Researchers found that tumors shed between seven and 18 mutations in neoantigen-coding genes after developing resistance to immunotherapy drugs. This phenomenon could lead to new ways to improve current cancer immunotherapies.
A new set of clinical guidelines aims to prevent the development of peanut allergy in infants by introducing peanut-containing foods early. The recommendations focus on high-risk infants, suggesting introduction between 4-6 months, and those with mild eczema, around 6 months.
A VIMS research team has deployed a high-tech mooring beneath the Antarctic ice to monitor CO2 levels in the Southern Ocean year-round. The study aims to improve understanding of global climate change and its impacts on marine life.
A new study reveals that the brain region responsible for face recognition continues to grow in adulthood, contradicting the prevailing view of synaptic pruning as a key factor in brain development. The growth is linked to an increase in cell bodies, dendritic structures, and myelin sheath.
A new study uses airborne ice-penetrating radar to observe meltwater's year-round life under the Greenland ice. The research reveals extensive winter water storage beneath the ice, which affects glaciers' response to melting.
A recent study published in JAMA Oncology suggests that chemotherapy can still benefit patients with non-small-cell lung cancer who recover slowly from surgery. The study found that delaying chemotherapy by up to four months did not increase the risk of death and may even lower it compared to earlier treatment.
Mandatory ignition interlock laws are effective in reducing alcohol-involved fatal crashes, preventing approximately 1,250 fatalities. States with such laws have seen a seven percent decrease in the rate of fatal crashes with at least one driver having a blood alcohol content over the legal limit.
A team of researchers developed a non-invasive method to detect and quantify wood decay in living trees, which can help understand global carbon pools and tree health. The sonic tomography technology uses sound waves to image the trunk, allowing for the creation of color-coded images of decaying wood.
An international study argues that protecting 20-30% of fishing grounds can help sustain and rebuild unregulated fisheries, benefiting millions of people. Marine reserves can be an effective management tool in highly diverse and overfished areas.
The VA's MRSA Prevention Initiative has significantly reduced healthcare-associated infections, with a 87% decline in intensive care units and 80.1% drop in non-ICUs between 2007 and 2015. Active surveillance and infection prevention programs played a key role in this progress.
A recent study found that moderate and high levels of physical activity are associated with a decreased risk of heart disease and death from all causes among older adults. Exercise helps maintain a healthy body weight, lowers blood pressure, and improves the ratio of unhealthy to healthy cholesterol in the body.
Delicate fossil remains of tomatillos found in Patagonia, Argentina, show that the nightshade family existed 52 million years ago, far earlier than previously thought. The discovery provides a rare link between ancient and modern plants, challenging traditional views on plant evolution.
A large international survey found imperfections in primary and secondary prevention of skin cancer, with regional differences in sun protection behaviors. The study's results suggest that education level, gender, and socioeconomic status influence sun protection habits.
Researchers at the University of Alberta have discovered the precise atomic structure giving rise to negative differential resistance. This breakthrough enables practical applications in everyday electronics like phones and computers, promising faster, cheaper, and smaller devices.
Researchers found that Antarctic ocean temperatures became more layered, leading to coastal melting of ice sheets. This stratification is now happening again due to global warming, potentially triggering a three-meter rise in global sea levels.
Researchers found that taking an hour-long nap after lunch significantly improved mental health outcomes in older Chinese adults. The study revealed that napping for about an hour was associated with better performance on cognitive tests compared to shorter or longer naps.
Entomologists describe five new species and two newly recorded snout moth genera Lista in China, bringing total to ten species known from the country. The brightly colored wings of these moths have made them difficult to distinguish from one another, but this study sheds light on their taxonomy.
NYU Tandon has established a new research center, C2SMART, to tackle urban mobility challenges through data-driven solutions and innovative technologies. The five-year project aims to create a safer, more accessible, and resilient transportation system for cities worldwide.
Coral reefs face severe bleaching every year on 99% of the world's reefs within this century if current trends continue. However, more ambitious emissions reductions may extend their survival by an average of 11 years.
Severely obese teenagers who undergo gastric bypass surgery experience significant weight loss and improved health outcomes, including reduced diabetes and high cholesterol risks. However, some patients may need additional surgery or develop vitamin deficiencies, highlighting the importance of long-term follow-up and support.
A new analysis reveals that polar bears are at risk from Arctic pollutants, with the risk being 2-3 orders of magnitude higher than safety thresholds. International control measures have reduced risks for bear cubs, but new contaminants pose a growing threat to the ecosystem.
A team of astronomers led by Penn State's Niel Brandt has captured the deepest X-ray image ever obtained, revealing a treasure trove of supermassive black holes. The image, taken with Chandra observing time of about 11 weeks, shows that these massive objects grow in bursts rather than slowly accumulating matter.
A new study finds that beluga whales in Alaska are mirroring changes in Arctic sea ice timing, delaying their migration south by up to one month. However, another population remains unaffected by these changes, suggesting variability in response across populations and time.
A study published in Nature Communications found that nearly three quarters of immune traits are genetically determined, with adaptive responses being more influenced by genetics than previously thought. The research also highlights the importance of environmental factors such as diet on shaping innate immunity in adult life.
A new Yale study suggests that delaying chemotherapy after lung cancer surgery can lead to similar outcomes and lower risk of death. The research found that initiation between 57-127 days post-surgery had a similar impact as traditional timing, indicating a potential benefit for patients.
A comprehensive study on Hong Kong's marine biodiversity reveals the territory is home to over 26% of China's recorded marine species, comparable to regions like the Caribbean Sea and East Africa. The research highlights the importance of conserving marine habitats in Hong Kong, with only 2% currently protected.
A new Northwestern University study found that 13 speedy mini-apps, IntelliCare, significantly reduced depression and anxiety in participants who used them up to four times a day. The apps offer various exercises and strategies to improve mental well-being, resulting in a 50% decrease in depressive and anxiety symptoms.
The cancer death rate has decreased by 25% since its peak in 1991, resulting in 2.1 million fewer cancer deaths between 1991 and 2014. The decline is largely driven by reductions in smoking and improvements in early detection and treatment.
Researchers have solved the atomic structure of HIV's intasome, a key piece of machinery that integrates virus into human DNA. The discovery provides structural clues informing the development of new HIV drugs and sheds light on mechanisms of viral resistance.
The Mathematical Association of America honored Martha J. Siegel, Mark F. Schilling, and Robert D. Hough with prestigious awards for distinguished service and exemplary writing at the Joint Mathematics Meeting. The MAA recognized their contributions to advancing mathematical research and strengthening the community.
A Mayo Clinic study finds that vaginal microbes are distinct in women with endometrial cancer compared to those without the disease. Researchers hope to use vaginal swabs as an early screening tool and investigate the role of the microbiome in preventing endometrial cancer.
Researchers have discovered a potential new treatment for Alzheimer's disease by inhibiting the 12/15-lipoxygenase enzyme, which is elevated in patients with the condition. The study found that this inhibitor reverses cognitive decline and neuropathology in an AD mouse model, even after symptoms have already developed.
Killer whales in captivity require enhanced living conditions to elicit natural behaviors. Experts propose changes to environmental enrichment, feeding, and husbandry systems to prioritize psychological and physical wellbeing.
A new study reveals that 50% of Canadians are unaware they have high blood pressure, highlighting the need for increased awareness and education on managing the condition. Researchers also found a significant number of participants experienced hypertensive urgency or emergency, emphasizing the importance of proper management.
Researchers at Scripps Research Institute discovered that lipid rafts on cell surfaces act as compartments to keep enzymes from mixing with their binding partners. Disrupting these rafts through touch triggers a signal that communicates the touch to responsive proteins in the cell.
A new study suggests that off-grid solar energy can have significant economic benefits for people living in remote areas, but requires a special business model to succeed. Successful business models include community interaction, partnerships, local capacity building and addressing barriers unique to the off-grid market.
Researchers found no direct association between hot weather and increased Salmonella prevalence at free range egg production farms. The study emphasizes the critical role of hand hygiene in reducing food poisoning from eggs.
Scientists discovered Ebola virus RNA lingering in the lungs of a recovering patient for about five days after it cleared from blood. The findings support the possibility of active replication in the lungs, raising potential roles for lung infection in the disease's pathogenesis and transmission.
Ian Stewart won the MAA Euler Book Prize for his book In Pursuit of the Unknown, a journey through equations that shaped history. Tim Chartier received the Beckenbach Book Prize for his book When Life is Linear, which brings linear algebra alive in everyday life.
Researchers found that iron deficiency anemia reduces the risk of malaria by 16% in African children, compared to sickle-cell trait, which only reduces it by 4%. Iron supplementation reverses this protection, increasing the risk of P. falciparum malaria.
A new study provides an integrated marketing-operations framework to help companies design more effective service policies for their call centers. The framework considers the flow of customers through the call center and their subsequent behavior, allowing companies to design different service levels for various customer types.
Recent studies in density functional theory (DFT) have raised concerns about the accuracy of approximations used in computational chemistry. Researchers found that even with improved energy calculations, the quality of electron density simulations worsened over time. This contradiction highlights a fundamental flaw in DFT's approach.
The Damon Runyon-Rachleff Innovation Awards support novel approaches to fighting cancer with $2.1 million grants to nine innovative early-career scientists. Their projects aim to significantly impact cancer prevention, diagnosis, and treatment.
The phase I trial of CAR-T therapy with axicabtagene ciloleucel resulted in a durable complete remission rate of 43% among highly refractory diffuse large B-cell lymphoma patients. The treatment showed promising clinical activity, with an overall response rate of 71%, and manageable toxicity.
A study found that high monthly doses of vitamin D reduced acute respiratory infections in older long-term care residents by 40%. However, it also increased the number of falls experienced by these individuals. The study suggests daily dosing with high levels of vitamin D may be needed to minimize risk.
Researchers found small algae-grazing sea urchins and parrotfish may take the place of larger grazers to prevent algae from overgrowing reefs. These tiny organisms, comprising up to 95% of grazing biomass, can preempt shifts from coral to algae on degraded reefs.
A recent study found that the viability of certain bacteria, nematodes, and plants declined over 12 months in stored soil, regardless of source or storage conditions. However, mortality was higher when exposed to sunlight, moisture, and desiccation than protection.
A review in Angewandte Chemie emphasizes the importance of standardized analytic protocols to accurately assess microplastic contamination in aquatic ecosystems. The authors propose a list of nine arguments for harmonized methods, including improved sampling and processing techniques, to ensure reliable data and inform risk assessments.
A Stanford study suggests that the development of face recognition entails brain tissue growth, particularly in regions that distinguish faces from other objects. The research found microscopic tissue growth in these regions, which continues into adulthood and contributes to the differences between face and place recognition areas.
Researchers redate human settlement in Tibet, pushing back timeline by thousands of years; new findings suggest permanent residence may have been established due to wetter climate, enabling pre-agricultural peopling of the plateau.
New research published in Science suggests that humans established permanent settlements on the Tibetan Plateau around 7,400 years ago. The findings contradict previous estimates of 5,200 years ago, and are consistent with genetic adaptations to high-altitude environments dating back at least 8,000 years.
Exposure to second-hand tobacco smoke even before conception appears to impair fetal brain development throughout pregnancy, damaging regions involved in learning and memory. The impact was most severe with exposures occurring in late gestation, but adverse effects also occurred when mothers were exposed prior to conception.
A new review examines the potential health benefits of resistant starch, a form of starch not digested in the small intestine. It has been linked to improved blood sugar control and enhanced gut health through increased production of short-chain fatty acids.
A recent study finds that urban centers like Hong Kong can play a crucial role in conserving globally threatened species. Introduced populations of these species have been thriving outside their native habitats, providing an opportunity to augment declining populations in their native ranges and mitigate threats to local ecosystems.
A recent study published in Springer's journal Sex Roles found that awareness campaigns targeting women can be a powerful tool to encourage collective action against female sexual objectification. The research revealed that watching a critique video clip increased women's willingness to support protests, whereas men showed no such effect.
A new study published in Nature finds that hurricanes approaching the US coast are more likely to intensify during less active Atlantic periods, contradicting previous assumptions about hurricane behavior. This discovery suggests that coastal regions may be better protected by quieter periods in the basin.
Scientists have developed a new technique to examine blood vessels in the brain using 3D Image Analysis, allowing for greater understanding of how diseases like dementia, brain cancer, and stroke affect veins and capillaries. This innovative method could help identify early warning signs of these illnesses, potentially saving lives.
Researchers found that cell phones distract individuals with lower internet usage, impairing attention and judgment. Heavy internet users, however, use mobile phones as spatial cues to enhance visual search.
A researcher at the University of Kansas is examining the role of nonprofits in community cohesion and recovery after the Deepwater Horizon oil spill. The study aims to reveal the social-ecological drivers of response and current extent of recovery in approximately 92 communities using data from various disciplines.
Researchers have pinpointed the location in the sky of a Fast Radio Burst (FRB), allowing them to determine the distance and home galaxy of one of these mysterious pulses of radio waves. The precise location enables observations using multiple telescopes, which revealed a faint dwarf galaxy at the location of the bursts.