Case Western Reserve researchers develop a procedure that restores breathing function in paralyzed muscles even after a year of injury. The treatment approach combines enzyme injection and intermittent hypoxia therapy to boost serotonin levels, reactivating the diaphragm and restoring normal breathing.
Researchers at Case Western Reserve University have developed a novel scanning optical interferometry technique that enables the spatial mapping and visualization of high-order modes of Brownian motions. This breakthrough technology holds promise for multimodal sensing, signal processing, and computing applications.
Researchers at Case Western Reserve University are investigating child resiliency in the face of abuse and neglect. Their studies aim to identify protective factors that promote resilience in maltreated children, informing interventions and programs for social workers and policymakers.
Researchers will use brain imaging to discover the brain-behavior connections that influence decisions on goal-setting, activities, and controlling illness. They hope to develop new interventions to motivate patients to take better care of themselves.
Researchers have developed artificial platelet-like nanoparticles that combine morphological, mechanical, and surface chemical properties of natural platelets. These artificial platelets can simulate natural platelets' ability to collide with red blood cells, enabling selective clot formation at vascular injury sites.
The researchers suggest that dark matter may be composed of macroscopic objects, potentially assembled from ordinary and strange quarks or baryons. This idea challenges the current search for tiny exotic particles like WIMPS and axions.
The Prevention Research Center for Healthy Neighborhoods at Case Western Reserve University has won a $4.35 million grant renewal to support its efforts in designing and disseminating interventions that prevent chronic disease in urban neighborhoods. The center's collaboration with the Health Improvement Partnership-Cuyahoga County and...
A study by CWRU researcher Joseph Galanek found that training correctional officers on mental illness symptoms improves prison safety, security, and humane treatment of inmates. The research showed that trained officers could use their discretion to respond to mentally ill inmates without rigidly enforcing prison rules.
Researchers at Case Western Reserve University have been awarded a $250,000 grant to study the use of nanotechnology in treating pediatric glioma brain tumors. The team aims to develop targeted and less toxic treatment strategies for this devastating disease.
Researchers have discovered a new drug combination that disrupts two key signaling pathways that drive breast cancer growth, showing promise in treating the disease. The combination of rapamycin and dasatinib was found to be more effective than using either drug alone in killing tumors.
Researchers have discovered two compounds, OD36 and OD38, that specifically target and block RIPK2, an enzyme that activates inflammation. These compounds show promise in decreasing inflammation and may pave the way for more effective drugs.
A new study by Case Western Reserve University found that moderate sedation is used to calm anxiety in over half of patients, with fear of needles being the second most common reason. The study provides a guideline for when to use moderate sedation, but raises concerns about endodontist training and certification.
A study by Case Western Reserve University's social work school found that many women in poverty struggle to drop users in their lives, making it difficult to establish new networks of non-using friends and supporters. The researchers identified relationships in the network as a key factor in whether women used drugs or not.
Researchers at Case Western Reserve University have created a prosthetic hand system that allows amputees to discern familiar sensations across their artificial hands. The system, which uses electrical stimulation, has enabled patients to regain control over their prosthetic limbs and even perform tasks like holding grapes in their mou...
The Frances Payne Bolton School of Nursing at Case Western Reserve University has received the nation's largest Nurse Faculty Loan Program (NFLP) grant of $3.16 million. The grant will support 143 new nursing faculty members, including 28 full-time and 28 part-time students and 79 returning graduate students.
Rong Xu's research aims to automate identification of drug effects using artificial intelligence, data mining, and machine learning on thousands of existing drugs and over 100,000 diseases. Her approach could lead to a more efficient drug discovery process with a lower failure rate.
Researchers at Case Western Reserve University are working on two projects to deliver protection from aggressive breast cancer and deadly heart attacks using plant viruses. The first project aims to create a vaccine that tricks the immune system into attacking HER2 proteins, while the second project targets blood clots by delivering cl...
CWRU researchers are investigating how patients make end-of-life decisions, with a focus on improving the quality of life for patients and their loved ones. The four-year study aims to better understand the complex interactions between healthcare professionals, caregivers, and patients in making these decisions.
A study found that warmer winters lead to earlier breeding in wood frogs, resulting in fewer eggs and delayed tadpole development. However, more rain and snow appear to increase egg production, potentially counteracting the negative effects of warming.
The Case Center for Synchrotron Biosciences will assemble cutting-edge Nnew beamlines at Brookhaven National Laboratory, delivering ultra powerful x-rays to visualize nano-scale structures of molecules and proteins. The new facility will enable scientists to pinpoint disease-causing vulnerabilities and target therapeutic interventions.
Researchers have discovered that curcumin and peptides can increase levels of protein inhibitor PIAS3, which combats the progression of mesothelioma. This finding suggests that PIAS3 expression positively affects survival in mesothelioma patients, offering a potential therapeutic strategy.
Researchers found that caregivers experience high levels of anxiety when caring for a newly diagnosed family member with mental illness, which decreases over time. The study also revealed differences in anxiety symptoms among women and ethnic groups, highlighting the need for interventions to support caregivers.
The Hartman Foundation is investing $300,000 in the co-op program to provide real-world learning experiences for engineering students. The foundation aims to increase participation and make the program more accessible.
The Case School of Engineering at Case Western Reserve University has received a $2 million gift from the Parker Hannifin Foundation to establish an endowed chair in electrical engineering and computer science. The position will be named after Parker Hannifin Corporation's founder, Art Parker.
Scientists at Case Western Reserve University have found that a leaky gut is the underlying cause of non-AIDS complications in HIV-positive patients. The study, published in PLOS Pathogens, reveals that bacterial products seep out of the colon and trigger inflammation throughout the body.
Researchers at Case Western Reserve University are studying ways to make solid oxide fuel cells last longer and more efficiently. They will test small lab-scale fuel cells under accelerated ageing conditions to identify the culprits behind performance loss.
Case Western Reserve University astronomers will study the outskirts of spiral galaxy M101 using Hubble Space Telescope data. The research aims to determine how galaxies form over time, with findings that could challenge current understanding of galaxy formation.
Women seek anti-aging clinicians to treat menopausal symptoms, valuing personalized attention and perceived safety of bioidentical hormones. The study found that these women prioritize relieving symptoms, feeling energized, and avoiding chronic illnesses associated with aging.
Researchers have deciphered how insulin binds to target cells, unlocking a protective hinge that triggers biological signals. This mechanism has attracted international study since the landmark 1969 elucidation of insulin's storage structure, enabling new molecular designs for safer and more effective insulin products.
Researchers at CWRU aim to boost cancer trial participation by educating oncology nurses. The $1.6 million NCI grant-funded program will test a web-based educational tool, Oncology Nurse IMPACT, to address barriers and increase discussions about clinical trials between nurses and patients.
Researchers have yet to identify a specific cause or risk factor for brain tumors, but ionizing radiation is recognized as a risk factor in therapeutic doses. Recent studies have ruled out associations between brain tumors and cell phone use, cigarette smoking, or other environmental factors.
A global research team led by Case Western Reserve scientist discovered a genetic dysfunction connected to hydrocephalus, illustrating how one error can contribute to excessive cerebrospinal fluid. The study found that Dvl genes regulate the placement and alignment of cilia in ependymal cells, essential for efficient fluid movement.
Researchers at Case Western Reserve University identified a promising new pathway to disabling bacterial infection: blocking bacteria's access to iron in the body. They found that bacteria can feed on iron supplied by both bacterial and mammalian siderophore, allowing them to proliferate and make the host ill.
Researchers at Case Western Reserve University will analyze genetic data from 11,000 individuals to identify rare variants that may protect or contribute to Alzheimer's risk. The goal is to illuminate the genetic architecture of Alzheimer's and discover therapeutic targets.
Researchers from Case Western Reserve University report a high degree of satisfaction among caregivers who received support teams for terminal cancer patients. The intervention improved satisfaction in five areas: pain relief, managing pain, speed in treating symptoms, information about side effects, and coordination of care.
Researchers have developed nanoparticles that increase survival rates and show no signs of interference in healing after blast trauma. The artificial platelets, called hemostatic nanoparticles, were found to be effective in stopping bleeding and increasing survival rates.
Researchers discover synthetic triterpenoids suppress colon cancer onset by impeding inflammation and increasing 15-hydroxyprostaglandin dehydrogenase gene expression. Oral administration in mice shows promise for chemoprevention, with potential to delay or halt colon cancer development.
Case Western Reserve researchers discovered thousands of novel long non-coding RNA transcripts that can direct protein synthesis in cells. This breakthrough challenges conventional wisdom on lncRNA's role and holds promise for treating cancer and genetic disorders.
Case Western Reserve scientists pinpoint the channeling of cell's energy flow in moving metal ions using advanced imaging technologies. This finding has the potential to inform future research on treating diseases such as Parkinson's, chronic liver disease, and heart disease.
A Case Western Reserve University engineer has devised a technique to reconstitute collagen into tough fibers and induce adult stem cells to grow into tendons, which could lead to regenerating bulk volume of the tendon. The technology may also be used to repair hernias or urinary incontinence.
A pilot study at CWRU Dental School and UH Case Medical Center investigates the use of human beta-defensin-3 (hBD-3) to detect oral cancers. High levels of hBD-3 have been found in precancerous tissues and some oral cancers, suggesting its potential as an early diagnosis tool.
Researchers at Case Western Reserve University found that existing cancer treatment bortezomib increases levels of the vascular-protective gene KLF2, preventing blood clot formation. This discovery has potential implications for managing thrombosis in patients with predispositions to clot formation.
Recent study finds satellite dwarf galaxies in the Milky Way and Andromeda do not behave as predicted by the standard model of galaxy formation. The galaxies are instead found in huge disks, moving in the same direction, like planets in our solar system. This mismatch raises concerns about the accuracy of the standard model of cosmology.
Steinberg's book examines the massive changes to land and water that began with Henry Hudson's 1609 adventure, transforming wetlands and water quality. The city's dense, urban development has engulfed areas once home to 55 distinct ecological communities.
A new study challenges prevailing views of empathy's effects on moral judgment, finding that compassion can produce counterintuitive results. More compassionate people tend to oppose utilitarian choices like sacrificing one person to save many or euthanasia, suggesting a stronger sense of the sanctity of human life.
A personality study found that entitlement is associated with sexist attitudes in both men and women. Entitled men are more likely to view women as manipulative and demanding, while entitled women see them as weak and in need of extra care. This study highlights the dangers of unchecked entitlement and its link to gender inequality.
Researchers at Case Western Reserve University have identified a new class of genetic switches, called seed enhancers, that guide the development of pluripotent stem cells. These enhancers play roles from before birth to adulthood and hold promise for regenerative medicine and disease prevention.
The FDA has approved medications that raise blood pressure, increasing the risk of heart attacks and strokes, despite inadequate safety data. The agency is urged to establish guidelines and require pharmaceutical companies to provide cardiovascular safety data on these medications.
A new species of praying mantis, the bush tiger mantis, has been discovered in Rwanda's Nyungwe Forest National Park by a Case Western Reserve University student. The female mantis hunts prey on the ground and underbrush, while the male flies.
Dr. Neal Meropol, Chief of Hematology and Oncology at Case Western Reserve University, is honored as an ASCO Fellow for his exceptional volunteer service and dedication to cancer care. He has served on the ASCO Board of Directors and various committees, contributing to the organization's mission to improve cancer care.