Researchers have discovered that the malaria-causing parasite Plasmodium vivax shares the same genetic variations despite being found on different continents. The sequencing of its genome could help understand how the parasite lives and causes malaria, and may lead to new treatments for drug-resistant strains.
A Case Western Reserve University study found that AA-related Helping activities significantly lower alcohol use and increase interest in others over time. Participation in these activities also correlates with increased step-work and meeting attendance, strengthening the commitment to the program.
The researchers successfully packaged siRNA in a hydrogel complex that can be injected into target tissues, allowing for prolonged control over cell behavior. The technology has the potential to guide stem cells to grow into desired cell types, starve tumors by blocking blood vessel growth, and induce cancer cell death.
A new study from Case Western Reserve University's School of Dental Medicine found that a mother's emotional health and education level during her child's earliest years influence their oral health at age 14. The study analyzed the teeth of 224 adolescent participants and discovered that mothers with higher education levels, healthy em...
Researchers at Case Western Reserve University developed synthetic platelets that double the survival rate of internal injury victims in the first hour after injection. The nanoparticles work by creating healthy clots and binding to natural platelets to form larger clots, reducing bleeding time.
Researchers at Case Western Reserve University have identified a new oncogene, FAM83B, which contributes to the development of breast cancer. Elevated expression of this gene is associated with the more aggressive triple-negative subgroup, highlighting the need for new therapeutic options.
Researchers have identified a new direction for cancer therapy by discovering a mutant form of the Chk1 gene that permanently stops cancer cell proliferation and causes cell death. This finding has the potential to reduce toxicity in cancer treatment, allowing physicians time to fix genetic errors.
A Case Western Reserve University researcher suggests that using platinum in fuel cells is inefficient due to energy loss, prompting the search for alternative catalysts. The ideal bonding strength between platinum and intermediate molecules can improve efficiency.
Researchers from Case Western Reserve University School of Medicine developed a mouse model that mimics the N48K mutation in Usher III, leading to understanding of how deafness occurs. This new model enables exploration of prospective therapeutics to rescue mutant protein localization and hearing.
A survey of 3,800 home healthcare providers found that many agencies lack written policies on handling infection control for antibiotic-resistant infections. The study highlights the need for simple and quick actions like hand washing, vaccinations, and patient isolation to decrease infections in home care settings.
Developing a reliable measure of mental illness stigma in adolescents is crucial for encouraging teens to seek help. A study published in the Journal of Nursing Measurement found that the Revised Attribution Questionnaire (r-AQ) can be considered reliable and valid for assessing stigma among this age group.
A research team at Case Western Reserve University discovered that gold catalysts in the form of a triangle or higher order structures can produce longer, faster-growing nanowires. These wires could be used to build next-generation invisible computer chips and highly-sensitive sensors.
The university's School of Medicine will train and place additional psychiatrists, primary care physicians, advance practice nurses, dentists, and other practitioners to serve Medicaid beneficiaries. The program aims to expand healthcare workforce focused on Medicaid patients' needs.
A team of researchers has discovered a novel combination of two previously approved FDA drugs that can be used to treat advanced/late stage lung cancer by activating key genes involved in the disease. The treatment targets a pathway to accelerate cancer diagnosis and treatment.
Engineers at Case Western Reserve University have developed integrated amplifier circuits that can operate under extreme temperatures, revolutionizing data collection in nuclear reactors and rocket engines. The silicon carbide amplifiers can improve signal strength and produce more reliable information.
A 23-year study found children's use of imagination in play increased over time, while comfort and engagement with play activities also rose. Additionally, children today expressed fewer negative emotions during play compared to previous generations.
A comprehensive review by Charlene Krejci found female hormones fluctuate throughout women's lives, allowing bacteria to grow and exacerbate conditions like bone loss and pre-term births. Women need to be vigilant about maintaining healthy teeth and gums to prevent or lessen severity of these health issues.
A Case Western Reserve University class has been awarded a Science magazine prize for its innovative approach to teaching biology and computer science. The 'Dynamics of Biological Systems' class uses an inquiry-based learning model, where students work on real-world problems using online interactive tools and mathematical models.
A substance in human mesenchymal stem cells promotes nerve restoration and myelin sheath repair in rodent models of multiple sclerosis. Hepatocyte growth factor, a key instigator, decreases inflammation and increases signaling molecules counteracting it, leading to neural cell growth and nerve rewinding.
Researchers discovered a causal link between chronic skin inflammation and cardiovascular disease, with aggressive reversal of psoriasis reducing the risk. A mouse model demonstrated that persistent inflammation leads to vessel wall inflammation and blood clot formation, which can increase stroke or heart attack risk.
Researchers at Case Western Reserve University have discovered a parallel between bacterial and human cell behavior, shedding light on potential treatments for diseases. The study found that nitric oxide plays a fundamental regulatory role in controlling bacterial function via S-nitrosylation.
Researchers found DNA links between oral bacteria and failed hip or knee replacements in a study of 36 patients. The study suggests that treating periodontal disease may reduce costly joint replacements.
Researchers at Case Western Reserve University have developed a magnetic nanochain delivery system that explodes chemotherapy drugs inside tumors, killing cancer cells more efficiently. The technology reduced tumor growth by up to 90% and increased survival rates in rats with triple-negative breast cancer.
Researchers at Case Western Reserve University identified a set of master switches, called Variant Enhancer Loci (VELs), that regulate key genes in colon cancer. VELs are epigenetic changes that can potentially be reversed and may play a role in determining individual susceptibility to colon cancer.
A new study finds that mothers of children with obsessive-compulsive disorder (OCD) are more critical than parents of other children, which can lead to poorer treatment outcomes. The research suggests that parental criticism is not a characteristic of the parent in general, but rather a specific response to their child's anxiety.
Researchers found that corneal thickening occurs in FECD patients before swelling is observed, necessitating regular monitoring and potential surgical intervention. The study's findings have the potential to improve patient care for Fuchs corneal dystrophy.
Case Western Reserve researchers identify Kruppel-like Factor 15 (KLF15) as a key player in the body's ability to burn fat during exercise, increasing muscle force production. The discovery sheds light on the molecular mechanisms behind exercise benefits and may lead to therapeutic strategies for metabolic disorders.
Case Western Reserve University has erected its third and largest wind turbine, a 1-megawatt utility-scale power generator, to provide working laboratories for researchers. The turbines are being used to develop better products and improve efficiency, with the ultimate goal of establishing a wind-energy supply chain in Northeast Ohio.
Researchers developed a brief survey to identify depressive thinking patterns that may lead to serious depression if not addressed early. A score of 7 on the Depression Cognition Scale (DCS) represents the point at which individuals should initiate strategies to change negative thoughts into positive ones.
A new method for mass-producing high-quality graphene nanosheets has been developed by researchers, enabling the production of sheets at a lower cost than current methods. The technique uses dry ice and an industrial process to create flakes of graphite with opened-up edges, making them soluble in solvents and allowing for easy separat...
A Case Western Reserve University psychology study found that being assertive with God can strengthen one's faith. The researchers discovered that if a person views God as cruel, protest towards God is seen as more acceptable.
A team of researchers at Case Western Reserve University has developed a novel technique called fine-grained power gating, which can eliminate wasted energy in computer processors. This method reduces power consumption by up to 40% and also minimizes heat production, resulting in significant cost savings.
A team of researchers at Case Western Reserve University School of Medicine has developed a new theranostic agent for the treatment of acute lymphoblastic leukemia (ALL). The agent combines a diagnostic test with targeted therapy to provide personalized treatments for pediatric leukemia.
Researchers discovered that a precise 24-hour rhythm, known as circadian rhythm, controls nitrogen balance in mammals. Disruptions can lead to life-altering diseases, including diabetes and cardiovascular disease.
A new study from Case Western Reserve University highlights the importance of discussing quality of life with critically ill patients. The researchers found that many family meetings lacked essential information about a patient's desired quality of life, making it difficult for decision-makers to make informed choices.
A new study published in Neurotoxicology and Teratology found that prenatal exposure to ecstasy can lead to developmental delays, poorer motor skills, and increased social problems in infants. The study compared infants exposed to ecstasy with those not exposed and found significant differences in their growth and cognitive development.
Researchers discovered that heavier isotopes separate from lighter isotopes as magma cools down due to their greater mass and momentum. This separation, called fractionation, can provide insights into the formation of igneous rocks.
Researchers at Case Western Reserve University School of Medicine discovered a novel genetic factor linking the body's natural circadian rhythm to heart electrical activity. This discovery provides insights into day-night variation in arrhythmia susceptibility and may lead to innovative approaches for diagnosis, prognosis, and treatment.
Researchers discover bexarotene rapidly clears amyloid from the brain and reverses cognitive deficits in mouse models of Alzheimer's disease. The results show significant promise for a new therapy, with more than half of amyloid plaques cleared within 72 hours.
The Cleveland Traumatic Neuromechanics Consortium (TNC) will investigate and develop better protection and treatment strategies for head, neck and spinal injuries. The center will combine engineering and clinical expertise from both institutions to make a significant positive difference in people's lives.
A new study from Case Western Reserve University found that people-pleasers often eat more in social situations to avoid upsetting others. This behavior can lead to regret and emotional distress, as individuals feel intense pressure to match the eating habits of those around them.
A study found no significant difference in length of stay between safety-net and non-safety-net hospitals. To improve patient outcomes, quality improvement initiatives should focus on changes within and outside the department, along with supplying necessary resources.
A CWRU study reveals that pet ownership helps women manage their HIV/AIDS through social roles such as advocate, pet owner, and faith believer. The research highlights the importance of these lesser-known roles in self-management behavior.
A new study reveals that inmates with severe mental illnesses have lower recidivism rates than those with substance abuse issues or no diagnosis. The research, published in the International Journal of Law and Psychiatry, found that those with mental illnesses alone had better outcomes even compared to those with no problems.
Researchers at Case Western Reserve University developed an implantable biofuel cell that converts a cockroach's internal chemicals into electricity. The device can provide enough power to control the bug or transmit sensor data, and has shown promise for long-term use without harming the insect.
A recent study by researchers at Case Western Reserve University found that mothers who successfully integrate the care of their technology-dependent child into family life experience improved family functioning and normalcy. Mothers whose children no longer require technologies showed the greatest improvement.
Researchers at Case Western Reserve University have identified a gene activator, Mef2, crucial to the development of schistosomes in humans. The discovery provides a potential target for a vaccine to prevent the disease, which affects over 200 million people worldwide.
Researchers found that high-contrast bingo cards enhance thinking and playing skills for individuals with cognitive difficulties and visual perception problems caused by dementia. Boosting contrast also enables people with dementia to move safely around their homes and improve eating habits.
Researchers at Case Western Reserve University School of Medicine received a $6.75 million grant to investigate the role of innate immunity in inflammatory bowel disease (IBD). They discovered a deficit in infection-fighting cells, leading to a buildup of harmful agents in the body.
CLiPS program, led by Case Western Reserve University, receives $40 million NSF funding renewal for its transformative polymer research and educational programs. The program supports underrepresented students in STEM careers through the Polymer Envoys program.