Researchers at Michigan Medicine are creating mini-guts in a dish using human stem cells to study the complex interaction between microbes, cells, and disease-causing bacteria. The 'guts in a dish' model aims to aid research on a wide range of diseases, including gastrointestinal disorders and emerging infections.
A wristband that measures motion throughout a 24-hour cycle may help identify patients with major depressive disorder who will respond best to commonly prescribed drugs like Prozac. The study found that night owls are more likely to be depressed and respond to SSRIs.
Researchers at RIKEN have successfully demonstrated the integer quantum Hall effect in a new type of film, known as a 3D topological insulator. By quantizing surface Dirac states, they overcame limitations that had hindered previous efforts to harness these materials for low-power consumption electronics.
Researchers used PET/CT scans to study the behavior of lugworms in sediment, revealing how they burrow and interact with their surroundings. This technique provides insights into the ecological models of benthic animals, highlighting the importance of understanding their activities for maintaining ocean health.
Alessandro Vindigni's research reveals four-way junctions as a critical mechanism for resolving DNA lesions, enabling cells to resume replication and maintain genetic stability. New enzymes, including DNA2, play a key role in this process.
Researchers developed a lab-on-a-chip device that can diagnose Cryptosporidium infections in as little as 10 minutes, offering potential improvements in treatment outcomes for rural areas in China. The device is easy to use and has diagnostic capabilities comparable to current standards, with the potential to reduce costs and timeframe.
Researchers detect lagging dark matter clump in galaxy collision, suggesting interaction with forces other than gravity. This finding rules out the standard theory of Cold Dark Matter, potentially revealing new physics and behavior.
A recent study by Virginia Tech researchers found that the body's muscle begins to process nutrients differently after just five days of a high-fat diet. This change can have dire consequences on the rest of the body and may lead to the development of diabetes and other diseases.
PharmaMar is presenting data on its anticancer candidates PM1183 and plitidepsin, showing synergistic effects against breast cancer cell lines and SCLC mouse tumor models. The company's studies also highlight the potential of plitidepsin as a novel therapeutic target in multiple myeloma.
A new Duke University study in mice found that immune cells consuming an important amino acid called arginine may contribute to the development of Alzheimer's disease. Blocking this process with a small-molecule drug prevented characteristic brain plaques and memory loss in mouse models, suggesting a potential new treatment strategy.
A study by Genes and Cancer group at Bellvitge Biomedical Research Institute found that the inactivation of PARD3 gene promotes tumor cell invasion and metastasis in lung cancer. Restoring PARD3 levels significantly reduced the risk of metastasis in animal models.
In a deadly, rapidly spreading infectious disease like Ebola, traditional randomized clinical trials may be inadequate. Alternative trial designs can provide useful information and are morally justifiable, says a new article in the American Journal of Bioethics.
A team of researchers from the University of Waterloo has developed a novel design for electromagnetic energy harvesting based on the full absorption concept, which enables the collection of essentially all electromagnetic energy that falls onto a surface. This technology has vast applications in space solar power and wireless power tr...
A team of Finnish scientists has created a nano-scale map of toner ink thickness on paper, revealing that wood fibers receive relatively thin coatings and roughness dictates ink thickness rather than chemical variations.
Researchers at Arizona State University have identified a new mechanism of charge transport through DNA, differing from previously recognized patterns. The discovery has important implications for the design of functional DNA-based electronic devices and understanding health risks associated with oxidative damage to DNA.
Researchers have created a comprehensive family tree of living and extinct baleen whales stretching back nearly 40 million years. The study estimates that there were over 70 species, with many lineages branching out into unique body shapes and feeding strategies before extinction occurred between 30-23 million years ago.
Researchers at Queen's University Belfast have launched a revolutionary personalized treatment program to improve bowel cancer survival rates. The S-CORT Consortium will employ state-of-the-art techniques to define the genetic make-up of bowel cancer cells, collected from over 2,000 patients, and develop personalized care plans.
A study found that socially anxious youth in treatment who participated in low-intensity service activities during AA meetings had better outcomes and higher abstinence rates. This approach helped them tolerate interpersonal differences and uncomfortable feelings, developing emotional maturity and self-acceptance.
The number of labiaplasty procedures in the NHS has risen five-fold over 10 years, with over 2,000 operations performed in 2010. Women often seek FGCS due to misconceptions about normal vulval anatomy, and GPs should educate patients before referring them to a gynaecologist.
A new material developed at CU-Boulder can separate ethylene from ethane more efficiently, reducing energy consumption. This could save up to 46 million megawatt-hours of electricity per year in the US, equivalent to seven average-sized nuclear power plants.
Researchers have genetically modified Salmonella to kill cancer cells and shrink tumors, offering a potential new therapy. The modified bacteria can target and destroy cancer cells while remaining safe for patients.
A recent study found that disabled girls and women are at risk of abuse by carers and intimate partners due to their physical and social isolation. The research highlights the need for specialist support services and organizations to help these vulnerable individuals.
A new study found that a UV light robot can kill over 90% of bacteria in hospital rooms, including MRSA. The system has been shown to be effective in reducing bacterial growth and preventing hospital-acquired infections.
Scientists have developed a new method to monitor Europe's nature protection areas by analyzing reflected light signals from laser pulses. The technique allows for the identification of different types of vegetation, including weeds and vehicle tracks, and provides detailed 3D maps of the landscape.
A pilot study published in Addiction journal found that extended-release naltrexone significantly reduced opioid relapse rates among mostly heroin-dependent men released from New York City jails. After one month, 88% of participants in the control group relapsed, compared to 38% in the treatment group.
The European Science Foundation emphasizes the importance of addressing rare, high-impact geohazards that can lead to global disasters. The report aims to develop robust risk management plans and increase general resilience in the face of surprise events.
The Relativistic Heavy Ion Collider (RHIC) has shattered its own record for producing polarized proton collisions at 200-giga-electron-volt collision energy. The accelerator now delivers 1200 billion collisions per week, more than double the number achieved in 2012.
A European study involving over 7,000 participants provides new insight into public interest in medicines research and development. The survey found that those with previous experience were almost five times more likely to have good knowledge of medicines R&D.
A new study found that participating in civic activities with others can reverse the normal brain shrinkage associated with aging. Seniors who engaged in meaningful social activities showed significant increases in brain volume and improved memory function over two years.
Scientists discovered that a species of bone-eating worm, Osedax, originated at least 100 million years ago and subsisted on prehistoric reptile bones. The discovery suggests that Osedax may have prevented many skeletons from becoming fossilized, affecting our knowledge of extinct marine life.
Women's human rights addressing maternal mortality and morbidity is crucial globally. Healthcare professionals play a vital role in tackling gender inequalities and domestic violence by embedding human rights principles into care delivery.
Research suggests heroin assisted treatment can improve outcomes, reduce harm, and lower societal costs for a subgroup of patients who do not benefit from conventional treatments. This approach could provide savings that could be redirected to addiction prevention programs.
A new study published in the journal Bone found a strong link between lean muscle mass and healthy bone development in children aged six and seven. The research, led by Dr Rebecca Moon, suggests that higher muscle mass is associated with larger, denser bones and reduced risk of osteoporosis.
Syngenta's use of advanced analytics and operations research led to improved crop production, reducing the time and cost required to develop crops with high productivity. The company's innovative tools have resulted in over $287 million in cost savings and a high probability of delivering a portfolio value exceeding $1.5 billion.
Researchers analyzed genomic data from 16,000 individuals to understand the impact of mutations in two genes associated with a blood disorder. They found that about 1.3% carry a mutation in at least one gene, and algorithms predicted varying levels of harm from these mutations.
A study from the University of Missouri found that violent video games do not affect adults with autism spectrum disorder differently than typically developing adults. Over 100 participants, half with autism and half without, showed similar aggression levels after playing violent or nonviolent games for 15 minutes.
A study found that appropriate patient selection and pharmacist-led monitoring are associated with higher adherence rates to dabigatran. Modifiable site-level practices, such as collaboration between pharmacists and clinicians for nonadherent patients, also improved adherence rates.
Scientists have discovered that Neanderthals from the French region of Poitou-Charentes performed perimortem corporal manipulations on adults and children, including cutting, beating, and fracturing bones. The bone fragments analyzed show clear signs of these manipulations, which may be related to rituals or cannibalism.
A new species of tree-killing bark beetle has been described in a paper published online in the Annals of the Entomological Society of America. The mesoamerican pine beetle was found to work in concert with the southern pine beetle, causing catastrophic damage to pines in Central America.
Researchers found that interactive tools can boost persuasiveness of websites, particularly modality interactivity, which absorbs users and limits thoughts, while message interactivity increases thoughts and promotes positive attitudes towards the message.
A new study finds that simultaneous marijuana and alcohol users have double the odds of drunk driving, social consequences, and harms to self compared to those who use either substance alone. The research also reveals that concurrent users tend to have heavier drinking patterns.
The Lancet Respiratory Medicine publishes two Reviews on obstructive sleep apnea, discussing its effects on brain health and cognitive performance. The articles also explore the potential for personalized treatment approaches and emerging diagnostics in managing OSA.
A new study from Oregon State University found that injury prevention programs are not widely used in high school soccer and basketball teams, despite their benefits. Only 21% of coaches were using a program, and most reported using similar activities but not an official program.
Researchers have been focusing on long-term solutions, but Levy argues that new approaches are needed to prevent infection and disease. He highlights six questions that deserve more attention, including the role of innate immune response, CD8+ T cells, and strategies for an HIV vaccine and cure.
Researchers found that chronic drinking is associated with higher CYP2E1 and CYP2U1 protein expression in the prefrontal cortex (PFC) and amygdala (AMG), particularly in the AMG. This could lead to interactions between metabolism of drugs and endogenous substrates, altering drug response and brain physiology.
Researchers found children with high self-control had 40% less time unemployed as adults, highlighting early life self-control as a powerful predictor of job success. Long-term benefits include increased employment rates and productivity.
Scientists at UiT The Arctic University of Norway have discovered a new source of methane in the Arctic Ocean, abiotic methane formed by chemical reactions in the oceanic crust. This finding challenges previous assumptions about the origin of methane and suggests vast systems of methane hydrate throughout the Arctic.
Researchers found that Veterans Health Administration patients managed by pharmacists who educated and monitored them showed improved adherence rates. Pharmacist-led patient management was key to this success, involving regular education and follow-up to ensure medication was taken as prescribed.
A team of scientists using NASA's WISE observatory has found no evidence of advanced extraterrestrial life in 100,000 galaxies. The study searched for signs of highly advanced civilizations in mid-infrared wavelengths, a radiation detectable by the satellite.
Researchers at TSRI find that nicotine exposure promotes alcohol dependence in rat models, with those exposed to both nicotine and alcohol showing rapid escalation of drinking behavior and compulsive consumption.
The Centre for Operations Excellence at UBC Sauder School wins the prestigious UPS George D. Smith Prize for its effective and innovative preparation of students in operations research practice. The prize aims to emphasize the importance of operations research practice and encourage programs worldwide to focus on preparing students.
Scientists at MIT created a new cancer therapy that activates both the innate and adaptive immune systems to attack tumors. The treatment combines an antibody drug with IL-2, which boosts immune responses, resulting in complete tumor disappearance in 80-90% of mice.
INFORMS awards Chevron its annual INFORMS Prize for its long history of applying analytics and O.R. to various aspects of the energy company, enabling data-driven decisions that improve safety, reliability, efficiency, and resource recovery.
A new study found that parents' country of origin influences the risk of stillbirth in Canada, with higher risks seen for couples from Nigeria, Portugal, Jamaica, and Guyana. Genetic factors may contribute to this increased risk, although environmental factors also play a role.
Researchers compared long-term survival, stroke, reoperation, and bleeding events after bioprosthetic vs mechanical prosthetic mitral valve replacement among 3,433 patients. They found no significant difference in survival at 15 years, but significant differences in risk of reoperation, bleeding, and stroke between the two groups.
Researchers at the University of Sheffield suggest that deep borehole disposal could dispose of all UK's high-level nuclear waste in just six boreholes, 5km deep. The concept has several advantages over current solutions, including reduced construction costs, easier site selection, and lower environmental impact.
A new Kaiser Permanente study found that children whose mothers developed gestational diabetes by the 26th week of pregnancy had a 63% increased risk of being diagnosed with an autism spectrum disorder. The study also found that early screening for autism in children of women with gestational diabetes may be warranted.
A study published in PLOS Medicine proposes a multi-stage approach to testing Ebola treatments, which may be quicker than traditional randomized trials while still providing robust results. This alternative design could potentially triage treatments faster and recommend them without further RCTs under certain circumstances.
A Phase 2 study found that the experimental antibody anti-LINGO-1 significantly improved conduction in people with acute optic neuritis, a common precursor to multiple sclerosis. The treatment also led to improved recovery of myelin, a fatty substance surrounding nerves damaged in MS.
Researchers Luigi D'Ascenzo and Pascal Auffinger classify 17 carboxyl(ate) motifs in crystal structures using stereochemical considerations. They provide a systematic naming system and implications for crystal engineering, pharmaceutical research, and biomolecular sciences.
A new method to simulate soiling and weathering processes has been approved by ASTM International, reducing product rating time from three years to just three days. This allows for the introduction of high-performance cool roofs worldwide.
Researchers from the University of Texas at Austin found that Typhoon Haiyan's storm surge contaminated two aquifers on the island of Samar, with one taking up to 10 years to recover. The study highlights the need for strategies to mitigate groundwater contamination in coastal areas affected by climate change.
Researchers identify JAK/STAT3 cell signaling pathway as driver of ALK-negative anaplastic large cell lymphoma (ALCL), a particularly aggressive form of non-Hodgkin's lymphoma. Compounds targeting this pathway show promise in inhibiting disease progression, offering new hope for effective treatments.
Aerospace engineers at MIT have developed a carbon nanotube film that can heat and solidify composites without massive ovens, using only 1% of the energy. The technique has been tested on common carbon-fiber materials and found to produce composites with similar properties as traditionally manufactured materials.
Researchers found that infected ants clean themselves more frequently but restrict allogrooming with healthy group members. This self-restriction helps contain the pathogen's spread in the ant colony, benefiting all social animals under epidemic threat.
Benjamin C. Jantzen wins NSF CAREER Award to study enabling machines to carry out scientific research on their own. His approach, Dynamical Kinds Theory, aims to create a robot scientist by developing computer algorithms that can automatically choose relevant variables for investigation.
A new study suggests that injecting stem cells into the eye may preserve vision in people with early-stage age-related macular degeneration. The treatment, which uses adult-derived human cells, has shown promise in laboratory rats and could potentially be used to slow or reverse the effects of the disease.
A study by Case Western Reserve researchers found that low-intensity service participation can reduce relapse rates among socially anxious youths with substance addiction. Service activities, such as setting up chairs or making coffee, facilitate the transition back into the community and cut the risk of relapse approximately in half.
The MESSENGER spacecraft is using its altimeter instrument to help with navigation during close approaches to Mercury's surface. The team is using the altimeter's precise measurements of distance from the spacecraft to the surface to assess the accuracy of their orbit predictions.
Researchers have discovered a new biomarker, ASRGL1, that can identify women with uterine cancer at high risk of recurrence. The study found that patients with low levels of ASRGL1 had a higher risk of recurrence and died from the disease.
Researchers discovered that Salmonella lowers its cytoplasmic pH in response to acidic environments, triggering the secretion of virulence proteins. This low-pH signal activates an intracellular cascade that induces the formation of a nanomachine used for injecting virulence proteins into host cells.
A recent paper by University of South Carolina paleoceanographer Kelly Gibson shows that rapid climate change affected marine ecosystems in the Cariaco Basin, a body of water off Venezuela's coast. The study used nitrogen isotope ratios to estimate changes in primary productivity and carbon sequestration in the ocean.
A study found that data breaches of protected health information (PHI) reported by HIPAA-covered entities increased from 214 in 2010 to 265 in 2013, affecting 29.1 million records. Most breaches occurred via electronic media or theft.
San Diego State University researchers have developed a platform to identify drugs that interrupt viral proliferation, using dengue virus as an example. A novel drug, Thiostrepton, was identified which may someday be used to combat the disease.
Researchers at Ohio State University have developed a new automated treadmill that uses sonar to change speeds automatically, mimicking the experience of running outdoors. The device provides an accurate measure of aerobic capacity and has been shown to improve VO2 max scores by 4-7% compared to standard treadmills.
A traditional herb-derived remedy has been combined with two plants to create an antimalarial tea, which has been licensed and sold as a treatment for malaria in West Africa. The medication, derived from Cochlospermum planchonii, Phyllanthus amarus, and Cassia alata, was traditionally used to alleviate malarial symptoms.
Researchers have developed a graphene-based photodetector capable of converting absorbed light into an electrical voltage in less than 50 femtoseconds. The device utilizes ultrafast pulse-shaped laser excitation and highly sensitive electrical readout to achieve this ultrafast conversion.
Dartmouth researchers have identified a specific temperature that stimulates an antitumor immune response, which resists metastatic disease. Using iron nanoparticles and alternating magnetic fields, they found that temperatures of 43 degrees centigrade trigger the systemic immune response.
Researchers at UC Davis are receiving $5 million in grants from the US Department of Agriculture's National Institute of Food and Agriculture. The funding will be used to develop new technologies and methods to prevent cross-contamination in produce processing, identify genetic traits of lactic acid bacteria found on fruits and vegetab...
Researchers found that honokiol reduces excess growth of cardiac muscle cells, decreases ventricular wall thickness, and protects heart muscle cells from oxidative stress. Honokiol activates SIRT3, a protective protein associated with delayed aging, stress resistance, and metabolic regulation.
Hippos' organic matter provides essential nutrients to river fish and aquatic insects, highlighting the ecological importance of hippos in river ecosystems. The study's findings are crucial for understanding the impact of climate change and human development on hippo populations and entire food webs.
Research by Dr Keelin Howard found that Facebook can provide social support and connection for recovery from mental health problems. However, excessive or problematic use can exacerbate symptoms of paranoia, anxiety, and depression. Participants developed strategies to protect their mental well-being on the platform.
A UCLA study found that 77% of California physicians understand the basics of the Patient Protection and Affordable Care Act, with 59% supporting it. The survey also revealed a correlation between doctors' political affiliations and medical specialties.
Lorne Tyrrell, a renowned virologist, has been awarded the 2015 Killam Prize for Health Sciences for his groundbreaking work on viral hepatitis. His research has led to the development of an effective treatment for hepatitis B and is being continued in efforts to create a vaccine for hepatitis C.
A study published in Clinical Toxicology found that US poisonings are underreported by 60-90%, with charges approaching $8 billion annually. Alcohol and illicit drug use were the most common reasons for hospital visits.
While some health apps have shown promise in improving weight loss and physical activity, others have yielded conflicting results. Iltifat Husain argues that doctors should recommend tested and validated apps to help people stay healthy. Des Spence cautions that many health apps are untested and may even cause anxiety and medical harm.
Research reveals suppression of brain area responsible for object recognition by that for face recognition is necessary for 'normal' face recognition. Mathematical simulation shows neural networks between brain areas are essential for 'normal' face recognition, potentially shedding light on disorders like developmental prosopagnosia.
Research suggests that probiotic Lactobacillus rhamnosus GG modifies the activity of other gut bacteria, fostering a healthy immune system and promoting several species of beneficial microbes. The discovery could lead to more effective strategies for maintaining a balanced gut ecosystem.
Researchers at the University of Washington are using an investigational Medtronic device to develop a new deep brain stimulation system for treating essential tremor. The system aims to increase battery life, reduce side effects, and allow patients to adjust their stimulation voluntarily.
A recent study found that organic farming systems provide greater economic value than conventional systems, with ecosystem services like pest control and nitrogen release generating higher profits. The research suggests that government incentives or market rewards can encourage the adoption of sustainable practices in agriculture.
Researchers observed four colliding galaxies and found a lag between dark matter and its associated galaxy, suggesting that dark matter interacts with forces other than gravity. This discovery could be the first evidence for rich physics in the dark sector, helping scientists better understand dark matter's nature.
Researchers used X-ray fluorescence to visualize structural damage in lithium-ion batteries due to fast charging cycles, leading to reduced storage capacity. The study found that even a few charging cycles cause damage to the inner structure of the battery material.
A comprehensive literature review shows lower rates of breastfeeding initiation and continuation among minority women compared to White women. Ob/gyns can use data to support breastfeeding in clinical practices and public policy, helping to overcome cultural and social factors that affect minority women's decisions.
A new study from Duke University Medical Center reveals that divorced women are nearly twice as likely to have a heart attack compared to stably-married peers. The study also found that the cumulative effect of divorce can have a lasting imprint on people's health, with women facing worse outcomes than men after divorce.
The LOCUST program demonstrates autonomous collaborative behavior in defensive or offensive missions using information-sharing between UAVs. The technology enables swarms of compact UAVs to take off from various platforms, providing a cost-effective and reduced-risk combat power multiplication.
Researchers used 3D printing to create artificial flowers, one curved and one flat, to investigate how flower shape affects foraging behavior in hawkmoths. The study found that hawkmoths fed more successfully from the curved flowers, suggesting they use touch rather than sight to find nectar.
The World Health Organization has announced a new statement on the public disclosure of clinical trial results, including timelines for researchers to report their findings. The new statement aims to ensure that all interventional clinical trials are reported and publicly disclosed.
Researchers from Concordia University investigate how an after-school program in Quebec uses social media to revolutionize learning for at-risk youth. Students engage with artist-educators on multimedia projects, developing professional skills and building self-expression through digital arts and new media.
A large study found a significant association between intrauterine exposure to gestational diabetes and an increased risk of autism spectrum disorders in offspring. Maternal pre-existing type 2 diabetes was not significantly associated with this risk.
A new study provides an accurate description of citrus evolution, tracing the genus back to a single common ancestor and identifying six genes driving genetic variation. The research also sheds light on the emergence of popular citrus species like mandarins and lemons.
A large-scale genome-wide association study found that men whose fathers had liver disease are more likely to develop alcoholic cirrhosis. The study, published in Alcoholism: Clinical & Experimental Research, suggests that genetic factors may play a role in this increased risk.
The Lantana camara species complex's unresolved composition is a major impediment to its effective management. The complex's high diversity and rapid adaptive evolution make it challenging to identify and predict invasiveness.
Washington State University researchers have developed a new method to create polyurethane using plant oils, offering a more environmentally friendly alternative to traditional polyurethane. The new method allows for the creation of materials with varying flexibility and stiffness, making it suitable for a range of applications., Resea...