotional and physical fallout associated with this demanding role.
Researchers found consistent differences in prostate shape and transitional zone between men with and without prostate cancer. The findings suggest a potential biomarker for disease diagnosis and aggressiveness.
A new study aims to develop a combination therapy using interleukin-2 and a monoclonal antibody to eradicate HIV. The treatment, if successful, could reduce latent HIV reservoirs and cure the infection.
A breakthrough study by Dr. Xinglong Wang has linked ALS and dementias to TDP-43 toxicity in mitochondria, offering new hope for treatment. His team discovered a small-molecule peptide that can reverse symptoms of ALS in mice, paving the way for potential therapeutic approaches.
Researchers at Case Western Reserve University have uncovered the structure of a cancer cell receptor protein, paving the way for the development of new cancer-fighting drugs. The study identified key binding sites that can be targeted to modulate the protein's function and prevent tumor growth and metastasis.
Researchers at Case Western Reserve University have directly measured the diffusion length of perovskite solar films, showing that electrons can travel long distances without deteriorating. The findings suggest that solar cells could be made thicker without harming their efficiency, potentially leading to better solar panels.
A new quality control system in cells has been identified, which recognizes and destroys faulty genetic material by targeting the ribosome and messenger RNA. This discovery could potentially be used to develop new treatments for genetic diseases.
The university will explore a 'molecular diversity' of potential glucose-responsive insulin analogs to develop rapid-acting, glucose-responsive insulins that become active when blood sugar is high and inactive when low. The goal is to mitigate the risk of blood sugar levels being too high or too low for patients with type 1 diabetes.
A new NIH-funded study aims to test ways family members can maintain their health while caring for relatives with bipolar disorder. Researchers will match caregivers with tailored self-management techniques, including breathing exercises and training in self-help skills, to reduce stress and improve overall health.
Case Western Reserve University researchers are scaling up a prototype iron-flow battery to provide cleaner and cheaper power when renewable energy sources are ebbing or demand is peaking. The battery can store excess electricity and increase overall efficiency.
Researchers discovered that blocking IL-6 in psoriasis patients may not prevent skin inflammation, but its levels are central to thrombosis events triggered by skin inflammation. A compensatory 'workaround' mechanism involving other immune system molecules is proposed to explain the findings.
A new study by Case Western Reserve University links avoiding spiritual struggles with poorer mental health outcomes, including higher levels of depression and anxiety. People who fully engage with these struggles report better mental health than those who avoid them.
Researchers at Case Western Reserve University developed a portable sensor called ClotChip that can quickly and accurately assess blood's clotting ability. This technology has the potential to revolutionize the diagnosis and treatment of blood clots, allowing for faster and more precise assessments.
Case Western Reserve University, NASA Glenn Research Center, and the University of Toledo are collaborating on a $1 million project to integrate distributed energy sources with buildings and grid. The Northern Ohio Building-to-Grid Integration Demonstration will test strategies for optimizing energy consumption across various conditions.
A Case Western Reserve University researcher has found that addiction treatment results improved when teens in a residential program stopped smoking. Teens who quit smoking showed lower cravings for alcohol and drugs, similar to their peers who smoked, but with better treatment duration and global functioning.
Case Western Reserve University researchers create sensor-enabled geometric blocks to assess cognitive skills, revealing hyperactivity and performance accuracy. The technology allows for customizable testing and training for individuals of any age, including those with developmental disabilities or brain trauma.
A new approach, SystemChange, focuses on manipulating environments to change habits without relying on individual motivation. This approach has proven effective in reducing screen time, improving sleep, and developing healthy eating and exercise habits.
Researchers have developed a dry adhesive that bonds in extreme temperatures, offering properties for space exploration and electronics management. The gecko-inspired adhesive maintains strength in liquid nitrogen and molten silver, and even gets stickier with increasing heat.
Researchers have developed a portable, battery-operated device that can quickly and accurately detect malaria in the bloodstream using magnets and lasers. The Magneto-Optical Detector (MOD) has the potential to save $1.2 billion annually on anti-malaria efforts by reducing false positives and negatives.
Researchers at Case Western Reserve University developed a new method called InFlo to assess cell communication networks and identify disease-specific anomalies. InFlo predicts how cells send signals across networks to cause cancer or other disease, with applications in basic and translational research.
Researchers have developed a system that enables amputees to feel a range of intensity levels on their prosthetic hands, allowing them to hold objects, operate machinery, and interact with others. The system uses electrical stimulation to mimic natural touch, decoding the intensity of pressure in the nervous system.
A five-year study in Harvard and Duke forests found that adding warmth predicted in climate-change models destabilized forest ant communities. The loss of stability makes communities less resilient and slower to rebound when disturbed, with relative abundance of thermophilic species growing while heat-intolerant species declining.
A study from Case Western Reserve University found that older men adhere closely to an idealized masculinity script incompatible with the realities of later life. This script leaves senior men without a blueprint to behave or handle emotions, contributing to health problems and difficulties in caregiving.
A $1.65 million Department of Defense grant will support the development of a brain-machine-brain interface (BMBI) aimed at helping TBI and stroke patients regain motor function. The BMBI records signals from one part of the brain, processes them in real time, then bridges the injury by stimulating a second part of the brain.
The study, published in The Electricity Journal, suggests that the increasing availability of cheap shale gas has led to a decline in coal-generated electricity. The researchers found that despite proposed new EPA rules, power plants have continued to favor gas due to its technological and economic advantages.
Researchers developed a computer program to automatically count the number of tubules in breast cancer tissue specimens, finding a correlation with Oncotype DX gene expression test risk scores. The study aims to provide an affordable and quick alternative to current genomic tests for predicting chemotherapy needs.
A new analysis by Case Western Reserve University found that testing backlogged sexual assault kits can prevent future sexual assaults and save victims millions of dollars. The study estimates that serial sexual offenders are more common than previously thought, with a 25% recidivism rate among rapists.
A Case Western Reserve University researcher proposes a framework to address ethical questions surrounding potentially revolutionary research on part-human, part-animal embryos. The researcher suggests prioritizing animal welfare while enabling scientific progress in areas of biomedical importance.
Researchers from Case Western Reserve University identified structurally abnormal genes in esophageal adenocarcinoma, which could serve as potential indicators of aggressive esophageal adenocarcinoma. The study found gene fusions that were highly associated with poorer patient survival and may aid tumor development.
Researchers at Case Western Reserve University aim to understand the role of intestinal innate immunity in Crohn's disease. They will investigate how mice develop experimental Crohn's disease and replicate these findings in humans, with the goal of developing new medications and treatments to cure the devastating ailment.