Scientists have developed a method to produce nanodiamonds using ethanol vapor at room temperature and pressure, requiring no surface growth. The discovery holds promise for various applications, including flexible electronics, implants, and drug delivery devices.
Researchers at Case Western Reserve University will use molecular imaging agents to detect tumors in the earliest stages of growth, aiming to improve cancer diagnosis and treatment outcomes. The $1.9 million grant will enable them to translate their discoveries into clinical practice.
Case Western Reserve University School of Medicine has received a five-year, $1 million NIH grant to develop the Cleveland Stroke Clinical Trials Regional Coordinating Center. The project aims to improve prevention and treatment of strokes and rehabilitation for stroke patients through collaboration among five Cleveland institutions.
Researchers at Case Western Reserve University discovered that recombinant human prion protein inhibits the propagation of prions, which cause fatal brain diseases. The study's findings have significant implications for treating prion diseases, including Creutzfeldt–Jakob disease and mad cow disease.
Case Western Reserve University researchers discover that non-specific RNA binding proteins can be specific about where they bind to RNA molecules, seeking out particular sequences. This finding advances understanding of how proteins control gene expression and sheds light on diseases such as cancer and neurodegenerative disorders.
Researchers tested a biofeedback device on 20 grandmothers, finding a significant reduction in stress and negative emotions. The device tracks heart rate variability to help women cope with added responsibilities, showing promise for long-term benefits.
Researchers at Case Western Reserve University have developed a new eco-friendly material for better power-converting magnets in wind turbines and electric cars. The material reduces neodymium-iron-boron production costs from $60 per kilogram to around $10 per kilogram, improving the magnetic remanence of the resulting magnets.
A low-cost, energy-efficient method to extract titanium from ore has been selected by ARPA-E, promising a 60% reduction in titanium costs. The CWRU team's direct electrolytic process eliminates the need for expensive reducing agents, simplifying production and boosting domestic titanium manufacturing.
Researchers are developing a drug to prevent inflammation around implanted electrodes, which causes brain cells to degenerate and compromise the blood-brain barrier. Testing is underway to determine if administering the drug can improve outcomes and extend the lifespan of brain implants.
Researchers have developed a novel molecular probe detectable by PET imaging, providing the first non-invasive visualization of myelin integrity in the entire spinal cord. The discovery brings new hope for accurate diagnosis and prognosis, allowing clinicians to monitor disease progression and evaluate therapy efficacy.
A systematic review by CWRU researchers found that parents of chronically ill children experience significant stress due to the added demands of caregiving, including managing medical treatments and school issues. The study suggests that parenting stress can be intervened upon with targeted support and coping strategies.
Scientists at Case Western Reserve University have developed a method to create three-dimensional gradients of signals that guide stem cell behavior. The system can help discern recipes for tissue and organ repair and replacements by controlling the spatial presentation of growth factors, physical triggers, and adhesion ligands.
The landmark study discovered four novel gene variations linked to blood pressure in African-Americans, which also show associations across other populations. Genetic factors account for 40-50% of individuals' susceptibility to hypertension.
Case Western Reserve researchers identified Kruppel-like factor (KLF) 15 as a master regulator of vascular health, blocking blood vessel inflammation that can lead to heart attacks and strokes. The discovery offers hope for targeted anti-inflammatory therapies for vascular disease.
A new study from Case Western Reserve University reveals the SRY gene master switch is vulnerable to change, allowing for variability in male development. This could explain why human males develop near the edge of sexual ambiguity, making them more prone to dramatic changes in fetal development.
A long-term study of 240 grandmothers caring for their grandchildren found that these caregivers experience persistent depressive symptoms and strain on their health. Researchers suggest that grandmothers may benefit from resourcefulness training to reduce depressive symptoms.
Low-cost intervention holds potential to eradicate debilitating tropical disease. Insecticide-treated bed nets reduce transmission of lymphatic filariasis to undetectable levels in the absence of additional medication.
A psoriasis researcher has received a third NIH grant to explore the nervous system's involvement in psoriasis. The study aims to identify new targets for drug development and improve patient care by investigating nerve-derived peptides critical to sustaining the disease.
Researchers at CWRU School of Dental Medicine have discovered the link between an oral bacterium and colorectal cancer. They found that Fusobacterium nucleatum can trigger cancerous cell growth by modulating E-cadherin/ß-catenin signaling.
A new guide created by researchers at Case Western Reserve University and Cleveland Clinic provides valuable information for parents of children with epilepsy and mental health problems. The guide covers topics such as child development, treatment options, and navigating the school system for support.
A new avatar-based decision technology called eSMARTT aims to ease the process of making healthcare decisions for loved ones who are unable to make their own choices. The system provides interactive simulations, decision coaching, and personalized resources to help caregivers navigate this difficult decision-making process.
Researchers discovered a new molecular pathway causing heart failure and showed that JQ1 blocks this pathway to protect the heart. The compound works within the cell's nucleus, preventing damaging stress responses.
Researchers are developing a brain implant that senses dopamine levels and suppresses reward signals to treat and possibly cure drug abuse. The device will be tested on anesthetized laboratory rats next month.
Researchers found a genetic process among rodents that challenges assumptions about sex determination and the pace of evolution. A novel protein domain added to the Sry gene acts as a genetic capacitor, providing protection against mutations but also allowing for rapid evolutionary change.
Researchers developed a modified prion protein that resists changing its shape, preventing the propagation of neurodegenerative diseases. The study provides a novel pharmacologic strategy to develop new drugs targeting prion protein and stabilizing its normal shape.
Researchers will assess the effectiveness of palliative care home health visits in treating people with HIV and other chronic illnesses. The four-year study aims to improve quality of life and outcomes for patients with HIV, focusing on symptom management, coping, and advance care planning.
Recent research questions the idea of discrete brain areas for specific cognitive functions like mind-wandering and attention reorienting. Instead, studies suggest that brain activation is due to the release of suppression rather than additional task-related processes.
A new four-year grant will support research on Fusobacterium, a prevalent oral bacteria linked to stillbirth, post-birth sepsis, and premature births. The study aims to understand why some subspecies enter the bloodstream and cause diseases, potentially leading to disease prevention.
Researchers at Case Western Reserve University traced chronic health problems of adult inner-city women to childhood abuse and neglect. The study found that childhood trauma affects physical health in adulthood through lifetime drug dependence, smoking, and psychological distress.
Researchers found that work provides emotional support and extra financial resources for women with HIV, enabling them to better self-manage daily tasks. The study also highlights the importance of job training programs and microenterprises in improving the lives of these women.
Researchers at Case Western Reserve University have developed a therapeutic approach to restore nitric oxide levels in donated blood, improving tissue oxygen delivery and kidney function. The treatment, called renitrosylation therapy, may hold great promise for millions of patients who receive regular blood transfusions.
A new Case Western Reserve University study reveals that children exposed to domestic violence between ages 3-5 are more likely to exhibit aggressive behavior in school. The research found no behavioral differences among these children until they reached school age.
Researchers at Case Western Reserve University found that gene HEXIM1 enhances heart health by increasing blood vessel growth, making hearts healthier and more efficient. HEXIM1 also suppresses breast cancer metastasis.
Researchers found that normal-weight babies plateaued at about two months and rarely deviated from their weight over height until age 5. In contrast, overweight or obese babies crossed the 17th percentile much later and continued an upward climb.
A new study suggests that suspending humanity through objectification can prevent war crimes, while dehumanizing others evokes disgust and disempathy. By understanding the brain's workings in these situations, researchers aim to develop a more effective military strategy that minimizes harm.
Researchers have discovered an inexpensive and easily produced metal-free catalyst that performs better than platinum in oxygen-reduction reactions. The catalyst is more stable and tolerant of carbon monoxide poisoning and methanol crossover.
Case Western Reserve University researchers found that 52% of individuals with PTSD also report symptoms of depression. The study, published in the Journal of Traumatic Stress, analyzed data from 57 peer-reviewed studies and concluded that both genders diagnosed with PTSD equally suffer from depression.
The university has received a five-year, $1.76 million grant from the National Institute of Nursing Research for a pre- and postdoctoral fellowship program in palliative care. The goal is to train nurse scientists to advance knowledge on effective palliation for patients with advanced diseases.
In large quantum systems, entanglement becomes ubiquitous above a threshold of about 200 particles, enabling super high-speed communications and quantum computing. The study provides parameters to harness this property.
A study of 1,089 nurses from diverse countries found that global views on end-of-life care preferences diverge between patients and themselves. Lack of knowledge about the patient's wishes and duty as a caregiver were key factors influencing these differences.
Researchers found that water on the moon and Earth came from small meteorites called carbonaceous chondrites in the first 100 million years after the solar system formed. The ratio of deuterium to hydrogen in the moon's water matches that found in chondrites, suggesting a common source.
Researchers at Case Western Reserve University School of Medicine have identified a novel method to disrupt a common cancer pathway, suggesting a new treatment for breast, colon, melanoma and other cancers. The breakthrough was achieved by targeting a mutation in the PIK3CA gene.
Case Western Reserve University spinoff ReXceptor has secured $1.4 million to advance its novel Alzheimer's treatment strategy. The company plans to initiate early-stage human clinical trials using bexarotene, a medication that significantly clears amyloid beta in mice.
Researchers from Case Western Reserve University found that emotional intelligence (EI) is a strong predictor of clinical performance in dental school. Students with high EI scores achieved better grades and demonstrated stronger communication skills in the clinic.
Researchers developed an efficient method of analyzing brain activity using magnetoencephalography (MEG) to detect autism in children. The approach showed significant differences in functional connectivity and background noise between autistic and non-autistic brains, with 94% accuracy.
Researchers at CWRU School of Medicine discover a technique to directly convert skin cells into myelinating brain cells, potentially treating multiple sclerosis and cerebral palsy. The new method enables rapid production of functional oligodendrocytes, which provide insulation for neurons.
Researchers at Case Western Reserve University developed a new material system that permits 3D patterning to regulate stem cell behavior, offering promise for studying influences on cell fate decisions. The technique enables local control over cell proliferation and differentiation, potentially allowing the engineering of complex tissues.
A recent CWRU study found that mothers with postpartum depression prefer online interventions for anonymous access to professional advice. The study also highlights the need for accessible resources to help new mothers cope with depression, which affects up to 15% of new mothers.
Researchers at Case Western Reserve University have created a material that mimics the squid's beak to make medical devices safer and more comfortable. The new material has a mechanical gradient that acts as a shock absorber, reducing wear and tear on surrounding soft tissues.
ConservoCare is developing a medical device to restore bladder function lost due to injury or illness. The device uses high-frequency electrical nerve stimulation to eliminate sphincter spasms and allow on-demand control of bladder function.