A research program led by Carlos M. Ferrario aims to unravel the mechanisms of novel peptides in heart disease and atrial fibrillation. The team will conduct studies to evaluate new therapies to halt the progression of heart disease.
Johns Hopkins researchers have developed a new tool for understanding ALS by transforming skin cells into brain cells affected by the disease. The resulting cell library, now publicly available, will enable scientists to study the disease in greater detail and potentially discover new treatments.
Researchers from CNIO have discovered that the MCRS1 protein induces increased mTOR activity in response to excess nutrients, leading to cell growth and proliferation. This correlation was found in human colorectal cancer samples, suggesting a potential link between MCRS1 activity and disease prognosis.
The Visio.M project creates a subjectively pleasant climate for passengers in the most energy-efficient manner. The system uses Peltier elements to heat or cool seats directly, reducing waste heat and improving comfort.
The study tested Google Glass for real-time dermatological consultations in emergency departments, finding that patients preferred video consultations over phone calls. The device allowed doctors to appreciate the gestalt of skin eruptions and interact with each other remotely, improving diagnosis accuracy.
Researchers found that the brain's visual cortex retains fundamental topographical and functional connectivity organizational principles, including retinotopic mapping, in people born blind. The study dispels the notion that blindness impairs brain development.
Researchers have developed a credit-card-sized gas chromatography platform that can analyze volatile compounds within seconds. The hybrid integrated approach allows for individual components to be miniaturized on separately fabricated chips, increasing the system's portability and throughput.
Scientists at the University of Southampton have developed a drug that can reverse resistance to immunotherapy in certain leukaemias and non-Hodgkin lymphomas. The new antibody, BI-1206, works by binding to a molecule called FcγRIIB and enhancing cancer killing, promising improved treatment outcomes for patients with blood cancers.
Researchers at NIH/NIEHS are studying the health impacts of the 2010 oil spill on Gulf Coast residents, including cleanup workers and local communities. The study found increased physical symptoms and mental health concerns among cleanup workers, highlighting the need for further research and preparedness.
Research shows that traditional values and religiosity are stronger predictors of female participation in the workforce than education. The study compares attitudes of over 3,000 immigrant women with 40,000 non-emigrant European women, finding a significant positive correlation between cultural norms and work behavior.
A new gene involved in blood-forming stem cells has been discovered by U-M researchers, providing insights into the body's ability to create and maintain a healthy blood supply. The Ash1l gene plays a critical role in regulating hematopoietic stem cell maintenance and self-renewal potential.
The USPSTF completed a systematic evidence review to inform an upcoming update of Task Force recommendations on screening asymptomatic adults for type 2 diabetes. Screening was found to help delay progression to diabetes by identifying those who could benefit from treatment, but did not improve mortality rates.
Researchers have uncovered how beneficial bacteria form a waterproof coating on plant roots to shield them from microbes that cause disease. This protective film incorporates proteins with shape-changing properties, enabling it to repel water and potentially harmful molecules.
Researchers discovered calcium perchlorate, which lowers the freezing point, allowing for liquid water close to the Martian surface. The presence of brine suggests that large lakebeds and riverbeds existed on Mars, contradicting previous theories about a dry planet.
A smartphone-based device developed by Massachusetts General Hospital researchers uses hologram technology to collect detailed microscopic images for digital analysis of cancer cells and tissues. The D3 system can detect cancer proteins with high accuracy, categorizing biopsy samples as high-risk or low-risk in under an hour.
Vitamin E deficiency may lead to neurological damage by interrupting the supply of essential nutrients and robbing the brain of necessary building blocks. The study found that zebrafish fed a vitamin E deficient diet had lower levels of DHA-PC, a critical component of brain cells.
Researchers discovered that MeCP2 binds to non-CG methylation patterns in the adult brain, which is unique to maturing and adult nervous systems. This finding explains why Rett syndrome symptoms appear after one to two years of age.
A study published in Western Journal of Emergency Medicine found that emergency departments can provide a promising venue for addressing opioid deaths through education on overdose prevention and naloxone rescue kit distribution. The program reached a high-risk population, equipped them with kits, and encouraged witness intervention.
Researchers at MIT have developed a probabilistic programming language called Picture that can solve computer-vision tasks using short programs. The new system, which is competitive with conventional systems, has been shown to improve error rates on certain tasks, such as human pose estimation.
A team of Brazilian researchers review the risk assessments for carbon geological storage technology and suggest caution is needed due to uncertainty about leakage from geological deposits. The scientific consensus emphasizes the importance of reducing emissions at source rather than relying on this method.
Researchers found that different production methods, including natural fermentation and micro-oxygenation, impact the chemical profiles of Pinot Noir wines. The study suggests that winemakers should include information about added chemicals on wine labels.
Researchers found that acetaminophen blunts positive emotions in users, reducing the intensity of both pleasant and disturbing photos. This study provides new insights into the broader consequences of using common pain relievers like Tylenol.
Indiana University is conducting a groundbreaking study to explore how environmental signals affect women's persistence and performance in STEM fields. The research, supported by the National Science Foundation, uses real-world data and behavioral experiments to validate its findings.
A quarter of all atrial fibrillation patients at the lowest risk for stroke receive unnecessary blood thinners from cardiology specialists. Researchers found that males and older patients were more likely to be prescribed oral anticoagulation despite having no risk factors for stroke.
A study published in Cell Reports reveals that pain signaling pathways influence the sensitivity of opioid receptors on neuron surfaces. The findings may help develop non-addictive pain management drugs.
Researchers developed a high-sensitivity cardiac troponin T algorithm to rule out and rule-in heart attacks in emergency departments. The study found that the new strategy accelerated management of patients with suspected acute MI by allowing safe rule-out and accurate rule-in in 3 out of 4 patients.
The Iowa State University Department of Mathematics has received the American Mathematical Society's Award for an Exemplary Program or Achievement in a Mathematics Department. The department has made significant improvements in undergraduate teaching, increasing retention rates and expanding its diversity through outreach programs like...
The National Institutes of Health has awarded $8 million in grants to support research on HIV/AIDS, tuberculosis, and related co-morbidities. The funding will support research conducted at eight South African institutions, linking scientists with U.S. researchers.
Researchers used novel molecular and analytic tools to study how similar diatom species utilize resources differently, known as niche partitioning, in Narragansett Bay. The study found that two species of chain-forming diatoms coexist but use available nutrients, specifically nitrogen and phosphorus, differently.
Researchers at Berkeley Lab found a technique to switch magnetic domain wall chirality, paving the way for desired electronic memory and logic functions. This breakthrough could lead to smaller, faster, and more energy-efficient devices through solid-state magnetic memory.
The first Heine H. Hansen Award recipient, Pieter Postmus, has made significant contributions to lung cancer research and education globally. He was recognized for his work in developing research programs in pulmonary circulation, pneumothorax, and thoracic oncology.
A new study suggests that mental practice helps establish common team goals, set priorities, and maintain situation awareness among trauma resuscitation teams. This improves team behavior, including improved communication, and can improve patient safety and reduce medical errors.
A new study found that nearly 50% of emergency departments have a pediatric coordinator, leading to improved readiness and a 70% national score increase since 2003. The assessment identified areas for improvement, including disaster plans and equipment availability.
Researchers found that polyphenols in green tea and apples inhibit VEGF signaling, a key driver of blood vessel formation. This mechanism could help prevent chronic conditions like heart disease and cancer.
A study has identified a molecular signature that drives the growth and survival of triple negative breast cancer cells. The research reveals that high levels of Myc protein and low levels of TXNIP correlate with poor patient outcomes.
A new Finnish study found that low birth weight at birth is associated with a higher risk of disability pension due to mental disorders. This can lead to an early exit from the workforce, resulting in a substantial loss to the economy.
Scientists at Helmholtz Zentrum München have identified a new isoform of neutrophil elastase involved in the pathogenesis of pulmonary emphysema. The cleaved form of the enzyme is particularly aggressive and resistant to inhibitors, leading to increased tissue damage.
A new study has found a significant link between muscle-building supplements and an increased risk of developing testicular cancer. Men who used these supplements were more than 65% likely to develop the disease compared to those who did not use them.
A recent study found that US emergency departments have improved their pediatric readiness, with a median weighted pediatric readiness score of 68.9, up from a previous score of 55. This improvement is attributed to the implementation of a comprehensive assessment by a national coalition.
Researchers have designed an organic electronic device with record-breaking ultra-long charge carrier lifetimes, opening up possibilities for new classes of devices such as sensitive photo detectors and flexible memory elements. This breakthrough could lead to more efficient solar cells, low-carbon electricity generation, and reduced e...
A new study suggests Richard III kept his severe scoliosis hidden until his death in 1485, controlled by the king's body image and posthumous reputation. The treatment of his dead body after the Battle of Bosworth is linked to his later historical and literary reputation as 'Crookback Richard'.
A study by Saint Louis University researchers found that salt pill consumption neither improved nor worsened performance in endurance athletes. High-dose sodium supplementation did not impact thermoregulation or related measures such as sweat rate, perceived exertion, and cardiovascular drift.
Researchers have developed a method to increase radiation's effectiveness in killing cancer cells by using gold nanoparticles tethered to acid-seeking compounds. The approach, published in PNAS, shows promising results and may improve radiation treatment for cancer patients.
A study published in BMJ Open found that the UK's research funding for dementia and stroke is still too low, with cancer receiving nearly two-thirds of the £856 million allocated. The social care costs of dementia outweigh those of other conditions, highlighting the need for increased investment in these areas.
New research reveals that logging can cause significant declines in invertebrate diversity, but ecosystems can adapt to these changes by shifting responsibilities among species. In contrast, vertebrates are less diverse and more vulnerable to new challenges, making them a risky substitute for invertebrates.
Researchers from the University of Liverpool found that south east Iceland is actually composed of a fragment of continental crust, extending offshore to the east. This discovery has significant implications for our understanding of mantle plumes and plate tectonics, with potential impacts on natural resources in the region.
Researchers explore whether genetic variations can modify the placebo effect, potentially leading to better patient selection for clinical trials. Genetic tests could help identify individuals who are unlikely to benefit from treatment, allowing for more efficient and effective medical care.
A new Penn Medicine study found that patients seen in emergency departments have misperceptions about opioid dependence and want more information about their pain management options. Patients desire better communication from physicians about their pain management options, along with discussion of the risks of opioid dependence.
Researchers developed LevelCheck software to assist surgeons in identifying the correct vertebra during spine surgery. The software achieves 100% accuracy in just 26 seconds, helping prevent wrong-level surgeries and improving patient safety.
Researchers analyzed data on 325 cancer patients hospitalized with pneumonia and found that severe illness and organ dysfunction are better predictors of outcome than multiresistant bacteria. The study suggests personalized treatment protocols can reduce mortality in these patients.
Researchers discovered how bacteria differentiate between self and foreign DNA using the CRISPR system, which involves identifying rapidly replicating DNA and utilizing DNA repair processes to create immune memory.
A new NYU study examines prevalence and correlates of hashish use among US high school seniors, finding that males are more likely to use the potent form. The study also found that frequency of marijuana use increases risk for recent hashish use, with students who feel 'hooked' on marijuana nearly doubling their odds
A new study found that 79% of southeast African birds were infected with haemosporidian parasites, including novel malaria parasite lineages. The study's findings indicate that lifestyle characteristics of birds can influence their association with different parasite genera.
A survey of 1,095 adults found that patients prefer simple explanations and doctor queries over burdensome consent regulations. The study's findings will inform US Office of Human Research Protections and FDA regulations on patient permissions for research conducted during clinical care.
A Vanderbilt University study finds that pregnant women prescribed opioids are more likely to give birth to babies with drug withdrawal syndrome. The study highlights the dangers of overprescription and the need for state and federal policy makers to address the opioid epidemic's impact on mothers and infants.
A recent study has identified distinct patient profiles in terms of associated violence and/or criminal acts, influencing treatment development. The findings reveal significant differences in sociodemographic, consumption, and psychopathological variables between patients with and without these issues.
A study analyzing Welsh data reveals that children with type 1 diabetes are at a significantly higher risk of hospital admission compared to their non-diabetic peers. The research found that younger children and those from lower socioeconomic backgrounds are most at risk, highlighting the need for improved support and care.
Researchers have developed a method to grow organic-inorganic hybrid perovskite nanowires into elongated crystals that make extremely promising lasers. The tiny lasers are nearly 100% efficient and can create many colors of light, making them suitable for mini optoelectronics, computers, and sensors.
A study found that cannabidiol, a non-psychoactive component of marijuana, significantly reduced seizures in children with severe epilepsy. The drug was shown to decrease seizures by an average of 54 percent and improve convulsive seizure activity. However, side effects were reported in 6% of participants.
A new study comparing gene therapy to half-matched transplants for SCID-X1 reveals that gene therapy leads to faster immune development, fewer infections, and reduced hospitalizations. Gene therapy shows promise as a viable alternative treatment for infants with this rare immune disorder.
The Midwest Political Science Association (MPSA) will recognize and reward outstanding research projects presented at its annual conference. This year, fourteen papers have been selected for prestigious awards across various categories, including the AJPS Best Article Award and the Kellogg/Notre Dame Award.
Researchers have discovered a protein biomarker that may indicate the presence of more aggressive prostate cancer. The biomarker, Runx2 phosphorylation, is closely associated with aggressive disease and has the potential to be a new drug target.
Scientists have developed a new approach combining ptychographic X-ray imaging and fluorescence microscopy to study the role of trace elements in biological functions. This technique demonstrates unparalleled sensitivity for measuring trace element distribution in thicker specimens at cryogenic temperatures.
Researchers at Mayo Clinic have developed a profile to identify patients most at risk of developing pancreatic cancer. The study analyzed data from 1,126 patients and found that factors such as history of smoking, obesity, jaundice, and cyst size on imaging scans are associated with high risk.
Researchers discovered that deep-brain stimulation (DBS) reduces excessive synchronization of brain activity in the motor cortex, a region governing body movements. This reduction leads to improved symptoms and facilitated movement in patients with Parkinson's disease.
Family physicians play a crucial role in advising young women about egg freezing, providing accurate information on its benefits and risks. The procedure can help preserve fertility, but costs are high, and evidence on success rates is limited.
A new study suggests that vaccinating 12-year-old boys against HPV can save $8 million to $28 million over their lifetimes due to reduced incidence of HPV-related oropharyngeal cancer. The study's findings have significant implications for public health policy in countries where HPV vaccination is not currently funded.
VTT created a morphine test printed on paper using antibodies, which enables rapid analysis of morphine presence in samples. The technology has potential applications in workplaces and traffic control.
A new study from the University of Missouri found that personalized computer feedback can significantly mitigate problem gambling behaviors in college-aged adults. Participants who received individualized feedback from a computer showed a significant decline in problem gambling behavior compared to those who received standard informati...
Researchers at RIKEN Brain Science Institute identified IRBIT as a key player in regulating dopamine levels in the brain. The absence of IRBIT leads to hyperactivity and abnormal social behavior in mice, highlighting its role in maintaining balance.
University of Iowa researchers found that human chins are an evolutionary adaptation, emerging as faces became smaller. The study suggests that mechanical forces like chewing did not create the chin, but rather a geometric change in face shape led to its development.
A research team has identified a drug target for ATRA, a treatment for acute promyelocytic leukemia (APL), by targeting the Pin1 enzyme. The discovery offers a promising new way to fight aggressive or drug-resistant cancers by degrading cancer stem cells and blocking multiple cancer-driving pathways.
Research predicts that warming seas will constrain fish habitats, leading to reduced abundance of commercial species. The study used a model combining fisheries datasets and climate projections to predict future distributions of UK favourite fish.
A new analysis of meteorite composition helps scientists work out when the Earth formed its layers, confirming the first crust had formed around 4.5 billion years ago. The team measured hafnium and lutetium in zircon crystals from a rare meteorite, which originated early in the solar system.
The University of Illinois College of Medicine will create a Center for Alcohol Research in Epigenetics (CARE) to investigate the impact of long-term alcohol exposure on genes. Researchers will explore how epigenetic changes influence gene expression and behavior, aiming to develop new pharmacotherapies for alcoholism.
A clinical trial found that zoledronic acid improved bone mineral density and reduced bone turnover in frail elderly women with osteoporosis. The treatment group showed significant increases in hip and spine bone mineral density at 12 and 24 months, while the placebo group showed decreases.
Researchers have discovered two protein 'architects', MOZ and BMI1, which play opposing roles in guiding embryonic development. These proteins regulate Hox gene expression, ensuring the correct formation of body segments and tissues. The study sheds new light on how environmental factors can impact early embryo development.
A team of researchers identified four mechanisms in collagen that work together to reduce stress concentrations at the tip of a tear. These mechanisms - rotation, straightening, stretching, and sliding - can be replicated in synthetic materials to improve strength and resistance to tearing.
Tropical Cyclone Solo weakened under strong vertical wind shear, passing by New Caledonia on April 11 before being downgraded to a remnant low-pressure area. NASA's Aqua satellite captured an image of the remnants on April 13, revealing an elongated system with dissipated clouds.
Researchers discovered that a protein called Tmem231 plays a crucial role in regulating ciliary membrane composition and function. This study sheds light on the mechanisms underlying Meckel syndrome and other human diseases characterized by defects in cilia.
Researchers found chimpanzees could plan route in computer mazes, while monkey species struggled with harder mazes requiring inhibition and anticipation. Human children also performed well, but showed variability in abilities across ages.
Scientists at the Weizmann Institute of Science have successfully regenerated heart cells in adult mice using a previously unknown signaling pathway. By activating ERBB2, a protein that plays a role in heart development, researchers were able to induce cardiac cell renewal and regeneration without excessive growth or scarring.
Moffitt scientists developed a novel technique to analyze the MDMX protein, revealing its auto-inhibitory segment that controls p53 activity. This discovery may help identify patients more likely to respond to an MDMX-targeted cancer drug.
A new technique based on Optical Coherence Tomography allows conservators to analyze the hidden layers in priceless paintings without removing physical samples. This enables detailed information on the chemical composition of paint and coatings applied over time.
A workplace intervention increased employed parents' daily time with their children by an average of 39 minutes per day, found a study published in Pediatrics. The Support-Transform-Achieve-Results (STAR) program improved family life by increasing employees' control over schedules and supervisor support for personal and family lives.
The study of genomics effects on placebos introduces the concept of 'the placebome,' identifying a network of genes that significantly influence medicine and clinical trial design. Genetic variations in neurotransmitter pathways modify placebo effects, suggesting placebos play a larger role in healthcare than previously recognized.
Research by Robin Lumsdaine found that women with new grandchildren are 9% more likely to retire early than those without. This decision can significantly impact income adequacy later in life. Policymakers may need to consider childcare needs and flexible work arrangements to encourage older workers to stay in the workforce.
A new study by McGill University researchers found that a 12-week tango course improved balance and functional mobility in 40 Parkinson's patients, while also showing modest benefits in cognitive functions. The dance style's social interaction and physical activity may have therapeutic value for PD patients.
The Sugar app, developed at Worcester Polytechnic Institute, is entering a pilot clinical study to assess its effectiveness in managing diabetes. The app tracks blood sugar levels, weight, exercise, and wound care, providing patients with personalized messages and insights.
Researchers discovered a previously invisible biological process that may be implicated in the rapid growth of some cancers. The new study reveals that a well-known cancer protein called mTOR can hand off its work to another protein, CDK1, when cells are dividing.
A Nation Empowered: Evidence Trumps Excuses aims to empower parents, educators, and policymakers with tools to implement acceleration strategies. The report presents evidence-based research on the benefits of acceleration for gifted students, dispelling myths and misconceptions about its dangers.
Research published in BMJ Open found that children with type 1 diabetes are almost five times more likely to be hospitalized compared to their peers. The study, which analyzed data from over 1577 Welsh children, also revealed that pre-schoolers and those from disadvantaged backgrounds are most at risk of hospital admission.
A KAIST research team has developed a hyper-stretchable elastic-composite energy harvester called a nanogenerator. The device can harvest mechanical energy to produce high power output with large elasticity and excellent durability.
Countries with higher cancer spending have consistently lower cancer mortality rates, with a 17% decrease in amenable mortality. Increased spending on breast cancer treatment also leads to improved survival rates without significant cost increases, but more research is needed to contain costs.
Researchers at the University of Akron have developed a polymer coating that allows medical sensors implanted in the body to communicate with it. The coating, which is biocompatible and conductive, can monitor biomarkers such as blood sugar levels around the clock.
Researchers found that lung tissue can repair itself by using mature lung cells to regenerate new ones. Type 1 cells can transform into Type 2 cells to produce surfactant and help with gas exchange. This discovery has implications for treating conditions like COPD.
The Dark Energy Survey has released a series of detailed maps of dark matter, created with the world's most powerful digital camera. The analysis will help scientists understand dark matter's role in galaxy formation and probe the nature of mysterious dark energy.
Scientists have identified a 'safe haven' effect in melanoma cells that shields them from targeted treatments. Adding a second experimental drug targeting a protein called FAK has shown promising results in slowing down tumor growth and improving cell death rates.
A new open-access article provides cutting-edge resources for identifying parasitoid wasps in Africa and Madagascar, with over 306 described species and 54 genera available for research. The resource aims to facilitate future work on the taxonomy of these wasps and their importance in ecosystems.
Researchers at ITMO University and Australian National University created an invisible cylindrical object in the microwave range without metamaterial coatings. The method is based on Fano resonances, where waves scattered via resonant and non-resonant mechanisms have opposite phases and are mutually destroyed.
Researchers have developed a new technology that accurately identifies high-risk changes in exhaled breath, indicating stomach cancer development. The nanoarray analysis method shows promise for non-invasive screening and monitoring of those at risk.
Despite significant genetic mutations, Ebola's functional level has remained the same over the past four decades. This suggests that vaccines and treatments developed during current outbreaks may be effective against future outbreaks.
Researchers found that the human immune system can control re-awakened HIV with a vaccine-based approach, reducing virus levels to 50 copies per ml within six weeks. This study demonstrates the potential of a 'kick and kill' strategy, which could lead to an effective cure for HIV.
Research by University of Michigan Medical School found that brain 'hubs' consistently attract information flow, shedding light on how the brain processes and transfers critical information. This discovery may help better understand principles of information processing in the brain.
Recent studies in Cancer Cell and Trends in Immunology review the intricate relationship between the immune system and cancer. Research has shown that harnessing anti-tumor immunity can be a promising approach to treating various cancers.
RAVE empowers clinicians to write personalized decision support rules based on their experience with patients, enhancing patient care and safety. The tool's checks and balances ensure that rules meet specified criteria and are only accessible to the intended users.
A new study by University of Washington astronomer Benjamin Charnay and co-authors proposes that violent methane storms high in Titan's dense atmosphere could be the answer to the moon's eastward-sloping sand dunes. The storms produce strong gusts much faster than Titan's usual winds, dominating sand transport and realigning the dunes.