The university will explore a 'molecular diversity' of potential glucose-responsive insulin analogs to develop rapid-acting, glucose-responsive insulins that become active when blood sugar is high and inactive when low. The goal is to mitigate the risk of blood sugar levels being too high or too low for patients with type 1 diabetes.
An international expert workshop has outlined a strategy for reducing and replacing animal use in acute systemic toxicity testing. The report, published in Toxicology In Vitro, presents recommendations including gathering high-quality reference data and global harmonization.
Researchers identified LATS as a key player in breast cancer development and treatment. The enzyme's absence leads to increased luminal precursor cells, which can give rise to tumors, and stabilized proteins YAP and TAZ that boost cell proliferation.
A new study from Georgia Institute of Technology reveals that Charon, Pluto's largest moon, significantly reduces the stripping of Pluto's atmosphere by solar wind when positioned between the sun and Pluto. This barrier creates a more acute angle of Pluto's bow shock, slowing down atmospheric loss.
Ocrelizumab has been shown to significantly reduce new attacks in patients with relapsing MS, slow symptom progression in primary progressive MS, and decrease brain lesions. The drug also demonstrated lower rates of disability progression and fewer infusion-related reactions compared to placebo.
A new study from UCLA suggests modifying federal health guidelines to use a risk calculator that takes into account more factors, potentially increasing effectiveness of PrEP in preventing HIV transmission. The calculator uses real-world data and is expected to be useful for gay and bisexual men who have sex with men.
A Danish cohort study found that breast cancer screening was not associated with a reduction in advanced tumors, but rather an increase in nonadvanced tumors and ductal carcinoma in situ (DCIS). The study estimates that approximately 1 in 3 invasive tumors diagnosed in screened women represent overdiagnosis.
Researchers optimized GaN-on-Silicon transistor composition to achieve high electron mobility, enabled by buffer layers that reduce strain and defects. The team achieved an electron mobility of 1,800 cm2/V-sec, paving the way for fully functional high-frequency devices for 5G applications.
Groundwater exploitation causes drying in deep soil layers but wetting in upper layers, leading to unsustainable terrestrial water storage. The atmosphere responds with cooling over certain regions and increased precipitation due to evapotranspiration from groundwater irrigation.
Researchers propose a high-value health plan that combines consumer-driven HDHPs with exemptions for clinical services proven to benefit patients. The concept has already gained bipartisan appeal in the US House bill.
Pediatric tuberculosis remains a concern in Canada, particularly among Aboriginal communities and children from endemic countries. Effective treatment requires a multidisciplinary approach, including clinicians, nurses, and social workers.
A recent study found that people who engage in physical activity on weekends have significantly lower all-cause mortality rates compared to those who are inactive. The research suggests that even short periods of moderate-intensity exercise can have health benefits, especially for individuals with busy weekday schedules. Experts recomm...
Tropical Depression 01W formed near Mindanao on January 8, 2017, and quickly weakened due to wind shear. The depression moved west through Mindanao towards the South China Sea, bringing moderate to heavy rains and rough seas to the region.
The human appendix has been viewed as a vestigial organ with little known function, but recent research suggests it serves as a secondary immune organ. The appendix has evolved independently in several mammal lineages and is often found in species with higher concentrations of lymphoid tissue.
A recent study found that children born to mothers who took acid-blocking drugs during pregnancy were at least one third more likely to visit a doctor for asthma symptoms. The researchers emphasize the need for further studies to confirm this association and determine whether the medicines cause asthma in children.
A new UTSA study examines how phishing e-mails thrive on overconfidence, finding that self-efficacy is a major factor. The researchers created experimental surveys with subjects choosing between genuine and phishing emails, revealing why certain tactics appeal to different people.
Two new phytoplankton groups have been found to favor warmer oceans, defying the expectation that eukaryotic species decline in these conditions. The discovery was made using over 6,000 RNA sequences and time-series sampling, providing insight into future ocean ecosystems.
A team of researchers at King's College London has discovered a method to stimulate the renewal of living stem cells in tooth pulp using an Alzheimer's drug. This novel approach aims to promote natural tooth repair and potentially reduce the need for fillings or cements.
Researchers at UNC School of Medicine found that mice reared in darkness show degraded dorsal stream responses, highlighting the importance of early visual experience for proper development. This discovery has implications for understanding vision restoration and recovery from bilateral cataracts.
Researchers found a strong correlation between domoic acid levels in shellfish and El Niño events and the Pacific Decadal Oscillation. A new model predicts domoic acid risks in the Pacific Northwest, helping coastal managers protect public health.
A new study finds that prostate cancer treatment rates dropped by 42% due to changes in screening recommendations, but treatment rates among those diagnosed remained high. Low-risk patients with limited life expectancy can now opt for surveillance instead of treatment.
A widespread outbreak of RSV and HMPV in a long-term dementia care ward infected 73% of patients, emphasizing the need for improved protocols to protect vulnerable residents. The facility has since implemented active screening, efficient separation, and partnered with a private laboratory for rapid respiratory viral testing.
Researchers at EMBL have traced the physical connection between the prefrontal cortex and brainstem that inhibits instinctive behavior. The study found that this connection, specifically to the PAG region of the brainstem, prevents social animals from acting out impulses.
Research found that consuming high amounts of unprocessed red meat increases the risk of developing diverticulitis by 58%. Replacing daily portions with poultry or fish may lower this risk, with a 20% reduced risk observed. Insufficient dietary fibre intake and smoking are also thought to play roles in the development of the condition.
Researchers argue that the linear no-threshold hypothesis, which suggests all radiation is harmful, is inaccurate and has led to widespread fear of low-dose radiation. Studies show that low doses stimulate protective responses, reducing cancer risk rather than increasing it.
A new study found that hospitals in Medicare Accountable Care Organizations (ACOs) reduced readmissions faster than non-ACO hospitals, with ACO hospitals decreasing their rates by 14.9%, compared to a 13.1% decrease for non-ACO hospitals.
The National Commission on Prevention Priorities has released updated rankings for clinical preventive services, highlighting the most effective and cost-effective options. The top three services include immunizing children, tobacco-use screening, and alcohol misuse screening, with scores of 10 out of a possible 10.
A new study found that Medicaid expansion is associated with increased insurance coverage and improvements in asthma treatment, BMI screening, pap testing, and blood pressure control. Care quality also improved on seven measures, including care for asthma, pap testing, and hypertension, particularly among Hispanics.
A landmark study reveals that men with a family history of prostate cancer and the BRCA2 gene fault have a more aggressive form of prostate cancer. The study shows that these cancers are genetically similar to advanced cancers, explaining why BRCA2 patients have poor outcomes.
A new study finds that even low-deductible plans can result in high out-of-pocket costs for individuals with chronic health conditions. The researchers analyzed data from over 17,000 people and found that those with high-deductible plans spent more than 10% of their total income on healthcare costs.
A study in Health Affairs explores Brazil's Estratégia de Saúde da Família program and its impact on mortality rates. The findings indicate that expanding primary healthcare can reduce mortality rates, but effective implementation depends on strong local governance.
Researchers analyzed 35 million articles from British regional newspapers to detect major events, gender bias, and cultural shifts. The study found significant changes in representation over time, with women's presence increasing after 1900 but still being underrepresented.
A massive genetic study of humpback whales has confirmed the need to protect unique populations in the Arabian Sea. The study, which analyzed over 3,000 skin samples from individual whales, revealed previously unknown degrees of relatedness between different whale populations.
New international guidelines aim to improve healthcare for nearly 300,000 pregnant women with thyroid disease each year. The guidelines provide evidence-based recommendations for diagnosis, treatment, and management of thyroid illness during pregnancy.
Researchers at MIT have found that some catalysts produce oxygen from within their crystal structure, contrary to previous assumptions. The study's findings could help fine-tune metal-oxide catalysts for enhanced energy storage processes.
A new study from the University of Michigan found that older kids are more likely to view confessing as right, while younger children connect positive emotions to lying and negative emotions to confession. Parents can foster open communication by listening without anger, making it critical for teens grappling with adult issues.
Researchers identified a new biological target for treating spinal muscular atrophy by boosting an experimental medicine with Nusinersen. In mouse studies, the combination therapy improved survival time, body weight, and motor movements, suggesting potential benefits for people with the disease.
Computing science researchers at the University of Alberta have developed a technique to automate geotagging for news articles and other online documents. The model integrates two competing hypotheses: inheritance and near-location, achieving high accuracy in matching named entities to geographical locations.
A study found an average gap of 3-9% in compensation for minorities and females serving on corporate boards. Despite being paid more overall, they often hold fewer leadership positions due to a lack of representation on key committees.
The study reveals three new species of land flatworms from the Brazilian Araucaria forest, contributing to the region's high biodiversity. The discovery sheds light on the importance of these organisms as bioindicators for habitat impact assessment.
Researchers found that chemicals extracted from prickly pear and brown seaweed improve cellular and animal models of neurodegenerative proteinopathies. The study suggests these substances may target pathways affected by multiple neurodegenerative conditions.
Delirium is an often-undiagnosed syndrome affecting nearly 18% of long-term care residents, characterized by disorganized thinking and attention deficits. Prevention strategies include avoiding non-essential surgery, maintaining hydration, and minimizing medication exposure.
Sepsis is a life-threatening organ malfunction caused by infection, associated with significant hospital deaths. Recognizing sepsis as a separate cause can lead to improved hygiene, nutrition, vaccination rates, and quality of life for those affected.
Researchers have identified potential therapies for myotonic dystrophy type I (MD1) by targeting AMPK and mTORC1 pathways, which are disrupted in MD1 muscle tissue. Treatment with drugs that activate these pathways improves muscle function and reduces abnormal gene splicing.
A study revealed that it takes two years or more for one-third of women with PCOS to receive a diagnosis, highlighting the need for improved education and support. The authors call for international guidelines and resources to improve diagnosis experience and health outcomes for women with PCOS.
A recent study led by Georgia State University researcher found that living in segregated communities can affect colorectal cancer diagnosis timing. Residents of highly segregated Asian communities are more likely to receive late diagnoses, while those in African American communities are less likely.
Researchers found altered brain circuitry in premature infants as early as 24 weeks gestation, which may lead to neurodevelopmental disorders like autism and cerebral palsy. The study suggests that factors contributing to early birth may impact brain development in the womb.
Researchers at the University Health Network have discovered a genetic fingerprint that explains why up to 30% of men with localized prostate cancer develop aggressive disease after radiotherapy or surgery. This finding could help clinicians personalize effective treatments from diagnosis, leading to improved cure rates.
Researchers argue that waste methane can be turned into valuable chemicals through biomanufacturing, which could meet industry's needs and reduce environmental impact. By operating at smaller scales, biomanufacturing facilities can be closer to feedstocks and point of need, facilitating faster innovation.
Research from the University of Oxford found that a woman's family background is the major factor in delaying motherhood, with education contributing only 1.5 months to the total six-month delay.
A new study by Michigan Medicine found that hospitals' decisions on sending surgery patients to healing destinations greatly impact healthcare spending. The choice between inpatient, home, or outpatient care drives post-acute spending, with inpatient rehabilitation being a key driver of total 90-day costs.
Researchers observed that brain cell powerhouses, called mitochondria, can quickly become dysfunctional after injury like stroke or trauma. However, they often resume their normal shape once blood and oxygen are restored, suggesting a potential new avenue for improving recovery from such injuries.
Researchers at WSU have discovered a new type of cooperative photosynthesis that allows bacteria to transfer electrons, enabling anaerobic photosynthesis. This process has significant implications for engineering microbial communities for waste treatment and bioenergy production.
A new study published in Diabetologia suggests that enterovirus infections are associated with the onset of autoimmunity in children who develop type 1 diabetes. The study found a higher incidence of enterovirus infections in children with T1D compared to control children, particularly those who developed islet autoantibodies.
Researchers from Linköping University and the University of Las Palmas de Gran Canaria analyzed prehistoric seeds to discover that barley was one of the main crops on the island of Gran Canaria over 1,000 years ago. The study suggests that the Canary Islands were colonized by tribes from northern Morocco nearly 2,000 years ago.
Research finds bilingual brains are more efficient, recruiting fewer regions and specialized areas to process information. Bilinguals show improved focus and interference control, benefiting daily life and potentially staving off signs of aging.
In the immediate aftermath of a devastating earthquake, Israeli tourists demonstrated remarkable leadership skills, quickly springing into action to help others. The study's findings highlight the importance of group cohesion and connection to their military background in coping with traumatic events.
A Singapore-based study found an association between insufficient sleep and gestational diabetes mellitus (GDM) in a multi-ethnic Asian population. Short sleep duration was linked to increased risk of GDM, with the highest frequency among women who slept less than six hours a night.
A comprehensive review of post-disaster mental health issues found high rates of PTSD and depression in Japan earthquake survivors. The study highlights specific risk factors, such as resettlement and small social networks, and emphasizes the need for long-term support.
A new study published in PNAS reveals that peace brings people together in Scandinavian countries, while groups band together against other groups for a united cause in conflict-ridden war zones. In countries with a mix of indigenous and immigrant populations, intergroup relations are more challenging, leading to ambivalent stereotypes...
The American Psychological Association emphasizes the importance of psychologists in patient-centered medical homes, highlighting their role in improving health outcomes, decreasing costs, and enhancing patient experience. Behavioral health problems are prevalent among medical patients, compounding care delivery and effectiveness.
The American College of Cardiology has published a new document to manage patients with nonvalvular atrial fibrillation who need surgery. The guideline provides guidance on temporarily stopping anticoagulation medications, choosing alternative treatments, and restarting blood thinners after surgery.
Scientists at ORNL have developed a novel crystallization method to capture carbon dioxide directly from ambient air. The method uses a guanidine sorbent that can be heated at relatively low temperatures to release the gas, reducing energy consumption and emissions.
Research found that nearly 1,400 US servicemen sustained genitourinary (GU) injuries during the Iraq and Afghanistan wars. The majority of patients suffered severe testicular and/or penile injuries, often part of polytraumatic injuries. Novel treatments are needed to address long-term sexual and reproductive health concerns.
Researchers found that increasing parental physical activity and reducing sedentary behavior correlates with increased physical activity behaviors in children. The study used movement monitors to objectively measure physical activity and found a significant association between parent and child behavior.
A study published in JAMA Internal Medicine found that men and women who engage in physical activity on just one or two occasions per week have a lower risk of death from all causes, cardiovascular disease, and cancer. The 'weekend warriors' spent an average of 300 minutes per week doing moderate- to vigorous-intensity physical activity.
A new study suggests that natural progesterone supplementation can increase pregnancy success in women with a history of recurrent pregnancy loss. The research found that over two-thirds of pregnancies were successful in women who received progesterone, compared to barely half in those who did not.
A landmark global scale study found that populations at the northern and southern range edges are most sensitive to ocean acidification, leading to reduced growth and genetic diversity. The research provides insights into how ocean acidification will shape species' distributions in the future.
The study reveals differences in protein arrangement between immature Zika and other flaviviruses, shedding light on the virus's role in infection and disease. Understanding the structure of the immature form could help develop effective antiviral treatments and vaccines for diseases like microcephaly.
A new mathematical model describes ecological invasions as a random walk, categorizing randomness into spatial, demographic, and temporal factors. The model replicates key properties observed in computer simulations, resolving an ongoing argument between ecologists and mathematicians.
Researchers at Columbia University Medical Center found that transfusing older blood (over 5 weeks) can lead to excessive iron release, potentially harming patients. The study suggests reducing the maximum storage limit of red blood cells from 6 weeks to 5 weeks.
Researchers at Mayo Clinic have identified a key drug target, CDK4/6, which regulates the spread of triple-negative breast cancer. The study found that inhibiting this protein with CDK 4/6 inhibitors can prevent the metastasis of triple-negative breast cancer to distant organs.
President Obama expresses confidence in a clean energy economy driven by economic growth and cost savings. He cites evidence of reduced emissions and carbon dioxide drops alongside businesses profiting from renewable energy investments.
A new computational model reveals a winner-take-all operation is enabled by a configuration of inhibitory neurons. The model, developed by MIT researchers, uses theoretical computer science to prove that a specific arrangement of inhibitory neurons is necessary for the operation.
Researchers at IRB Barcelona identify a fundamental role of JAK/STAT signalling pathway in regulating limb development and growth. The study reveals three key functions of JAK/STAT in specifying wing formation and growth, with implications for understanding human congenital diseases.
A new study found that the Affordable Care Act (ACA) improved health care access and utilization among Latinos, but persistent disparities persist. The study suggests expanding the law to undocumented immigrants could help combat these disparities.
A new study found that the Affordable Care Act (ACA) increased mammography use among all economic subgroups, including those with lower incomes. However, colonoscopy screening rates remained unchanged despite eliminating out-of-pocket expenses under the ACA. The findings suggest that other barriers to colonoscopy access may still exist.
A new NIH-funded study found that in underserved populations, parents' physical activity levels directly correlate with their preschoolers' activity levels. The research suggests interventions could focus on helping parents model an active lifestyle for their children to combat obesity. Low-income and ethnic minority families are dispr...
Scientists at UCL and dunnhumby developed a model to predict when people will try new products, analyzing purchase data from over 280,000 shoppers. The study found that shopping behavior is consistent across product categories, with individuals having individual 'exploration personalities' when they shop.
Rettsyndrome.org has reached a milestone of $40 million in research funding for Rett syndrome treatments. The organization has funded over 40M in high-quality research grants and programs to date.
Research at the University of Iowa shows that high-dose vitamin C selectively kills cancer cells by generating hydrogen peroxide, a reactive oxygen species. Cancer cells with low catalase activity are more susceptible to damage and death when exposed to high amounts of vitamin C.
Researchers identified genetic variants that affect Crohn's disease severity, but found these variants do not determine individual risk of developing the condition. The study suggests new pathways for treating established disease.
A study found that adults who performed the recommended amount of weekly physical activity in one or two sessions had lower risks for death from all causes, cardiovascular disease, and cancer. The risk reductions were similar among weekend warriors and insufficiently active adults.
Researchers at UC Riverside have identified a novel strategy for controlling viral diseases by targeting the interaction between a viral effector protein and a host hormone. The study found that the cucumber mosaic virus manipulates plants to release odors attractive to aphids, which transmit the virus.
A new study from Columbia Business School sheds light on the secret sauce to developing creative ideas, finding that a balance between novelty and familiarity makes an idea more creative. The researchers developed a tool that analyzes word combinations in real-time and recommends words to improve ideas.
A Johns Hopkins Medicine study found that social ecology influences on personal experiences and interactions with family, peers, and healthcare providers hinder young men's use of sexual and reproductive health care. Long wait times, costs, and concerns about privacy also deter seeking care.
A new optomechanical device uses a microscopic silicon disk to confine optical and mechanical waves, achieving high coupling rates and making it highly customizable. The device's design allows for independent tailoring of its performance with different light frequencies or mechanical wave frequencies.
A study published in Diabetes journal found epigenetic changes in the DPP4 gene are associated with fatty liver development in both mice and humans. These changes, detected at six weeks of age, lead to increased enzyme production and correlate with fat content in the liver.
The study reveals that Chinese hydropower operations have significantly altered the Mekong River's dry and wet season flows, affecting its ecological productivity. The changes in river flow have been particularly pronounced since 2014, with the Nuozhadu dam project having the largest impact on downstream Cambodia.
A new review found functional rehabilitation and minimally invasive surgery to be effective treatment options for Achilles tendon tears, especially in recreational athletes. Surgical repair may be optimal for high-performance athletes, offering improved strength and power.
A study found that performing even a third of the recommended activity is beneficial for older adults with arthritis. Participants who achieved a minimum of 45 minutes of moderate activity, such as brisk walking, per week were 80% more likely to improve or sustain high function over two years.
A new collaboration between UMD and NOAA has developed reference datasets that can be used to calibrate weather satellites. This improvement enables more accurate weather forecasting and monitoring of climate change.
Researchers create new catalytic approach to prepare compounds essential to drug discovery with high selectivity and 20 times less solvent than alternative methods. The new strategy was used to prepare the anti-cancer agent pacritinib, which is now in advanced clinical trials.
A study by University of Michigan researchers found that growing multiple algal species helps stabilize biocrude production and makes the system more reliable. However, competition among species often causes mixtures to produce less biocrude than individual species.
A new model developed by researchers at Binghamton University uses cognitive dissonance to help individuals recognize their online addiction and reduce its effects. Increasing users' awareness of the consequences of their behavior can create discomfort, motivating them to exert self-control.
A new study published in the American Journal of Clinical Nutrition found that a high-cholesterol diet or frequent consumption of eggs do not increase the risk of memory disorders. In fact, egg consumption was associated with better cognitive performance in certain tests.
A new study of 119 children with osteogenesis imperfecta found that bisphosphonate treatment did not change the radiological appearance of femur fractures.
The 'test and treat' scheme aims to reduce GP consultations and antibiotic prescriptions, but lacks robust evaluation and may not be cost-effective. The NHS England plan is based on limited data from a small pilot, which raises concerns about its scalability and potential impact.
A recent study by Cedars-Sinai found that implementing rigorous catheter safeguards can significantly reduce bloodstream infections related to central venous catheters. The study, which analyzed data from 113 hospitals, showed a 57% reduction in infection rates while producing net savings of $1.85 million for each site over three years.
Two studies reveal that cancer cells can tolerate genetic mutations by inactivating the BCL9L gene and slowing down division to avoid mistakes, allowing them to thrive and evolve. This understanding may lead to new ways to target cancer cells and improve treatment efficacy.
A new study reveals that liberals and conservatives share similar moral roots, particularly concerning sanctity, making constructive discussion challenging. The findings suggest a stalemate in the culture war due to each side considering certain issues as sacrosanct or fair for revision.
The National Commission on Prevention Priorities releases updated rankings of clinical preventive services, identifying high-impact services for improving population health. The top three services are immunizing children, tobacco-use screening and brief intervention, and alcohol misuse screening with brief intervention.
Greater primary care physician involvement at the end of life is associated with less costly and less intensive care. Regions with more primary care involvement have lower Medicare spending in the last two years of life and fewer ICU days in the last six months.
The Spanish system has made organ donation a routine consideration when a patient dies, with professionals exploring patients' wishes regarding organ donation. The model's success lies in its coordination and organization, making it applicable to other countries with adaptations depending on the healthcare system and factors.
Researchers have discovered that Dab2 controls a population of fat stem cells that slowly disappears with maturity. This finding may reinforce the importance of steering children away from high-fat diets and lead to new pharmaceutical strategies to combat childhood obesity.
Lead acetate, combined with mastic resin and linseed oil, enabled artists to create quick-drying paint layers for the first time. This innovation allowed for faster production times, facilitating the development of modern styles in the 19th century.
A new study suggests that progesterone could be a key to preventing recurrent miscarriage in women who suffer multiple pregnancy losses. Researchers found that micronized plant-derived progesterone improved endometrial function and prevented pregnancy loss.
A research team at Nanjing University found that PKM2 promotes exosome release by phosphorylating SNAP-23, which controls the dock and release of secretory granules or exosome-containing multivesicular bodies. This study demonstrates for the first time that PKM2 plays an essential role in promoting tumor cell exocytosis.
A series of moisture-laden storms has affected the western US, including California and the Pacific Northwest, causing extreme rain events and blanketeting the region in snow. The National Weather Service is forecasting heavy snows and periods of rain with potential flooding or flash flooding along the West Coast.
Dutch clinicians have developed a personalized dosing strategy for treating multidrug-resistant tuberculosis, reducing hearing loss from 40% to 10%. By monitoring drug concentrations and effectiveness, they were able to decrease doses without compromising efficacy.
A study found that only 55% of breastfed infants received the recommended daily vitamin D supplementation. Mothers preferred to supplement themselves, citing safety as their top concern. Higher doses of vitamin D could be incorporated into maternal supplementation routines to enrich breast milk and improve intakes in breastfed infants.
Researchers find that methane and other short-lived greenhouse gases impact sea levels for hundreds of years after being cleared from the atmosphere, with some effects even more long-lasting. The study highlights the importance of understanding climate change duration and its consequences for coastal regions.
A new study found that patients given psychological support before heart surgery scored lower on disability tests, had better mental quality-of-life, and reported more physical activity. Personalized support appeared to have the greatest benefit, and a short-term intervention can be easily implemented in cardiac surgery units.
A new study by NOAA-supported researchers has developed a climate-based risk analysis model to predict domoic acid concentrations in shellfish. This model can help seafood industry managers stay ahead of harmful algae events, supporting timely fishery closures or openings and safeguarding public health.