A weakened form of the malaria parasite safely activated strong immune responses in healthy volunteers, whose antibodies completely protected mice from malaria infection. The GAP3KO vaccine candidate has shown promising results and will move forward to a phase 1b trial using controlled human malaria infection.
A pilot study found yoga interventions improved health-related QOL for children with cancer and their families, including social and emotional well-being. Certified yoga instructors delivered the program in various settings, tailored to the children's physical condition or mobility issues.
Researchers found that users who are actively shopping in a category are more likely to search for any brand, but as users move from recognition to purchase intent, they become increasingly more likely to search for the specific brand. Brand owners are also more likely to search for their brand, even when not actively shopping.
A new study by Lily Fang of INSEAD found that China's success in innovation is hindered by weak intellectual property protection, which leads to lower quality patents and fewer international citations. The study suggests that improving IP protection is crucial for China's sustainable growth
Researchers found eelgrass population stable across Puget Sound basin despite increased human population and shoreline development. Localized declines have been observed at individual beaches, with other shorelines showing healthy eelgrass growth.
Researchers analyzed 559 esophageal and gastric cancer samples to discover two main types of esophageal cancer differ markedly in molecular characteristics. The study suggests grouping patients according to molecular subtype for more effective clinical trials and new treatment approaches.
Research suggests that hurricanes approaching the US coast are more likely to intensify during less active Atlantic periods, weakening instead of strengthening. This relationship accounts for part of the weak correlation between Atlantic hurricane activity and major landfalls.
A review of dermatology clinical trials found that racial and ethnic groups are underrepresented among study participants, with most being white. The lack of diversity is attributed to inadequate reporting of ethnicity and race, which may lead to a more homogenous population. To address this issue, the review suggests prioritizing raci...
Study findings reveal that IL-7 and IL-15 signal Th17 cells to chronically reside in the body, contributing to autoimmune disorders. The study suggests targeting these cytokines may lead to new therapies for chronic autoimmune diseases.
A clinical trial with human volunteers has found a next-generation malaria vaccine to be well-tolerated and stimulate an appropriate immune response. The vaccine uses genetically attenuated parasites that are incapable of multiplying in the human liver but effectively stimulate the immune system.
People over 85 are more likely to experience social exclusion, with increased difficulty accessing healthcare and social opportunities. Researchers call for improved technology access and government support to help older adults maintain social connections and care.
Researchers found that adding cone-like structures between graphene and nanotubes enhances heat dissipation by reducing the number of heptagons. This could lead to improved performance in next-generation nano-electronics.
Duke University researchers have developed a new approach to deep brain stimulation that reduces energy consumption by up to 75% without compromising treatment efficacy. The algorithm uses computational evolution to design tailored patterns for individual patients, leading to improved symptoms and reduced battery replacement procedures.
A new study from the University of Eastern Finland found that vitamin D deficiency may increase the risk of chronic headache. Men with lower serum vitamin D levels reported more frequent headaches.
Researchers at Scripps Florida have developed a new protease tool to study protein structure and post-translational modifications, which can alter protein stability and function. The new tool helps shed light on these chemical changes and could lead to new tools for mass spectrometry.
Michigan State University has secured a $1 million USAID grant to build a mosquito factory in Yucatan, Mexico, to combat the Zika virus. The project aims to use Wolbachia bacteria to reduce mosquito populations and prevent disease transmission.
Researchers found that three Amazonian species have lost or disabled genes for detecting short wavelengths of light, allowing them to thrive in the murky environment. The study reveals a unique genetic adaptation that enables these fish to perceive their surroundings differently.
Researchers successfully grew functional human stomach and intestinal tissues using pluripotent stem cells, enabling the study of diseases such as gastric cancer. The discovery allows for the modeling of new treatments and understanding of human development and health.
A team of researchers has localized the source of a Fast Radio Burst (FRB) to an older dwarf galaxy over 3 billion light years away. The galaxy is believed to harbor a supermassive black hole and may be connected to other energetic events such as supernovae and gamma-ray bursts.
Researchers at Penn State have developed a novel biodegradable nanoparticle-based system that utilizes immune cells to target and deliver cancer-fighting drugs directly to tumors. This innovative approach combines the body's natural immune response with targeted delivery, showing promise for effective treatment of various cancers.
A new study suggests that fewer people perceive e-cigarettes as a safer alternative to smoking tobacco, dropping from 50% in 2012 to 43% in 2014. The researchers found no association between awareness of e-cigarettes and attempts at quitting among current smokers.
The Arctic coast's thawing permafrost leads to increased erosion, releasing greenhouse gases and nutrients into the sea. This alters ecosystems, affects traditional fishing grounds, and impacts the Arctic population's way of life.
A randomized, Phase III study will enroll 600 people with suboptimal diets to evaluate the effects of a specific diet on cognitive abilities and brain health. The MIND diet, which includes foods like fish, berries, nuts, and leafy greens, aims to improve brain health by developing new dietary guidelines.
Researchers at the University of Nottingham have created a technique to produce chemically functionalised spider silk that can be tailored for drug delivery, regenerative medicine, and wound healing. The synthetic silk can be 'clicked' with antibiotics or fluorescent dyes using 'click-chemistry', allowing for controlled release.
A new crystal structure of organic-inorganic hybrid materials has been discovered, offering promise for the development of optoelectronic devices such as light-emitting diodes and lasers. The material displays interesting optical properties, including high photo luminescence, making it a potential candidate for efficient light emission.
Researchers at University of Chicago and Wayne State University reaffirm the reliability of Type Ia supernovae for measuring cosmic distances. The findings contradict recent claims that these supernovae are inconsistent in their brightness.
Cornell University researchers have identified a distant cosmic source of 'fast radio bursts' emitting massive energy pulses from across the universe, exceeding 3 billion light-years away.
Researchers found that the Inuit gut microbiome is remarkably similar to that of urbanized Westerners, with subtle differences in relative abundances of individual taxa. Dietary fiber is identified as a major factor driving the overall composition of the microbiome.
Researchers developed a sensor that uses Raman spectroscopy to detect molecular markers of IBD in the colon, helping to distinguish between ulcerative colitis and Crohn's disease. The device could provide an objective gold standard for diagnosis and guide personalized treatment approaches.
A team of researchers from York University, NASA, and Johns Hopkins University have identified icy features on Pluto, including penitentes, which are bowl-shaped depressions with spires around the edge. The study suggests that these features may exist on other planets where environmental conditions are similar.
A new study found humpback whales traveling further in the southwest Indian Ocean than previously thought, revealing important breeding habitats off Madagascar. The research also showed different movement patterns for males and females, with potential implications for conservation efforts.
A new study by Duke University found that increasing politicians' pay does not encourage more working-class people to run for office. Research shows that high-paying jobs attract professionals rather than lower-paid individuals, making it difficult for blue-collar workers to break into politics.
Katherine High discusses gene therapy progress for hemophilia and inherited retinal disorders, highlighting key scientific, regulatory, and commercial challenges. Her leadership in the field has been critical to its current success.
A new study by Drexel University found that lower neighborhood socioeconomic status increases heart disease and stroke risk among black residents. Every step down on an established disadvantage scale resulted in a 25% increase in risk of cardiovascular disease.
Patients with mental health emergencies in Massachusetts wait an average of 16.5 hours for hospital admission and 21.5 hours for transfer to another facility compared to 4.2 hours for medical patients.
The University of Illinois Chicago will continue its research on risk and protective factors for drinking among lesbian or bisexual women, led by Tonda Hughes. The five-year study aims to examine the impact of stressful experiences on psychological suffering and hazardous drinking in adult sexual-minority women.
A systematic review confirms Zika virus infection as a cause of Guillain-Barre Syndrome (GBS) and congenital brain abnormalities. The study analyzed 72 studies on Zika and GBS, finding at least eight criteria for causality met, while another 36 studies showed seven out of ten criteria satisfied.
The new special issue of Future Oncology explores the field of psycho-oncology, which aims to integrate biomedical and psychosocial aspects of cancer care. The issue highlights the importance of developing a multi-disciplinary approach to cancer care, from both social and biomedical standpoints.
Patients taking antidepressants for depression are more likely to report gastrointestinal and cardiovascular side effects if they also have panic disorder, according to a new study. Co-occurring panic disorder is associated with an increased risk of worsening depressive symptoms.
This study investigates molecular changes in the OTOF gene in patients with auditory neuropathy and identifies the c.35delG mutation in the GJB2 gene. Cochlear implants show excellent outcomes, with improved speech development and language acquisition in patients with severe/profound hearing loss.
A team of researchers at Ohio State University has developed a device that converts waste heat into electricity, producing a voltage output 10 times higher than previous results. The innovation uses a composite material of nickel and platinum to amplify the voltage output through magnetism.
A study found that maternal depression in early childhood increases children's susceptibility to psychopathology and social-emotional problems. Mother-child interaction patterns also play a crucial role in this effect. Improving mother-child interactions may help reduce the effects of maternal depression on children's development.
Researchers studied groundwater hydrology of proglacial valleys in the Andes, finding that 29% of stream discharge comes from groundwater. The study aimed to improve hydrological modeling of proglacial catchments throughout South America.
Researchers found substantial inequities in care practices for Duchenne muscular dystrophy (DMD) patients across seven European countries. The standard of care for DMD typically includes corticosteroid medication, physiotherapy, regular echocardiograms, and regular check-ups, but adherence to guidelines was low, particularly among non-...
Researchers at the University of Illinois used quantum simulation to replicate the properties of a topological insulator, directly observing its protected boundary state. This breakthrough enables further investigations into topological systems and their unique transport properties.
Researchers have developed a 3D printable sonic tractor beam that can trap small beads, insects, and even biological samples using sound waves. The device is created by designing a metamaterial with tubes of different lengths, which shape the sound waves to create a trapping environment.
A new study has confirmed the presence of ticks carrying Lyme disease in nine eastern national parks, highlighting the need for visitors to take precautions. The Centers for Disease Control and Prevention and National Park Service collected ticks along hiking trails and found all nine parks had infected blacklegged ticks.
Researchers at Children's Hospital Los Angeles found a correlation between reduced regional cerebral blood flow in the Broca's area of the frontal lobe and more severe stuttering. The study also suggests that disturbances in speech processing areas of the brain are likely central to stuttering.
Researchers at Rice University have made breakthroughs in understanding how concrete responds to stress at the atomic level. By studying the internal structure of tobermorite, they found that defects can lead to increased strength and toughness by allowing layers to glide past each other.
Researchers found that consuming zinc-enriched foods can reduce oxidative stress and DNA damage in humans. The study suggests a new strategy for measuring the impact of zinc on health, with implications for mitigating micronutrient deficiencies worldwide.
Researchers identified MMP9 as a tumor suppressor role in colitis-associated cancer (CAC), which is driven by chronic inflammation. The study found that MMP9 suppresses tumors by activating the MMP9-Notch1-ARF-p53 axis pathway.
A new study predicts that California will experience three more extreme precipitation events per year by 2100 as the Earth's climate warms. The researchers developed a technique to identify large-scale patterns in atmospheric data, significantly reducing uncertainty in extreme storm predictions.
A new study found that educating diners about the environmental impact of food waste reduces waste, but this benefit disappears when participants know their scraps will be composted. The study highlights the complexity of managing food waste and suggests a nuanced approach to address the issue.
Researchers identify opposing signaling pathways that determine the formation of hair follicles and sweat glands in humans, similar to mice but separated by time. This discovery has potential to improve methods for culturing human skin tissue used in grafting procedures.
Research reveals that genes affecting social communication in children overlap with those for autism and schizophrenia, but influence risk differently at various stages of development. This study provides new insights into the genetic basis of psychiatric disorders and their relationship to social competence.
New analysis suggests US is unlikely to experience large-scale Zika outbreak due to access to clean water and air conditioning. However, localized outbreaks remain a concern, particularly in southern states with lower socioeconomic conditions.
Researchers estimate that up to 76 percent of the world's population is overfat, including normal-weight individuals with increased risk factors for chronic disease. The study suggests a new pandemic has quietly overtaken the world, and argues for a change in global health efforts against chronic and metabolic diseases.
Recent years have seen a substantial increase in articles within radiology journals addressing patient-centered care, with only a limited number of journals publishing multiple original research articles. The study identified four journals that had published more than one original research article on the topic.
Research by Imperial College London suggests targeting specific brain pathways may lead to future treatments for gambling addiction. The study found connections between the parts of the brain that control impulses are weakened in people with gambling addiction.
A large study found that 45% more women with breast cancer experience cognitive impairment compared to healthy individuals. Factors like anxiety, younger age, and black race contribute to cognitive decline.