Researchers have developed nanoparticles carrying siRNA to silence the β3 integrin gene, which regulates cancer cell spread. The treatment significantly inhibited metastasis in mouse models, including five mice with human triple-negative breast cancer.
Researchers at Case Western Reserve University found that treating gum disease can improve prostate inflammation symptoms and quality of life for men with prostatitis. The study, which treated 27 men with moderate to severe gum disease, showed significant improvements in PSA levels and symptom scores.
A study by Case Western Reserve University found that a caregiver's education level significantly influences their children's oral health habits. The researchers aim to encourage parents to adopt better dental care behaviors.
Case Western Reserve University is collaborating with Microsoft on reality technology to transform learning in various subjects. The partnership aims to provide innovative education required for a healthcare future that is still being imagined, with applications in fields such as art history, engineering, and astronomy.
Scientists have identified 35 genes and three long intervening noncoding RNA molecules that spur aggressive activity in HER2+ breast cancer. These findings provide a new target for treatment approaches, potentially leading to RNA-based therapeutics.
The Alana Foundation has awarded $1.7 million to Case Western Reserve University and MIT to advance research on new chemical compounds for treating Down syndrome. The study will test the effects of these compounds on cells involved in cognitive function, aiming to improve cognitive abilities in individuals with the condition.
A Case Western Reserve University researcher has won a $500,000 NSF CAREER grant to develop tiny sensors capable of detecting insecticides in Lake Erie or determining subtypes of human cancers. The technology combines antibodies with plant viruses to create a large surface area for targeting pollutants or cancer cells.
Scientists at Case Western Reserve University found that two topical medicines can activate mouse and human brain stem cells, reversing paralysis and repairing damage caused by multiple sclerosis. The approach offers a potential new way to reverse disability in MS patients.
A Case Western Reserve University researcher found that housework improves physical and emotional well-being in older adults with chronic illnesses. The study, which analyzed data from 337 participants aged 65-94, revealed that maintaining a clean home has a positive impact on mental health, contrary to expectations.
A study by Case Western Reserve researchers found that low-intensity service participation can reduce relapse rates among socially anxious youths with substance addiction. Service activities, such as setting up chairs or making coffee, facilitate the transition back into the community and cut the risk of relapse approximately in half.
Researchers discover nitric oxide plays key role in controlling blood flow to tissues, enabling oxygen delivery; low levels linked to heart diseases and blood disorders. Nitric oxide-deficient mice exhibit impaired oxygenation and increased risk of heart attacks.
Case Western Reserve University researchers have developed a metal-free bifunctional electrocatalyst that performs as well or better than most metal and metal oxide electrodes in zinc-air batteries. The carbon-based catalyst works efficiently in both oxygen reduction and oxygen evolution reactions, making the battery rechargeable.
Case Western Reserve University is leading an international team studying resistance to bacteria causing TB. The goal is to develop a new approach to treating and curing the disease by understanding how resistant individuals fight off infections.
Researchers found that financial constraints, transportation problems, and stigma associated with the disease were major barriers to accessing penicillin injections. Despite these obstacles, patients reported personal motivation and injection reminders helped them stay on schedule and manage their symptoms.
Researchers found that a combination of metformin and vitamin D3 significantly improved outcomes in animal studies, inhibiting tumor growth and reducing polyp formation. The dual-compound effect was more effective than either option alone, with modest amounts needed to achieve the benefits.
A newly discovered frog species, Pristimantis mutabilis, has the ability to change its skin texture in minutes to blend into its surroundings. The frogs were found in Ecuador's cloud forest and their shape-shifting capability challenges traditional methods of species identification.
A two-year clinical trial using low doses of ketamine may hold promise for reversing the devastating symptoms of Rett Syndrome, a neurodevelopmental disorder found almost exclusively in females. The trial aims to measure changes in breathing patterns and overall clinical severity among up to 35 participants.
Researchers found that most people with HIV exercise at home, but not intensely enough. The study suggests designing a flexible plan to maximize health benefits of exercising.
A single oral dose of azithromycin has shown promising results in eliminating yaws from Papua New Guinea, with an 83.8% success rate among infected residents. To achieve global eradication, Kazura advocates for improved infrastructure, mapping systems, and community commitment.
Researchers discovered that Valacyclovir can reduce HIV-1 levels independently of herpes infection, promising new avenues for drug development. The study's findings suggest the potential for a broader range of HIV-fighting drugs and could inform the design of new agents based on Valacyclovir's molecular structure.
Researchers found that different codons in the genetic code are deciphered at varying rates, affecting protein production. This knowledge can be used to manipulate gene expression and potentially treat illnesses by altering decoding rates.
A review of nutrition and weight-loss interventions found a gap in approaches for people with neurological disabilities, who struggle to lose weight due to limited mobility. The study identified 27 behavior-changing techniques targeting weight-loss for people with disabilities, including self-monitoring and managing time.
Researchers at CWRU found that African-American cancer patients with depression often experience different symptoms than white patients, including irritability and social isolation. These findings suggest that culturally sensitive depression measures are needed to accurately diagnose and treat black cancer patients.
Researchers found that bigmouth sleepers adapt by changing their behaviors, sex ratio, and physical appearance to survive on insects, snails, and crustaceans when isolated from their normal prey. The study suggests that evolution may be occurring in a predictable way, with the ability to anticipate ecological changes.
Researchers at Case Western Reserve University have made a major breakthrough in developing a metal-free catalyst that performs as well as costly metal catalysts in an acidic fuel cell. The new carbon-based catalyst corrodes less and is more durable than traditional materials, paving the way for low-cost clean energy production.
Pushpa Pandiyan's research reveals that uncontrolled Th17 cells can lead to inflammation and health issues. Her study uses immunodeficient mice to model the process, which could lead to new treatments for infections like Candida albicans.
A study by Joshua Grubbs and Julie Exline found that individuals who attribute their bad behavior to being born in this way are more prone to feelings of anger towards God. This can lead to depression, conflict with deity, and poor recovery from illness.
Researchers at CWRU's Mandel School of Applied Social Sciences are studying how prenatal cocaine exposure affects young adults, with a focus on substance abuse and behavior issues. The four-year study will examine the effects of early cocaine exposure on cognitive development and adaptive functioning.
Researchers at Case Western Reserve University found that the period between final cancer treatment and first post-treatment checkup is a critical time for healthy lifestyle changes. Family members expressed strong intentions to engage in health-promoting behaviors, but also reported high levels of emotional distress.
Case Western Reserve University researcher Michael Pollino developed a computer model that suggests optimal sizes for 'rocking steel-braced frames' to dissipate seismic energy. These designs could provide better earthquake resilience and repairability, potentially reducing costs.
Researchers are finalizing contract negotiations for a $4.4 million grant to speed development of a mobile system amputees can use anywhere, enabling them to touch and feel things out in the community. The team aims to have a product people can take home and use daily within five years.
Researchers will investigate gut leakage in HIV patients, leading to systemic inflammation and organ damage. They aim to determine if gut repair improves overall health.
A team of researchers from Case Western Reserve University has discovered new features of the 'Whirlpool Galaxy', M51a, using a 20-hour exposure photograph. The image reveals faint plumes extending from the galaxy's northeast and south, providing valuable insights into its history and interaction with neighboring galaxies.
Researchers at Oregon Health & Sciences University successfully tested a peptide developed by Case Western Reserve neurosciences professor Jerry Silver, PhD, which showed 100% success in animal models, regenerating nerves into heart attack scar tissue and preventing arrhythmia.
A 55,000-year-old skull discovered in Israel's West Galilee provides evidence of modern humans and Neanderthals co-inhabiting the area. The skull, containing a relatively small brain, shares features with modern man's skull, suggesting possible interbreeding between the two species.
Case Western Reserve University researchers aim to reduce false negative results in Ebola diagnosis by developing a positive control using plant virus nanoparticles. The goal is to create a reliable test for early detection and monitoring of the virus.
A new behavioral intervention aims to change caregivers' perceptions about oral health, encouraging them to seek dental care for their children. The study, funded by National Institute of Dental and Craniofacial Research, will test a referral letter and educational materials to improve the oral health of children nationally.
Researchers identified four proteins - stefin A1, slc25a5, serpinb3b, and KLK6 - that appear most likely to contribute to psoriasis. These findings advance efforts to understand the disease's causes and develop treatments.
Researchers at Case Western Reserve University discovered coenzyme A's crucial role in cell metabolism and its regulation of nitric oxide. The study identified hundreds of proteins influenced by coenzyme A-driven protein nitrosylation, with potential implications for understanding disease mechanisms.
Researchers at Case Western Reserve University have discovered new gene mutations specific to colon cancers in African Americans, offering hope for targeted treatments. The study found that these distinct molecular differences may hold the key to reducing devastating effects of the disease on this population.
A study by Case Western Reserve University found Ohio's Behavioral Health/Juvenile Justice initiative benefits young offenders diverted to community-based agencies for mental health treatment and substance abuse help. Most showed improvements in functioning and decreased delinquency symptoms.
Researchers found that family function is affected by the mental illness diagnosis type and caregiver sense of coherence. Caregiver strain and client dependence are associated with greater family disruption. Interventions for all family members may improve cohesion and support.
Byproducts from gum disease bacteria can reactivate dormant HIV in T-cells, leading to higher virus replication. This discovery highlights the significance of treating periodontal disease early for individuals with HIV infections.
Researchers at Case Western Reserve University identified a way to increase the presence of the 53BP1 protein, which weakens cancer cells and makes them more susceptible to radiation and chemotherapy. The breakthrough could lead to improved cancer treatment outcomes if supported by animal model tests.
Researchers at CWRU developed a 24-week home-based exercise program using customized pamphlets to help people with MS stay physically active. The program showed promise in improving physical function and reducing symptom severity, particularly for women with relapsing-remitting MS.
Researchers at CWRU School of Medicine discovered the mechanism behind enzyme Lecithin: retinol acyltransferase (LRAT) storing vitamin A, essential for vision. The study reveals that modifying LRAT's enzymatic activity can be used to transport small molecule drugs to the eye, reducing systemic side effects.
Researchers will investigate SUDEP's causes, risk factors, and potential interventions through a collaborative effort involving eight US epilepsy centers and one UK center. The grant aims to accelerate progress toward successful interventions by leveraging diverse expertise and combining large datasets.
Researchers developed a new peptide that promotes functional recovery following spinal cord injury, with 21 out of 26 animals regaining bladder control, movement, or both. The peptide allows nerve fibers to overcome scarring and promotes serotonergic sprouting, enabling critical functions to be restored.
Researchers at Case Western Reserve University found that witnessing parental violence can trigger negative behaviors in children, with girls internalizing the trauma and boys acting out aggressively. The study highlights the importance of early interventions to help children develop emotionally and interact socially.
Case Western Reserve researchers have identified a protein mutation that prevents proper gonadal tissue development, leading to cancer and other issues. The discovery highlights the importance of the SRY protein in regulating male sex determination and has implications for understanding birth defects and cancer.