Researchers at Case Western Reserve University created a complete model to describe serotonin's role in brain development and structure. The study supports the importance of serotonin for normal functioning of neurons, synapses, and networks in the cortex.
A study by Case Western Reserve University School of Medicine found that a tailored video education program improved cancer patients' knowledge and reduced negative attitudes towards clinical trials. The PRE-ACT program was more effective than text-based information in encouraging participants to consider clinical trials.
A plant virus shell triggers a potent immune response in mice, wiping out tumors and preventing metastatic disease. The treatment, using cowpea mosaic virus nanoparticles, shows promise as an effective and low-toxicity alternative to traditional therapies.
Researchers identified 52 genetic variations associated with AMD across 34 gene regions, offering hope for developing diagnostic tests and therapeutics. The study also found rare genetic variations in one subtype of AMD, which could explain why anti-VEGF therapy is less effective in some patients.
A leading researcher at the Case Western Reserve University School of Nursing is developing new treatments for cystic fibrosis, a life-threatening genetic disease. The scientist will lead two studies to explore gene-modifying treatments that can minimize CF symptoms, including medications and genetic correction.
Researchers at Case Western Reserve University have created flexible, wire-shaped microsupercapacitors that can be woven into garments to power wearable electronics. The capacitors increase energy density and capacitance by coating a titanium wire with aligned carbon nanotubes, allowing for more efficient charging and discharging.
Researchers at Case Western Reserve University found that habitat characteristics explain differences in immune defense traits of frogs between populations. Microbiome differences and altered natural peptide secretions may alter the amphibian's immune defense capabilities. The study suggests that land use changes can influence animal t...
Researchers at Case Western Reserve University will create software to perform virtual energy audits, helping building owners identify efficiency problems and cost-effective solutions. The project aims to enhance the nation's economic and energy security by improving building energy efficiency.
Researchers at Case Western Reserve University are developing a new type of pain relief using high-frequency electrical stimulation. The study aims to understand why this method is more effective than traditional stimulation, with potential applications in the fight against opioid addiction.
Flies use their halteres to navigate challenging situations, including flying and climbing. The study found that some species rely on the organs to sense their movement in space and maintain visual focus.
Researchers at Case Western Reserve University have developed a stem cell treatment that mediates an immune response to spinal cord injury, reducing tissue damage and preserving function. The treatment, involving multipotent adult progenitor cells (MAPCs), was effective in preventing the cascade of immune responses that often lead to l...
Researchers at Case Western Reserve University are creating a 'pathology image informatics platform' to analyze and share digital pathology imaging data, focusing on prostate and breast cancers. The project aims to unlock the potential of images in cancer prediction.
A team of scientists at Case Western Reserve University has produced the first image of a human protein binding with ribonucleic acid (RNA), shedding light on how some viruses, including HIV, replicate their genetic material. The discovery could lead to new strategies to block viral replication and limit or halt infection.
Dr. Jackson T. Wright Jr.'s decades-long clinical research helped create and fine-tune approaches to address hypertension in African-American populations, leading to significant reductions in cardiovascular events and mortality. His work has also informed the development of treatment guidelines for hypertension, addressing health dispa...
Scientists at Case Western Reserve University School of Medicine have discovered a repair and renewal mechanism in protein movement within hair cells of the inner ear. The study found that constant movement and replacement of proteins serve a maintenance and even repair function, potentially reversing hearing loss.
Researchers at CWRU identified key neurons in cockroach brain that control movement, including speed and direction. By stimulating these neurons, scientists can replicate the insect's movements, shedding light on how insects navigate and providing insights into robotic navigation systems.
The study aims to investigate a combination approach to help patients stop smoking, particularly those who are socially and economically disadvantaged. A randomized trial will be conducted in eight clinics serving over 25,000 patients to evaluate the effectiveness of pairing Teachable Moment Communication Process with Ask-Advise-Connec...
Case Western Reserve University's Institute for Functional Restoration and Synapse Biomedical form a partnership to commercialize technology restoring movement in paralyzed patients. The partnership aims to bring the technology to those who need it, ensuring sustainable access through non-profit efforts.
Case Western Reserve University researcher Efstathios Karathanasis has received a $2.82 million grant to develop a treatment that eradicates glioblastoma multiforme with one safe dose. The treatment uses chain-like nanoparticles carrying chemotherapy medicine and inhibitors to target brain tumor cells.
A new grant will test Interactive Virtual Decision Support for End of Life and Palliative Care (INVOLVE) with 270 patients at University Hospitals Case Medical Center. The technology aims to alleviate stress and regret in families making critical-care decisions.
Researchers found that sensory feedback shapes motor variability, allowing for normal behavior and adaptation. The study suggests maintaining variability is essential, contrary to the common view of it as a problem to overcome.
A CWRU researcher has received a $1.9 million grant to transform synthetic platelet technology into devices that dissolve clots to prevent serious health risks like stroke and heart attack. The technology, called SynthoPlate, has already shown promising results in treating bleeding disorders.
Researchers have developed an open-source computational tool to calculate van der Waals forces between molecules and predict molecular organization. The software, Gecko Hamaker, enables the design and fabrication of new mesoscale systems with improved stability and functionality.
Researchers found a biomarker that can predict which HER2-negative breast cancer patients will respond to bevacizumab treatment, allowing for early switch to more effective options. This discovery could spare patients from severe side effects and improve overall survival rates.
Researchers at Case Western Reserve University will analyze data from over 5 million solar panels worldwide to identify factors contributing to degradation. By applying an epidemiological approach, they aim to develop more reliable designs and extend the lifespan of solar panels.
Researchers at Case Western Reserve University and Harvard University are developing a microfactory to produce a formula for joint cartilage. The project aims to identify key cues that steer stem cell behavior towards cartilage production, with the ultimate goal of engineering functional tissue.
Scientists identify novel long non-coding RNA DACOR1 that suppresses tumor cells in colon cancer. Reactivating DACOR1 can slow or stop cancer cell growth, and may lead to therapy development for colon cancer prevention.
Researchers create a one-step process to make seamless carbon-based nanomaterials that possess superior thermal, electrical and mechanical properties in three dimensions. The material enables high efficiency batteries, supercapacitors, and solar cells, and has potential for applications such as energy storage, sensors, and wearable ele...
Researchers at Case Western Reserve University have developed a system that directly charges lithium-ion batteries with solar cells, achieving an efficiency of 7.8%, the most efficient reported to date.
Case Western Reserve University researchers are developing sensors to alert structural and wildland firefighters of hazards in the air after they've entered the 'fire overhauling or mop up' phase. The sensors will expand on NASA's compact particulate and gas sensors to detect toxic gases, including formaldehyde and acrolein.
A new study by biologists from Case Western Reserve University suggests exposure to road salt increases the size of wood frogs, but also shortens their lives. Wood frog tadpoles exposed to road salt grew larger and turned into larger frogs at metamorphosis than those raised without being subjected to the contaminant.
Researchers at Case Western Reserve University have developed a magnetic resonance imaging (MRI) contrast agent that can detect small aggressive breast cancer tumors and micrometastases. The agent binds to molecular markers expressed in high-risk primary tumors and metastases, generating increased image contrast.
Researchers at Case Western Reserve University have developed a fast and inexpensive test to determine whether Asian carp invading Lake Erie are sterile or can reproduce. The technique uses microscopic examination of fish blood cells, allowing conservation agents to quickly identify problem animals and remove them from the population.
The study aims to assess the effect of a new food hub, Hub 55, on residents' dietary habits and health outcomes in Cleveland. Researchers will compare patterns between residents near the hub and those in a similar community without access to a food hub.
Researchers found that high blood sugar molecules can weaken the body's natural defenses against infections. Dicarbonyls, breakdown products of glucose, interfere with antimicrobial peptides that fight inflammation and infection. This discovery could contribute to developing new treatments for people with uncontrolled diabetes.
Researchers discovered KLF4's pivotal role in controlling mitochondrial biology, which produces energy for cells. The study found that a lack of KLF4 leads to reduced energy production, particularly problematic in the heart, leading to heart failure and death.
Researchers found that lack of confidence, physical and mental impairments, and environmental factors hinder people with MS from engaging in meaningful activities. Building confidence is crucial to overcome these barriers and promote healthy behaviors.
Researchers developed an algorithm dubbed ENVE to detect genetic aberrations in tumors using deep sequencing data. The algorithm resolves most noise issues and reveals areas where genetic changes have gone awry, potentially leading to more effective treatments for multiple types of cancer.
A new study at Case Western Reserve University's Frances Payne Bolton School of Nursing found that coping by avoidance when making decisions for relatives in ICU can lead to PTSD. The study surveyed 77 people and found 42% had clinically significant PTSD symptoms, with death of the patient being a strong predictor.
Researchers at Case Western Reserve University are developing a platform to collect, analyze disparate clinical information from multiple sources, ensuring comparability and reproducibility. The goal is to integrate datasets for enhanced approaches to care and treatment of conditions like epilepsy and lung cancer.
Researchers found that KLF15 helps maintain metabolic balance by controlling the availability of nutrients in the body. The discovery may also contribute to understanding diseases characterized by excessive bile acid production.
A newborn's first stool may indicate a child's risk for persistent cognitive problems, according to a new Case Western Reserve University study. High levels of fatty acid ethyl esters (FAEE) in meconium can predict lower IQ scores and developmental issues.
Researchers found that prenatally exposed adolescents were 2.2 times more likely to engage in sexual intercourse before age 15 than non-exposed peers. Girls who reported behavior problems during their preteen years were also at higher risk, with 42% of those living with birth mothers or relatives reporting early sex.
Researchers at Case Western Reserve University used stereomicroscopy to create detailed 3D images of mouse models of IBD, revealing distinct patterns related to health and disease. The findings suggest two mouse models most closely resembling human forms of the illness.
Researchers have developed a new drug that stimulates tissue stem cells to repair damaged tissues more quickly, showing promise in treating diseases such as ulcerative colitis and bone marrow transplants. The drug, known as SW033291, increases prostaglandin E2 levels and promotes tissue healing without adverse side effects.
A new study by Case Western Reserve University School of Dental Medicine researchers found that dental implants result in higher overall satisfaction among postmenopausal women with osteoporosis. Women with dental implants reported the highest satisfaction in emotional and sexual areas, while those without restorations scored lower.
A new scoring method for the Trauma Symptoms Checklist for Children (TSCC) has been developed to improve analysis of trauma results. The method groups six mental health factors into two areas, reducing labor intensity and increasing interpretability for social workers.
The development of a two-photon ophthalmoscope aims to enhance retina imaging and detect eye diseases earlier, with potential applications in other organs as well. The instrument's super-magnification capabilities could accelerate the discovery of new eye therapies.
Researchers found that oral thrush activates a mechanism in T-reg cells to transform inflammation-fighting cells into cells that allow the disease to flourish. The study may lead to new ways to fight diseases by identifying chronic inflammation and blocking inflammatory proteins.
Case Western Reserve University's nursing school will train researchers to study complex chronic illnesses, aiming to reduce health disparities and develop new treatments. The program, funded by a $1.79 million NIH grant, focuses on African-American and Hispanic populations most at risk for multiple chronic illnesses.