Researchers found that the activated S6 ribosomal protein P-S6S240 was present in 32% of high-grade tumors and associated with shorter progression-free survival. PI3K/mTOR inhibitors showed promising results in two patient-derived xenograft models, suggesting a potential treatment option for patients with this type of uterine sarcoma.
Research reveals that sons of cocaine-using fathers are at risk for learning deficits and memory loss. Epigenetic mechanisms alter gene expression in the brain, depleting essential molecules like D-serine, leading to impaired synaptic plasticity.
Research by UCL scientists found a strong association between long-term stress and obesity, with people experiencing chronically elevated cortisol levels being more prone to weight gain and persistent overweight status.
The revival of for-profit medical education has the potential to address the nation's physician shortage and offer more affordable tuition options. However, critics argue that these schools must demonstrate they can operate profitably while maintaining academic quality.
A new study found that HIV-infected individuals with kidney failure are less likely to receive a transplant, especially from living donors. The study highlights the need for expanded access to organs for HIV+ patients to address disparities in transplantation.
Analytic modeling helps identify social network connections among stakeholders, revealing strengths and weaknesses in communication and collaboration. This approach enables policy makers to allocate resources effectively, addressing scale mismatch and multi-level governance.
A recent study found that massive warm-water eddies in the Caribbean Sea contribute to intense hurricanes like Matthew. The research team measured ocean temperature, salinity, and currents to better understand these oceanic features.
The USDA's National Institute of Food and Agriculture has awarded grants totaling $4,790,100 to non-land-grant universities for agricultural science programs. These grants will support education, research, and outreach activities in agriculture, renewable resources, and related disciplines.
A new study called Latino Core aims to learn about the aging process and risk factors for Alzheimer's disease in older Latino adults. The study will enroll over 300 participants and include yearly visits, memory exams, and brain donation to understand the pathophysiology of dementia in this population.
Researchers have discovered a new class of compounds that kill adult and egg stages of the human whipworm, a parasite infecting 500 million people. These compounds could lead to effective treatments and vaccines for whipworm infections, which cause physical and mental damage.
A diet rich in fruit and vegetables is associated with a significantly lower risk of chronic lung disease (COPD) in former and current smokers. The study found that each additional daily serving was linked to a 4-8% lower risk, with the strongest influence coming from apples, green leafy vegetables, and peppers.
A Dartmouth Institute study found that regions with high specialist to primary care ratios have more overuse of low-value services, and the use of these services remained relatively consistent over time. The study also highlighted a concerning 'potential for double jeopardy in health services receipt among black Americans'.
The study aims to assess how siloed municipal water agencies in Texas can transition to an Integrated Urban Water Management model. The Institute for Sustainable Energy will focus on integrated water utility financial modeling, providing recommendations for a viable path to IUWM in Texas.
A Swedish study found that insufficient weight gain during pregnancy is associated with a higher risk of nonaffective psychosis, including schizophrenia spectrum disorders, in children. The study of 526,042 individuals born between 1982 and 1989 found that mothers who experienced extremely inadequate gestational weight gain were more l...
Two UCSB faculty members, Stefano Tessaro and Andrea Young, have been selected as recipients of the prestigious Alfred P. Sloan Research Fellowship for their outstanding contributions to cryptography and condensed matter physics. The fellowships will support their research efforts in building solid theoretical foundations for cryptogra...
A team of scientists has discovered how bacteria make the coenzyme F430, which facilitates the conversion of carbon dioxide (CO2) into methane gas. This breakthrough could lead to the development of more effective and easier-to-grow methanogenic bacteria for energy production.
A recent study found that children exposed to severe deprivation in Romanian institutions aged 0-3 experience mental health problems in early adulthood. Despite living in supportive families, these children had higher rates of social, emotional, and cognitive problems throughout their lives.
A new classification system for viruses based on their structure could help identify and treat emerging viruses. The system uses computational tools to detect similarities in the genetic code of viruses with similar outer structures, suggesting a common ancestor.
The study reveals that arrestin's C-edge loops interact directly with the membrane, forming a new type of binding. This discovery opens up new avenues for understanding the role of the membrane in GPCR-arrestin interactions and developing drugs with fewer side effects.
A study by Laurine Gilles and colleagues sheds light on the genetics behind haploid induction in maize, revealing the molecular identity of a key gene that promotes fertilization. The identification of 'Not Like Dad' is an important breakthrough to fully understand the process and translate this breeding tool to other crops.
The ASTER Trial shows no significant difference in revascularization rate and safety between Penumbra's aspiration system and stent retrievers for acute ischemic stroke patients with large vessel occlusions. The study provides evidence supporting the use of aspiration as a frontline thrombectomy approach.
Most people would rather remain ignorant of upcoming events, even if they could make them happy, due to concerns about regret and suffering. People who decline knowledge of the future are more risk-averse and frequently purchase life insurance, suggesting they anticipate negative outcomes.
A study found that male birds' mobbing behavior, such as dive bombing and aerial swoops, serves not only as protection against predators but also as a way to showcase their physical qualities to attract females. When females from the same species are present, males increase their participation in these displays.
Tropical Cyclone 08P formed on Feb 22, strengthening to a tropical storm with winds near 40mph. The cyclone is moving southeast at 38mph, fueled by wind shear despite forming under adverse conditions.
Scientists at Vanderbilt University created a 3D organ-on-a-chip that can mimic the heart's biomechanical properties, allowing for the study of cardiac diseases, drug screening, and personalized medicine. The device replicates the mechanical conditions of the living heart, including electrical and biochemical environments.
Researchers have discovered a new way to identify and test new drugs using differential mobility spectrometry (DMS), which analyzes drug molecules based on their response to an electrical field. This technique can measure drug properties in seconds, allowing for high-throughput testing of hundreds or thousands of drugs.
Researchers at Umeå University discover a new mechanism for protein EHD2, which stabilizes the cell membrane by forming oligomers. This discovery sheds light on the role of caveolae in maintaining cellular structure and function.
A new study identified six 'hot spots of marine biodiversity' severely impacted by climate change and fishing pressures, including the Atlantic, Indian, and Pacific Oceans. Industrial fishing has reduced global fish stocks, with harvest pressure expected to further exacerbate decline in these areas.
Weekly Tai Chi sessions reduced systolic blood pressure by 10.25mmHg and increased high-density lipoprotein (HDL) by 0.16mmol/L in adults with known stroke risk factors. The study suggests that continuing Tai Chi exercise may help prevent strokes.
Researchers at Hebrew University of Jerusalem discovered how enteropathogenic bacteria sense host attachment and reorganize gene expression to exploit cells. This understanding may lead to new strategies to combat bacterial infections.
Tropical Cyclone Bart formed and weakened rapidly, becoming a short-lived storm after just two days. Its maximum sustained winds reached 35 knots before the system accelerated into mid-latitude wind flow, marking its end.
The first Iberian lynx infected with the pseudorabies virus has been identified, highlighting the need for conservation efforts to protect this endangered species. The study found that the virus can have a negative impact on wild Iberian lynxes under threat of extinction, and researchers suggest vaccination as a potential strategy.
Researchers uncovered 91 genes linked to neurodevelopmental disorders, including 38 previously unknown risk factors. The study found overlap between conditions like autism and intellectual impairments, with some genes associated with both. Additional findings suggest less severe mutations may cause autism without intellectual disability.
Scientists have developed biomaterials that can mimic the characteristics of bone marrow, allowing them to alter blood cell development. The study's findings hold promise for treating hematopoietic cancers such as leukemia and improving our understanding of bone marrow failure.
A new study found that intensive lowering of systolic blood pressure to below 120 mm Hg would prevent 107,500 deaths per year in the United States. This reduction would be primarily among men aged 75 or older.
A new study conducted by RTI International found that many edible marijuana products lack clear labels, making it difficult for consumers to know what they are consuming. The study suggests improvements such as web-based education and graphics on labels can inform buyers and the public about safe consumption practices
Researchers have developed a transparent heating pad with embedded conductive silver nanowires that allows users to see through it and monitor their skin's color. The device is flexible, biocompatible, and can heat quickly when applied with a coin-cell battery, making it a potential solution to prevent burns from thermotherapy.
A new study confirms the existence of 'living fossils' by measuring evolutionary rates in the tuatara, a reptile that has remained relatively unchanged for millions of years. The research found that the tuatara's anatomy is remarkably conservative and shows slow evolution compared to its fossil relatives.
A Northwestern University study found that eliminating certain receptor genes in mice leads to obsessive-compulsive disorder (OCD)-like behaviors, such as excessive grooming. The research provides strong evidence for the biological basis of OCD and may lead to new treatments for the disorder.
A repurposed drug has been shown to prevent progression into diabetes in 80% of overweight patients with prediabetes, reversing the condition altogether in 60%. The study found that adding daily self-administered injections of liraglutide to diet and exercise significantly improved weight loss outcomes compared to placebo.
Researchers found that people with severe gum disease had higher HbA1C values and were more likely to have pre-diabetes or suspected diabetes. This suggests that severe gum disease may be an early sign of undiagnosed diabetes, making screening in dental practices a feasible option.
Older adults who underwent surgery for a herniated lumbar disk experienced similar improvements in disability, health-related quality of life, and leg pain compared to younger patients. However, they had more perioperative complications and longer hospital stays.
A study from Sahlgrenska Academy reveals a clear reduction in mean BMI and the frequency of childhood overweight and obesity among 8-year-old boys. The percentage of boys suffering from overweight or obesity decreased to its lowest levels since the early 1990s, with significant declines in both weight and obesity percentages.
Researchers from Florida Atlantic University developed a portable device that can detect the Zika virus using just a saliva sample, providing an affordable and rapid solution to diagnose the outbreak. The device, based on technology developed for HIV detection, aims to distinguish between Zika and other flaviviruses.
In a groundbreaking study, researchers at the University of Iowa have shown that gestational hypertension can be reversed in offspring born to hypertensive rats. The study's findings may offer a promising approach to addressing fetal programming and preventing the transfer of health risks from mothers to children.
Researchers have identified early biomarkers of Huntington's disease in a five-year-old HD sheep, revealing metabolic changes prior to physical symptoms. These findings suggest that the disease affects important bodily processes before they become apparent, and could lead to the development of new treatments.
Researchers found that ED patients with ultrasounds interpreted by nonradiologists underwent more follow-up imaging studies, with a mean increase of 1.08, 1.22, and 1.34 procedures within seven, fourteen, and thirty days respectively.
Researchers propose a new therapy for Gaucher disease by blocking the molecule C5aR1, which drives inflammation and organ damage. The treatment may offer fewer risks and lower costs than current therapies.
Researchers have uncovered adult and juvenile remains of a giant rodent species (Isostylomys laurdillardi) in Uruguay, raising questions about its classification. The study suggests that previously found fossils were from the same species as the newly discovered adults.
Researchers developed patient-size based diagnostic reference levels and achievable doses for 10 common CT head, neck and body examinations. The study found that using national benchmarks can reduce overall radiation dose and encourage facilities to optimize protocols.
Researchers have developed a single flexible fiber that can deliver optical, electrical, and chemical signals to the brain, enabling precise recordings of neuronal activity. This breakthrough could provide a significantly more accurate understanding of brain function and interconnections.
Researchers found that itch and mild pain signals can be transmitted through the same spinal cord neurons, with GRP neurons acting as a 'braking system' to mitigate intense pain. In mice without these neurons, pain responses were increased and scratching behaviors were altered.
A new report reveals over 5,000 likely transshipments between 2012-2016, with potential for millions more, highlighting the need for improved regulation and monitoring of transshipment in the global seafood market. The study also identifies clusters of transshipment along EEZs of countries with limited monitoring capabilities.
Research presented at American Stroke Association's International Stroke Conference 2017 found that people with middle age heart disease risks, such as diabetes, high blood pressure or smoking, are at higher risk for dementia later in life. The study, which enrolled 15,744 participants, revealed that the risk of dementia was significan...
Scientists have observed a tiny difference in the decay patterns of beauty baryons, suggesting that antibaryons may not be identical to their matter counterparts. This finding is significant because it could provide insight into why matter survived the Big Bang while antimatter did not.
A meta-analysis of 95 studies found that consuming more than five portions of fruit and vegetables daily reduced disease risk, with the greatest benefit seen in eating ten portions or 800g a day. This amount was associated with significant reductions in heart attack, stroke, cancer, and premature death risk.
Scientists have developed a simple rule to predict when the Earth's climate warms out of an ice age, using astronomical changes in the Earth's orbit around the Sun. The model predicts interglacials occurring roughly every 100,000 years, which explains why we've been in a warm period for the last 11,000 years.
Scientists have created a groundbreaking brain-machine interface that allows for bidirectional communication between the brain and prosthetic limbs. By transmitting sensory feedback to the brain, researchers were able to induce an artificial sensation of movement in paralyzed patients. This innovative technology holds promise for devel...
A new study published in PLOS ONE found that people who spend time in jails and prisons are more likely to develop certain types of cancer than the general population in Ontario. The study also revealed that these individuals have a higher mortality rate from cancer, particularly for men.
Researchers at Memorial Sloan Kettering Cancer Center have developed more potent CAR T cells using CRISPR/Cas9 genome editing, which can kill tumor cells longer and resist exhaustion. This breakthrough could lead to safer and more effective use of immunotherapy in cancer patients.